Ligand (R)-malic acid

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Basic Ligand Information

Molecular Structure
Picture of (R)-malic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O5
(R)-malic acid
BJEPYKJPYRNKOW-UWTATZPHSA-N
Synonyms:
(2R)-2-hydroxybutanedioic acid, (R)-malate, D-(+)-malate, D-(+)-malic acid, D-malate, D-malic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
maleate + H2O = (R)-malate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
-
D-malate + NAD+ = pyruvate + NADH + CO2
show the reaction diagram
-
D-malate + acceptor = oxaloacetate + reduced acceptor
show the reaction diagram
-
D-malic acid + NADPH + ATP = ? + NADP+ + AMP + phosphate
show the reaction diagram
-
succinyl-CoA + (R)-malate = succinate + (R)-malyl-CoA
show the reaction diagram
-
D-malate = D-lactate + CO2
show the reaction diagram
-
D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
-
(R)-malate = glyoxylate + acetate
show the reaction diagram
-
(R)-malate = ?
show the reaction diagram
-
D-malate = ?
show the reaction diagram
-
ATP + D-malate + CoA = ADP + phosphate + D-malyl-CoA
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-malyl-CoA + H2O = (R)-malate + CoA
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
107% activity at 10 mM
-
0.025 - 0.050 mM
-

Inhibitor in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
inhibition only in absence of AMP
-
competitive versus L-tartrate and meso-tartate
-
competitive inhibitor
-
10 mM, 83% inhibition
-
K-salt of
-

3D Structure of Enzyme-Ligand-Complex (PDB) (68 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
13.3
-
-
0.283
-
-
0.00001
-
smaller than 0.00001 s-1

KM Value (25 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.5
-
-
8.3
-
pH 4.5, 25°C, activity of cell extract

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
215
-
-
5
-
Ki above 5 mM; larger than 5 mM
2.5
-
-

References & Links

Links to other databases for (R)-malic acid

ChEBI
PubChem
ChEBI
PubChem