Ligand L-homoserine

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Basic Ligand Information

Molecular Structure
Picture of L-homoserine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO3
L-homoserine
UKAUYVFTDYCKQA-VKHMYHEASA-N
Synonyms:
(S)-homoserine, L-hSer


Show all pahtways known for Show all BRENDA pathways known for L-homoserine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
show the reaction diagram
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ATP + L-homoserine = ADP + O-phospho-L-homoserine
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + H2O = methylthioadenosine + L-homoserine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (89 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-homoserine + H2O + NAD+ = 4-hydroxy-2-oxobutanoate + NH3 + NADH
show the reaction diagram
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L-homoserine + H2O + NAD+ = 4-hydroxy-2-oxobutanoate + NH3 + NADH
show the reaction diagram
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L-homoserine + H2O + O2 = 2-oxo-4-hydroxybutyric acid + NH3 + H2O2
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S-adenosyl-L-methionine + L-homoserine = ?
show the reaction diagram
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oxalyl-CoA + L-homoserine = ?
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L-homoserine + sulfide = ?
show the reaction diagram
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L-homoserine + glyoxylate = 4-hydroxy-2-oxobutanoate + glycine
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L-aspartate 4-semialdehyde + L-homoserine = L-2,4-diaminobutanoate + 4-hydroxy-2-oxobutanoic acid
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L-homoserine = 2-oxobutanoate + NH3 + H2O
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ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-homoserine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-homoserine
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ATP + L-Glu + L-homoserine = ADP + phosphate + gamma-L-Glu-L-homoserine
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Product in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-homoserine lactone + H2O = L-homoserine
show the reaction diagram
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L-hSer-7-amido-4-carbamoylmethylcoumarin + H2O = L-hSer + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
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-
L-cystathionine = L-homoserine + L-cysteine
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Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-
competitive inhibitor with respect to both ammonia and glutamine
-
40 mM, weak inhibition
-
27-34% inhibition of the reaction
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1 mM, 13% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (38 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.4
-
-

KM Value (94 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10.4
-
-
1.4
-
cosubstrate phenylpyruvate
12.5
-
-
171
-
pH 8.5, 37°C, recombinant enzyme

Ki Value (11 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.1
-
pH 8.0, 25°C, recombinant detagged enzyme
1.32
-
pH 6.8, 37 C
16
-
-
7.7
-
pH 8.0, 25°C, aspartokinase III

References & Links

Links to other databases for L-homoserine

ChEBI
PubChem
ChEBI
PubChem