Ligand D-glutamic acid

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Basic Ligand Information

Molecular Structure
Picture of D-glutamic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO4
D-glutamic acid
WHUUTDBJXJRKMK-GSVOUGTGSA-N
Synonyms:
(2R)-2-aminopentanedioic acid, D-Glu, D-glutamate


Show all pahtways known for Show all BRENDA pathways known for D-glutamic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glutamic acid + H2O + O2 = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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D-glutamate + H2O + O2 = ?
show the reaction diagram
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D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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ATP + UDP-N-acetylmuramyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
poly(gamma-glutamic acid) + H2O = D-Glu + L-Glu
show the reaction diagram
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-
D-alanine + 2-oxoglutarate = pyruvate + D-glutamate
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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N-acetyl-D-glutamate + H2O = acetate + D-glutamate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (67 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glutamic acid + H2O + O2 = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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D-glutamate + H2O + O2 = ?
show the reaction diagram
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D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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D-Glu + H2O + oxidized 2,6-dichlorophenolindophenol = 2-oxoglutarate + NH3 + reduced 2,6-dichlorophenolindophenol
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D-glutamate + oxidized 2,6-dichloroindophenol + H2O = 2-oxo-glutarate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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L-glutamine + D-glutamic acid = NH3 + gamma-L-glutamyl-D-glutamate
show the reaction diagram
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D-glutamate + 2-oxoadipate = 2-oxoglutarate + 2-aminoadipate
show the reaction diagram
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ATP + UDP-MurNAc-L-Ala-D-Glu + D-Glu = ?
show the reaction diagram
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ATP + D-Glu = ADP + phosphate + D-Glu-D-Glu
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Product in Enzyme-catalyzed Reactions (72 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
poly(gamma-glutamic acid) + H2O = D-Glu + L-Glu
show the reaction diagram
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cephalosporin C + 2-oxoglutarate = 7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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D-glutamine amide + H2O = D-glutamic acid + NH3
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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N-carbamoyl-D-Glu + H2O = D-Glu + NH3 + CO2
show the reaction diagram
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N-acetyl-D-glutamate + H2O = acetate + D-glutamate
show the reaction diagram
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D-glutamyl-7-aminocephalosporanic acid + H2O = 7-aminocephalosporanic acid + D-glutamate
show the reaction diagram
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5-oxo-D-proline + H2O = D-glutamate
show the reaction diagram
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L-Glu = D-Glu
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate activation at D-glutamate concentrations above 4 mM
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activation and induction
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activates
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Inhibitor in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
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0.015 mM, 47% inhibition
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competitive to D-alanine, noncompetitive to 2-oxoglutarate
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slight inhibition
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10 mM, 54% inhibition
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D-Glu (in the absence of 2-oxoacids) inhibits the aminodeoxychorismate lyase activity of the enzyme
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3D Structure of Enzyme-Ligand-Complex (PDB) (67 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (66 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0833
-
-
35.6
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pH 8.0, 37°C

KM Value (101 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
9
-
pH 8.0, 37°C

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.6
-
-

References & Links

Links to other databases for D-glutamic acid

ChEBI
PubChem
ChEBI
PubChem