Ligand sisomycin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of sisomycin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H37N5O7
sisomycin
URWAJWIAIPFPJE-YFMIWBNJSA-N
Synonyms:
sisomicin

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + sisomicin = CoA + N3'-acetylsisomicin
show the reaction diagram
-
GTP + sisomicin = GDP + sisomicin 2''-phosphate
show the reaction diagram
-
ATP + sisomicin = diphosphate + 2''-adenylylsisomicin
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 45% residual activity at 1 mM
-
pH-dependent inhibition, non-competitive inhibitor for ATP
-
uncompetitive substrate inhibition
-
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants
-

3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.063
-
pH 6.0, 37C
10217
0.154
-
-
16221

References & Links

Links to other databases for sisomycin

ChEBI
PubChem
ChEBI
PubChem