Ligand FMNH2

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Basic Ligand Information

Molecular Structure
Picture of FMNH2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H23N4O9P
FMNH2
NKWXLUHTIUGLRF-PEZGSVAQSA-N
Synonyms:
6,7-dimethyl-9-(1'-D-ribityl)-2-iminoisoalloxazine 5'-phosphate, FMNH, FMNH-, reduced FMN


Show all pahtways known for Show all BRENDA pathways known for FMNH2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
nitrilotriacetate + FMNH2 + H+ + O2 = iminodiacetate + glyoxylate + FMN + H2O
show the reaction diagram
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dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2 = 2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
show the reaction diagram
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a long-chain alkane + FMNH2 + O2 = a long-chain primary alcohol + FMN + H2O
show the reaction diagram
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2-methylpropanamine + FMNH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FMN + H2O
show the reaction diagram
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ethylenediaminetetraacetate + 2 FMNH2 + 2 O2 = ethylenediamine-N,N'-diacetate + 2 glyoxylate + 2 FMN + 2 H2O
show the reaction diagram
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dimethyl sulfone + FMNH2 + O2 = methanesulfinate + formaldehyde + FMN + H2O
show the reaction diagram
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FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NAD+ = FMN + NADH + H+
show the reaction diagram
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7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN
show the reaction diagram
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sulfite + 3 FMNH2 = sulfide + 3 FMN + 3 H2O
show the reaction diagram
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dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 cob(II)yrinic acid a,c-diamide + FMN = cob(I)yrinic acid a,c-diamide + FMNH2
show the reaction diagram
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L-dihydroorotate + FMN = orotate + FMNH2
show the reaction diagram
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2-amino-2-deoxyisochorismate + FMN = 3-enolpyruvoylanthranilate + FMNH2
show the reaction diagram
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FMN + NADPH + H+ = FMNH2 + NADP+
show the reaction diagram
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FMN + NAD(P)H = FMNH2 + NAD(P)+
show the reaction diagram
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trimethylamine + H2O + FMN = dimethylamine + formaldehyde + FMNH2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (188 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
long-chain aldehyde + FMNH2 + O2 = long-chain fatty acid + FMN + H2O + hv
show the reaction diagram
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phenol + FMNH2 + O2 = catechol + FMN + H2O
show the reaction diagram
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2-methylpropanamine + FMNH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FMN + H2O
show the reaction diagram
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dimethyl sulfone + FMNH2 + O2 = methanesulfinate + formaldehyde + FMN + H2O
show the reaction diagram
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FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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FMNH2 + NAD+ = FMN + NADH + H+
show the reaction diagram
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7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN
show the reaction diagram
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FMNH2 + nitrate = FMN + nitrite
show the reaction diagram
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nitrite + FMNH2 = NH4+ + FMN
show the reaction diagram
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5,10-methylenetetrahydrofolate + dUMP + FMNH2 = dTMP + tetrahydrofolate + FMN
show the reaction diagram
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dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (45 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xanthine + FMN + H2O = urate + FMNH2
show the reaction diagram
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formate + FMN = CO2 + FMNH2
show the reaction diagram
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formate + FMN = CO2 + FMNH2
show the reaction diagram
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formate + FMN = CO2 + FMNH2
show the reaction diagram
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FMN + NADPH + H+ = reduced FMN + NADP+
show the reaction diagram
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FMN + NADH = FMNH2 + NAD+
show the reaction diagram
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phenylglyoxylate + FMN + CoA-SH = benzoyl-S-CoA + CO2 + FMNH
show the reaction diagram
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4-hydroxybenzaldehyde + FMN + H2O = 4-hydroxybenzoate + FMNH2 + ?
show the reaction diagram
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pyruvate + CoA + FMN = acetyl-CoA + CO2 + FMNH + H+
show the reaction diagram
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oxalate + FMN = CO2 + FMNH2
show the reaction diagram
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CO + H2O + FMN = CO2 + FMNH2
show the reaction diagram
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L-dihydroorotate + FMN = orotate + FMNH2
show the reaction diagram
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2-amino-2-deoxyisochorismate + FMN = 3-enolpyruvoylanthranilate + FMNH2
show the reaction diagram
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FMN + NADH + H+ = FMNH2 + NAD+
show the reaction diagram
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FMN + NADPH + H+ = FMNH2 + NADP+
show the reaction diagram
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trimethylamine + H2O + FMN = dimethylamine + formaldehyde + FMNH2
show the reaction diagram
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ATP + 6,7-dimethyl-9-(1'-D-ribityl)-2-iminoisoalloxazine = ADP + 6,7-dimethyl-9-(1'-D-ribityl)-2-iminoisoalloxazine 5'-phosphate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (47 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
4-5-fold higher activity than acitivity with methylene blue as the electron donor
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the enzyme can use FADH or FMNH2 as flavin cofactor
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luciferase
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can donate electrons directly to adenylyl sulfate reductase
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can substitute for FADH2, with about 60% loss effectivity
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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slightly stimulatory in combination with NADH
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.018
-
pH 7.5, 22C

KM Value (46 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.064
-
pH 7.5, 22C
3
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+ nitrate

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.231
-
pH 7.5, 22C

References & Links

Links to other databases for FMNH2

ChEBI
PubChem
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PubChem