Ligand mesaconic acid

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Basic Ligand Information

Molecular Structure
Picture of mesaconic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O4
mesaconic acid
HNEGQIOMVPPMNR-NSCUHMNNSA-N
Synonyms:
(2E)-2-methylbut-2-enedioate, (2E)-2-methylbut-2-enedioic acid, 2-methylfumarate, 2-methylfumaric acid, mesaconate, methylfumarate


Show all pahtways known for Show all BRENDA pathways known for mesaconic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
show the reaction diagram
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mesaconate + NADH = methylsuccinate + NAD+
show the reaction diagram
-
L-dihydroorotate + mesaconate = orotate + 2-methylbutanedioate
show the reaction diagram
-
mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-citramalate = mesaconate + H2O
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition with and without preincubation
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
12.2
-
37°C, pH 7.8

KM Value (28 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.4
-
-

References & Links

Links to other databases for mesaconic acid

ChEBI
PubChem
ChEBI
PubChem