Ligand 5beta-cholestane-3alpha,7alpha,12alpha-triol

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Basic Ligand Information

Molecular Structure
Picture of 5beta-cholestane-3alpha,7alpha,12alpha-triol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H48O3
5beta-cholestane-3alpha,7alpha,12alpha-triol
RIVQQZVHIVNQFH-XJZYBRFWSA-N
Synonyms:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane, 5beta-cholestan-3alpha,7alpha,12alpha-triol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+ = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+
show the reaction diagram
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5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+ = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.066 mM, 62% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 5beta-cholestane-3alpha,7alpha,12alpha-triol

ChEBI
PubChem
ChEBI
PubChem