Ligand (S)-scoulerine

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Basic Ligand Information

Molecular Structure
Picture of (S)-scoulerine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H21NO4
(S)-scoulerine
KNWVMRVOBAFFMH-HNNXBMFYSA-N
Synonyms:
(-)-scoulerine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-scoulerine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-nandinine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
(S)-scoulerine + NADPH + H+ + O2 = (S)-cheilanthifoline + NADP+ + 2 H2O
show the reaction diagram
-
(S)-scoulerine + O2 = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-reticuline + O2 = (S)-scoulerine + H2O2
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-scoulerine + 2-oxoglutarate + O2 = ?
show the reaction diagram
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(S)-scoulerine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-nandinine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
(S)-scoulerine + NADPH + H+ + O2 = nandinine + ?
show the reaction diagram
-
(S)-scoulerine + NADPH + H+ + O2 = (S)-cheilanthifoline + NADP+ + 2 H2O
show the reaction diagram
-
(S)-scoulerine + H2O2 = (S)-reticuline + O2
show the reaction diagram
(S)-scoulerine + O2 = ?
show the reaction diagram
-
S-Adenosyl-L-methionine + (S)-scoulerine = S-Adenosyl-L-homocysteine + jatrorrhizine
show the reaction diagram
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S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + N-methyl-(S)-scoulerine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-Adenosylmethionine + (S)-norreticuline = S-Adenosylhomocysteine + (S)-scoulerine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition comparable to camptothecin
-

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0025
-
-

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00054
-
CYP719A3 variant, determined with HPLC
0.00054
-
microsomal protein, pH 7.6, 30°C
0.035
-
-
0.146
-
pH 8.8, 37°C

References & Links

Links to other databases for (S)-scoulerine

ChEBI
PubChem
ChEBI
PubChem