Ligand D-ribofuranose

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Basic Ligand Information

Molecular Structure
Picture of D-ribofuranose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10O5
D-ribofuranose
HMFHBZSHGGEWLO-SOOFDHNKSA-N
Synonyms:
D-ribose, D-ribose[side 2], ribose


Show all pahtways known for Show all BRENDA pathways known for D-ribofuranose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-ribose + NAD+ = ? + NADH
show the reaction diagram
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D-ribose + ferricenium ion = ? + ferrocene
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ATP + D-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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D-Ribose = D-Ribulose
show the reaction diagram
ATP + H2O + D-ribose/out = ADP + phosphate + D-ribose/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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1-methyladenosine + H2O = 1-methyladenine + D-ribose
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beta-nicotinamide D-riboside + H2O = D-ribose + nicotinamide
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inosine + H2O = hypoxanthine + D-ribose
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7-methylxanthosine + H2O = 7-methylxanthine + D-ribose
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adenosine + H2O = 6-aminopurine + D-ribofuranose
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D-arabinose = D-ribose
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Substrate in Enzyme-catalyzed Reactions (74 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-ribose + NADP+ + H2O = D-ribonate + NADPH
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D-ribose + NAD+ = D-ribono-1,4-lactone + NADH
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D-ribose + NADP+ = ? + NADPH
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D-ribose + NADP+ = ? + NADPH
show the reaction diagram
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D-ribose + NAD+ = ? + NADH
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ribose + NADPH + H+ = ribitol + NADP+
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D-ribose + NADH = ?
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D-ribose + NADPH = ? + NADP+
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D-ribose + NADP+ = ? + NADPH + H+
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D-ribose + NADP+ = D-ribonolactone + NADPH
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D-ribose + O2 = ? + H2O2
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D-ribose + NADP+ = ?
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D-xylulose 5-phosphate + D-ribose = glyceraldehyde 3-phosphate + sedoheptulose
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UDP-alpha-D-glucose + D-ribose = ?
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soluble starch + ribose = ?
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ATP + D-ribose = ADP + D-ribose 1-phosphate
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ATP + ribose = ADP + ribose 1-phosphate
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ATP + D-ribose = ADP + D-ribose 5-phosphate
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ATP + D-ribose = ?
show the reaction diagram
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ATP + D-ribose = ?
show the reaction diagram
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ATP + D-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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ATP + D-ribose = ?
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D-Ribose = D-Ribulose
show the reaction diagram
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D-Ribose = D-Ribulose
show the reaction diagram
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D-Ribose = ?
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D-Ribose = D-Ribulose
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D-Ribose = D-Ribulose
show the reaction diagram
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ATP + H2O + D-ribose/out = ADP + phosphate + D-ribose/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (165 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ribitol + NADP+ = D-ribose + NADPH
show the reaction diagram
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sedoheptulose 7-phosphate + formaldehyde = dihydroxyacetone + ribose
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D-glucose + D-ribose 5-phosphate = D-glucose 6-phosphate + D-ribose
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
-
D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
-
D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
-
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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1-methyladenosine + H2O = 1-methyladenine + D-ribose
show the reaction diagram
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beta-nicotinamide D-riboside + H2O = D-ribose + nicotinamide
show the reaction diagram
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adenosine + H2O = adenine + D-ribose
show the reaction diagram
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adenosine + H2O = adenine + D-ribose
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adenosine + H2O = adenine + D-ribose
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adenosine + H2O = adenine + D-ribose
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D-ribulose = D-ribose
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D-arabinose = D-ribose
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L-arabinose = D-ribose
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D-ribulose = D-ribose
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates isoenzyme Hex II
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Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
incubation of Aspergillus niger glucose oxidase with 1 mM ribose for up to 8 days results in 96% loss in activity
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0.4 M, 59% inhibition
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substrate inhibition
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weak
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formation of a Schiff base with the critical lysine residue of the enzyme is involved in inhibition of the enzyme by hexoses and pentoses
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (37 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
17.7
-
pH 7.5, 80°C
0.38
-
with 1,4-benzoquinone as electron acceptor, at pH 6.5 and 37°C
5.1
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at pH 7.5 and 85°C
0.515
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30°C
72
-
pH 7.5, 40°C, recombinant enzyme

KM Value (79 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
670
-
-
212
-
pH 7.5, 37°C
333
-
-
111
-
AR2
180
-
with 1,4-benzoquinone as electron acceptor, at pH 6.5 and 37°C
71.5
-
-
230
-
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4.8
-
pH 8.0, 25°C
5
-
pH 6.7, 85°C
951
-
at pH 7.5 and 85°C
110
-
pH 7.5, 40°C, recombinant enzyme

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
8.74
-
pH 7.2, 37°C
37
-
pH 7.4, 25°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
95
-
pH 7.8, 40°C

References & Links

Links to other databases for D-ribofuranose

ChEBI
PubChem
ChEBI
PubChem