Ligand (+)-citramalate

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Basic Ligand Information

Molecular Structure
Picture of (+)-citramalate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H8O5
(+)-citramalate
XFTRTWQBIOMVPK-YFKPBYRVSA-L
Synonyms:
(2S)-2-hydroxy-2-methylbutanedioate, (2S)-2-methyl malate, (2S)-methylmalate, (3S)-citramalate, (L)-citramalate, (S)-2-methylmalate, (S)-citramalate, L-citramalate, S-citramalate


Show all pahtways known for Show all BRENDA pathways known for (+)-citramalate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + pyruvate + H2O = CoA + (2S)-2-hydroxy-2-methylbutanedioate
show the reaction diagram
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acetate + pyruvate = (+)-citramalate
show the reaction diagram
-
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
show the reaction diagram
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succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA
show the reaction diagram
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(2S)-2-methyl malate = pyruvate + acetate
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(2S)-methylmalate = ?
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(S)-citramalate = mesaconate + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetate + pyruvate = (+)-citramalate
show the reaction diagram
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-
-
mesaconate + H2O = (S)-citramalate
show the reaction diagram
-
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.00001
-
smaller than 0.00001 s-1

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.1
-
55°C, pH not specified in the publication, recombinant enzyme

References & Links

Links to other databases for (+)-citramalate

ChEBI
PubChem
ChEBI
PubChem