Ligand gentamicin

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Basic Ligand Information

Molecular Structure
Picture of gentamicin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H43N5O7
gentamicin
CEAZRRDELHUEMR-GHFPSGLISA-N
Synonyms:
gentamycin

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + gentamicin = ADP + gentamicin 2''-phosphate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces lon protease by subinhibitory concentrations
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces nonsense suppression
-
substrate inhibition
-
the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration
-
slight inhibition of purified elastase
-
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.16
-
-

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
36.6
-
-
0.0021
-
at pH 7.4 and 25C

References & Links

Links to other databases for gentamicin

ChEBI
PubChem
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PubChem