Ligand resorcinol

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Basic Ligand Information

Molecular Structure
Picture of resorcinol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6O2
resorcinol
GHMLBKRAJCXXBS-UHFFFAOYSA-N
Synonyms:
1,3-dihydroxybenzene, 1,3-dihydroxy benzene, 3-hydroxyphenol, benzene-1,3-diol, resorcine


Show all pahtways known for Show all BRENDA pathways known for resorcinol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O
show the reaction diagram
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resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O
show the reaction diagram
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resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O
show the reaction diagram
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1,3-dihydroxybenzene + CO2 = 2,6-dihydroxybenzoate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O
show the reaction diagram
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resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O
show the reaction diagram
-
resorcinol + NADH + O2 = hydroxyquinol + NAD+ + H2O
show the reaction diagram
-
resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O
show the reaction diagram
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resorcinol + O2 = ?
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1,2,3,5-tetrahydroxybenzene + resorcinol = phloroglucinol + hydroxyhydroquinone
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2,4-diacetylphloroglucinol + resorcinol = ?
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resorcinol + H2O = ?
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resorcinol + pyruvate + NH3 = 2,4-dihydroxyphenyl-L-Ala
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
m-hydroxybenzoate + NADH + O2 = 1,3-dihydroxybenzene + CO2 + NAD+ + H2O
show the reaction diagram
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resorcinol sulfate + H2O = resorcinol + sulfate
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2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2
show the reaction diagram
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2,4-dihydroxybenzoate = 3-hydroxyphenol + CO2
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3,5-Dihydroxybenzoate = 1,3-Dihydroxybenzene + CO2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak inhibition
-
10 mM, 40% inhibition
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0.2 mM, 99% inhibition; 0.2 mM, 99% inhibition
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competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+
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51% inhibition at 0.1 mM, reversible inhibitor
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substrate inhibition
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0.25 mM, 27% inhibition
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complete inhibition of the reaction of hydroxyhydroquinone with itself
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1 mM, 50% inhibition of phosphorylase A and B, 23% inhibition of phosphorylase C
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competitive
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potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview
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cleavage of Tyr
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
18.34
-
pH 7.0, 25°C
0.571
-
30°C, pH not specified in the publication

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.46
-
pH 7.0, 25°C
0.77
-
at pH 7.0 and 25°C

Ki Value (11 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10.2
-
-
1.8
-
-
0.00000872
-
pH 8.0, 37°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for resorcinol

ChEBI
PubChem
ChEBI
PubChem