Ligand TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose

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Basic Ligand Information

Molecular Structure
Picture of TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H31N3O13P2
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose
FFPCARSBUVGIOB-BKRCCOPCSA-N
Synonyms:
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose, dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-xylo-hexopyranose, dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose, dTDP-D-desosamine, dTDP-D-desosaminose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B = dTDP + erythromycin D
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tylactone + dTDP-D-desosaminose = dTDP + 5-O-desosaminyl-tylactone
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-xylo-hexopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-xylo-hexopyranose
show the reaction diagram
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.7
-
pH 8.0, 25°C, in the presence og 0.001 mM EryC and 1 mM of each substrate, more than 300 turnovers are observed in 2.5 min, indicating that the kcat must be greater than 100/min. This is one of the highest turnover numbers reported for an antibiotic glycosyl transferase

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose

ChEBI
PubChem
ChEBI
PubChem