Ligand coenzyme F420

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Basic Ligand Information

Molecular Structure
Picture of coenzyme F420 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C29H36N5O18P
coenzyme F420
GEHSZWRGPHDXJO-NALJQGANSA-N
Synonyms:
coenzyme F-420, coenzyme SF420, factor gamma-F420-2, oxidized coenzyme F420, oxidized F420

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420
show the reaction diagram
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formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420
show the reaction diagram
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biliverdin + coenzyme F420 + H+ = bilirubin + reduced coenzyme F420
show the reaction diagram
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coenzyme F420 + NADPH + H+ = reduced coenzyme F420 + NADP+
show the reaction diagram
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+ = reduced coenzyme F420 + 2 oxidized ferredoxin
show the reaction diagram
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5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
show the reaction diagram
oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoBS
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
menaquinone + reduced coenzyme F420 = menaquinol + oxidized coenzyme F420
show the reaction diagram
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2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O
show the reaction diagram
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5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 = 5,10-methylenetetrahydromethanopterin + coenzyme F420
show the reaction diagram
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reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine
show the reaction diagram
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N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2 = coenzyme B + coenzyme M + coenzyme F420
show the reaction diagram
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sulfite + reduced coenzyme F420 = hydrogen sulfide + oxidized coenzyme F420
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420
show the reaction diagram
-
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420
show the reaction diagram
-
CO + H2O + coenzyme F420 = CO2 + reduced coenzyme F420
show the reaction diagram
-
biliverdin + coenzyme F420 + H+ = bilirubin + reduced coenzyme F420
show the reaction diagram
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tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420
show the reaction diagram
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oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+ = reduced coenzyme F420 + 2 oxidized ferredoxin
show the reaction diagram
-
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
show the reaction diagram
coenzyme B + coenzyme M + reduced ferredoxin + H+ + coenzyme F420 = coenzyme B-coenzyme M disulfide + ferredoxin + H2 + reduced coenzyme F420
show the reaction diagram
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoBS
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3-dimethyl-1,4-naphthoquinone + reduced coenzyme F420 = 2,3-dimethyl-1,4-naphthoquinol + oxidized coenzyme F420
show the reaction diagram
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2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O
show the reaction diagram
-
-
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 = 5,10-methylenetetrahydromethanopterin + coenzyme F420
show the reaction diagram
-
sulfite + reduced F420 = sulfide + oxidized F420
show the reaction diagram
-
-
sulfite + reduced coenzyme F420 = sulfide + oxidized coenzyme F420
show the reaction diagram
-
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N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2 = coenzyme B + coenzyme M + coenzyme F420
show the reaction diagram
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sulfite + reduced coenzyme F420 = hydrogen sulfide + oxidized coenzyme F420
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the reaction is dependent on the cofactor F420
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enzyme system is stimulated
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3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
85
-
pH 5.8, 37°C

KM Value (38 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
pH 5.8, 37°C
0.006
-
pH 7.5, temperature not specified in the publication
0.002
-
pH 7.0, temperature not specified in the publication

References & Links

Links to other databases for coenzyme F420

ChEBI
PubChem
ChEBI
PubChem