Ligand TSAVLQSGFRK-NH2
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Basic Ligand Information
Molecular Structure
C52H89N17O15
TSAVLQSGFRK-NH2
DJXUDPXHZBYWEX-OBIVOGKVSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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TSAVLQSGFRK-NH2 + H2O = TSAVLQ + SGFRK-NH2
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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12.2
-
pH 7.3, room temperature
4753
-
pH 7.5, 37°C, mutant enzyme R188I
KM Value (2 results)
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0.0338
-
pH 7.5, 37°C, mutant enzyme R188I
1.15
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pH 7.3, room temperature
References & Links
Literature References (3)
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Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase
2006
Lai, L.; Han, X.; Chen, H.; Wei, P.; Huang, C.; Liu, S.; Fan, K.; Zhou, L.; Liu, Z.; Pei, J.; Liu, Y.
Curr. Pharm. Des.
12
4555-4564
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
2004
Fan, K.; Wei, P.; Feng, Q.; Chen, S.; Huang, C.; Ma, L.; Lai, B.; Pei, J.; Liu, Y.; Chen, J.; Lai, L.J.
Biol. Chem.
279
1637-1642
Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
2008
Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Saito, H.; Nosaka, K.
Bioorg. Med. Chem.
16
9400-9408
Links to other databases for TSAVLQSGFRK-NH2
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