Ligand D-cysteine

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Basic Ligand Information

Molecular Structure
Picture of D-cysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7NO2S
D-cysteine
XUJNEKJLAYXESH-UWTATZPHSA-N
Synonyms:
D-Cys
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for D-cysteine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-cysteine + H2O + O2 = 2-oxo-3-thiopropionic acid + NH3 + H2O2
show the reaction diagram
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acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine
show the reaction diagram
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D-cysteine + H2O = sulfide + NH3 + pyruvate
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-cysteine + oxidized acceptor = ? + NH3 + reduced acceptor
show the reaction diagram
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D-cysteine + H2O + methylene blue = 3-mercapto-2-oxopropanoate + NH3 + reduced methylene blue
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acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine
show the reaction diagram
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D-cysteine + H2O = sulfide + NH3 + pyruvate
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D-cysteine = ?
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D-Cys + H2O = ?
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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ATP + L-Glu + D-Cys = ADP + phosphate + gamma-L-Glu-D-Cys
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-cystine + 2 GSH = 2 D-cysteine + GSSG
show the reaction diagram
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O-acetyl-D-serine + sulfide = D-cysteine + ?
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine
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increase of product formation
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stimulation, 135% of non-stimulated activity
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1 mM, 150% of initial activity
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at pH 8.2-8.4 as effective as L-Cys
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Inhibitor in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive against L-serine, noncompetitive against NADP+
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2 mM, 8% residual activity
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inhibition of gamma-elimination
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0.1 mM, 60% inhibition
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10 mM
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in the presence of Cd2+
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2 mM, 72% residual activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (7 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
5950
-
pH 7.5, 20C
654
-
double mutant Pseudomonas putida E295S+L322T

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
21.41
-
-
1.55
-
pH 7.5, 20C
0.34
-
double mutant Pseudomonas putida E295S+L322T
5.3
-
-
0.18
-
-

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.24
-
-

References & Links

Links to other databases for D-cysteine

ChEBI
PubChem
ChEBI
PubChem