Ligand 3-hydroxy-3-methylglutaryl-CoA

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Basic Ligand Information

Molecular Structure
Picture of 3-hydroxy-3-methylglutaryl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H44N7O20P3S
3-hydroxy-3-methylglutaryl-CoA
CABVTRNMFUVUDM-SJBCKIPMSA-N
Synonyms:
(R,S)-3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-methyl-glutaryl-CoA, 3-hydroxy-3-methylglutarate-CoA, 3-hydroxy-3-methyl glutaryl-CoA, 3-hydroxy-3-methylglutaryl CoA, 3-hydroxy 3-methylglutaryl CoA, beta-hydroxy-beta-methylglutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, DL-3-methylglutaryl-CoA, hydroxymethylglutaryl-CoA, R,S-3-hydroxy-3-methylglutaryl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ = mevalonate + CoA + NAD+
show the reaction diagram
-
hydroxymethylglutaryl-CoA + H2O = hydroxymethylglutarate + CoA
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
show the reaction diagram
-
-
succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxy-3-methylglutaryl-CoA + L-carnitine = 3-hydroxy-3-methylglutaryl-L-carnitine + CoA
show the reaction diagram
-
hydroxymethylglutaryl-CoA + H2O = hydroxymethylglutarate + CoA
show the reaction diagram
-
3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
show the reaction diagram
-
(R,S)-3-hydroxy-3-methylglutaryl-CoA = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
show the reaction diagram
-
-
beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA = beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.05 mM
-
only with hydroxymethylglutaryl-CoA reductase as substrate
-
does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.023
-
-
0.26
-
-

KM Value (44 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.25
-
-

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID

References & Links

Links to other databases for 3-hydroxy-3-methylglutaryl-CoA

ChEBI
PubChem
ChEBI
PubChem