Ligand D-arginine

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Basic Ligand Information

Molecular Structure
Picture of D-arginine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14N4O2
D-arginine
ODKSFYDXXFIFQN-SCSAIBSYSA-N
Synonyms:
D-Arg
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-arginine + H2O = ?
show the reaction diagram
-
D-arginine = L-arginine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine = D-arginine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-arginine + H2O + O2 = ?
show the reaction diagram
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D-arginine + oxidized 2,6-dichloroindophenol + H2O = 2-oxo-5-guanidinopentanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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acetyl-CoA + D-arginine = CoA + N-acetyl-D-arginine
show the reaction diagram
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D-arginine + H2O = D-ornithine + urea
show the reaction diagram
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D-arginine + H2O = D-ornithine + urea
show the reaction diagram
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D-arginine = L-arginine
show the reaction diagram
-
ATP + D-Arg = ADP + phosphate + D-Arg-D-Arg
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-carbamimidamido-2-iminopentanoic acid + NADPH + H+ = D-arginine + NADP+
show the reaction diagram
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L-Tyr-D-Arg + H2O = L-Tyr + D-Arg
show the reaction diagram
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N-acetyl-D-arginine + H2O = acetate + D-arginine
show the reaction diagram
-
-
L-arginine = D-arginine
show the reaction diagram
-
-
L-arginine = D-arginine
show the reaction diagram
-
-
L-arginine = D-arginine
show the reaction diagram
-
-
L-arginine = D-arginine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3% of the activity with L-arginine
-
3% of the activity with L-arginine
-
212% activity in the presence of 10 mM D-arginine
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Inhibitor in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
competitive inhibition
-
complete inhibition of coaggregation of Porphyromonas gingivalis with other oral bacteria by L- and D-arginine
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0.1 mM D-arginine reduces DDAH activity to 24.7%
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3D Structure of Enzyme-Ligand-Complex (PDB) (47 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (40 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.058
-
in 50 mM CHES/HCl, pH 9.5 containing 10 mM dithiothreitol, at 37°C

KM Value (35 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
24.1
-
-
2.6
-
-
0.31
-
-
0.0206
-
pH 7.5, 37°C

References & Links

Links to other databases for D-arginine

ChEBI
PubChem
ChEBI
PubChem