Ligand N,N-dimethylglycine

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Basic Ligand Information

Molecular Structure
Picture of N,N-dimethylglycine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2
N,N-dimethylglycine
FFDGPVCHZBVARC-UHFFFAOYSA-N
Synonyms:
dimethylglycine


Show all pahtways known for Show all BRENDA pathways known for N,N-dimethylglycine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2
show the reaction diagram
-
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine
show the reaction diagram
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S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + N-methylglycine = S-adenosyl-L-homocysteine + N,N-dimethylglycine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2
show the reaction diagram
-
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycine betaine + cob(I)alamin = dimethylglycine + methylcob(III)alamin
show the reaction diagram
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-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight
-
1 mM, 24% inhibition
-
competitive inhibition, versus sarcosine, 40% inhibition at 250 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (20 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (31 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.45
-
pH 7.2, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
57
-
pH 8.0, 25°C
130
-
-

References & Links

Links to other databases for N,N-dimethylglycine

ChEBI
PubChem
ChEBI
PubChem