Ligand mevalonic acid

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Basic Ligand Information

Molecular Structure
Picture of mevalonic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O4
mevalonic acid
KJTLQQUUPVSXIM-UHFFFAOYSA-N
Synonyms:
(R,S)-mevalonate, (R,S)mevalonate, (RS)-mevalonate, (RS)mevalonate, DL-mevalonate, mevalonate, R,S-mevalonate, RS-mevalonate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + mevalonate = ADP + phosphomevalonate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ = mevalonate + CoA + NAD+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mevalonate-5-phosphate + H2O = mevalonate + phosphate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive vs. phosphomevalonate, noncompetitive vs. ATP
-
mixed inhibition
-

Enzyme Kinetic Parameters

KM Value (52 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.62
-
50°C, pH not specified in the publication

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.081
-
pH 7.4, recombinant isozyme HMGR1
268
0.26
-
standard conditions, substrate inhibition
792

References & Links

Links to other databases for mevalonic acid

ChEBI
PubChem
ChEBI
PubChem