Ligand (R)-citramalate

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Basic Ligand Information

Molecular Structure
Picture of (R)-citramalate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H8O5
(R)-citramalate
XFTRTWQBIOMVPK-RXMQYKEDSA-N
Synonyms:
(-)-citramalate, (2R)-2-hydroxy-2-methyl-butanedioate, (2R)-2-hydroxy-2-methylbutanedioate, (2R)-2-methyl malate, (2R)-methylmalate, (R)-2-methylmalate, D-2-methylmalate, D-citramalate


Show all pahtways known for Show all BRENDA pathways known for (R)-citramalate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA
show the reaction diagram
-
(2R)-2-methyl malate = pyruvate + acetate
show the reaction diagram
-
(2R)-methylmalate = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
citraconate = D-citramalate
show the reaction diagram
-
2-Methylmaleate + H2O = (R)-2-Methylmalate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
no inhibition by (+)-citramalate
-
Ki: 0.083 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
13
-
55°C, pH and temperature not specified in the publication

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.2
-
55°C, pH and temperature not specified in the publication
0.29
-
pH 7.5, 25°C
2.2
-
; wild type enzyme, at pH 7.5 and 25°C; wild type enzyme, in 50 mM K+-HEPES (pH 7.5 and 25°C)

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.083
-
-

References & Links

Links to other databases for (R)-citramalate

ChEBI
PubChem
ChEBI
PubChem