Ligand L-2-aminoadipic acid

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Basic Ligand Information

Molecular Structure
Picture of L-2-aminoadipic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H11NO4
L-2-aminoadipic acid
OYIFNHCXNCRBQI-BYPYZUCNSA-N
Synonyms:
(2S)-2-aminohexanedioate, L-2-amino-1,6-hexandioate, L-2-aminoadipate, L-2-aminohexane-1,6-dioate, L-2-aminohexanedioate, L-alpha-Aminoadipate, L-alpha-aminohexanedioate, L-aminoadipate


Show all pahtways known for Show all BRENDA pathways known for L-2-aminoadipic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-2-aminoadipate + NADPH + H+ + ATP = (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
show the reaction diagram
-
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
show the reaction diagram
-
L-2-aminoadipic acid = D-2-aminoadipic acid
show the reaction diagram
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3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O = 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-2-aminoadipate + NADPH + H+ + ATP = (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
show the reaction diagram
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acetyl-CoA + L-2-aminoadipate = CoA + 2-acetylaminohexanedioate
show the reaction diagram
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L-2-aminohexane-1,6-dioate + 2-oxoglutarate = 2-oxohexane-1,6-dioate + L-glutamate
show the reaction diagram
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3-(imidazol-4-yl)-2-oxopropyl phosphate + L-2-aminoadipate = L-histidinol phosphate + 2-oxoadipate
show the reaction diagram
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L-2-aminoadipate + H2O = ?
show the reaction diagram
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L-2-aminoadipic acid = D-2-aminoadipic acid
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate = L-2-aminoadipate + NADPH + H+ + ATP
show the reaction diagram
-
-
2-oxoadipate + NADPH + NH3 = L-2-aminoadipate + NADP+ + H2O
show the reaction diagram
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2-oxoadipate + L-glutamate = L-2-aminoadipate + 2-oxoglutarate
show the reaction diagram
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L-glutamine + 2-oxoadipate = 2-oxoglutaramate + L-2-amino-1,6-hexandioate
show the reaction diagram
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L-phenylalanine + 2-oxoadipate = phenylpyruvate + L-2-aminoadipate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. L-alpha-aminoadipate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (7 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
66
-
pH 8, 30°C
2.4
-
His-tagged recombinant FnGR, in potassium phosphate buffer (10 mM, pH 8.0)
0.85
-
pH 8.0, 60°C

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
pH 8, 30°C
26
-
His-tagged recombinant FnGR, in potassium phosphate buffer (10 mM, pH 8.0)
2.1
-
pH 8.0, 60°C

References & Links

Links to other databases for L-2-aminoadipic acid

ChEBI
PubChem
ChEBI
PubChem