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Disease on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury.
MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice.
Adenocarcinoma
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Adenoma
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Adenoma, Liver Cell
Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging.
Alzheimer Disease
Comment on "Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model".
Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.
Response to Comment on "Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model".
Anaplasmosis
Repression of tick microRNA-133 induces organic anion transporting polypeptide expression critical for Anaplasma phagocytophilum survival in the vector and transmission to the vertebrate host.
Arthritis, Rheumatoid
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients.
Asthma
SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.
Astrocytoma
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Atherosclerosis
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Blast Crisis
High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML.
Bone Resorption
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Brain Neoplasms
Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.
Breast Neoplasms
2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
A Review of Daclatasvir Drug-Drug Interactions.
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Application of Human Placental Villous Tissue Explants to Study ABC Transporter Mediated Efflux of 2,4-Dinitrophenyl-S-Glutathione.
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Circumvention of the multidrug-resistance protein (MRP-1) by an antitumor drug through specific inhibition of gene transcription in breast tumor cells.
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier.
Contribution of Uptake and Efflux Transporters to Oral Pharmacokinetics of Furosemide.
Correction to: Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes.
Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans.
Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer.
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.
Drug Transport Across the Placenta.
Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs?
Drug-drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist.
Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects.
Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778?875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.
Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin.
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).
Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding.
Highly expressed SLCO1B3 inhibits the occurrence and development of breast cancer and can be used as a clinical indicator of prognosis.
Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Identification of molecular markers for metastasis-related genes in primary breast cancer cells.
Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach.
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.
In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor.
In Vitro Evaluation of the Drug Interaction Potential of Doravirine.
In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters.
In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters.
In Vitro Models used in Drug Discovery: Drug absorption and Metabolism.
Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells.
Influence of ABCC2, SLCO1B1, and ABCG2 polymorphisms on the pharmacokinetics of olmesartan.
Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen.
Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives.
Interaction of food additives with intestinal efflux transporters.
Interactions between cyazofamid and human drug transporters.
Interactions of bilastine, a new oral H? antihistamine, with human transporter systems.
Intestinal absorption mechanism of mirabegron, a potent and selective ??-adrenoceptor agonist: involvement of human efflux and/or influx transport systems.
Intestinal transport of sophocarpine across the Caco-2 cell monolayer model and quantification by LC/MS.
Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression.
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study.
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Irinotecan pathway genotype analysis to predict pharmacokinetics.
Isolation of endothelial cells, pericytes and astrocytes from mouse brain.
Lack of Interactions Between an Antisense Oligonucleotide with 2'-O-(2-Methoxyethyl) Modifications and Major Drug Transporters.
Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer.
Lapatinib sensitizes quiescent MDA-MB-231 breast cancer cells to doxorubicin by inhibiting the expression of multidrug resistance-associated protein-1.
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer.
Navigating Transporter Sciences in Pharmacokinetics Characterization Using Extended Clearance Classification System (ECCS).
New proteins configure a brain drug resistance map in tuberous sclerosis.
Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?
Oral drug delivery utilizing intestinal OATP transporters.
Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide.
Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta.
Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells.
P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir.
Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients.
Pharmacogenetics of target genes across doxorubicin disposition pathway: a review.
Pharmacokinetics of cobicistat boosted-elvitegravir administered in combination with rosuvastatin.
Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro.
Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.
Quantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8.
RLIP76 expression as a prognostic marker of breast cancer.
Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies.
SLCO1B1 and ABCG2 Gene Polymorphisms in a Thai Population.
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters.
The Drug-Drug Interaction Profile of Presatovir.
The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay.
The effect of IL-1? on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells.
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression.
The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug-drug interactions.
The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys.
Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir.
Transporter-mediated drug-drug interactions.
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer.
USE OF TRANSPORTER KNOCKDOWN CACO-2 CELLS TO INVESTIGATE THE IN VITRO EFFLUX OF STATIN DRUGS.
Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats.
Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early-Stage Drug Development.
[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma.
Carcinogenesis
A potential function of RLIP76 in the ovarian corpus luteum.
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.
RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane.
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Carcinoma
A potential function of RLIP76 in the ovarian corpus luteum.
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma.
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.
RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
[Expression of ATP-binding cassette transporter genes in nasopharyngeal carcinoma.]
Carcinoma, Hepatocellular
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of ?-catenin and hepatocyte nuclear factor 4? in hepatocellular carcinoma.
Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.
Carcinoma, Mucoepidermoid
Nuclear Multidrug-Resistance Related Protein 1 Contributes to Multidrug-Resistance of Mucoepidermoid Carcinoma Mainly via Regulating Multidrug-Resistance Protein 1: A Human Mucoepidermoid Carcinoma Cells Model and Spearman's Rank Correlation Analysis.
Carcinoma, Non-Small-Cell Lung
ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines.
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity.
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Carcinoma, Renal Cell
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
Cardiotoxicity
Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia.
Cataract
Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs.
Chemical and Drug Induced Liver Injury
Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects.
Cholangitis
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.
Cholangitis, Sclerosing
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Cholestasis
Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of oatp1.
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Effect of Yin-Zhi-Huang on up-regulation of Oatp2, Ntcp, and Mrp2 proteins in estrogen-induced rat cholestasis.
Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis.
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.
Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.
Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver.
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.
Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate.
Cholestasis, Extrahepatic
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Cholestasis, Intrahepatic
Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy.
Colonic Neoplasms
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15.
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).
RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
Colorectal Neoplasms
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.
CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer.
Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer.
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.
Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Influence of the Functional Polymorphisms in the Organic Anion Transporting Polypeptide 1B1 in the Susceptibility to Colorectal Cancer.
miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76.
Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome.
Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study.
Confusion
RLIP76 in defense of radiation poisoning.
Congenital Abnormalities
Adenosine triphosphate-dependent copper transport in isolated rat liver plasma membranes.
Diabetes Mellitus, Type 2
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.
Dynamic Contrast-Enhanced MRI of OATP Dysfunction in Diabetes.
Drug Resistant Epilepsy
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
New proteins configure a brain drug resistance map in tuberous sclerosis.
Drug-Related Side Effects and Adverse Reactions
Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.
Endometrial Neoplasms
Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin.
Epilepsy
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients.
RLIP76, a non-ABC transporter, and drug resistance in epilepsy.
The association between polymorphisms in RLIP76 and drug response in epilepsy.
Fatty Liver
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.
Glaucoma
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Correction: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.
Glaucoma, Angle-Closure
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Correction: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.
Glioblastoma
Increased RLIP76 expression in IDH1 wild?type glioblastoma multiforme is associated with worse prognosis.
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues.
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Prognostic significance of the immunohistochemical expression of O-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Glioma
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
RLIP76 Depletion Enhances Autophagic Flux in U251 Cells.
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Genetic factors related to unconjugated hyperbilirubinemia amongst adults.
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]
Glucosephosphate Dehydrogenase Deficiency
Genetic factors related to unconjugated hyperbilirubinemia amongst adults.
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
Hepatic Veno-Occlusive Disease
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Hepatitis B, Chronic
ABCC4, ABCC5 and SLC28A1 polymorphisms: host genome on responses of chronic hepatitis B patients with entecavir treatment.
Hepatitis C, Chronic
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Hepatoblastoma
Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells.
Herpes Zoster
Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression.
Hyperbilirubinemia, Neonatal
Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates.
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]
Hypoglycemia
P300 regulates the human RLIP76 promoter activity and gene expression.
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.
Infections
An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.
Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection.
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Repression of tick microRNA-133 induces organic anion transporting polypeptide expression critical for Anaplasma phagocytophilum survival in the vector and transmission to the vertebrate host.
When Should Statins Be Stopped?
Insulin Resistance
A central role of RLIP76 in regulation of glycemic control.
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
P300 regulates the human RLIP76 promoter activity and gene expression.
Ischemic Stroke
Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP).
Jaundice, Chronic Idiopathic
The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion.
Jaundice, Neonatal
Gene Mutation in Neonatal Jaundice - Mutations in UGT1A1 and OATP2 Genes.
Kidney Neoplasms
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
RLIP76 Targeted Therapy for Kidney Cancer.
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
RLIP76: A Target for Kidney Cancer Therapy.
Leukemia
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.
Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line.
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.
Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells.
RLIP76: A Target for Kidney Cancer Therapy.
Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino-[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines.
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Leukemia, Erythroblastic, Acute
Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates.
Leukemia, Myeloid, Acute
Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma.
FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.
P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups.
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
Leukopenia
Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.
Liver Cirrhosis
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment.
Liver Cirrhosis, Biliary
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.
Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen.
Liver Diseases
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression.
Liver Neoplasms
The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer.
Lung Neoplasms
ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines.
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.
Anticancer activity of 2'-hydroxyflavanone towards lung cancer.
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation.
Increased expression and function of P-glycoprotein in peripheral blood CD56+ cells is associated with the chemoresistance of non-small-cell lung cancer.
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer.
Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression.
Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin.
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.
Role of RLIP76 in doxorubicin resistance in lung cancer (Review).
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity.
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers.
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
[Role and clinical significance of RLIP76 in regulation of multi-drug resistance of small cell lung cancer].
[Substantiation of Expressive Markers Use to Personalize Lung Cancer Chemotherapy].
Lupus Erythematosus, Systemic
P-glycoprotein-1 functional activity in CD5+CD7+ and CD20+ lymphocytes in systemic lupus erythematosus children: relation to disease activity, complications and steroid response.
Lymphatic Metastasis
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Lymphoma
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas.
Lymphoma, T-Cell
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Malaria
Gene synteny and chloroquine resistance in Plasmodium chabaudi.
Malformations of Cortical Development
Multidrug-resistance protein 1 in focal cortical dysplasia.
Melanoma
A potential function of RLIP76 in the ovarian corpus luteum.
May 2006 NEIHS News.
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
Regression of melanoma in a murine model by RLIP76 depletion.
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
RLIP76 silencing inhibits cell proliferation and invasion in melanoma cell line A375.
RLIP76: A Target for Kidney Cancer Therapy.
RLIP76: a versatile transporter and an emerging target for cancer therapy.
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.
Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.
Upregulation of miR-124 by physcion 8-O-?-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76.
Meningioma
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
Metabolic Syndrome
RLIP76 protein knockdown attenuates obesity due to a high-fat diet.
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.
Microphthalmos
Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia.
Muscular Diseases
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy.
Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy.
Towards companion diagnostics for the management of statin therapy.
Neoplasm Metastasis
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane.
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study.
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Neoplasms
2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
A potential function of RLIP76 in the ovarian corpus luteum.
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.
Cancer growth regulation by 4-hydroxynonenal.
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Chloroquine resistance reversal agents as promising antimalarial drugs.
Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.
Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo.
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.
Deregulation of miR-128 in ovarian cancer promotes cisplatin resistance.
Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.
Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues.
DNA methylation profiles of organic anion transporting polypeptide 1B3 in cancer cell lines.
Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells.
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.
Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines.
Evaluation of the Effects of Repeat-Dose Dabrafenib on the Single-Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate).
Exploring cysteine regulation in cancer cell survival with a highly specific "Lock and Key" fluorescent probe for cysteine.
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Expression of multidrug resistance-related protein (mrp-1), lung resistance-related protein (lrp) and topoisomerase-ii (topo-ii) in wilms' tumor: immunohistochemical study using tma methodology.
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children.
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis.
Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation.
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Identification of GAS1 as an epirubicin resistance-related gene in human gastric cancer cells with a partially randomized small interfering RNA library.
Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas.
Increased anti-tumour efficacy of doxorubicin when combined with sulindac in a xenograft model of an MRP-1-positive human lung cancer.
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.
Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice.
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study.
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc.
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells.
Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer.
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters.
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase.
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Maternal western-style diet enhances the effects of chemically-induced mammary tumors in female rat offspring through transcriptome changes.
MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma.
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76.
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype.
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.
Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression.
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
P300 regulates the human RLIP76 promoter activity and gene expression.
Phytochemical Inhibition of Multidrug Resistance Protein-1 as a Therapeutic Strategy for Hemangioendothelioma.
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis.
Preliminary individual adjuvant chemotherapy for primary central nervous system lymphomas based on the expression of drug-resistance genes.
Prognostic significance of the immunohistochemical expression of O-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF.
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
Regression of melanoma in a murine model by RLIP76 depletion.
Regression of prostate cancer xenografts by RLIP76 depletion.
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance.
RLIP76 and Cancer.
RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
RLIP76 expression as a prognostic marker of breast cancer.
RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.
RLIP76 is a major determinant of radiation sensitivity.
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
RLIP76 silencing inhibits cell proliferation and invasion in melanoma cell line A375.
RLIP76 Targeted Therapy for Kidney Cancer.
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.
RLIP76: A Target for Kidney Cancer Therapy.
RLIP76: a versatile transporter and an emerging target for cancer therapy.
RNAi-combined nano-chemotherapeutics to tackle resistant tumors.
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.
Selected isothiocyanates rapidly induce growth inhibition of cancer cells.
SF3B1 mutations constitute a novel therapeutic target in breast cancer.
Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition. identification of novel chemotherapeutic drug resistance modulators.
Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
The anticancer agent prodigiosin is not a multidrug resistance protein substrate.
The complexity of tumour angiogenesis based on recently described molecules.
The FOXM1-ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells.
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.
The pharmacology of cancer resistance.
The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.
The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.
Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.
Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1.
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
Varied clinical significance of ATP-binding cassette C sub-family members for lung adenocarcinoma.
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
[Correlation of metastasis-free survival in patients with breast cancer and changes in the direction of expression of multidrug resistance genes during neoadjuvant chemotherapy].
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Nephrotic Syndrome
Overexpression of P-glycoprotein and MRP-1 are pharmacogenomic biomarkers to determine steroid resistant phenotype in childhood idiopathic nephrotic syndrome.
Nervous System Diseases
Multidrug resistance-associated proteins: expression and function in the central nervous system.
Neuroblastoma
DNA (cytosine) methyltransferase overexpression is associated with acquired drug resistance of murine neuroblastoma cells.
NDRG1 promotes the multidrug resistance of neuroblastoma cells with upregulated expression of drug resistant proteins.
RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.
SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells.
Targeting p53 Null Neuroblastomas through RLIP76.
[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma.
Neuroectodermal Tumors
Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.
Non-alcoholic Fatty Liver Disease
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
Pharmacokinetic herb-disease-drug interactions: Effect of ginkgo biloba extract on the pharmacokinetics of pitavastatin, a substrate of Oatp1b2, in rats with non-alcoholic fatty liver disease.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Obesity
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.
RLIP76 protein knockdown attenuates obesity due to a high-fat diet.
The inhibition of hepatic Pxr-Oatp2 pathway mediating decreased hepatic uptake of rosuvastatin in rats with high-fat diet-induced obesity.
Oligodendroglioma
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Osteoporosis
Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study.
Osteosarcoma
Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAAT? axis.
Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma.
Ovarian Neoplasms
Clinical Significance of Organic Anion Transporting Polypeptide Gene Expression in High-Grade Serous Ovarian Cancer.
Decreased LRIG1 in Human Ovarian Cancer Cell SKOV3 Upregulates MRP-1 and Contributes to the Chemoresistance of VP16.
RLIP76: A Target for Kidney Cancer Therapy.
Pancreatic Neoplasms
A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells.
microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer.
RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer.
Role of hypoxia inducible factor-1? in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia.
Prostatic Neoplasms
Expression of OATP family members in hormone-related cancers: potential markers of progression.
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Regression of prostate cancer xenografts by RLIP76 depletion.
RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer.
RLIP76: a versatile transporter and an emerging target for cancer therapy.
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.
Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway.
Renal Insufficiency
6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.
Recovery of OATP1B Activity after Living Kidney Transplantation in Patients with End-Stage Renal Disease.
Renal Insufficiency, Chronic
Simultaneous quantification of coproporphyrin-I and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease.
Retinoblastoma
Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.
Rhabdomyolysis
When Should Statins Be Stopped?
Rhabdomyosarcoma
Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation.
Sarcoma
Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein.
Sarcoma, Synovial
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.
Seizures
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
The association between polymorphisms in RLIP76 and drug response in epilepsy.
Small Cell Lung Carcinoma
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.
Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin.
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
[Role and clinical significance of RLIP76 in regulation of multi-drug resistance of small cell lung cancer].
Stomach Neoplasms
CIAPIN1 Confers Multidrug Resistance by Upregulating the Expression of MDR-1 and MRP-1 in Gastric Cancer Cells.
Docetaxel enhances the cytotoxicity of cisplatin to gastric cancer cells by modification of intracellular platinum metabolism.
RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1.
[Corrigendum] RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
Stroke
Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats.
Tuberous Sclerosis
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
New proteins configure a brain drug resistance map in tuberous sclerosis.
Urolithiasis
MRP-1 and BCRP Promote the Externalization of Phosphatidylserine in Oxalate-treated Renal Epithelial Cells: Implications for Calcium Oxalate Urolithiasis.
Uterine Cervical Neoplasms
Increased Gene Expression of the ABCC5 Transporter without Distinct Changes in the Expression of PDE5 in Human Cervical Cancer Cells during Growth.
Vaccinia
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes.
Vascular Diseases
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Gender Disparity in Susceptibility to Oxidative Stress and Apoptosis Induced by Autoantibodies Specific to RLIP76 in Vascular Cells.