Reference on EC 7.6.2.1 - P-type phospholipid transporter
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vermeulen, W.P.; Briede, J.J.; Roelofsen, B.
Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg-ATPase activity
Mol. Membr. Biol.
13
95-102
1996
Homo sapiens
Morris, M.B.; Auland, M.E.; Xu, Y.H.; Roufogalis, B.D.
Characterization of the Mg2+-ATPase activity of the human erythrocyte membrane
Biochem. Mol. Biol. Int.
31
823-832
1993
Homo sapiens
Beleznay, Z.; Zachowski, A.; Devaux, P.F.; Ott, P.
Characterization of the correlation between ATP-dependent aminophospholipid translocation and Mg2+-ATPase activity in red blood cell membranes
Eur. J. Biochem.
243
58-65
1997
Homo sapiens
Bartosz, G.; Batosz, M.; Sokal, A.; Gebicki, J.M.
Stimulation of erythrocyte membrane Mg2+-ATPase activity by dinitrophenol and other membrane-disturbing agents
Biochem. Mol. Biol. Int.
34
521-529
1994
Homo sapiens
Daleke, D.L.; Lyles, J.V.
Identification and purification of aminophospholipid flippases
Biochim. Biophys. Acta
1486
108-127
2000
Bos taurus, Homo sapiens
Beleznay, Z.; Zachowski, A.; Devaux, P.F.; Navazo, M.P.; Ott, P.
ATP-dependent aminophospholipid translocation in erythrocyte vesicles: stoichiometry of transport
Biochemistry
32
3146-3152
1993
Homo sapiens
Devaux, P.F.; Zachowski, A.; Morrot, G.; Cribier, S.; Fellmann, P.; Geldwerth, D.; Bitbol, M.; Herve, P.
Control of the transmembrane phospholipid distribution in eukaryotic cells by aminophospholipid translocase
Biotechnol. Appl. Biochem.
12
517-522
1990
Bos taurus, Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
Auland, M.E.; Morris, M.B.; Roufogalis, B.D.
Separation and characterization of two Mg2+-ATpase activities from human erythrocyte membrane
Arch. Biochem. Biophys.
312
272-277
1994
Homo sapiens
Auland, M.E.; Roufogalis, B.D.; Devaux, P.F.; Zachowski, A.
Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes
Proc. Natl. Acad. Sci. USA
91
10938-10942
1994
Homo sapiens
Tang, X.; Halleck, M.S.; Schlegel, R.A.; Williamson, P.
A subfamily of P-type ATPase with aminophospholipid transporting activity
Science
272
1495-1497
1996
Bos taurus
Ding, J.; Wu, Z.; Crider, B.P.; Ma, Y.; LI, X.; Slaughter, C.; Gong, L.; Xie, X.S.
Identification and functional expression of four isoforms of ATPase II, the putative aminophospholipid translocase
J. Biol. Chem.
275
23378-13386
2000
Bos taurus (Q29449), Bos taurus
Middelkoop, E.; van der Hoek, E.E.; Bevers, E.M.; Comfurius, P.; Slotboom, A.J.; op den Kamp, J.A.F.; Lubin, B.H.; Zwaal, R.F.A.; Roelofsen, B.
Involvement of ATP-dependent aminophospholipid translocation in maintaining phospholipid asymmetry in diamide-treated human erythrocytes
Biochim. Biophys. Acta
981
151-160
1989
Homo sapiens
Connor, J.; Schroit, A.J.
Transbilayer, movement of phosphatidylserine in erythrocytes. Inhibitors of aminophospholipid transport block the association of photolabeled lipid to its transporter
Biochim. Biophys. Acta
1066
37-42
1991
Homo sapiens
Herzing, L.B.; Kim, S.J.; Cook, E.H., Jr.; Ledbetter, D.H.
The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression
Am. J. Hum. Genet.
68
1501-1505
2001
Homo sapiens (O60312)
Romsicki, Y.; Sharom, F.J.
Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter
Biochemistry
40
6937-6947
2001
Mesocricetus auratus
Castegna, A.; Lauderback, C.M.; Mohmmad-Abdul, H.; Butterfield, D.A.
Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease
Brain Res.
1004
193-197
2004
Meriones unguiculatus
Doerrler, W.T.; Raetz, C.R.
ATPase activity of the MsbA lipid flippase of Escherichia coli
J. Biol. Chem.
277
36697-36705
2002
Escherichia coli
Perez-Victoria, F.J.; Gamarro, F.; Ouellette, M.; Castanys, S.
Functional cloning of the miltefosine transporter: A novel P-type phospholipid translocase from Leishmania involved in drug resistance
J. Biol. Chem.
278
49965-49971
2003
Leishmania donovani
Pomorski, T.; Lombardi, R.; Riezman, H.; Devaux, P.F.; van Meer, G.; Holthuis, J.C.M.
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis
Mol. Biol. Cell
14
1240-1254
2003
Saccharomyces cerevisiae
Saito, K.; Fujimura-Kamada, K.; Furuta, N.; Kato, U.; Umeda, M.; Tanaka, K.
Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae
Mol. Biol. Cell
15
3418-3432
2004
Saccharomyces cerevisiae
Fuchs, M.; Carey, M.C.; Cohen, D.E.
Evidence for an ATP-independent long-chain phosphatidylcholine translocator in hepatocyte membranes
Am. J. Physiol. Gastrointest. Liver Physiol.
273
1312-1319
1997
Rattus norvegicus, no activity in Xenopus laevis
Noji, T.; Yamamoto, T.; Saito, K.; Fujimura-Kamada, K.; Kondo, S.; Tanaka, K.
Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast
Biochem. Biophys. Res. Commun.
344
323-331
2006
Saccharomyces cerevisiae
Chang, Q.L.; Gummadi, S.N.; Menon, A.K.
Chemical modification identifies two populations of glycerophospholipid flippase in rat liver ER
Biochemistry
43
10710-10718
2004
Rattus norvegicus
Wolfs, J.L.; Comfurius, P.; Rasmussen, J.T.; Keuren, J.F.; Lindhout, T.; Zwaal, R.F.; Bevers, E.M.
Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction
Cell. Mol. Life Sci.
62
1514-1525
2005
Homo sapiens
Devaux, P.F.; Lopez-MOntero, I.; Bryde, S.
Proteins involved in lipid translocation in eukaryotic cells
Chem. Phys. Lipids
141
119-132
2006
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Leishmania infantum, Rattus norvegicus
Hessel, E.; Herrmann, A.; Mller, P.; Schmetkamp, P.P.M.; Hofmann, K.P.
The transbilayer distribution of phospholipids in disc membranes is a dynamic equilibrium. Evidence for rapid flip and flop movement
Eur. J. Biochem.
267
1473-1483
2000
Bos taurus
Hrafnsdottir, S.; Menon, A.K.
Reconstitution and partial characterization of phospholipid flippase activity from detergent extracts of the Bacillus subtilis cell membrane
J. Bacteriol.
182
4198-4206
2000
Bacillus subtilis, Bacillus subtilis 1E51
Camberg, J.L.; Sandkvist, M.
Molecular analysis of the Vibrio cholerae type II secretion ATPase EpsE
J. Bacteriol.
187
249-256
2005
Homo sapiens
Vishwakarma, R.A.; Vehring, S.; Mehta, A.; Sinha, A.; Pomorski, T.; Herrmann, A.; Menon, A.K.
New fluorescent probes reveal that flippase-mediated flip-flop of phosphatidylinositol across the endoplasmic reticulum membrane does not depend on the stereochemistry of the lipid
Org. Biomol. Chem.
3
1275-1283
2005
Rattus norvegicus
Natarajan, P.; Wang, J.; Hua, Z.; Graham, T.R.
Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function
Proc. Natl. Acad. Sci. USA
101
10614-10619
2004
Saccharomyces cerevisiae
Verhoeven, A.J.; Hilarius, P.M.; Dekkers, D.W.; Lagerberg, J.W.; de Korte, D.
Prolonged storage of red blood cells affects aminophospholipid translocase activity
Vox Sang.
91
244-251
2006
Homo sapiens
Sahu, S.K.; Gummadi, S.N.; Manoj, N.; Aradhyam, G.K.
Phospholipid scramblases: an overview
Arch. Biochem. Biophys.
462
103-114
2007
Homo sapiens (O15162), Homo sapiens (Q9NRQ2), Homo sapiens (Q9NRY6), Homo sapiens (Q9NRY7), Mus musculus (P58196), Mus musculus (Q9JJ00), Caenorhabditis elegans (Q21318)
Paterson, J.K.; Renkema, K.; Burden, L.; Halleck, M.S.; Schlegel, R.A.; Williamson, P.; Daleke, D.L.
Lipid specific activation of the murine P4-ATPase Atp8a1 (ATPase II)
Biochemistry
45
5367-5376
2006
Mus musculus
Smriti, T.; Nemergut, E.C.; Daleke, D.L.
ATP-dependent transport of phosphatidylserine analogues in human erythrocytes
Biochemistry
46
2249-2259
2007
Homo sapiens
Liu, J.; Epand, R.F.; Durrant, D.; Grossman, D.; Chi, N.W.; Epand, R.M.; Lee, R.M.
Role of phospholipid scramblase 3 in the regulation of tumor necrosis factor-alpha-induced apoptosis
Biochemistry
47
4518-4529
2008
Homo sapiens
Soupene, E.; Kuypers, F.A.
Identification of an erythroid ATP-dependent aminophospholipid transporter
Br. J. Haematol.
133
436-438
2006
Mus musculus
Razmara, M.; Hu, H.; Masquelier, M.; Li, N.
Glycoprotein IIb/IIIa blockade inhibits platelet aminophospholipid exposure by potentiating translocase and attenuating scramblase activity
Cell. Mol. Life Sci.
64
999-1008
2007
Homo sapiens
Zuellig, S.; Neukomm, L.J.; Jovanovic, M.; Charette, S.J.; Lyssenko, N.N.; Halleck, M.S.; Reutelingsperger, C.P.; Schlegel, R.A.; Hengartner, M.O.
Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis
Curr. Biol.
17
994-999
2007
Caenorhabditis elegans
Camberg, J.L.; Johnson, T.L.; Patrick, M.; Abendroth, J.; Hol, W.G.; Sandkvist, M.
Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids
EMBO J.
26
19-27
2007
Vibrio cholerae serotype O1
Regev, R.; Katzir, H.; Yeheskely-Hayon, D.; Eytan, G.D.
Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane
FEBS J.
274
6204-6214
2007
Homo sapiens (O43520)
Morita, S.Y.; Kobayashi, A.; Takanezawa, Y.; Kioka, N.; Handa, T.; Arai, H.; Matsuo, M.; Ueda, K.
Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4
Hepatology
46
188-199
2007
Homo sapiens
Perez-Victoria, F.J.; Sanchez-Canete, M.P.; Castanys, S.; Gamarro, F.
Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites
J. Biol. Chem.
281
23766-23775
2006
Leishmania donovani
Papadopulos, A.; Vehring, S.; Lopez-Montero, I.; Kutschenko, L.; Stoeckl, M.; Devaux, P.F.; Kozlov, M.; Pomorski, T.; Herrmann, A.
Flippase activity detected with unlabeled lipids by shape changes of giant unilamellar vesicles
J. Biol. Chem.
282
15559-15568
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae sec61
Stevens, H.C.; Nichols, J.W.
The proton electrochemical gradient across the plasma membrane of yeast is necessary for phospholipid flip
J. Biol. Chem.
282
17563-17567
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae LMY65
Tyurina, Y.Y.; Basova, L.V.; Konduru, N.V.; Tyurin, V.A.; Potapovich, A.I.; Cai, P.; Bayir, H.; Stoyanovsky, D.; Pitt, B.R.; Shvedova, A.A.; Fadeel, B.; Kagan, V.E.
Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation
J. Biol. Chem.
282
8498-8509
2007
Homo sapiens
Leung, R.; Gwozdz, A.M.; Wang, H.; Bang, K.W.; Packham, M.A.; Freedman, J.; Rand, M.L.
Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity
J. Thromb. Haemost.
5
560-570
2007
Homo sapiens
Alder-Baerens, N.; Lisman, Q.; Luong, L.; Pomorski, T.; Holthuis, J.C.
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles
Mol. Biol. Cell
17
1632-1642
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae EHY227
Furuta, N.; Fujimura-Kamada, K.; Saito, K.; Yamamoto, T.; Tanaka, K.
Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway
Mol. Biol. Cell
18
295-312
2007
Saccharomyces cerevisiae
Liu, K.; Hua, Z.; Nepute, J.A.; Graham, T.R.
Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD/Sla1p endocytic pathway
Mol. Biol. Cell
18
487-500
2007
Saccharomyces cerevisiae
Liu, K.; Surendhran, K.; Nothwehr, S.F.; Graham, T.R.
P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes
Mol. Biol. Cell
19
3525-3535
2008
Saccharomyces cerevisiae
Wang, X.; Wang, J.; Gengyo-Ando, K.; Gu, L.; Sun, C.L.; Yang, C.; Shi, Y.; Kobayashi, T.; Shi, Y.; Mitani, S.; Xie, X.S.; Xue, D.
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
Nat. Cell Biol.
9
541-549
2007
Caenorhabditis elegans
Wyles, J.P.; Wu, Z.; Mirski, S.E.; Cole, S.P.
Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1
Nucleic Acids Res.
35
4076-4085
2007
Homo sapiens
Chen, S.; Wang, J.; Muthusamy, B.; Liu, K.; Zare, S.; Andersen, R.J.; Graham, T.R.
Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane
Traffic
7
1503-1517
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae CCY 2811
Sahu, S.K.; Gummadi, S.N.
Flippase activity in proteoliposomes reconstituted with Spinacea oleracea endoplasmic reticulum membrane proteins: evidence of biogenic membrane flippase in plants
Biochemistry
47
10481-10490
2008
Spinacia oleracea
Eckford, P.D.; Sharom, F.J.
Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport
Biochemistry
47
13686-13698
2008
Cricetulus griseus
Sanyal, S.; Frank, C.G.; Menon, A.K.
Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum
Biochemistry
47
7937-7946
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae YCF40
Folmer, D.E.; Elferink, R.P.; Paulusma, C.C.
P4 ATPases - Lipid flippases and their role in disease
Biochim. Biophys. Acta
1791
628-635
2009
Mus musculus (Q148W0), Mus musculus
Riekhof, W.R.; Voelker, D.R.
The yeast plasma membrane P4-ATPases are major transporters for lysophospholipids
Biochim. Biophys. Acta
179
620-627
2009
Saccharomyces cerevisiae
Poulsen, L.R.; Lopez-Marques, R.L.; Palmgren, M.G.
Flippases: still more questions than answers
Cell. Mol. Life Sci.
65
3119-3125
2008
Saccharomyces cerevisiae
Masuda, M.; Nakai, E.; Mizutani, T.
Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)
Drug Metab. Lett.
2
238-244
2008
Homo sapiens
Muthusamy, B.P.; Raychaudhuri, S.; Natarajan, P.; Abe, F.; Liu, K.; Prinz, W.A.; Graham, T.R.
Control of protein and sterol trafficking by antagonistic activities of a P4-ATPase and oxysterol binding protein homologue
Mol. Biol. Cell
20
2920-2931
2009
Saccharomyces cerevisiae
Barta, C.A.; Sachs-Barrable, K.; Feng, F.; Wasan, K.M.
Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers
Mol. Pharm.
5
863-875
2008
Homo sapiens
Ruiz, N.
Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli
Proc. Natl. Acad. Sci. USA
105
15553-15557
2008
Escherichia coli
Sanyal, S.; Menon, A.K.
Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase
Proc. Natl. Acad. Sci. USA
106
767-772
2009
Rattus norvegicus
Gong, E.Y.; Park, E.; Lee, H.J.; Lee, K.
Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase
Reproduction
137
345-351
2009
Mus musculus (Q6UQ17), Mus musculus
Eckford, P.D.; Sharom, F.J.
The reconstituted Escherichia coli MsbA protein displays lipid flippase activity
Biochem. J.
429
195-203
2010
Escherichia coli (P60752), Escherichia coli
Barber, L.A.; Palascak, M.B.; Joiner, C.H.; Franco, R.S.
Aminophospholipid translocase and phospholipid scramblase activities in sickle erythrocyte subpopulations
Br. J. Haematol.
146
447-455
2009
Homo sapiens
Coleman, J.A.; Kwok, M.C.; Molday, R.S.
Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes
J. Biol. Chem.
284
32670-32679
2009
Bos taurus (C7EXK4), Mus musculus (P98200), Homo sapiens (Q9NTI2)
Krijnen, P.A.; Sipkens, J.A.; Molling, J.W.; Rauwerda, J.A.; Stehouwer, C.D.; Muller, A.; Paulus, W.J.; van Nieuw Amerongen, G.P.; Hack, C.E.; Verhoeven, A.J.; van Hinsbergh, V.W.; Niessen, H.W.
Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
J. Mol. Cell. Cardiol.
49
781-790
2010
Rattus norvegicus
Zhang, X.; Oppenheimer, D.G.
IRREGULAR TRICHOME BRANCH 2 (ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis
Plant J.
60
195-206
2009
Arabidopsis thaliana (Q9XIE6)
Takagi, K.; Iwamoto, K.; Kobayashi, S.; Horiuchi, H.; Fukuda, R.; Ohta, A.
Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast
Biochem. Biophys. Res. Commun.
417
490-494
2012
Saccharomyces cerevisiae
Sebastian, T.T.; Baldridge, R.D.; Xu, P.; Graham, T.R.
Phospholipid flippases: Building asymmetric membranes and transport vesicles
Biochim. Biophys. Acta
1821
1068-1077
2012
Arabidopsis thaliana, Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32660), Saccharomyces cerevisiae (P39524), Saccharomyces cerevisiae (Q12674), Homo sapiens, Caenorhabditis elegans (C7U324), Caenorhabditis elegans (G5EBH1), Caenorhabditis elegans (O18182), Caenorhabditis elegans (P91203), Caenorhabditis elegans (Q7YXV5)
van der Velden, L.M.; Wichers, C.G.; van Breevoort, A.E.; Coleman, J.A.; Molday, R.S.; Berger, R.; Klomp, L.W.; van de Graaf, S.F.
Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases
J. Biol. Chem.
285
40088-40096
2010
Homo sapiens (Q9Y2Q0), Homo sapiens
Takatsu, H.; Baba, K.; Shima, T.; Umino, H.; Kato, U.; Umeda, M.; Nakayama, K.; Shin, H.W.
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner
J. Biol. Chem.
286
38159-38167
2011
Homo sapiens
Smith, B.A.; ONeil, E.J.; Lampkins, A.J.; Johnson, J.R.; Lee, J.J.; Cole, E.L.; Smith, B.D.
Evaluation of fluorescent phosphatidylserine substrates for the aminophospholipid flippase in mammalian cells
J. Fluoresc.
22
93-101
2012
Cricetulus griseus, Homo sapiens
Siggs, O.M.; Arnold, C.N.; Huber, C.; Pirie, E.; Xia, Y.; Lin, P.; Nemazee, D.; Beutler, B.
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
Nat. Immunol.
12
434-440
2011
Mus musculus (Q9QZW0)
Lopez-Marques, R.L.; Poulsen, L.R.; Palmgren, M.G.
A putative plant aminophospholipid flippase, the Arabidopsis P4 ATPase ALA1, localizes to the plasma membrane following association with a beta-subunit
PLoS ONE
7
e33042
2012
Arabidopsis thaliana, Arabidopsis thaliana (P98204)
Baldridge, R.D.; Graham, T.R.
Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases
Proc. Natl. Acad. Sci. USA
109
E290-E298
2012
Saccharomyces cerevisiae (P32660), Saccharomyces cerevisiae (P39524), Saccharomyces cerevisiae
Kim, J.E.; Han, M.; Hanl, K.S.; Kim, H.K.
Vitamin E inhibition on platelet procoagulant activity: involvement of aminophospholipid translocase activity
Thromb. Res.
127
435-442
2011
Homo sapiens
Nilsson, L.; Jonsson, E.; Tuck, S.
Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase
Traffic
12
1839-1849
2011
Caenorhabditis elegans (C7U324), Caenorhabditis elegans
Lee, S.; Uchida, Y.; Wang, J.; Matsudaira, T.; Nakagawa, T.; Kishimoto, T.; Mukai, K.; Inaba, T.; Kobayashi, T.; Molday, R.S.; Taguchi, T.; Arai, H.
Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase
EMBO J.
34
669-688
2015
Homo sapiens (Q9NTI2), Homo sapiens (Q9Y2Q0)
Onat, O.E.; Gulsuner, S.; Bilguvar, K.; Nazli Basak, A.; Topaloglu, H.; Tan, M.; Tan, U.; Gunel, M.; Ozcelik, T.
Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion
Eur. J. Hum. Genet.
21
281-285
2013
Homo sapiens (Q9NTI2), Homo sapiens
Kleinegris, M.C.; Koek, G.H.; Mast, K.; Mestrom, E.H.; Wolfs, J.L.; Bevers, E.M.
Ribavirin-induced externalization of phosphatidylserine in erythrocytes is predominantly caused by inhibition of aminophospholipid translocase activity
Eur. J. Pharmacol.
693
1-6
2012
Homo sapiens
Kato, U.; Inadome, H.; Yamamoto, M.; Emoto, K.; Kobayashi, T.; Umeda, M.
Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration
J. Biol. Chem.
288
4922-4934
2013
Cricetulus griseus
Takatsu, H.; Tanaka, G.; Segawa, K.; Suzuki, J.; Nagata, S.; Nakayama, K.; Shin, H.W.
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane
J. Biol. Chem.
289
33543-33556
2014
Homo sapiens (O43520), Homo sapiens (P98196), Homo sapiens (P98198), Homo sapiens (Q8NB49), Homo sapiens
Naito, T.; Takatsu, H.; Miyano, R.; Takada, N.; Nakayama, K.; Shin, H.W.
Phospholipid flippase ATP10A translocates phosphatidylcholine and is involved in plasma membrane dynamics
J. Biol. Chem.
290
15004-15017
2015
Homo sapiens (O60312), Homo sapiens (O94823), Homo sapiens (Q9P241)
Ansari, I.U.; Longacre, M.J.; Paulusma, C.C.; Stoker, S.W.; Kendrick, M.A.; MacDonald, M.J.
Characterization of P4 ATPase phospholipid translocases (flippases) in human and rat pancreatic beta cells: their gene silencing inhibits insulin secretion
J. Biol. Chem.
290
23110-23123
2015
Rattus norvegicus (D4AA47), Homo sapiens (O43520), Homo sapiens (P98198), Homo sapiens (Q2NLD0), Homo sapiens
Baldridge, R.D.; Graham, T.R.
Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases
Proc. Natl. Acad. Sci. USA
110
E358-E367
2013
Saccharomyces cerevisiae (P32660), Saccharomyces cerevisiae (P39524)
Vestergaard, A.L.; Coleman, J.A.; Lemmin, T.; Mikkelsen, S.A.; Molday, L.L.; Vilsen, B.; Molday, R.S.; Dal Peraro, M.; Andersen, J.P.
Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2
Proc. Natl. Acad. Sci. USA
111
E1334-E1343
2014
Bos taurus (C7EXK4)
Perandres-Lopez, R.; Sanchez-Canete, M.P.; Gamarro, F.; Castanys, S.
Functional role of highly conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase
Biochem. J.
475
887-899
2018
Leishmania sp.
van der Mark, V.A.; de Jonge, H.R.; Chang, J.C.; Ho-Mok, K.S.; Duijst, S.; Vidovic, D.; Carlon, M.S.; Oude Elferink, R.P.; Paulusma, C.C.
The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator
Biochim. Biophys. Acta
1863
2280-2288
2016
Homo sapiens (O43520), Homo sapiens
Roland, B.; Graham, T.
Decoding P4-ATPase substrate interactions
Crit. Rev. Biochem. Mol. Biol.
51
513-527
2016
Saccharomyces cerevisiae
Takada, N.; Naito, T.; Inoue, T.; Nakayama, K.; Takatsu, H.; Shin, H.W.
Phospholipid-flipping activity of P4-ATPase drives membrane curvature
EMBO J.
37
pii: e97705
2018
Homo sapiens (O60312)
Vestergaard, A.L.; Mikkelsen, S.A.; Coleman, J.A.; Molday, R.S.; Vilsen, B.; Andersen, J.P.
Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit
FEBS Lett.
589
3908-3914
2015
Bos taurus
Yamamoto, T.; Fujimura-Kamada, K.; Shioji, E.; Suzuki, R.; Tanaka, K.
Cfs1p, a novel membrane protein in the PQ-loop family, is involved in phospholipid flippase functions in yeast
G3 (Bethesda)
7
179-192
2017
Saccharomyces cerevisiae
Takatsu, H.; Baba, K.; Shima, T.; Umino, H.; Kato, U.; Umeda, M.; Nakayama, K.; Shin, H.
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent
J. Biol. Chem.
286
38159-38167
2015
Saccharomyces cerevisiae
Tanaka, Y.; Ono, N.; Shima, T.; Tanaka, G.; Katoh, Y.; Nakayama, K.; Takatsu, H.; Shin, H.W.
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane
Mol. Biol. Cell
27
3883-3893
2016
Homo sapiens (O75110), Homo sapiens
Chalat, M.; Moleschi, K.; Molday, R.S.
C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
Mol. Biol. Cell
28
452-462
2017
Bos taurus
Takatsu, H.; Takayama, M.; Naito, T.; Takada, N.; Tsumagari, K.; Ishihama, Y.; Nakayama, K.; Shin, H.W.
Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
Nat. Commun.
8
1423
2017
Homo sapiens (Q8NB49)
Botella, C.; Sautron, E.; Boudiere, L.; Michaud, M.; Dubots, E.; Yamaryo-Botte, Y.; Albrieux, C.; Marechal, E.; Block, M.A.; Jouhet, J.
ALA10, a phospholipid flippase, controls FAD2/FAD3 desaturation of phosphatidylcholine in the ER and affects chloroplast lipid composition in Arabidopsis thaliana
Plant Physiol.
170
1300-1314
2016
Arabidopsis thaliana
Yamagami, K.; Yamamoto, T.; Sakai, S.; Mioka, T.; Sano, T.; Igarashi, Y.; Tanaka, K.
Inositol depletion restores vesicle transport in yeast phospholipid flippase mutants
PLoS ONE
10
e0120108
2015
Saccharomyces cerevisiae, Saccharomyces cerevisiae YEF473
Roland, B.P.; Graham, T.R.
Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase
Proc. Natl. Acad. Sci. USA
113
E4460-E4466
2016
Saccharomyces cerevisiae
Wang, J.; Molday, L.L.; Hii, T.; Coleman, J.A.; Wen, T.; Andersen, J.P.; Molday, R.S.
Proteomic analysis and functional characterization of P4-ATPase phospholipid flippases from murine tissues
Sci. Rep.
8
10795
2018
Mus musculus (O54827), Mus musculus (P70704), Mus musculus (P98197), Mus musculus (P98199), Mus musculus (P98200), Mus musculus (Q148W0), Mus musculus (Q6DFW5), Mus musculus (Q6UQ17), Mus musculus (Q8K2X1), Mus musculus (Q9QZW0), Mus musculus
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