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Disease on EC 7.4.2.6 - ABC-type oligopeptide transporter

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.
Alzheimer Disease
[Effect of electroacupuncture stimulation of "Baihui" (GV 20) and " Yongquan" (KI 1) on expression of hippocampal amyloid-? and low density lipoprotein receptor-related protein-1 in APP/PS 1 transgenic mice].
Anemia
Double knockout Nme1/Nme2 mouse model suggests a critical role for NDP kinases in erythroid development.
Breast Neoplasms
Nuclear transport receptor karyopherin-?2 promotes malignant breast cancer phenotypes in vitro.
Carcinoma
An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2.
KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1.
Carcinoma, Hepatocellular
Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1.
Carcinoma, Squamous Cell
KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1.
Cholera
The oligopeptide transporter (Pept-1) in human intestine: biology and function.
Colitis
Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis.
SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress.
Colitis, Ulcerative
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.
Cystic Fibrosis
Lubiprostone: evaluation of the newest medication for the treatment of adult women with constipation-predominant irritable bowel syndrome.
Dengue
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.
Essential Hypertension
Erythrocytic cation transport receptor numbers and activity in pregnancies complicated by essential hypertension and pre-eclampsia.
Hepatitis C
The core protein of hepatitis C virus is imported into the nucleus by transport receptor Kap123p but inhibits Kap121p-dependent nuclear import of yeast AP1-like transcription factor in yeast cells.
Herpesviridae Infections
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2.
Hypersensitivity
Reverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisiae.
Hyperthyroidism
Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo.
Infections
Identification of Mycobacterium avium genes expressed during in vivo infection and the role of the oligopeptide transporter OppA in virulence.
Inflammatory Bowel Diseases
Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.
Lactobacillus plantarum Consumption Increases PepT1-Mediated Amino Acid Absorption by Enhancing Protein Kinase C Activity in Spontaneously Colitic Mice.
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.
Influenza, Human
Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers.
Iron Deficiencies
Iron deficiency triggered transcriptome changes in bread wheat.
Lyme Disease
Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci.
The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen.
Meningitis, Pneumococcal
In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis.
New Virulence Factors Identified in Pneumococcal Meningitis.
Neoplasms
Atomic basis of CRM1-cargo recognition, release and inhibition.
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity.
Cell membrane fluid-mosaic structure and cancer metastasis.
Importin-?/karyopherin-?1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.
Protecting PTEN in the Nucleus.
Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking.
Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Neurofibrosarcoma
EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis.
Otitis
Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins.
Pancreatic Neoplasms
Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells.
KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro.
Pre-Eclampsia
Erythrocytic cation transport receptor numbers and activity in pregnancies complicated by essential hypertension and pre-eclampsia.
Prostatic Hyperplasia
Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
Prostatic Neoplasms
Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
Streptococcal Infections
Effects of oligopeptide permease in group a streptococcal infection.
Tuberculosis
A peptide permease mutant of Mycobacterium bovis BCG resistant to the toxic peptides glutathione and S-nitrosoglutathione.
An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.
Evaluation of the immunogenicity of pBudCE4.1 plasmids encoding mycolyl-transferase Ag85A and phosphate transport receptor PstS-3 from Mycobacterium tuberculosis.
Immunogenicity and protective efficacy of tuberculosis DNA vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3.
Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis.
Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system.
Virus Diseases
Pharmacokinetic studies and LC-MS/MS method development of ganciclovir and dipeptide monoester prodrugs in Sprague Dawley rats.
Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: intestinal absorption and liver metabolism.