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Disease on EC 7.3.2.1 - ABC-type phosphate transporter

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DISEASE
TITLE OF PUBLICATION
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abc-type phosphate transporter deficiency
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Clinical and molecular characterization of a Brazilian patient with Pit-1 deficiency.
Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.
Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice.
Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency.
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
Achondroplasia
Clinical Characteristics, Etiologies and Pathophysiology of Patients with Severe Short Stature with Severe GH Deficiency: Questionnaire Study on the Data Registered with the Foundation for Growth Science, Japan.
Acidosis
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Metabolic acidosis inhibits soft tissue calcification in uremic rats.
Vascular calcification and metabolic acidosis in end stage renal disease.
Acromegaly
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Silent somatotroph pituitary adenomas: an update.
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
ACTH-Secreting Pituitary Adenoma
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph.
Acute Kidney Injury
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts.
Regulation of the renal sodium-dependent phosphate cotransporter NaPi2 (Npt2) in acute renal failure due to ischemia and reperfusion.
Adenocarcinoma
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
Vitamin D, Pit-1, GH, and PRL: possible roles in breast cancer development.
Adenoma
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
A growth hormone-secreting adenoma with incomplete nerve bundle formation.
ACTH and alpha-Subunit are Co-expressed in Rare Human Pituitary Corticotroph Cell Adenomas Proposed to Originate from ACTH-Committed Early Pituitary Progenitor Cells.
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1.
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings.
Decreased follistatin gene expression in gonadotroph adenomas.
Dietary modulation of the expression of genes involved in short-chain fatty acid absorption in the rumen epithelium is related to short-chain fatty acid concentration and pH in the rumen of goats.
Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation.
Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma - commentary.
Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas.
Expression of adrenocorticotropic hormone, prolactin and transcriptional factors in clinically nonfunctioning pituitary adenoma.
Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas.
Expression of GATA-2 in human pituitary adenomas.
Expression of human Pit-1 product in the human pituitary and pituitary adenomas. Immunohistochemical studies using an antibody against synthetic human Pit-1 product.
Expression of Pit-1 and estrogen receptor messenger RNA in prolactin-producing pituitary adenomas.
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Expression of Pit-1 and related proteins in diverse human pituitary adenomas.
Expression of Pit-1 mRNA and activin/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.
Expression of steroidogenic factor 1 and pituitary specific transcription factor 1 in rat pituitary adenomas.
Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features.
GH and PRL gene expression by nonradioisotopic in situ hybridization in TSH-secreting pituitary adenomas.
Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1.
Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas.
Immunohistochemical expression of Pit-1 protein in human pituitary adenomas.
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions.
In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas.
Inhibition of intestinal villus cell Na/K-ATPase mediates altered glucose and NaCl absorption in obesity-associated diabetes and hypertension.
Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Molecular basis of pituitary oncogenesis.
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Neuropathology of Pituitary Adenomas and Sellar Lesions.
PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.
Pathological study of thyrotropin-secreting pituitary adenoma: plurihormonality and medical treatment.
Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution.
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Pit-1 gene expression in human pituitary adenomas.
Pit-1 gene expression in the human pituitary and pituitary adenomas.
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
Pit-1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Pituitary adenomas that show a faint GH-immunoreactivity but lack fibrous body: Pit-1 adenoma with endocrinologically low activity.
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas.
Silent pituitary plurihormonal adenoma: clinical relevance of immunohistochemical analysis
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Skull Base Tumors: Neuropathology and Clinical implications.
Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.
Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma.
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Alzheimer Disease
Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.
Ankylosis
Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide.
Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification.
Autoimmune Diseases
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Autoimmune Hypophysitis
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.
Pathogenesis of Anti-PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells.
Bone Diseases
Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
Bone Diseases, Metabolic
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
FGFR3 and FGFR4 do not mediate renal effects of FGF23.
Breast Neoplasms
A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy.
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters.
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element.
Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer.
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment.
High SLC20A1 Expression Is Associated With Poor Prognoses in Claudin-low and Basal-like Breast Cancers.
In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters.
Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide.
Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients.
Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.
Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation.
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Targeting phopshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists.
The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors.
The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys.
Vitamin D, Pit-1, GH, and PRL: possible roles in breast cancer development.
Calcinosis
Early manifestation of nephropathy in rats with arterial calcinosis.
Carcinogenesis
Immunohistochemical analysis of GH-producing adenomas--with special emphasis on plurihormonality of individual tumor cells by double staining.
Pit-1 gene expression in human pituitary adenomas.
Pit-1 gene expression in the human pituitary and pituitary adenomas.
Pit-1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Carcinoid Tumor
Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor.
Carcinoma
Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation.
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
Carcinoma, Ductal
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors.
Carcinoma, Hepatocellular
[Inhibited effect of phosphorylated insulin-like growth factor binding protein-1 on hepatoma cells in vitro]
Carcinoma, Ovarian Epithelial
Generation of Monoclonal Antibodies Against Tumor-Associated Antigen MX35/sodium-Dependent Phosphate Transporter NaPi2b.
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.
Carcinoma, Squamous Cell
[Screening and functional analysis of microRNA expression in HPV16-positive squamous carcinoma of the cervix ?in the Uygur of southern Xinjiang].
Chagas Disease
TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi.
Cholestasis, Extrahepatic
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction.
Choriocarcinoma
Expression of pit-1 messenger ribonucleic acid and protein in the human placenta.
Pit-1/growth hormone factor 1 splice variant expression in the rhesus monkey pituitary gland and the rhesus and human placenta.
Congenital Abnormalities
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
Evidence of a congenital midline brain anomaly in pituitary dwarfs: a magnetic resonance imaging study in 101 patients.
Congenital Hypothyroidism
A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus.
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
[Molecular endocrinology of thyroid diseases]
Cystic Fibrosis
Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Drug-Related Side Effects and Adverse Reactions
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Ductus Arteriosus, Patent
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Dwarfism
Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism.
Genetic mapping of the human pituitary-specific transcriptional factor gene and its analysis in familial panhypopituitary dwarfism.
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
Pituitary-specific transcription factor Pit-1 in the rdw rat with growth hormone- and prolactin-deficient dwarfism.
Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice.
The Ames dwarf gene is required for Pit-1 gene activation.
The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.
Dwarfism, Pituitary
Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.
Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.
Pit-1 and pituitary function.
Pituitary dwarfism in the R271W Pit-1 gene mutation.
Dyslipidemias
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Familial Hypophosphatemic Rickets
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function.
Phosphate matters when investigating hypercalcemia: a mutation in SLC34A3 causing HHRH
Processing and stability of type IIc sodium-dependent phosphate cotransporter mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria.
Fanconi Syndrome
Time Course of Pathogenic and Adaptation Mechanisms in Cystinotic Mouse Kidneys.
Galactorrhea
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Ganglioneuroma
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Genetic Diseases, Inborn
Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.
Glycogen Storage Disease
NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.
Probing into the function of the gene product responsible for glycogen storage disease type Ib.
Gout
Erratum to: Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.
Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout.
The renal urate transporter SLC17A1 locus: confirmation of association with gout.
Granulomatous Disease, Chronic
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Growth Hormone-Secreting Pituitary Adenoma
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Free alpha-subunit and intact TSH secretion in vitro are closely associated in human somatotroph adenomas.
Impact of gsp oncogene on the expression of genes coding for Gsalpha, Pit-1, Gi2alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity.
Impact of SLC20A1 on the Wnt/??catenin signaling pathway in somatotroph adenomas.
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Hemangioma
Review: molecular thyroidology.
Herpes Simplex
Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1.
Hypercholesterolemia
Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice.
Hyperglycemia
Combined effects of hyperphosphatemia and hyperglycemia on the calcification of cultured human aortic smooth muscle cells.
Hyperoxaluria
Human SLC26A1 gene variants: a pilot study.
Hyperparathyroidism, Secondary
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Secondary hyperparathyroidism and phosphate sensing in parathyroid glands.
Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.
Hyperphosphatemia
Combined effects of hyperphosphatemia and hyperglycemia on the calcification of cultured human aortic smooth muscle cells.
Correlation among hyperphosphatemia, type II sodium phosphate transporter activity, and vitamin D metabolism in Fgf-23 null mice.
Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD.
Effects of Phosphonoformic Acid and Renagel on Renal Type IIa Sodium-Dependent Phosphate Cotransporter mRNA Expression in Hyperphosphatemia Rats.
EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease-mineral bone disorder.
In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.
Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.
Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.
Regulation of the Rat Intestinal Na-dependent Phosphate Transporters by Dietary Phosphate.
Significant Species Differences in Intestinal Phosphate Absorption between Dogs, Rats, and Monkeys.
Sirtuin-1 and Its Relevance in Vascular Calcification.
Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.
Hyperprolactinemia
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Hypersensitivity
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.
The role of OsNLA1 in regulating arsenate uptake and tolerance in rice.
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system.
Hypertension
Association Between SLC20A1 and Sodium-Lithium Countertransport.
Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide.
Hyperthyroidism
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Hypoalbuminemia
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Hypophosphatasia
Genetic hypercalcemia.
Hypophosphatemia
1alpha-Hydroxylase gene ablation and Pi supplementation inhibit renal calcification in mice homozygous for the disrupted Npt2a gene.
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule.
Chromosome assignments of genes for human Na(+)-dependent phosphate co-transporters NaPi-3 and NPT-1.
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.
Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis.
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice.
Hypophosphatemia and calcium nephrolithiasis.
Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH.
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.
Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.
Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
Regulation of Phosphorus Homeostasis by the Type IIa Na/Phosphate Cotransporter.
Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporter.
Hypophosphatemia, Familial
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
Increase in phosphaturia by inhibition of renal sodium-dependent phosphate cotransporter NPT2a.
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
Klotho: a novel regulator of calcium and phosphorus homeostasis.
Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.
Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors.
Sirolimus Induced Phosphaturia is Not Caused by Inhibition of Renal Apical Sodium Phosphate Cotransporters.
The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.
Hypophysitis
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Hypopituitarism
Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.
Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.
Pit-1 and hypopituitarism.
Severe congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation.
[Congenital multiple anterior pituitary hormone deficiencies. An approach of pituitary ontogenesis]
Hypothyroidism
A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.
A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus.
A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans.
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene.
Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.
Description of a Brazilian patient bearing the R271W Pit-1 gene mutation.
Genetics of growth hormone gene expression.
Molecular basis of familial growth hormone deficiency.
Pit-1 and pituitary function.
Pituitary transcription factors: from congenital deficiencies to gene therapy.
Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency.
Review: molecular thyroidology.
The Ames dwarf gene is required for Pit-1 gene activation.
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
The R271W mutant form of Pit-1 does not act as a dominant inhibitor of Pit-1 action to activate the promoters of GH and prolactin genes.
[Homeoproteins and pituitary adenoma]
Infections
Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.
An improved susceptibility test based on Amberlite reveals the potential antilisterial activity of fosfomycin in vitro.
Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.
Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity.
European and African maize cultivars differ in their physiological and molecular responses to mycorrhizal infection.
Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulated.
Focus assay on FeLIX-dependent feline leukemia virus.
Global pattern of gene expression of Xanthomonas axonopodis pv. glycines within soybean leaves.
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Lack of functional Pit-1 and Pit-2 expression on hematopoietic stem cell lines.
Masking of retroviral envelope functions by oligomerizing polypeptide adaptors.
Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice.
Phosphate Transporter PstSCAB of Campylobacter jejuni Is a Critical Determinant of Lactate-Dependent Growth and Colonization in Chickens.
Rapid retroviral infection of human haemopoietic cells of different lineages: efficient transfer in fresh T cells.
Retrovirus receptor PiT-1 of the Felis catus.
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
Targeting of c-Met and Urokinase Expressing Human Glioma Cell Lines by Retrovirus Vector Displaying Single-Chain Variable Fragment Antibody.
The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.
The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter.
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection.
The Rice Phosphate Transporter Protein OsPT8 Regulates Disease Resistance and Plant Growth.
Tissue tropism of avian reoviruses is genetically determined.
Infertility, Male
The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation.
Insulin Resistance
Elk-1, C/EBPalpha, and Pit-1 confer an insulin-responsive phenotype on prolactin promoter expression in Chinese hamster ovary cells and define the factors required for insulin-increased transcription.
Kidney Failure, Chronic
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Leishmaniasis, Visceral
Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis.
Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L. donovani.
Leukemia
A family of retroviruses that utilize related phosphate transporters for cell entry.
A new structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape Leukemia virus.
Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines.
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region.
Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.
Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver.
Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
Expression of the gibbon ape leukemia virus receptor-1 in rhesus macaque tissues.
Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus.
Immunodetection of a type III sodium-dependent phosphate cotransporter in tissues and OK cells.
Inter-retroviral fusion mediated by human immunodeficiency virus or murine leukemia virus glycoproteins: independence of cellular membranes and membrane vesicles.
Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2.
Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration.
RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.
Retroviral retargeting by envelopes expressing an N-terminal binding domain.
Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry.
Retrovirus receptor PiT-1 of the Felis catus.
Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.
The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter.
Up-regulation of the Pit-2 phosphate transporter/retrovirus receptor by protein kinase C epsilon.
Leukemia, Feline
A new structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape Leukemia virus.
Retrovirus receptor PiT-1 of the Felis catus.
Lipedema
Pit-1 Mutation and Lipoedema in a Family.
Lung Neoplasms
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
Malnutrition
Expression of a xanthine permease and phosphate transporter in cultures and field populations of the harmful alga Aureococcus anophagefferens: tracking nutritional deficiency during brown tides.
Meningitis
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Mesothelioma
Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus.
Metabolic Diseases
Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells.
Multiple Endocrine Neoplasia Type 2b
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Neoplasm Metastasis
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Inhibition of cell migration by PITENINs: the role of ARF6.
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Neoplasms
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly.
A single- center experience of prolactin-producing pituitary adenomas without hyperprolactinemia: Its incidence and clinical management.
A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoter.
Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin.
Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.
Advances and controversies in the classification and grading of pituitary tumors.
Analysis of Pit-1 in regulating mouse TSH beta promoter activity in thyrotropes.
Autoimmune pituitary disease: New concepts with clinical implications.
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression.
Clinical and Molecular Features of a TSH-Secreting Pituitary Microadenoma.
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations.
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.
Expression and alternative splicing of Pit-1 messenger ribonucleic acid in pituitary adenomas.
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Expression of Pit-1 and related proteins in diverse human pituitary adenomas.
GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors.
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment.
High SLC20A1 Expression Is Associated With Poor Prognoses in Claudin-low and Basal-like Breast Cancers.
How Valuable Is the RT-qPCR of Pituitary-Specific Transcription Factors for Identifying Pituitary Neuroendocrine Tumor Subtypes According to the New WHO 2017 Criteria?
Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1.
Identification of a novel function of PiT1 critical for cell proliferation and independent from its phosphate transport activity.
Identification of Transporters Involved in Beraprost Sodium Transport In Vitro.
Impact of SLC20A1 on the Wnt/??catenin signaling pathway in somatotroph adenomas.
Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells.
Inhibition of cell migration by PITENINs: the role of ARF6.
Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications.
Localization of somatostatin receptor subtype mRNA in the rat gastrointestinal tract and regulation of SSTR1 gene expression.
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma).
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole.
Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients.
Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity.
PD-L1 Is Preferentially Expressed in PIT-1 Positive Pituitary Neuroendocrine Tumours.
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Pit-1 gene expression in human pituitary adenomas.
Pit-1 gene expression in the human pituitary and pituitary adenomas.
Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Pituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Plurihormonal Pituitary Tumor of Pit-1 and SF-1 Lineages, with Synchronous Collision Corticotroph Tumor: a Possible Stem Cell Phenomenon.
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.
Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors.
Silent somatotroph pituitary adenomas: an update.
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Skull Base Tumors: Neuropathology and Clinical implications.
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Sodium-dependent phosphate cotransporters and vascular calcification.
Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer.
Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma.
Utility of GATA-3 Expression in the Analysis of Pituitary Neuroendocrine Tumour (PitNET) Transcription Factors.
Vascular calcification--is aldosterone a culprit?
[Etiopathogenesis of pituitary tumors]
[Homeoproteins and pituitary adenoma]
Nephrocalcinosis
Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.
Impaired urinary osteopontin excretion in Npt2a-/- mice.
Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.
Response of Npt2a knockout mice to dietary calcium and phosphorus.
Nephrolithiasis
Hypophosphatemia and calcium nephrolithiasis.
NPT2a gene variation in calcium nephrolithiasis with renal phosphate leak.
Response of Npt2a knockout mice to dietary calcium and phosphorus.
Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization.
[Novel phosphate regulating genes and osteoporosis]
Neuroblastoma
Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene.
Neuroendocrine Tumors
PD-L1 Is Preferentially Expressed in PIT-1 Positive Pituitary Neuroendocrine Tumours.
Obstetric Labor, Premature
Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnancies.
Osteomalacia
FGFR3 and FGFR4 do not mediate renal effects of FGF23.
Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia.
Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
Osteoporosis
[Novel phosphate regulating genes and osteoporosis]
Osteosarcoma
Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I.
Ovarian Neoplasms
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.
Pituitary ACTH Hypersecretion
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Pituitary Neoplasms
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor.
An alternatively spliced Pit-1 isoform altered in its ability to trans-activate.
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.
Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1.
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Correlation of Pit-1 gene expression and Pit-1 content with proliferation and differentiation in human myeloid leukemic cells.
Expression and alternative splicing of Pit-1 messenger ribonucleic acid in pituitary adenomas.
Expression of GATA-2 in human pituitary adenomas.
Expression of human Pit-1 product in the human pituitary and pituitary adenomas. Immunohistochemical studies using an antibody against synthetic human Pit-1 product.
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Expression of Pit-1 and related proteins in diverse human pituitary adenomas.
Expression of Pit-1 mRNA and activin/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.
Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features.
Functional significance of prop-1 gene expression in pituitary adenomas.
Giant plurihormonal pituitary adenoma in a child - case study.
Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas.
Immunohistochemical expression of Pit-1 protein in human pituitary adenomas.
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions.
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen.
In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas.
Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.
Introduction to molecular endocrine pathology.
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
No Evidence for WT1 Involvement in a Beta-Catenin-Independent Activation of the Wnt Signaling Pathway in Pituitary Adenomas.
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Pit-1 gene expression in human pituitary adenomas.
Pit-1 gene expression in the human pituitary and pituitary adenomas.
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
Pit-1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Pit-1/ghf-1 transcription factor expression in rodent pituitaries.
Pituitary adenomas that show a faint GH-immunoreactivity but lack fibrous body: Pit-1 adenoma with endocrinologically low activity.
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Pituitary transcription factors in the immunohistochemical and molecular diagnosis of pituitary tumours - a systematic review.
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Plurihormonal Pituitary Tumor of Pit-1 and SF-1 Lineages, with Synchronous Collision Corticotroph Tumor: a Possible Stem Cell Phenomenon.
Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors.
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Steroidogenic Factor 1, Pit-1, and Adrenocorticotropic Hormone: A Rational Starting Place for the Immunohistochemical Characterization of Pituitary Adenoma.
The ontogeny of pit-1 expression in the human fetal pituitary gland.
The rat growth hormone-releasing hormone receptor gene: structure, regulation, and generation of receptor isoforms with different signaling properties.
The Role of T-box Transcription Factor in a Pituitary Adenoma Diagnostic Algorithm.
The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph.
The transcriptional regulation of the growth hormone gene is conserved in vertebrate evolution.
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
[Homeoproteins and pituitary adenoma]
Potassium Deficiency
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Pre-Eclampsia
Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and laminin?1 expressing cells.
Prolactinoma
Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Expression of Pit-1 and estrogen receptor messenger RNA in prolactin-producing pituitary adenomas.
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen.
Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses.
Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice.
Pituitary transcription factors: from congenital deficiencies to gene therapy.
[Homeoproteins and pituitary adenoma]
Proteinuria
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Pseudomonas Infections
Circadian Clock-Regulated Phosphate Transporter PHT4;1 Plays an Important Role in Arabidopsis Defense.
Renal Insufficiency
Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.
Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure.
Phosphate excretion and phosphate transporter messenger RNA in uremic rats treated with phosphonoformic acid.
Renal Insufficiency, Chronic
A novel SNP in the 5' regulatory region of organic anion transporter 1 is associated with chronic kidney disease.
Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease.
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.
Regulation of the Rat Intestinal Na-dependent Phosphate Transporters by Dietary Phosphate.
Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2.
[Progress in the identification of intestinal Pi transport inhibitors]
Retinoblastoma
[Etiopathogenesis of pituitary tumors]
Retroviridae Infections
Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2.
Rickets
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA: A NOVEL HOMOZYGOUS MUTATION IN SLC34A3 AND LITERATURE REVIEW.
Type IIc sodium-dependent phosphate transporter regulates calcium metabolism.
Rickets, Hypophosphatemic
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA: A NOVEL HOMOZYGOUS MUTATION IN SLC34A3 AND LITERATURE REVIEW.
Sarcoma, Avian
Genomic structure and functional analysis of promoter region of somatolactin gene of sea bream (Sparus aurata).
Severe Combined Immunodeficiency
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Sjogren's Syndrome
A 1.1-Mb transcript map of the hereditary hemochromatosis locus.
Starvation
A Brassica napus PHT1 phosphate transporter, BnPht1;4, promotes phosphate uptake and affects roots architecture of transgenic Arabidopsis.
A Constitutive Expressed Phosphate Transporter, OsPht1;1, Modulates Phosphate Uptake and Translocation in Phosphate-Replete Rice.
An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels.
Arabidopsis thaliana high-affinity phosphate transporters exhibit multiple levels of posttranslational regulation.
Arabidopsis WRKY45 Transcription Factor Activates PHOSPHATE TRANSPORTER1;1 Expression in Response to Phosphate Starvation.
Arbuscular mycorrhizal fungi differ in their ability to regulate the expression of phosphate transporters in maize (Zea mays L.).
Cloning and characterization of two phosphate transporters from Medicago truncatula roots: regulation in response to phosphate and to colonization by arbuscular mycorrhizal (AM) fungi.
Coregulated expression of the Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high-pH stress.
Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity.
Effects of phosphorus starvation versus limitation on the marine cyanobacterium Prochlorococcus?MED4 II: gene expression.
Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulated.
Functional properties and expression quantitative trait loci for phosphate transporter GmPT1 in soybean.
Genome-Wide Identification and Expression Profile Analysis of the PHT1 Gene Family in Gossypium hirsutum and Its Two Close Relatives of Subgenome Donor Species.
High level of zinc triggers phosphorus starvation by inhibiting root-to-shoot translocation and preferential distribution of phosphorus in rice plants.
Identification of Long Non-Coding RNAs and the Regulatory Network Responsive to Arbuscular Mycorrhizal Fungi Colonization in Maize Roots.
Identification of phosphatin, a drug alleviating phosphate starvation responses in Arabidopsis.
Involvement of OsSPX1 in phosphate homeostasis in rice.
miR444a has multiple functions in the rice nitrate-signaling pathway.
Molecular cloning and functional analysis of two phosphate transporter genes from Rhizopogon luteolus and Leucocortinarius bulbiger, two ectomycorrhizal fungi of Pinus tabulaeformis.
OsCYCP1;1, a PHO80 homologous protein, negatively regulates phosphate starvation signaling in the roots of rice (Oryza sativa L.).
OsPht1;8, a phosphate transporter, is involved in auxin and phosphate starvation response in rice.
OsPT2, a phosphate transporter, is involved in the active uptake of selenite in rice.
OsUEV1B, an Ubc enzyme variant protein, is required for phosphate homeostasis in rice.
Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p.
Phosphate transporter mediated lipid accumulation in Saccharomyces cerevisiae under phosphate starvation conditions.
Phosphate utilization efficiency correlates with expression of low-affinity phosphate transporters and noncoding RNA, IPS1, in barley.
Phosphate-Starvation-Inducible S-Like RNase Genes in Rice Are Involved in Phosphate Source Recycling by RNA Decay.
Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance.
Promoter deletion analysis elucidates the role of cis elements and 5'UTR intron in spatiotemporal regulation of AtPht1;4 expression in Arabidopsis.
Regulated expression of Arabidopsis phosphate transporters.
Regulation of cation-coupled high-affinity phosphate uptake in the yeast Saccharomyces cerevisiae.
Regulation of the pstSCAB operon in Corynebacterium glutamicum by the regulator of acetate metabolism RamB.
TaMIR1139: a wheat miRNA responsive to Pi-starvation, acts a critical mediator in modulating plant tolerance to Pi deprivation.
The cis-acting CTTC-P1BS module is indicative for gene function of LjVTI12, a Qb-SNARE protein gene that is required for arbuscule formation in Lotus japonicus.
The enhanced phosphorus use efficiency in phosphate-deficient and mycorrhiza-inoculated barley seedlings involves activation of different sets of PHT1 transporters in roots.
The Phosphate Transporter Gene OsPht1;4 Is Involved in Phosphate Homeostasis in Rice.
The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by the Arabidopsis thaliana root during phosphorus starvation.
The pstSCAB operon for phosphate uptake is regulated by the global regulator GlxR in Corynebacterium glutamicum.
The spatial expression patterns of a phosphate transporter (MtPT1) from Medicago truncatula indicate a role in phosphate transport at the root/soil interface.
The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity.
The Transcription Factor NIGT1.2 Modulates Both Phosphate Uptake and Nitrate Influx during Phosphate Starvation in Arabidopsis and Maize.
Transcriptional analysis of the pst operon of Escherichia coli.
Transcriptional regulation of plant phosphate transporters.
Superinfection
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
Tenosynovitis
Immune response to avian reovirus in chickens and protection against experimental infection.
Thymoma
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.
Autoimmune pituitary disease: New concepts with clinical implications.
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Thyroid Dysgenesis
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Thyroid Hormone Resistance Syndrome
Review: molecular thyroidology.
Tuberculosis
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.
B-subunit of phosphate-specific transporter from Mycobacterium tuberculosis is a thermostable ATPase.
Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions.
Expression, purification and improved antigenicity of the Mycobacterium tuberculosis PstS1 antigen for serodiagnosis.
Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.
Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors.
Intrinsic contributions of polar amino acid residues toward thermal stability of an ABC-ATPase of mesophilic origin.
Nucleotide-induced conformational change in the catalytic subunit of the phosphate-specific transporter from M. tuberculosis: implications for the ATPase structure.
Uremia
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Urinary Bladder Neoplasms
Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.
Urinary Tract Infections
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection.
Urolithiasis
Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.
[Genetic hypophosphatemia: recent advances in physiopathogenic concept]
Uterine Cervical Neoplasms
Induction of chinook salmon growth hormone promoter activity by the adenosine 3',5'-monophosphate (cAMP)-dependent pathway involves two cAMP-response elements with the CGTCA motif and the pituitary-specific transcription factor Pit-1.
Vascular Calcification
Accelerated atherosclerotic calcification and Monckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease.
Amplification of atherosclerotic calcification and Mönckeberg's sclerosis: a spectrum of the same disease process.
Calcitriol Accelerates Vascular Calcification Irrespective of Vitamin K Status in a Rat Model of Chronic Kidney Disease with Hyperphosphatemia and Secondary Hyperparathyroidism.
Calcium Overload Accelerates Phosphate-Induced Vascular Calcification Via Pit-1, but not the Calcium-Sensing Receptor.
Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells.
Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats.
Magnesium prevents phosphate-induced vascular calcification via TRPM7 and Pit-1 in an aortic tissue culture model.
Novel mechanisms in accelerated vascular calcification in renal disease patients.
Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1.
Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.
Regulation of the Sodium-Phosphate Cotransporter Pit-1 and its Role in Vascular Calcification.
Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2.
Sodium-dependent phosphate cotransporters and vascular calcification.
Trichostatin A, an HDAC Class I/II Inhibitor, Promotes Pi-Induced Vascular Calcification Via Up-Regulation of the Expression of Alkaline Phosphatase.
Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.
Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.
Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-alpha, and Pi.
[Mechanism of vascular calcification]