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Information on EC 7.2.4.3 - (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

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IUBMB Comments
This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
Decarboxylase, methylmalonyl coenzyme A, Methylmalonyl-CoA decarboxylase, Methylmalonyl-coenzyme A decarboxylase, MMCD, Propionyl coenzyme A carboxylase, Propionyl-CoA carboxylase, Sodium pump methylmalonyl-CoA decarboxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
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(S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2
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PATHWAY SOURCE
PATHWAYS
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