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Disease on EC 7.1.2.2 - H+-transporting two-sector ATPase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
A novel heterozygous mutation in the ATP6V0A4 gene encoding the V-ATPase a4 subunit in an adult patient with incomplete distal renal tubular acidosis.
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Absence of vacuolar H(+)-ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjögren's syndrome.
Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression.
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.
Angiotensin II stimulates vacuolar H+ -ATPase activity in renal acid-secretory intercalated cells from the outer medullary collecting duct.
ATP6B1 gene mutations associated with distal renal tubular acidosis and deafness in a child.
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.
cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
Controversies in preconditioning.
Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.
Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.
Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.
Development and Diseases of the Collecting Duct System.
Differential regulation of vacuolar H+ -ATPase subunits by transforming growth factor-?1 in salivary ducts.
Effect of metabolic or respiratory acidosis on rabbit renal medullary proton-ATPase.
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
Enzymatic and functional evidence for adaptation of the vacuolar H(+)-ATPase in proximal tubule apical membranes from rats with chronic metabolic acidosis.
Functional upregulation of H+-ATPase by lethal acid stress in cultured inner medullary collecting duct cells.
Gill morphology and acid-base regulation in freshwater fishes.
H+-ATPase in hyperkalemic distal renal tubular acidosis.
Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base Disturbance with Implications for Kidney Stone Disease.
Immunolocalization of vacuolar-type H+-ATPase in rat submandibular gland and adaptive changes induced by acid-base disturbances.
Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.
Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes.
Ischemic preconditioning reduces Na(+) accumulation and cell killing in isolated rat hepatocytes exposed to hypoxia.
Kidney vacuolar H+ -ATPase: physiology and regulation.
Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
Molecular Pathophysiology of Acid-Base Disorders.
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Myocardial acidosis and the mitigation of tissue ATP depletion in ischemic cardiac muscle: the role of the mitochondrial ATPase.
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Phospholipid changes during adaptation to acidosis in urinary bladder of Bufo marinus.
Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis.
Proximal renal tubular dysfunction in primary distal renal tubular acidosis.
Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.
Regulation and function of V-ATPases in physiology and disease.
Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.
Regulation of Luminal Acidification by the V-ATPase.
Regulation of the Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase.
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
Renal vacuolar H+-ATPase.
Role of vacuolar ATPase and Skp1 in Sjögren's syndrome.
Roles of vacuolar H+-ATPase in mice treated with norepinephrine and acetylcholine.
Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene.
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
The Calcineurin inhibitor FK506 (Tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport.
The effect of metabolic acidosis and alkalosis on the H+-ATPase of rat cerebral microvessels.
The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis.
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
Vacuolar ATPases and their role in vision.
Vacuolar-type ATPase: A proton pump to lysosomal trafficking.
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acidosis, Lactic
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates.
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Acidosis, Renal Tubular
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
A novel heterozygous mutation in the ATP6V0A4 gene encoding the V-ATPase a4 subunit in an adult patient with incomplete distal renal tubular acidosis.
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Absence of vacuolar H(+)-ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjögren's syndrome.
Angiotensin II stimulates vacuolar H+ -ATPase activity in renal acid-secretory intercalated cells from the outer medullary collecting duct.
ATP6B1 gene mutations associated with distal renal tubular acidosis and deafness in a child.
Development and Diseases of the Collecting Duct System.
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
H+-ATPase in hyperkalemic distal renal tubular acidosis.
Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base Disturbance with Implications for Kidney Stone Disease.
Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.
Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
Molecular Pathophysiology of Acid-Base Disorders.
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis.
Regulation and function of V-ATPases in physiology and disease.
Regulation of the Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase.
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
Renal vacuolar H+-ATPase.
Role of vacuolar ATPase and Skp1 in Sjögren's syndrome.
Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene.
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
Vacuolar ATPases and their role in vision.
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acidosis, Respiratory
Effect of metabolic or respiratory acidosis on rabbit renal medullary proton-ATPase.
Immunolocalization of proton pumps (H+-ATPase) in pavement cells of rainbow trout gill
Acquired Immunodeficiency Syndrome
Allele-specific expression of the Mgi- phenotype on disruption of the F1-ATPase delta-subunit gene in Kluyveromyces lactis.
The curious case of vacuolar ATPase: regulation of signaling pathways.
Acute Kidney Injury
Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats.
Retraction: Oligomycin, an F1FO-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats.
Urinary ATP synthase subunit ? is a novel biomarker of renal mitochondrial dysfunction in acute kidney injury.
Adenocarcinoma
Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma.
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.
F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation.
Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer.
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Adenocarcinoma of Lung
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
African Swine Fever
Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection.
Albinism
Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism.
Alkalosis
Adenylyl cyclase 6 is required for maintaining acid-base homeostasis.
Immunolocalization of vacuolar-type H+-ATPase in rat submandibular gland and adaptive changes induced by acid-base disturbances.
Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.
The effect of metabolic acidosis and alkalosis on the H+-ATPase of rat cerebral microvessels.
Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis.
Alphavirus Infections
Role of the vacuolar ATPase in the Alphavirus replication cycle.
Alveolar Bone Loss
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
Alzheimer Disease
?-amyloid Peptide Binds and Regulates Ectopic ATP Synthase ?-Chain on Neural Surface.
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
Anti-ATP Synthase Autoantibodies Induce Neuronal Death by Apoptosis and Impair Cognitive Performance in C57BL/6 Mice.
Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease.
ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis.
Broadening the horizon: Integrative pharmacophore-based and cheminformatics screening of novel chemical modulators of mitochondria ATP synthase towards interventive Alzheimer's disease therapy.
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.
Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease.
Deciphering the 'Elixir of Life': Dynamic Perspectives into the Allosteric Modulation of Mitochondrial ATP Synthase by J147, a Novel Drug in the Treatment of Alzheimer's Disease.
Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits.
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease.
Direct Transcriptional Effects of Apolipoprotein E.
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.
On the role of v-ATPase V0a1-dependent degradation in Alzheimer disease.
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Roles for H+ /K+ -ATPase and zinc transporter 3 in cAMP-mediated lysosomal acidification in bafilomycin A1-treated astrocytes.
The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease.
[Functional disorders of FOF1-ATPase in submitochondrial particles obtained from platelets of patients with a diagnosis of probable Alzheimer's disease]
Ameloblastoma
Immunolocalization of IP3R and V-ATPase in Ameloblastomas.
Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
Amyotrophic Lateral Sclerosis
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Dexpramipexole improves bioenergetics and outcome in experimental stroke.
Anemia
IF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice.
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
Anemia, Hypochromic
Bicarbonate blocks the expression of several genes involved in the physiological responses to Fe deficiency of Strategy I plants.
Arrhythmias, Cardiac
Left ventricular noncompaction (LVNC) and low mitochondrial membrane potential are specific for Barth syndrome.
Arthritis
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Arthritis, Rheumatoid
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Ataxia
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
A yeast-based assay identifies drugs active against human mitochondrial disorders.
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Stability of the m.8993T->G mtDNA mutation load during human embryofetal development has implications for the feasibility of prenatal diagnosis in NARP syndrome.
Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.
[Diseases caused by mutations in mitochondrial DNA].
Ataxia Telangiectasia
ATP synthase: an identified target gene of bantam in paired female Schistosoma japonicum.
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Atherosclerosis
Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target.
Genetics and molecular biology: a role for adipocyte lipid-binding protein in atherosclerosis.
[ATP synthase and apolipoprotein synthase: new players in atherosclerosis]
Atrial Fibrillation
Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep.
Autoimmune Diseases
Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice.
Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423.
Autoimmune Pancreatitis
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice.
Bacterial Infections
Identification of ATP synthase ? subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Beriberi
Citreoviridin induces myocardial apoptosis through PPAR-?-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium.
Blast Crisis
Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Blindness
Vacuolar ATPases and their role in vision.
Bone Diseases
A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase.
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Vacuolar ATPase as a drug discovery target.
Bone Resorption
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase.
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase.
A rationale for osteoclast selectivity of inhibiting the lysosomal V-ATPase a3 isoform.
A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts.
A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application.
Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption.
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
AZD8835 inhibits osteoclastogenesis and periodontitis-induced alveolar bone loss in rats.
Bis-enoxacin Inhibits Bone Resorption and Orthodontic Tooth Movement.
Bone resorptive activity of human peripheral blood mononuclear cells after fusion with polyethylene glycol.
Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R.
CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.
Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies.
Characterization of proton transport in bone-derived membrane vesicles.
Characterization of the osteoclast vacuolar H(+)-ATPase B-subunit.
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro.
Decreased bone resorption, osteoclast differentiation, and expression of vacuolar H+-ATPase in antisense DNA-treated mouse metacarpal and calvaria cultures ex vivo.
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption.
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength.
Diversity of proton pumps in osteoclasts: V-ATPase with a3 and d2 isoforms is a major form in osteoclasts.
Effects of 1?,25-(OH)2D3 on the formation and activity of osteoclasts in RAW264.7 cells.
Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Functional complementation of V-ATPase a subunit isoforms in osteoclasts.
Glucose-dependent regulation of osteoclast H(+)-ATPase expression: potential role of p38 MAP-kinase.
Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family.
Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening.
Inhibition of bone resorption in cultures of mouse calvariae by apicularen A.
Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase.
Inhibition of osteoclast bone resorption by disrupting V-ATPase a3-B2 subunit interaction.
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption.
Inhibition of the osteoclast V-ATPase by small interfering RNAs.
Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector.
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
LDC000067 suppresses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.
Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.
Na+/H(+)-antiporter activity is essential for the induction, but not the maintenance of osteoclastic bone resorption and cytoplasmic spreading.
New insights into the regulation of V-ATPase-dependent proton secretion.
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes.
Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo.
Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.
Prodigiosin 25-C and metacycloprodigiosin suppress the bone resorption by osteoclasts.
Proteomic analysis of osteoclast lipid rafts: the role of the integrity of lipid rafts on V-ATPase activity in osteoclasts.
Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films.
Selective inhibition of osteoclast vacuolar H(+)-ATPase.
Specific inhibitors of vacuolar H(+)-ATPase trigger apoptotic cell death of osteoclasts.
Suture materials affect peri-implant bone healing and implant osseointegration.
The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase.
The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.
The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption.
The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis.
Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.
V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption.
Vacuolar ATPase as a drug discovery target.
Vacuolar-type H+-ATPase-mediated acidosis promotes in vitro osteoclastogenesis via modulation of cell migration.
Vacuolar-type proton pump ATPases: Acidification and pathological relationships.
[3H]Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase.
[V-ATPase inhibitor baflomycine A1 inhibits bone resorption by osteoclast-like cells]
Brain Diseases
De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.
F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline.
In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.
Tall stature and progressive overweight in mitochondrial encephalopathy.
Brain Edema
CDP-choline: pharmacological and clinical review.
Citicoline: pharmacological and clinical review, 2006 update.
Brain Injuries
Dexpramipexole Enhances K+ Currents and Inhibits Cell Excitability in the Rat Hippocampus In Vitro.
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest.
Brain Injuries, Traumatic
Caffeine administration alters the behaviour and development of Galleria mellonella larvae.
Breast Neoplasms
AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
ATP synthase ecto-?-subunit: a novel therapeutic target for breast cancer.
Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.
Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression.
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity.
Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells.
Distribution of the ATPase inhibitor proteins of mitochondria in mammalian tissues including fibroblasts from a patient with Luft's disease.
DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.
Function of a subunit isoforms of the V-ATPase in pH homeostasis and In Vitro invasion of MDA-MB231 human breast cancer cells.
Function of V-ATPase a Subunit Isoforms in Invasiveness of MCF10a and MCF10CA1a Human Breast Cancer Cells.
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H?)-ATPase Inhibitors.
Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.
Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells.
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.
Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer.
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines.
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Rational design for heterologous production of aurovertin-type compounds in Aspergillus nidulans.
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
Role of the V1G1 subunit of V-ATPase in breast cancer cell migration.
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.
Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells.
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B.
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-? signaling.
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells.
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Carcinogenesis
Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.
Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors.
Functional expression of V-ATPases in the plasma membrane of glial cells.
Monitoring of dynamic ATP level changes by oligomycin-modulated ATP synthase inhibition in SW480 cancer cells using fluorescent "On-Off" switching DNA aptamer.
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling.
The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling.
Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin.
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis.
Carcinoma
A novel fatty acid-binding protein 5-estrogen-related receptor ? signaling pathway promotes cell growth and energy metabolism in prostate cancer cells.
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Aurora Kinase A Activates the Vacuolar H+-ATPase (V-ATPase) in Kidney Carcinoma Cells.
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells.
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas.
Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.
Mitochondria-mediated energy adaption in cancer: The H+-ATP synthase-geared switch of metabolism in human tumors.
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines.
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma.
The bioenergetic signature of cancer: a marker of tumor progression.
The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response.
The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
[Effect of protein inhibitors of mitochondrial ATPase in intact rat thymocytes and Ehrlich ascites carcinoma cells]
[LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity].
[Preparation of monoclonal antibody against lung cancer and identification of its targeting antigen]
[Research on relevance between mitochondrial ATP synthase and malignant tumor].
Carcinoma in Situ
Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Carcinoma, Ehrlich Tumor
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
On the mechanism of glycolysis stimulation by neutral detergents in 3T3 and Ehrlich ascites tumor cells.
Stimulation of glycolysis by placental polypeptides and inhibition by duramycin.
The Crabtree effect: a new look at the old problem.
Carcinoma, Hepatocellular
Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells.
Coupling between proteolytic processing and translocation of the precursor of the F1-ATPase beta-subunit during its import into mitochondria of intact cells.
Data of enzymatic activities of the electron transport chain and ATP synthase complexes in mouse hepatoma cells following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Different sensitivity of Zajdela hepatoma mitochondrial ATPase activity to uncouplers in digitonin-treated cells and isolated mitochondria.
ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit.
Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma.
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria.
Membranous effects on adenosine triphosphatase activities of mitochondria from rat liver and Morris hepatoma 3924A.
Mitochondrial ATPase activities of hepatoma BW7756 and ascites tumor cells. Influence of MG2+ ions, free fatty acids, and uncouplers.
Mitochondrial ATPase of Zajdela hepatoma. II. Mitochondria of Zajdela hepatoma contain less adenosine triphosphatase than mitochondria of rat liver.
Mitochondrial ATPase of Zajdela hepatoma. Presence of F1-specific antigenic determinants outside mitochondria.
Mitochondrial ATPase of Zajdela hepatoma. V. Mitochondria of Zajdela hepatoma contain membrane sectors of ATPase complex unassociated with F1.
Mitochondrial ATPase of Zajdela hepatoma. VI. Effect of extramitochondrial ATP and pH on uncoupler-sensitivity of mitochondrial ATPase activity.
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.
Overexpression of the inhibitor protein IF(1) in AS-30D hepatoma produces a higher association with mitochondrial F(1)F(0) ATP synthase compared to normal rat liver: functional and cross-linking studies.
Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma.
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Response of mitochondrial ATPase activity to uncouplers in isolated organelles and whole cells of Zajdela hepatoma.
Role of V-ATPases in solid tumors: Importance of the subunit C (Review).
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
The effect of the natural protein inhibitor on H+-ATPase hepatoma 22a mitochondria.
The inhibitor protein (IF1) promotes dimerization of the mitochondrial F1F0-ATP synthase.
[LASS2 interacts with V-ATPase and inhibits cell growth of hepatocellular carcinoma]
[Photodynamic action of hypocrellin A on hepatoma cell mitochondria and microsomes]
Carcinoma, Non-Small-Cell Lung
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen.
MicroRNA-7-5p's role in the O-GlcNAcylation and cancer metabolism.
Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin.
Carcinoma, Ovarian Epithelial
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Carcinoma, Papillary
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Carcinoma, Renal Cell
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma.
Carcinoma, Squamous Cell
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Cardiomegaly
Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidase.
Cardiomyopathies
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes.
Kinetic properties of mitochondrial ATPase during isoproterenol-induced cardiomyopathy.
Regulation of mitochondrial ATP synthase in cardiac pathophysiology.
Regulation of the mitochondrial ATP synthase is defective in rat heart during alcohol-induced cardiomyopathy.
Cardiomyopathy, Hypertrophic
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Cardiotoxicity
Optimizing Bedaquiline for cardiotoxicity by structure based virtual screening, DFT analysis and molecular dynamic simulation studies to identify selective MDR-TB inhibitors.
Cardiovascular Diseases
Direct Transcriptional Effects of Apolipoprotein E.
Proteomic analysis of right and left cardiac ventricles under aerobic conditions and after ischemia/reperfusion.
The ATP synthase glycine zipper of the c subunits: From the structural to the functional role in mitochondrial biology of cardiovascular diseases.
Celiac Disease
Identification of new celiac disease autoantigens using proteomic analysis.
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.
Chagas Disease
Heart FoF1-ATPase changes during the acute phase of Trypanosoma cruzi infection in rats.
The process of lipid storage in insect oocytes: The involvement of ?-chain of ATP synthase in lipophorin-mediated lipid transfer in the chagas' disease vector Panstrongylus megistus (Hemiptera: Reduviidae).
Cherubism
Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts.
Cholera
Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity.
Cholestasis
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
The synthesis of taurocholic and glycocholic acids in human liver homogenates and subcellular fractions in obstructive jaundice.
Choriocarcinoma
The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate interleukin-1beta production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells.
Colonic Neoplasms
AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells.
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells.
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
Colorectal Neoplasms
Analysis of metastasis associated signal regulatory network in colorectal cancer.
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer.
Cell surface F1-ATPase binds the Gastrin precursor, G-gly, and mediates its proliferative effects on colorectal cancer cells and vascular endothelial cells.
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes.
Oligomycin A promotes radioresistance in HT29 colorectal cancer cells and its mechanisms.
Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Contracture
Contracture in isolated adult rat heart cells. Role of Ca2+, ATP, and compartmentation.
Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition.
Coronary Disease
Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.
The potential role of mitochondrial ATP synthase inhibitory factor 1 (IF1) in coronary heart disease: a literature review.
COVID-19
A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19.
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.
Cutis Laxa
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa.
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.
Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa.
Vacuolar ATPases and their role in vision.
Vacuolar H(+)-ATPase meets glycosylation in patients with cutis laxa.
Cystic Fibrosis
A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte.
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Effect of salinity and temperature on the expression of genes involved in branchial ion transport processes in European sea bass.
Expression of carbonic anhydrase, cystic fibrosis transmembrane regulator (CFTR) and V-H(+)-ATPase in the lancelet Branchiostoma lanceolatum (Pallas, 1774).
Expression of ion transport-associated proteins in human efferent and epididymal ducts.
Heat treatment of thioredoxin fusions increases the purity of ?-helical transmembrane protein constructs.
Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates.
Human targets of Pseudomonas aeruginosa pyocyanin.
Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization.
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease.
The cellular localization of Na(+)/H(+) exchanger 1, cystic fibrosis transmembrane conductance regulator, potassium channel, epithelial sodium channel ? and vacuolar-type H+-ATPase in human eccrine sweat glands.
The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
Cysts
Apparent dominance of the G1-G3 genetic cluster of Echinococcus granulosus strains in the central inland region of Portugal.
ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Cytochrome-c Oxidase Deficiency
Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry.
Cytomegalovirus Infections
Cellular v-ATPase is required for virion assembly compartment formation in human cytomegalovirus infection.
Deafness
Confirmation of the ATP6B1 gene as responsible for distal renal tubular acidosis.
Familial renal tubular acidosis.
K(+) Pump: From Caterpillar Midgut to Human Cochlea.
Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts.
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies.
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
Dehydration
Comparative effects of allelochemical and water stress in roots of Lycopersicon esculentum Mill. (Solanaceae).
Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F(1)-ATPase by controlled dehydration.
The Gene Encoding Subunit A of the Vacuolar H+-ATPase From Cotton Plays an Important Role in Conferring Tolerance to Water Deficit.
Dementia
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
ATP Synthase, a Target for Dementia and Aging?
Direct Transcriptional Effects of Apolipoprotein E.
The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Dengue
Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion.
Dent Disease
A pure chloride channel mutant of CLC-5 causes Dent's disease via insufficient V-ATPase activation.
Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients.
Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
Functional coupling of V-ATPase and CLC-5.
Dental Caries
Streptococcus salivarius Isolates of Varying Acid Tolerance Exhibit F1F0-ATPase Conservation.
[Dynamic changes of aciduric virulence factor membrane-bound proton-translocating ATPase of Streptococcus mutans in the development of dental caries].
Dermatitis, Phototoxic
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
Dermatomyositis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Diabetes Mellitus
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus.
Diabetes Mellitus, Experimental
Insulin-status-dependent modulation of FoF1-ATPase activity in rat liver mitochondria.
Diabetes Mellitus, Type 2
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.
Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determines Glucose Metabolism in Women with a History of Gestational Diabetes.
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus.
Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.
V-ATPase blockade reduces renal gluconeogenesis and improves insulin secretion in type 2 diabetic rats.
Diabetic Cardiomyopathies
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.
Diabetic Nephropathies
ATP synthase subunit-? down-regulation aggravates diabetic nephropathy.
Diphtheria
In silico design of fusion toxin DT389GCSF and comparison of interaction it with GCSF receptor rather than DT486GCSF.
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase.
Down Syndrome
Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
Epigallocatechin-3-Gallate Plus Omega-3 Restores the Mitochondrial Complex I and F0F1-ATP Synthase Activities in PBMCs of Young Children with Down Syndrome: A Pilot Study of Safety and Efficacy.
Dysentery, Bacillary
Interfacial amino acids support Spa47 oligomerization and shigella type three secretion system activation.
MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors.
Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
Encephalitis, Japanese
Japanese encephalitis virus infection in Vero cells: the involvement of intracellular acidic vesicles in the early phase of viral infection was observed with the treatment of a specific vacuolar type H+-ATPase inhibitor, bafilomycin A1.
Endometriosis
Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls.
[Application of two dimensional electrophoresis,western blot and mass spectrum to screen markers of endometriosis]
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Epilepsy
ATP Synthase Subunit Beta Immunostaining is Reduced in the Sclerotic Hippocampus of Epilepsy Patients.
De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.
Esophageal Neoplasms
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling.
Esophageal Squamous Cell Carcinoma
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Extensively Drug-Resistant Tuberculosis
Mycobacterial enzyme targets and their inhibitors.
Fanconi Syndrome
Physiological importance of endosomal acidification: potential role in proximal tubulopathies.
Fatty Liver
Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity.
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Feline Infectious Peritonitis
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus.
Fragile X Syndrome
ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome.
Frontotemporal Dementia
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.
Frontotemporal Lobar Degeneration
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Fructose Intolerance
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.
Ganglion Cysts
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
Gastroesophageal Reflux
In Pursuit of the Parietal Cell - An Evolution of Scientific Methodology and Techniques.
Genetic Diseases, Inborn
Mitochondrial ATP synthase subunit c stored in hereditary ceroid-lipofuscinosis contains trimethyl-lysine.
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis.
Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms.
Glioblastoma
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Biomarker discovery: a proteomic approach for brain cancer profiling.
Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B.
Glioma
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.
Contribution of a H+ pump in determining the resting potential of neuroblastoma cells.
Functional expression of V-ATPases in the plasma membrane of glial cells.
Increase in secretion of glial cell line-derived neurotrophic factor from glial cell lines by inhibitors of vacuolar ATPase.
Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
The renal v-ATPase a4 subunit is expressed in specific subtypes of human gliomas.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Glomerulonephritis, IGA
Identification of G8969>A in mitochondrial ATP6 gene that severely compromises ATP synthase function in a patient with IgA nephropathy.
Glucose Intolerance
Inheritance of a mitochondrial DNA defect and impaired glucose tolerance in BHE/Cdb rats.
The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas.
Granular Cell Tumor
Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.
h+-transporting two-sector atpase deficiency
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
A plant proton-pumping inorganic pyrophosphatase functionally complements the vacuolar ATPase transport activity and confers bafilomycin resistance in yeast.
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration.
Anomalies of mitochondrial ATP synthase regulation in four different types of neuronal ceroid lipofuscinosis.
ATP synthase deficiency due to m.8528T>C mutation - a novel cause of severe neonatal hyperammonemia requiring hemodialysis.
ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
ATPAF1 deficiency impairs ATP synthase assembly and mitochondrial respiration.
Biochemical thresholds for pathological presentation of ATP synthase deficiencies.
Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency.
Expression and processing of the TMEM70 protein.
Hyperammonemic crisis in a child with ATP synthase deficiency caused by mtDNA mutation m.8851T>C.
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
Loss of LRPPRC causes ATP synthase deficiency.
Loss of mitochondrial ATP synthase subunit beta (Atp2) alters mitochondrial and chloroplastic function and morphology in Chlamydomonas.
m.8993T>G-Associated Leigh Syndrome with Hypocitrullinemia on Newborn Screening.
Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 epsilon subunit.
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry.
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
The ATP Synthase Deficiency in Human Diseases.
TMEM70 mutations are a common cause of nuclear encoded ATP synthase assembly defect: further delineation of a new syndrome.
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy.
TMEM70: a mutational hot spot in nuclear ATP synthase deficiency with a pivotal role in complex V biogenesis.
Two components in pathogenic mechanism of mitochondrial ATPase deficiency: energy deprivation and ROS production.
[Mitochondrial ATP synthase deficiency due to 8993T > G mutation on ATP6 gene].
[Molecular bases of diseases caused by mutations in genes encoding subunits of ATP synthase].
Hearing Loss
Inherited renal tubular acidosis.
Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts.
Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear.
Role of vacuolar ATPase and Skp1 in Sjögren's syndrome.
Vacuolar-type ATPase: A proton pump to lysosomal trafficking.
Heart Arrest
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest.
Heart Diseases
Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide.
Heart Failure
Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.
Electromechanical dyssynchrony and resynchronization of the failing heart.
Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Mitochondrial ATPase and high-energy phosphates in failing hearts.
Regulation of mitochondrial ATP synthase in cardiac pathophysiology.
Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction.
Hepatitis C
Crystal structure of the TLDc domain of human NCOA7-AS.
SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.
Hepatoblastoma
The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.
Histoplasmosis
The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.
Hyperalgesia
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
Osteoclasts play a part in pain due to the inflammation adjacent to bone.
Hypercholesterolemia
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Hyperemia
F0F1 ATP synthase activity is differently modulated by coronary reactive hyperemia before and after ischemic preconditioning in the goat.
Hyperglycemia
Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1.
Hepatic overexpression of ATP synthase ? subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice.
Hyperglycemia Decreases the Expression of ATP Synthase ? Subunit and Enolase 2 in Glomerular Epithelial Cells.
Mitochondrial ATP synthase regulates corpus cavernosum smooth muscle cell function in vivo and in vitro.
Hyperhomocysteinemia
[Carnitine chloride reduces the severity of experimental hyperhomocysteinemia and promotes lactate utilization by mitochondrial fraction of the rat epididymis].
Hyperlipidemias
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Hypersensitivity
A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance.
Phosphite-Mediated Suppression of Anthocyanin Accumulation Regulated by Mitochondrial ATP Synthesis and Sugar in Arabidopsis.
Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans.
Hypertension
A Common Genetic Variant in the 3'-UTR of Vacuolar H+-ATPase ATP6V0A1 Creates a Micro-RNA Motif to Alter Chromogranin A Processing and Hypertension Risk.
Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions.
Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target.
Increased proximal tubule NHE-3 and H+-ATPase activities in spontaneously hypertensive rats.
Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor.
Mitochondrial ATP synthase regulation in heart: defects in hypertension are restored after treatment with captopril.
NBCe2 (Slc4a5) Is Expressed in the Renal Connecting Tubules and Cortical Collecting Ducts and Mediates Base Extrusion.
Hyperthyroidism
A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics.
Thyroid status is a key regulator of both flux and efficiency of oxidative phosphorylation in rat hepatocytes.
Hypokalemia
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Hypopigmentation
The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype.
Hypospadias
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Hypotension
Alterations in the proton ATPase activity of rat liver mitochondria after hemorrhagic shock.
Hypothyroidism
Hypothyroidism leads to a decreased expression of mitochondrial F0F1-ATP synthase in rat liver.
Thyroid status is a key regulator of both flux and efficiency of oxidative phosphorylation in rat hepatocytes.
Immune System Diseases
Comparative transcriptome analysis of Eriocheir japonica sinensis response to environmental salinity.
Infections
A connection between antimicrobial properties of venom peptides and microbial ATP synthase.
A hypothetical model of crossing Bombyx mori nucleopolyhedrovirus through its host midgut physical barrier.
A therapeutic connection between dietary phytochemicals and ATP synthase.
Acquisition of the vacuolar ATPase proton pump and phagosome acidification are essential for escape of Francisella tularensis into the macrophage cytosol.
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Analysis and identification of tyrosine phosphorylated proteins in hemocytes of Litopenaeus vannamei infected with WSSV.
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice.
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.
ATP synthase inhibition of Mycobacterium avium is not bactericidal.
ATP synthesis is active on the cell surface of the shrimp Litopenaeus vannamei and is suppressed by WSSV infection.
Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1.
Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection.
Binding and entry of a non-enveloped T=4 insect RNA virus is triggered by alkaline pH.
Characterization of the oligomycin-sensitivity properties of the F1F0-ATPase in mitochondria from rats infected with the liver fluke Fasciola hepatica.
Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen.
Crystal structure of the TLDc domain of human NCOA7-AS.
Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis.
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.
Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray.
Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.
Energetics of heart mitochondria during acute phase of Trypanosoma cruzi infection in rats.
F1 ATP synthase ? subunit is a putative receptor involved in white spot syndrome virus infection in shrimp by binding with viral envelope proteins VP51B and VP150.
Fire blight host-pathogen interaction: proteome profiles of Erwinia amylovora infecting apple rootstocks.
Heart FoF1-ATPase changes during the acute phase of Trypanosoma cruzi infection in rats.
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion.
Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.
Intestinal Expression of H V-ATPase in the Mosquito Aedes albopictus is Tightly Associated with Gregarine Infection.
Involvement of the vacuolar H(+)-ATPase in animal virus entry.
Kinetic Characterization of the Shigella Type Three Secretion System ATPase Spa47 Using ?-32P ATP.
Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis.
Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.
Mycoplasma pneumoniae-derived lipopeptides induce acute inflammatory responses in the lungs of mice.
pH-independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes.
PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.
Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.
Role of the vacuolar-ATPase in Sindbis virus infection.
Shedding light on the role of photosynthesis in pathogen colonization and host defense.
Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors.
Staphylococcus aureus ATP Synthase Promotes Biofilm Persistence by Influencing Innate Immunity.
Streptococcus pyogenes transcriptome changes in inflammatory environment of necrotizing fasciitis.
Studies of the viral binding proteins of shrimp BP53, a receptor of white spot syndrome virus.
Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors.
The contribution of Candida albicans vacuolar ATPase subunit V1B encoded by VMA2 to stress response, autophagy, and virulence is independent of environmental pH.
The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression.
The role of F1 ATP synthase beta subunit in WSSV infection in the shrimp, Litopenaeus vannamei.
TMT-based quantitative proteomic analysis of the effects of Pseudomonas syringae pv. tabaci (Pst) infection on photosynthetic function and the response of the MAPK signaling pathway in tobacco leaves.
Transcriptional Inhibition of the F1F0-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.
Uncoating of human rhinovirus serotype 2 from late endosomes.
Variations in gene expression and genomic stability of human hepatoma cells integrated with hepatitis B virus DNA.
Yersinia pseudotuberculosis blocks the phagosomal acidification of B10.A mouse macrophages through the inhibition of vacuolar H(+)-ATPase activity.
[Role of proton motive force in the infection of E. coli K-12 cells by bacteriophage T4]
Infertility
ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans.
High-rate spontaneous reversion to cytoplasmic male sterility in sugar beet: a characterization of the mitochondrial genomes.
Infertility, Female
AP1G mediates vacuolar acidification during synergid-controlled pollen tube reception.
Infertility, Male
A fused mitochondrial gene associated with cytoplasmic male sterility is developmentally regulated.
ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
Comprehensive transcriptome-based characterization of differentially expressed genes involved in microsporogenesis of radish CMS line and its maintainer.
Mitochondrial Cytochrome c Oxidase and F1Fo-ATPase Dysfunction in Peppers (Capsicum annuum L.) with Cytoplasmic Male Sterility and Its Association with orf507 and Ψatp6-2 Genes.
Proteome Analysis of the Wild and YX-1 Male Sterile Mutant Anthers of Wolfberry (Lycium barbarum L.).
Reduced activity of ATP synthase in mitochondria causes cytoplasmic male sterility in chili pepper.
Regulation of Luminal Acidification by the V-ATPase.
Variations in the structure and transcription of the mitochondrial atp and cox genes in wild Solanum species that induce male sterility in eggplant (S. melongena).
Influenza, Human
18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells.
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection.
Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells.
Crystal structure of the TLDc domain of human NCOA7-AS.
F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding.
Human host factors required for influenza virus replication.
Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.
Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus.
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.
Insulin Resistance
beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-alpha.
Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
Dysfunctional oxidative phosphorylation shunts branched-chain amino acid catabolism onto lipogenesis in skeletal muscle.
Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes.
Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle.
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes.
Lower fasting muscle mitochondrial activity relates to hepatic steatosis in humans.
Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward into Insulin Resistance and Contractile Dysfunction.
Protocols and pitfalls in obtaining fatty acid-binding proteins for biophysical studies of ligand-protein and protein-protein interactions.
Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes.
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.
Insulinoma
Differential expression of vacuolar-type H+-ATPase between normal human pancreatic islet B-cells and insulinoma cells.
Fatty acids and glucose in high concentration down-regulates ATP synthase beta-subunit protein expression in INS-1 cells.
Insulinoma with hyperproinsulinemia during hypoglycemia and loss of expression of vacuolar-type H(+)-ATPase (V-ATPase) in the tumor tissue.
Mitochondrial ATP synthase--a possible target protein in the regulation of energy metabolism in vitro and in vivo.
Intellectual Disability
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Invasive Fungal Infections
The V-ATPase as a Target for Antifungal Drugs.
Kearns-Sayre Syndrome
Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Kidney Calculi
The Vacuolar H+-ATPase B1 Subunit Polymorphism p.E161K Associates with Impaired Urinary Acidification in Recurrent Stone Formers.
Kidney Neoplasms
Regulation of TFEB and V-ATPases by mTORC1.
Leigh Disease
A mitochondrial ATPase 6 mutation is associated with Leigh syndrome in a family and affects proton flow and adenosine triphosphate output when modeled in Escherichia coli.
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
A point mutation of mitochondrial ATPase 6 gene in Leigh syndrome.
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
A T-->C mutation at nt 8993 of mitochondrial DNA in a child with Leigh syndrome.
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration.
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.
De novo mutation in the mitochondrial ATP synthase subunit 6 gene (T8993G) with rapid segregation resulting in Leigh syndrome in the offspring.
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Fulminant Leigh syndrome and sudden unexpected death in a family with the T9176C mutation of the mitochondrial ATPase 6 gene.
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology.
Late-onset Leigh syndrome with m.9176T>C mutation in the mitochondrial ATPase 6 gene.
Modeling the Leigh syndrome nt8993 T-->C mutation in Escherichia coli F1F0 ATP synthase.
Phenotype-genotype correlations in Leigh syndrome: new insights from a multicentre study of 96 patients.
Two new mutations in the MT-TW gene leading to the disruption of the secondary structure of the tRNA(Trp) in patients with Leigh syndrome.
Leishmaniasis
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Leishmaniasis, Visceral
Cloning and characterization of a V-ATPase subunit C from the American visceral leishmaniasis vector Lutzomyia longipalpis modulated during development and blood ingestion.
Leukemia
Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.
Ectopic ATP synthase ? subunit proteins on human leukemia cell surface interact with platelets by binding glycoprotein IIb.
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling.
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy.
Leukemia, Erythroblastic, Acute
Severe energy impairment consequent to inactivation of mitochondrial ATP synthase as an early event in cell death: a mechanism for the selective sensitivity to H2O2 of differentiating erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Hypermethylation of CpG sites at the promoter region is associated with deregulation of mitochondrial ATPsyn-? and chemoresistance in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Deregulation of mitochondrial ATPsyn-? in acute myeloid leukemia cells and with increased drug resistance.
Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines.
Vacuolar ATPase as a possible therapeutic target in human acute myeloid leukemia.
Lewy Body Disease
Direct Transcriptional Effects of Apolipoprotein E.
Liver Cirrhosis, Biliary
Analysis of the clinical relevance of antimitochondrial antibodies to the ?- and ?-subunits of the F1F0-ATPase in patients with primary biliary cirrhosis.
Antimitochondrial antibodies (AMA) in primary biliary cirrhosis. I. Separation of the PBC antigen activity from mitochondrial ATPase activity.
Mitochondrial antibodies in primary biliary cirrhosis. VI. Association of the complement fixing antigen with a component of the mitochondrial F1-ATPase complex.
The association of the autoantigens of primary biliary cirrhosis with the mitochondrial H+-ATPase--a reassessment.
The in vitro production of antibodies to mitochondrial antigens by peripheral blood mononuclear cells from patients with primary biliary cirrhosis.
The M2 autoantigens of primary biliary cirrhosis are not subunits of the mitochondrial H+-ATPase.
Use of immunoblotting to characterize the mitochondrial antigens recognized by anti-mitochondrial autoantibodies.
Liver Diseases
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
One Ring to Rule Them All: Mitochondrial Circular RNAs Control Mitochondrial Function.
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
[Detection of antibodies to submitochondrial particles, F1-ATPase complex and liver specific lipoprotein in liver diseases using ELISA]
Liver Neoplasms
Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells.
The AKT-independent MET-V-ATPase-MTOR axis suppresses liver cancer vaccination.
Liver Neoplasms, Experimental
Isolation and comparative studies of mitochondrial F1-ATPase from Morris hepatoma and rat liver.
Kinetic properties of mitochondrial H+-adenosine triphosphatase in Morris hepatoma 3924A.
Lung Diseases
Decrease in cytosolic ATP/ADP ratio and activation of pyruvate kinase after in vitro addition of almitrine in hepatocytes isolated from fasted rats.
Lung Injury
Characterization of low-dose ozone-induced murine acute lung injury.
Serial analysis of gene expression in mice with lipopolysaccharide-induced acute lung injury.
Lung Neoplasms
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen.
MicroRNA-7-5p's role in the O-GlcNAcylation and cancer metabolism.
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.
Precise Cancer Anti-acid Therapy Monitoring Using pH-Sensitive MnO2@BSA Nanoparticles by Magnetic Resonance Imaging.
Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin.
Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549).
Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin.
Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation.
Temporal Phosphoproteome Dynamics Induced by an ATP Synthase Inhibitor Citreoviridin.
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Lupus Erythematosus, Systemic
Selection of a gene for apolipoprotein A1 using autoantibodies from a patient with systemic lupus erythematosus.
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Lymphatic Metastasis
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Lymphoma
Cyclic AMP-dependent phosphorylation of the precursor to beta subunit of mitochondrial F1-ATPase: a physiological mistake?
Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: implications on cellular origin.
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival.
Lymphoma, Follicular
Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and MTOR.
Lymphoma, Mantle-Cell
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.
Lysosomal Storage Diseases
Batten disease fibroblasts in culture accumulate mitochondrial ATP synthase subunit 9.
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.
Macular Degeneration
Vacuolar ATPases and their role in vision.
Malaria
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.
Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice.
ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.
Membrane potential of erythrocytic stages of Plasmodium chabaudi free of the host cell membrane.
Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase.
Proteolipid of vacuolar H(+)-ATPase of Plasmodium falciparum: cDNA cloning, gene organization and complementation of a yeast null mutant.
Selective toxicity of the antimalarial primaquine-evidence for both uncoupling and inhibitory effects of a metabolite on the energetics of mitochondria and its ATP synthase complex.
Vacuolar H(+)-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes.
Malnutrition
Effect of prolonged undernutrition on rat diaphragm mitochondrial respiration.
Medullary Sponge Kidney
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Melanoma
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish.
Immunity to the vacuolar ATPase complex accessory unit ATP6S1 in patients with malignant melanoma.
Induction of ATP synthase ß by H2O2 induces melanogenesis by activating PAH and cAMP/CREB/MITF signaling in melanoma cells.
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
Selective growth inhibition by suppression of F1Fo ATPase in canine malignant melanoma cell lines.
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Melanoma, Amelanotic
Differences in cytochrome oxidase and mitochondrial ATPase in melanotic and amelanotic melanoma.
Melanoma, Experimental
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
MELAS Syndrome
Quantification of OXPHOS gene transcripts during muscle cell differentiation in patients with mitochondrial myopathies.
Mesothelioma
BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
Metabolic Diseases
Nuclear genetic defects of mitochondrial ATP synthase.
Metabolic Syndrome
Abnormal lipid metabolism down-regulates adenosine triphosphate synthase ?-subunit protein expression in corpus cavernosum smooth muscle in vitro and in vivo.
Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates with Insulin Responsiveness.
Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood.
Metabolism, Inborn Errors
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Mitochondrial Diseases
A novel deficiency of mitochondrial ATPase of nuclear origin.
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
A yeast-based assay identifies drugs active against human mitochondrial disorders.
Antipeptide antibodies to the carboxy terminal and the DCCD binding region of the human mitochondrial ATP synthase beta-subunit.
Assembly of mitochondrial ATP synthase in cultured human cells: implications for mitochondrial diseases.
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Biochemical thresholds for pathological presentation of ATP synthase deficiencies.
Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders.
Functional assays in high-resolution clear native gels to quantify mitochondrial complexes in human biopsies and cell lines.
Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease.
Human Mitochondrial Pathologies of the Respiratory Chain and ATP Synthase: Contributions from Studies of Saccharomyces cerevisiae.
Infantile mitochondrial disorder associated with subclinical hypothyroidism is caused by a rare mitochondrial DNA 8691A>G mutation: a case report.
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 epsilon subunit.
Mitochondrial disease associated with the T8993G mutation of the mitochondrial ATPase 6 gene: a clinical, biochemical, and molecular study in six families.
Mitochondrial diseases and genetic defects of ATP synthase.
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
The Mitochondrial Permeability Transition in Mitochondrial Disorders.
Two components in pathogenic mechanism of mitochondrial ATPase deficiency: energy deprivation and ROS production.
[Hereditary disorders of mitochondrial ATP synthase]
Mitochondrial Encephalomyopathies
Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates.
Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochrome c oxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206.
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
Mitochondrial Myopathies
Different laboratory and muscle biopsy findings in a family with an m.8851T>C mutation in the mitochondrial MTATP6 gene.
Focal deficiency of cytochrome c oxidase and of mitochondrial ATPase with histochemical evidence of loosely coupled oxidative phosphorylation in a mitochondrial myopathy of a patient with bilateral ptosis. An enzyme histochemical, immunocytochemical and fine structural study.
Mitochondrial myopathy with diffuse activation and focal deficiency of mitochondrial ATPase and carnitine deficiency.
Mucopolysaccharidoses
Increased expression of subunit c of mitochondrial ATP synthase in brain tissue from neuronal ceroid lipofuscinoses and mucopolysaccharidosis cases but not in long-term fibroblast cultures.
Mucopolysaccharidosis I
P-Tau and Subunit c Mitochondrial ATP Synthase Accumulation in the Central Nervous System of a Woman with Hurler-Scheie Syndrome Treated with Enzyme Replacement Therapy for 12 Years.
Multiple Myeloma
Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3.
Multiple Sclerosis, Relapsing-Remitting
Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b.
Muscle Hypotonia
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa.
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Muscle Weakness
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Mitochondrial ATP synthase inhibition and nitric oxide are involved in muscle weakness that occurs in acute exposure of rats to monocrotophos.
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Muscular Atrophy
Muscular atrophy: activation of mitochondrial ATPase.
[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats]
Muscular Diseases
Activation of mitochondrial ATPase as evidence of loosely coupled oxidative phosphorylation in various skeletal muscle disorders. A histochemical fine-structural study.
Acute Sarcomeric M-Line Disease Associated With ATP Synthase Subunit ? Autoantibodies in Ankylosing Spondylitis.
Marked decrease of mitochondrial DNA with multiple deletions in a patient with familial mitochondrial myopathy.
Retraction notice to: VMA21 Deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification.
VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification.
VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy.
Myocardial Infarction
Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings.
Mitochondrial ATPase and high-energy phosphates in failing hearts.
Valsartan reverses post-translational modifications of the delta-subunit of ATP synthase during in vivo canine reperfused myocardial infarction.
Myocardial Ischemia
ATPase activity, IF1 content, and proton conductivity of ESMP from control and ischemic slow and fast heart-rate hearts.
Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase.
Effect of reversible ischemia on the activity of the mitochondrial ATPase: relationship to ischemic preconditioning.
Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle.
Effects of some L-carnitine derivatives on heart membrane ATPases.
IF1 function in situ in uncoupler-challenged ischemic rabbit, rat, and pigeon hearts.
Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia.
Regulation of mitochondrial matrix pH and adenosine 5'-triphosphatase activity during ischemia in slow heart-rate hearts. Role of Pi/H+ symport.
Reperfusion after brief repetitive ischemia in porcine myocardium does not alter expression of creatine kinase MM or mitochondrial ATPase mRNAs.
nadh:ubiquinone reductase (h+-translocating) deficiency
Phenotype-genotype correlations in Leigh syndrome: new insights from a multicentre study of 96 patients.
Neoplasm Metastasis
A humanized chimeric antibody Hai178 targeted to the ? subunit of F1F0 ATP synthase.
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.
Analysis of metastasis associated signal regulatory network in colorectal cancer.
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.
Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase.
BRAF-induced tumorigenesis is IKK?-dependent but NF-?B-independent.
Ectopic expression of the ATP synthase ? subunit on the membrane of PC-3M cells supports its potential role in prostate cancer metastasis.
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.
Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.
Functional expression of V-ATPases in the plasma membrane of glial cells.
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.
Integrated Analyses Reveal the Multi-Omics and Prognostic Characteristics of ATP5B in Breast Cancer.
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma.
Molecular basis of V-ATPase inhibition by bafilomycin A1.
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
The curious case of vacuolar ATPase: regulation of signaling pathways.
The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.
The role of mitochondrial ATP synthase in cancer.
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells.
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer.
Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance.
Neoplasms
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
?-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-? suppresses caspase-8 activation in apoptosis-resistant colon cancer cells.
A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions.
A dynamic invertible intramolecular charge-transfer fluorescence probe: real-time monitoring of mitochondrial ATPase activity.
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
A humanized chimeric antibody Hai178 targeted to the ? subunit of F1F0 ATP synthase.
A monoclonal antibody against F1-F0 ATP synthase beta subunit.
A novel fatty acid-binding protein 5-estrogen-related receptor ? signaling pathway promotes cell growth and energy metabolism in prostate cancer cells.
A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines.
A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival.
A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer.
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
A passive function of mitochondrial ATP synthase: target for tumor killer HAMLET.
ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells.
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition.
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.
An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.
An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.
Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.
ANT2 Isoform Required for Cancer Cell Glycolysis.
Anti-neoplastic action of aspirin against a T cell lymphoma involves alteration in tumor microenvironment and regulation of tumor cell survival.
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression.
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers.
ATP Synthase Subunit a Supports Permeability Transition in Yeast Lacking Dimerization Subunits and Modulates yPTP Conductance.
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
ATP6L promotes metastasis of colorectal cancer by inducing epithelial-mesenchymal transition.
Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression.
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
BRAF-induced tumorigenesis is IKK?-dependent but NF-?B-independent.
Brain lipid-binding protein: a marker of differentiation in neuroblastic tumors.
Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression.
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Callyspongiolide Is a Potent Inhibitor of the Vacuolar ATPase.
Cancer derived peptide of vacuolar ATPase 'a2' isoform promotes neutrophil migration by autocrine secretion of IL-8.
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Cancer-associated V-ATPase induces delayed apoptosis of protumorigenic neutrophils.
Caspase-8 Induces Lysosome-Associated Cell Death in Cancer Cells.
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity.
Combinational therapy targeting the MET-mTOR-ROS loop disrupts mitochondrial autoregulatory machinery of liver cancer.
Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.
Coordinate ?-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth.
Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity.
Development and applications of destruxins: A review.
Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: implications on cellular origin.
Different sensitivity of Zajdela hepatoma mitochondrial ATPase activity to uncouplers in digitonin-treated cells and isolated mitochondria.
Differential effects of 2,4-dinitrophenol and valinomycin (+ K+) on uncoupler-stimulated ATPase of human tumor mitochondria.
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.
Direct targeting of tumor cell F(1)F(0) ATP-synthase by radioiodine angiostatin in vitro and in vivo.
Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.
Distal intestinal gene expression in Atlantic salmon (Salmo salar L.) fed genetically modified maize
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity.
Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells.
Dual Targeting of v-ATPase and mTORC1 Signaling Disarms Multidrug-Resistant Cancers.
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC.
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
Elevated expression of the V-ATPase D2 subunit triggers increased energy metabolite levels in KrasG12D -driven cancer cells.
Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
Evidence for ectopic aerobic ATP production on c6 glioma cell plasma membrane.
Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma.
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.
F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells.
Functional expression of V-ATPases in the plasma membrane of glial cells.
Genetic basis for the increased expression of vacuolar H(+) translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells.
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.
Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1.
Glycolysis inhibitor screening identifies the bis-geranylacylphloroglucinol protonophore moronone from Moronobea coccinea.
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Heroin-Induces Differential Protein Expression by Normal Human Astrocytes (NHA).
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited.
HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.
Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases.
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells.
Identification of genes regulated by oleic acid in Jurkat cells by suppressive subtractive hybridization analysis.
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells.
Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Immunolocalization of IP3R and V-ATPase in Ameloblastomas.
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.
Increased content of natural ATPase inhibitor in tumor mitochondria.
Induction of EGF-dependent apoptosis by vacuolar-type H(+)-ATPase inhibitors in A431 cells overexpressing the EGF receptor.
Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.
Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines.
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.
Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.
Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity.
Inhibition of V-ATPases and Carbonic Anhydrases as Interference Strategy with Tumor Acidification Processes.
Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment.
Inhibition sites in F1-ATPase from bovine heart mitochondria.
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Integrated Analyses Reveal the Multi-Omics and Prognostic Characteristics of ATP5B in Breast Cancer.
Interfering with pH regulation in tumours as a therapeutic strategy.
Interplay Between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Nonneoplastic Milieu.
Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer.
Involvement of cytochrome c and caspases in apoptotic cell death of human submandibular gland ductal cells induced by concanamycin A.
Keratin subunit expression in human cultured melanocytes and mouse neural crest cells without formation of filamentous structures.
L-methionase: a therapeutic enzyme to treat malignancies.
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2?-mediated tumor progression.
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.
Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF.
Locally and systemically active glucocorticosteroids modify intestinal absorption of lipids in rats.
Macropinocytosis: Insights from immunology and cancer.
MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
MicroRNA-7-5p's role in the O-GlcNAcylation and cancer metabolism.
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Mitochondrial ATP synthase 6 as an endogenous control in the quantitative RT-PCR analysis of clinical cancer samples.
Mitochondrial ATPase activities of hepatoma BW7756 and ascites tumor cells. Influence of MG2+ ions, free fatty acids, and uncouplers.
Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment.
Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.
Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Molecular basis of V-ATPase inhibition by bafilomycin A1.
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy.
Monitoring of dynamic ATP level changes by oligomycin-modulated ATP synthase inhibition in SW480 cancer cells using fluorescent "On-Off" switching DNA aptamer.
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases.
Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network.
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.
Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.
On the mechanism of glycolysis stimulation by neutral detergents in 3T3 and Ehrlich ascites tumor cells.
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.
Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis.
Plasmalemmal vacuolar-type H+-ATPase in cancer biology.
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Protein changes in the albedo of citrus fruits on postharvesting storage.
Proton channels and exchangers in cancer.
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population-based case-control study.
Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer.
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells.
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin.
Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Recent Advances In Developing Novel Anti-Cancer Drugs Targeting Tumor Hypoxic and Acidic Microenvironments.
Recent Insights into the Structure, Regulation, and Function of the V-ATPases.
Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease.
Regulation and function of V-ATPases in physiology and disease.
Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
Regulation of endothelial signaling and migration by v-ATPase.
Regulation of Glycolytic and Mitochondrial Metabolism by Ras.
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids.
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.
Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment.
Repositioning of proton pump inhibitors in cancer therapy.
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B.
Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition.
Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy.
Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor.
Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics.
Role of V-ATPases in solid tumors: Importance of the subunit C (Review).
Selective upregulation of TNF? expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
Stimulation of glycolysis by placental polypeptides and inhibition by duramycin.
Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
Synthesis and bioevaluation of heterocyclic derivatives of Cleistanthin-A.
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis.
Targeting cell surface F(1)F(0) ATP synthase in cancer therapy.
Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity.
Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B.
Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling.
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
The Binding Site of the V-ATPase Inhibitor Apicularen Is in the Vicinity of Those for Bafilomycin and Archazolid.
The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil.
The Crabtree effect: a new look at the old problem.
The curious case of vacuolar ATPase: regulation of signaling pathways.
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study.
The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.
The Function of V-ATPases in Cancer.
The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.
The heme binding protein HRG-1 is induced by IGF-I and associates with the Vacuolar (H+) -ATPase to control endosomal pH and receptor trafficking.
The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis.
The milk-derived lactoferrin inhibits V-ATPase activity by targeting its V1 domain.
The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.
The role of mitochondrial ATP synthase in cancer.
The role of the ATPase inhibitor factor 1 (IF
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen.
The Warburg hypothesis and weak ELF biointeractions.
Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells.
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
TMSG-1 and its roles in tumor biology.
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.
Tumor-associated vacuolar ATPase subunit promotes tumorigenic characteristics in macrophages.
Turn up the cellular power generator with vitamin E analogue formulation.
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
Unique uncoupler-stimulation pattern of mitochondrial ATPase activity of tumor cells, brain, and fetal liver.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis.
V-ATPase in cancer progression: Two sides of the same coin.
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.
V-ATPase inhibition overcomes trastuzumab resistance in breast cancer.
V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells.
V-ATPase inhibitors and implication in cancer treatment.
V-ATPase is a candidate therapeutic target for Ewing sarcoma.
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy.
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer.
Vacuolar H(+)-ATPase signaling pathway in cancer.
Vacuolar H(+)-ATPase-an enzyme for all seasons.
Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy.
Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway.
Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance.
Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.
Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis.
ZT-25, a new vacuolar H(+)-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells.
[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].
[Research on relevance between mitochondrial ATP synthase and malignant tumor].
[Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells].
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Neoplasms, Squamous Cell
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Nervous System Diseases
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.
Defining the pathogenesis of human mtDNA mutations using a yeast model: The case of T8851C.
Neuralgia
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
An integrated review on new targets in the treatment of neuropathic pain.
Neuroblastoma
Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.
Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.
Contribution of a H+ pump in determining the resting potential of neuroblastoma cells.
Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
Neurodegenerative Diseases
Batten disease and mitochondrial pathways of proteolysis.
CLN6 p.I154del Mutation Causing Late Infantile Neuronal Ceroid Lipofuscinosis in a Large Consanguineous Moroccan Family.
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human ?-synuclein.
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.
Regulation and function of V-ATPases in physiology and disease.
Roles for H+ /K+ -ATPase and zinc transporter 3 in cAMP-mediated lysosomal acidification in bafilomycin A1-treated astrocytes.
Splice isoform and pharmacological studies reveal that sterol depletion relocalizes ?-synuclein and enhances its toxicity.
The ATP Synthase Deficiency in Human Diseases.
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases.
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates ?-synuclein toxicity in neurons.
Neuronal Ceroid-Lipofuscinoses
A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.
Abnormal degradative pathway of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid-lipofuscinosis (Batten disease).
Accumulation of mitochondrial ATP synthase subunit c in muscle in a patient with neuronal ceroid lipofuscinosis (late infantile form).
Analysis of CLN3-protein interactions using the yeast two-hybrid system.
Anomalies of mitochondrial ATP synthase regulation in four different types of neuronal ceroid lipofuscinosis.
Batten disease (ceroid-lipofuscinosis): the enigma of subunit c of mitochondrial ATP synthase accumulation.
Batten disease and mitochondrial pathways of proteolysis.
Batten disease and the ATP synthase subunit c turnover pathway: raising antibodies to subunit c.
Batten disease fibroblasts in culture accumulate mitochondrial ATP synthase subunit 9.
CLN6 p.I154del Mutation Causing Late Infantile Neuronal Ceroid Lipofuscinosis in a Large Consanguineous Moroccan Family.
Defect of proteolysis of mitochondrial ATP synthase subunit C in neuronal ceroid lipofuscinosis.
Delivery of liposome-sequestered hydrophobic proteins to lysosomes of normal and Batten disease cells.
Different patterns of hydrophobic protein storage in different forms of neuronal ceroid lipofuscinosis (NCL, Batten disease).
Distinct early molecular responses to mutations causing vLINCL and JNCL presage ATP synthase subunit C accumulation in cerebellar cells.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Familial Kufs' disease presenting as a progressive myoclonic epilepsy.
Follow-up study of subunit c of mitochondrial ATP synthase (SCMAS) in Batten disease and in unrelated lysosomal disorders.
In vitro culture of neurons from sheep with Batten disease.
Increased expression of subunit c of mitochondrial ATP synthase in brain tissue from neuronal ceroid lipofuscinoses and mucopolysaccharidosis cases but not in long-term fibroblast cultures.
Increased urine concentration of subunit c of mitochondrial ATP synthase in neuronal ceroid lipofuscinoses patients.
Ion pores made of mitochondrial ATP synthase subunit c in the neuronal plasma membrane and Batten disease.
Late-infantile Batten disease: purification of the subunit c of the mitochondrial ATP synthase from storage material.
Light and electron microscopic studies on subunit c in cultured fibroblasts in late infantile and juvenile Batten disease.
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease.
Lysosomal proteinosis based on decreased degradation of a specific protein, mitochondrial ATP synthase subunit C: Batten disease.
Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
Mitochondrial abnormalities in CLN2 and CLN3 forms of Batten disease.
Molecular basis of lysosomal accumulation of subunit c of mitochondrial ATP synthase in neuronal ceroid-lipofuscinosis.
Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease).
Neuronal ceroid-lipofuscinosis in Borderdale sheep.
New insight into lysosomal protein storage disease: delayed catabolism of ATP synthase subunit c in Batten disease.
Palmitate oxidation in muscle mitochondria of patients with the juvenile form of neuronal ceroid-lipofuscinosis.
Polyunsaturated fatty acids reverse the lysosomal storage and accumulation of subunit 9 of mitochondrial F1F0-ATP synthase in cultured lymphoblasts from patients with Batten disease.
Progress in neuropathology of the neuronal ceroid lipofuscinoses.
Rapid detection of subunit c of mitochondrial ATP synthase in urine as a diagnostic screening method for neuronal ceroid-lipofuscinoses.
Role of subunit-9 of mitochondrial ATP synthase in Batten disease.
Specific delay in the degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis is derived from cellular proteolytic dysfunction rather than structural alteration of subunit c.
Specific delay of degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis (Batten disease).
Specific storage of subunit c of mitochondrial ATP synthase in lysosomes of neuronal ceroid lipofuscinosis (Batten's disease).
Sphingolipid activator proteins (SAPs) in neuronal ceroid lipofuscinoses (NCL).
The relevance of the storage of subunit c of ATP synthase in different forms and models of Batten disease (NCLs).
Tissue and cellular distribution of subunit c of ATP synthase in Batten disease (neuronal ceroid-lipofuscinosis).
Topographic variabilities of immunoreactivity to subunit c of mitochondrial ATP synthase and lectin binding in late infantile neuronal ceroid-lipofuscinosis.
Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase.
Turnover of F1F0-ATP synthase subunit 9 and other proteolipids in normal and Batten disease fibroblasts.
[Batten disease (Neuronal ceroid lipofuscinoses)--accumulation of ATP synthase subunit c caused by the delay of lysosomal degradation]
Non-alcoholic Fatty Liver Disease
Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly.
Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis.
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
NAFLD Phenotype in Patients With V-ATPase Proton Pump Assembly Defects.
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Obesity
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.
Mitochondrial ATP synthase ?-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity.
Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes.
Protocols and pitfalls in obtaining fatty acid-binding proteins for biophysical studies of ligand-protein and protein-protein interactions.
Tall stature and progressive overweight in mitochondrial encephalopathy.
Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood.
Obesity, Maternal
Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus.
Ocular Hypertension
Effect of Ocular Hypertension on D-?-Aspartic Acid-Containing Proteins in the Retinas of Rats.
Ophthalmoplegia, Chronic Progressive External
Aberrant synthesis of ATP synthase resulting from a novel deletion in mitochondrial DNA in an African patient with progressive external ophthalmoplegia.
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.
Optic Atrophy
Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiation.
Optic Atrophy, Autosomal Dominant
OPA1 and mitochondrial solute carriers in bioenergetic metabolism.
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
Optic Atrophy, Hereditary, Leber
A mitochondrial mutation at nt 9101 in the ATP synthase 6 gene associated with deficient oxidative phosphorylation in a family with Leber hereditary optic neuroretinopathy.
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
Mutations in subunit 6 of the F1F0-ATP synthase cause two entirely different diseases.
Optic Nerve Diseases
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
Mutations in subunit 6 of the F1F0-ATP synthase cause two entirely different diseases.
Osteolysis
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.
Osteopetrosis
Chloride channel 7 (CLCN7) gene mutations in intermediate autosomal recessive osteopetrosis.
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family.
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis.
New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies.
Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.
Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPase a3 Subunit.
RANKL treatment releases the negative regulation of the poly(ADP-ribose) polymerase-1 on Tcirg1 gene expression during osteoclastogenesis.
Regulation and function of V-ATPases in physiology and disease.
The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit.
The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation and decreases in vitro osteoclastogenesis.
The R740S mutation in the V-ATPase a3 subunit results in osteoclast apoptosis and defective early-stage autophagy.
The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice.
V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
Vacuolar ATPase as a drug discovery target.
Vacuolar ATPases and their role in vision.
Vacuolar-type ATPase: A proton pump to lysosomal trafficking.
Osteoporosis
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
A rationale for osteoclast selectivity of inhibiting the lysosomal V-ATPase a3 isoform.
Development and applications of destruxins: A review.
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Future Developments in Osteoporosis Therapy.
Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector.
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
Membrane-bound peptides mimicking transmembrane Vph1p helix 7 of yeast V-ATPase: a spectroscopic and polarity mismatch study.
Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H(+)-ATPase as an emerging target.
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Selective inhibition of osteoclast vacuolar H(+)-ATPase.
Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity.
The Binding Site of the V-ATPase Inhibitor Apicularen Is in the Vicinity of Those for Bafilomycin and Archazolid.
The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis.
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis.
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
Osteosarcoma
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on pH gradient.
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell.
Effect of selenite on basic mitochondrial function in human osteosarcoma cells with chronic mitochondrial stress.
Hypoxic preconditioning-induced mitochondrial protection is not disrupted in a cell model of mtDNA T8993G mutation-induced F1F0-ATP synthase defect: the role of mitochondrial permeability transition.
The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study.
The Inhibitor Protein (IF1) of the F1F0-ATPase Modulates Human Osteosarcoma Cell Bioenergetics.
Osteosclerosis
Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice.
Ovarian Neoplasms
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway.
Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer.
Overweight
Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus.
Pancreatic Neoplasms
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
The marine natural product manzamine a targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Pancreatitis
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.
Paraganglioma
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Paralysis
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Parkinson Disease
?-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS).
Alternative mitochondrial quality control mediated by extracellular release.
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.
Inhibiting Stearoyl-CoA Desaturase Ameliorates ?-Synuclein Cytotoxicity.
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.
Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth.
Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates ?-synuclein toxicity in neurons.
Parkinsonian Disorders
Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles.
Pediatric Obesity
Mitochondrial ATPase subunit 6 and cytochrome B gene variations in obese Turkish children.
Pemphigoid, Bullous
Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population.
Periodontal Diseases
Comparative analysis of the effects of a novel vacuolar adenosine 5'-triphosphatase inhibitor, FR202126, and doxycycline on bone loss caused by experimental periodontitis in rats.
Periodontitis
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
Peritonitis
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus.
Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.
Pheochromocytoma
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Photophobia
The light sensitivity of ATP synthase mutants of Chlamydomonas reinhardtii.
Phytoplasma Disease
Silencing of ATP synthase ? reduces phytoplasma multiplication in a leafhopper vector.
Pneumocystis Infections
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Polycystic Kidney Diseases
Conserved role of ATP synthase in mammalian cilia.
Polycystic Ovary Syndrome
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Pre-Eclampsia
Placental Vacuolar ATPase Function Is a Key Link between Multiple Causes of Preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
New haplotypes of the ATP synthase subunit 6 gene of mitochondrial DNA are associated with acute lymphoblastic leukemia in Saudi Arabia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.
Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia.
Prostatic Neoplasms
A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer.
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
Ectopic expression of the ATP synthase ? subunit on the membrane of PC-3M cells supports its potential role in prostate cancer metastasis.
F-actin reorganization by V-ATPase inhibition in prostate cancer.
Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells.
Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.
Primary functional identification of gene TMSG-1.
Reduced Levels of ATP Synthase Subunit ATP5F1A Correlate with Earlier-Onset Prostate Cancer.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer.
Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.
[Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells].
protein-lysine desuccinylase (nad+) deficiency
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Proteinuria
Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney.
Proteostasis Deficiencies
Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPase a3 Subunit.
Pulmonary Disease, Chronic Obstructive
Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD.
Pulmonary Fibrosis
BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.
Quadriplegia
Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.
Relative Energy Deficiency in Sport
In vitro proliferation and differentiation potential of bone marrow-derived mesenchymal stem cells from ovariectomized rats.
Renal Insufficiency
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Reperfusion Injury
Calcium in renal cells. Modulation of calcium-dependent activation of phospholipase A2.
Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts.
Role of energy metabolism in the preconditioned heart--a possible contribution of mitochondria.
Retinal Degeneration
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.
Vacuolar ATPases and their role in vision.
Retinitis
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
A yeast-based assay identifies drugs active against human mitochondrial disorders.
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
Stability of the m.8993T->G mtDNA mutation load during human embryofetal development has implications for the feasibility of prenatal diagnosis in NARP syndrome.
[Diseases caused by mutations in mitochondrial DNA].
Retinitis Pigmentosa
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.
Retinoblastoma
Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line.
Mitochondrial ATP synthase alpha-subunit gene amplified in a retinoblastoma cell line maps to chromosome 18.
Regulation of the cell cycle in response to inhibition of mitochondrial generated energy.
Rhabdomyosarcoma
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
V-ATPase as an effective therapeutic target for sarcomas.
Root Resorption
Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth.
Sarcoidosis
Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis.
Sarcoma
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
Identification of the salusin-? receptor using proteoliposomes embedded with endogenous membrane proteins.
Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene.
V-ATPase as an effective therapeutic target for sarcomas.
Sarcoma, Ewing
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
V-ATPase is a candidate therapeutic target for Ewing sarcoma.
Seizures
Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease).
Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production.
Sepsis
Altered proteomic pattern in platelets of rats with sepsis.
Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis.
Hypoxia-Inducible Factor-1 ? Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver.
Suppression of mitochondrial ATPase inhibitor protein (IF1) in the liver of late septic rats.
[Value of ATP synthase C subunit in predicting cardiac function and outcomes of sepsis].
Sjogren's Syndrome
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Small Cell Lung Carcinoma
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Smith-Magenis Syndrome
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Spastic Paraplegia, Hereditary
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
Spondylitis, Ankylosing
Acute Sarcomeric M-Line Disease Associated With ATP Synthase Subunit ? Autoantibodies in Ankylosing Spondylitis.
Squamous Cell Carcinoma of Head and Neck
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
ST Elevation Myocardial Infarction
A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.
Starvation
8-Dehydrosterols induce membrane traffic and autophagy defects through V-ATPase dysfunction in Saccharomyces cerevisae.
Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae.
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14(L156R) is rescued by starvation and inhibition of vacuolar-ATPase.
Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.
Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis.
Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.
Expression of Manduca sexta V-ATPase genes mvB, mvG and mvd is regulated by ecdysteroids.
Fe deficiency differentially affects the vacuolar proton pumps in cucumber and soybean roots.
Gene expression patterns of sulfur starvation in Synechocystis sp. PCC 6803.
Glucose Starvation Increases V-ATPase Assembly and Activity in Mammalian Cells through AMP Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling.
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions.
Insect midgut K(+) secretion: concerted run-down of apical/basolateral transporters with extra-/intracellular acidity.
Perturbation of the Vacuolar ATPase: A NOVEL CONSEQUENCE OF INOSITOL DEPLETION.
Physiological and comparative proteome analyses reveal low-phosphate tolerance and enhanced photosynthesis in a maize mutant owing to reinforced inorganic phosphate recycling.
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.
Proteomics and bioinformatics analysis reveal potential roles of cadmium-binding proteins in cadmium tolerance and accumulation of Enterobacter cloacae.
Quantitative proteomic analysis of cell envelope preparations under iron starvation stress in Aeromonas hydrophila.
Regulation of GlnK activity: modification, membrane sequestration and proteolysis as regulatory principles in the network of nitrogen control in Corynebacterium glutamicum.
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
The contribution of Candida albicans vacuolar ATPase subunit V1B encoded by VMA2 to stress response, autophagy, and virulence is independent of environmental pH.
The sharp phase of respiratory inhibition during amino acid starvation in Escherichia coli is RelA-dependent and associated with regulation of ATP synthase activity.
Stomach Neoplasms
Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho?LRP6 expression in Wnt/?-catenin signaling.
Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma.
Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.
HAI-178 antibody-conjugated fluorescent magnetic nanoparticles for targeted imaging and simultaneous therapy of gastric cancer.
Long non-coding RNA MIF-AS1 promotes gastric cancer cell proliferation and reduces apoptosis to upregulate NDUFA4.
Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.
[Effect of synergistic polarization macrophage modulated by N-terminal domain of a2 vacuolar ATPase and macrophage colony stimulating factor on proliferation of gastric cancer cells].
Stroke
Anatomy of F1-ATPase powered rotation.
Determination of torque generation from the power stroke of Escherichia coli F1-ATPase.
Elastic coupling power stroke mechanism of the F1-ATPase molecular motor.
On the power per mitochondrion and the number of associated active ATP synthases.
Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors.
Single molecule measurements of F1-ATPase reveal an interdependence between the power stroke and the dwell duration.
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.
Synucleinopathies
Parkinson's disease: proteinopathy or lipidopathy?
Splice isoform and pharmacological studies reveal that sterol depletion relocalizes ?-synuclein and enhances its toxicity.
Tauopathies
P-Tau and Subunit c Mitochondrial ATP Synthase Accumulation in the Central Nervous System of a Woman with Hurler-Scheie Syndrome Treated with Enzyme Replacement Therapy for 12 Years.
Tetanus
Inhibitors of synaptic vesicle exocytosis reduce surface expression of postsynaptic glutamate receptors.
Thyroid Cancer, Papillary
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Thyroid Neoplasms
ATP Synthase Subunit a Supports Permeability Transition in Yeast Lacking Dimerization Subunits and Modulates yPTP Conductance.
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Tics
Inhibition of the V-ATPase by Archazolid A - a new strategy to inhibit EMT.
Ovarian tumor-initiating cells display a flexible metabolism.
Tongue Neoplasms
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Triple Negative Breast Neoplasms
Aurovertin B exerts potent antitumor activity against triple-negative breast cancer in vivo and in vitro via regulating ATP synthase activity and DUSP1 expression.
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
Trypanosomiasis, African
Isolation of F1-ATPase from the Parasitic Protist Trypanosoma brucei.
Tuberculosis
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.
A Mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline.
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.
ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra.
Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis.
Bedaquiline as part of combination therapy in adults with pulmonary multi-drug resistant tuberculosis.
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.
Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase.
Characterization of new mutations in the mycobacterial ATP synthase: New insights in the binding of the diarylquinoline TMC207 to the ATP synthase c-ring structure.
Current perspective of ATP synthase inhibitors in the management of the tuberculosis.
Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis.
Diarylquinolines, synthesis pathways and quantitative structure--activity relationship studies leading to the discovery of TMC207.
Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.
Emerging opportunities of exploiting mycobacterial electron transport chain pathway for drug-resistant tuberculosis drug discovery.
Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets.
Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria.
Halting ionic shuttle to disrupt the synthetic machinery-Structural and molecular insights into the inhibitory roles of Bedaquiline towards Mycobacterium tuberculosis ATP synthase in the treatment of tuberculosis.
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.
Molecular mechanistic insights into uncoupling of ion transport from ATP synthesis.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Natural products and other inhibitors of F1FO ATP synthase.
Novel antibiotics targeting respiratory ATP synthesis in gram-positive pathogenic bacteria.
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability.
Post translational modifications in tuberculosis: ubiquitination paradox.
Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase.
Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor.
Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis.
Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.
Shortening Buruli Ulcer Treatment with Combination Therapy Targeting the Respiratory Chain and Exploiting Mycobacterium ulcerans Gene Decay.
Structure and function of Mycobacterium-specific components of F-ATP synthase subunits ? and ?.
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study.
Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.
Synthetic approaches towards bedaquiline and its derivatives.
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi.
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
The Expanding Diversity of Mycobacterium tuberculosis Drug Targets.
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis.
The stimulating role of subunit F in ATPase activity inside the A1-complex of the Methanosarcina mazei Gö1 A1AO ATP synthase.
Thiol oxidation of mitochondrial FO-c subunits: a way to switch off antimicrobial drug targets of the mitochondrial ATP synthase.
Transcriptional Inhibition of the F1F0-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.
Variations of subunit {varepsilon} of the Mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207.
Tuberculosis, Multidrug-Resistant
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.
Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.
Synthetic approaches towards bedaquiline and its derivatives.
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
Tuberculosis, Pulmonary
Epiregulin (EREG) and human V-ATPase (TCIRG1): genetic variation, ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia.
Human V-ATPase gene can protect or predispose the host to pulmonary tuberculosis.
Tuberous Sclerosis
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Ureteral Obstruction
H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II.
Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis.
Uterine Cervical Neoplasms
P-glycoprotein and Vacuolar ATPase Synergistically Confer Anthracycline Resistance to Fission Yeast and Human Cells.
Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer.
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Vaccinia
Involvement of the vacuolar H(+)-ATPase in animal virus entry.
Ventricular Dysfunction
Human myocardial adenosine triphosphatase activities in health and heart failure.
Ventricular Fibrillation
Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep.
vesicle-fusing atpase deficiency
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation.
Vesicular Stomatitis
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus.
Virus Diseases
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection.
F1 ATP synthase ? subunit is a putative receptor involved in white spot syndrome virus infection in shrimp by binding with viral envelope proteins VP51B and VP150.
Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.
Japanese encephalitis virus infection in Vero cells: the involvement of intracellular acidic vesicles in the early phase of viral infection was observed with the treatment of a specific vacuolar type H+-ATPase inhibitor, bafilomycin A1.
Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection.
Role of the vacuolar-ATPase in Sindbis virus infection.
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.
Wolfram Syndrome
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
Yellow Fever
Vacuolar-type proton pumps in insect epithelia.
[histone h3]-lysine4 n-trimethyltransferase deficiency
Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.