Reference on EC 6.3.5.6 - asparaginyl-tRNA synthase (glutamine-hydrolysing)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Curnow, A.W.; Tumbula, D.L.; Pelaschier, J.T.; Min, B.; Sll, D.
Glutamyl-tRNAGln amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis
Proc. Natl. Acad. Sci. USA
95
12838-12843
1998
Bacillus subtilis, Deinococcus radiodurans, Haloferax volcanii, Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
Becker, H.D.; Min, B.; Jacobi, C.; Raczniak, G.; Pelaschier, J.; Roy, H.; Klein, S.; Kern, D.; Sll, D.
The heterotrimeric Thermus thermophilus Asp-tRNA(Asn) amidotransferase can also generate Gln-tRNA(Gln)
FEBS Lett.
476
140-144
2000
Bacillus subtilis, Deinococcus radiodurans, Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Tumbula-Hansen, D.; Feng, L.; Toogood, H.; Stetter, K.O.; Sll, D.
Evolutionary divergence of the archaeal aspartyl-tRNA synthetases into discriminating and nondiscriminating forms
J. Biol. Chem.
277
37184-37190
2002
Methanothermobacter thermautotrophicus
Raczniak, G.; Becker, H.D.; Min, B.; Sll, D.
A single amidotransferase forms asparaginyl-tRNA and glutaminyl-tRNA in Chlamydia trachomatis
J. Biol. Chem.
276
45862-45867
2001
Chlamydia trachomatis
Min, B.; Pelaschier, J.T.; Graham, D.E.; Tumbula-Hansen, D.; Sll, D.
Transfer RNA-dependent amino acid biosynthesis: An essential route to asparagine formation
Proc. Natl. Acad. Sci. USA
99
2678-2683
2002
Deinococcus radiodurans, Thermus thermophilus, Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
Ibba, M.; Sll, D.
Aminoacyl-tRNA synthesis
Annu. Rev. Biochem.
69
617-650
2000
Aeropyrum pernix, Archaeoglobus fulgidus, Bacillus subtilis, Deinococcus radiodurans, Thermus thermophilus, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii
Tumbula, D.L.; Becker, H.D.; Chang, W.Z.; Sll, D.
Domain-specific recruitment of amide amino acids for protein synthesis
Nature
407
106-110
2000
Aeropyrum pernix, Archaeoglobus fulgidus, Bacillus subtilis, Chlamydia trachomatis, Deinococcus radiodurans, Halobacterium salinarum, Helicobacter pylori, Methanocaldococcus jannaschii, Methanosarcina mazei, Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DELTAH, Saccharolobus solfataricus, Sulfurisphaera tokodaii
Akochy, P.M.; Bernard, D.; Roy, P.H.; Lapointe, J.
Direct glutaminyl-tRNA biosynthesis and indirect asparaginyl-tRNA biosynthesis in Pseudomonas aeruginosa PAO1
J. Bacteriol.
186
767-776
2004
Pseudomonas aeruginosa
Chuawong, P.; Hendrickson, T.L.
The nondiscriminating aspartyl-tRNA synthetase from Helicobacter pylori: anticodon-binding domain mutations that impact tRNA specificity and heterologous toxicity
Biochemistry
45
8079-8087
2006
Helicobacter pylori
Namgoong, S.; Sheppard, K.; Sherrer, R.L.; Soell, D.
Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNAAsn
FEBS Lett.
581
309-314
2007
Methanothermobacter thermautotrophicus
Sheppard, K.; Akochy, P.M.; Salazar, J.C.; Soell, D.
The Helicobacter pylori amidotransferase GatCAB is equally efficient in glutamine-dependent transamidation of Asp-tRNAAsn and Glu-tRNAGln
J. Biol. Chem.
282
11866-11873
2007
Helicobacter pylori
Bernard, D.; Akochy, P.M.; Bernier, S.; Fisette, O.; Brousseau, O.C.; Chenevert, R.; Roy, P.H.; Lapointe, J.
Inhibition by L-aspartol adenylate of a nondiscriminating aspartyl-tRNA synthetase reveals differences between the interactions of its active site with tRNAAsp and tRNAAsn
J. Enzyme Inhib. Med. Chem.
22
77-82
2007
Pseudomonas aeruginosa
Ramirez, B.L.; Howard, O.M.; Dong, H.F.; Edamatsu, T.; Gao, P.; Hartlein, M.; Kron, M.
Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2
J. Infect. Dis.
193
1164-1171
2006
Brugia malayi, Homo sapiens
Bailly, M.; Blaise, M.; Lorber, B.; Becker, H.D.; Kern, D.
The transamidosome: a dynamic ribonucleoprotein particle dedicated to prokaryotic tRNA-dependent asparagine biosynthesis
Mol. Cell
28
228-239
2007
Thermus thermophilus
Cardoso, A.M.; Polycarpo, C.; Martins, O.B.; Soell, D.
A non-discriminating aspartyl-tRNA synthetase from Halobacterium salinarum
RNA Biol.
3
110-114
2006
Halobacterium salinarum, Halobacterium salinarum NRC 1
Crepin, T.; Peterson, F.; Haertlein, M.; Jensen, D.; Wang, C.; Cusack, S.; Kron, M.
A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase
J. Mol. Biol.
405
1056-1069
2011
Brugia malayi (A0A0J9Y417)
Yu, Z.; Vodanovic-Jankovic, S.; Ledeboer, N.; Huang, S.X.; Rajski, S.R.; Kron, M.; Shen, B.
Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase
Org. Lett.
13
2034-2037
2011
Brugia malayi
Polydorides, S.; Amara, N.; Aubard, C.; Plateau, P.; Simonson, T.; Archontis, G.
Computational protein design with a generalized born solvent model: application to asparaginyl-tRNA synthetase
Proteins
79
3448-3468
2011
Thermus thermophilus
Fischer, F.; Huot, J.L.; Lorber, B.; Diss, G.; Hendrickson, T.L.; Becker, H.D.; Lapointe, J.; Kern, D.
The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code
Nucleic Acids Res.
40
4965-4976
2012
Helicobacter pylori
Yu, Z.; Vodanovic-Jankovic, S.; Kron, M.; Shen, B.
New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase
Org. Lett.
14
4946-4949
2012
Brugia malayi
Fuengfuloy, P.; Chuawong, P.; Suebka, S.; Wattana-Amorn, P.; Williams, C.; Crump, M.P.; Songsiriritthigul, C.
Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements
Protein Expr. Purif.
89
25-32
2013
no activity in Helicobacter pylori
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