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Reference on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Britton, H.G.; Rubio, V.
Carbamoyl-phosphate synthetase I. Kinetic of binding and dissociation of acetylglutamate and of activation and deactivation
Eur. J. Biochem.
171
615-622
1988
Rattus norvegicus
Manually annotated by BRENDA team
Lund, P.; Wiggins, D.
Inhibition of carbamoyl-phosphate synthase (ammonia) by Tris and Hepes. Effect on Ka for N-acetylglutamate
Biochem. J.
243
273-276
1987
Rattus norvegicus
Manually annotated by BRENDA team
Cohen, N.S.; Kyan, F.S.; Kyan, S.S.; Cheung, C.W.; Raijman, L.
The apparent Km of ammonia for carbamoyl phosphate synthetase (ammonia) in situ
Biochem. J.
229
205-211
1988
Rattus norvegicus
Manually annotated by BRENDA team
Guadalajara, A.M.; Rubio, V.; Grisolia, S.
Inactivation of carbamoyl phosphate synthetase (ammonia) by elastase as a probe to investigate binding of the substrates
Biochem. Biophys. Res. Commun.
117
238-244
1983
Frog, Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team
Lof, C.; Cohen, M.; Vermeulen, L.P.; van Roermund, C.W.T.; Wanders, R.J.A.; Meijer, A.J.
Properties of carbamoyl-phosphate synthetase (ammonia) in rat-liver mitochondria made permeable with toluene
Eur. J. Biochem.
135
251-258
1983
Rattus norvegicus
Manually annotated by BRENDA team
McIntyre, P.; Hoogenraad, N.
Isolation of an immunologically pure preparation of carabamylphosphate synthetase (ammonia) using chromatofocusing
FEBS Lett.
135
65-69
1981
Rattus norvegicus
Manually annotated by BRENDA team
Meijer, A.J.; Woerkom, G.M.; Steinman, R.; Williamson, J.R.
Inhibition by Ca2+ of carbamoylphosphate synthetase (ammonia)
J. Biol. Chem.
256
3443-3446
1981
Rattus norvegicus
Manually annotated by BRENDA team
Cohen, N.S.; Raijman, L.
The apparent Km of ATPMg for carbamoyl phosphate synthetase (ammonia) in situ
J. Biol. Chem.
255
3352-3357
1980
Rattus norvegicus
Manually annotated by BRENDA team
Raijman, L.; Jones, M.E.
Purification, composition, and some properties of rat liver carbamyl phosphate synthetase (ammonia)
Arch. Biochem. Biophys.
175
270-278
1976
Rattus norvegicus
Manually annotated by BRENDA team
Smith, D.D.; Campbell, J.W.
Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver
Proc. Natl. Acad. Sci. USA
85
160-164
1988
Gopherus berlandieri, Phyllomedusa sauvagii
Manually annotated by BRENDA team
Alonso, E.; Rubio, V.
Inactivation of mitochondrial carbamoyl phosphate synthetase induced by ascorbate, oxygen, and Fe3+ in the presence of acetylglutamate: protection by ATP and HCO3- and lack of inactivation of ornithine transcarbamylase
Arch. Biochem. Biophys.
258
342-350
1987
Rattus norvegicus
Manually annotated by BRENDA team
Powers-Lee, S.G.; Mastico, R.A.; Bendayan, M.
The interaction of rat liver carbamoyl phosphate synthetase and ornithine transcarbamoylase with inner mitochondrial membranes
J. Biol. Chem.
262
15683-15688
1987
Rattus norvegicus
Manually annotated by BRENDA team
Cerdan, S.; Lusty, C.J.; Davis, K.N.; Jacobson, J.A.; Williamson, J.R.
Role of calcium as an inhibitor of rat liver carbamylphosphate synthetase I
J. Biol. Chem.
259
323-331
1984
Rattus norvegicus
Manually annotated by BRENDA team
Lusty, C.J.
Catalytically active monomer and dimer forms of rat liver carbamoyl-phosphate synthetase
Biochemistry
20
3665-3675
1981
Rattus norvegicus
Manually annotated by BRENDA team
Britton, H.G.; Rubio, V.; Grisolia, S.
Synthesis of carbamoyl phosphate by carbamoyl phosphate synthetase I in the absence of acetylglutamate. Activation of the enzyme by cryoprotectants
Biochem. Biophys. Res. Commun.
99
1131-1137
1981
Rattus norvegicus
Manually annotated by BRENDA team
Rubio, V.; Ramponi, G.; Grisolia, S.
Carbamoyl phosphate synthetase I of human liver. Purification, some properties and immunological cross-reactivity with the rat liver enzyme
Biochim. Biophys. Acta
659
150-160
1981
Homo sapiens
Manually annotated by BRENDA team
Pierson, D.L.; Brien, J.M.
Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver
J. Biol. Chem.
255
7891-7895
1980
Homo sapiens
Manually annotated by BRENDA team
Mori, M.; Cohen, P.P.
Preparation of crystalline carbamyl phosphate synthetase-I from frog liver
J. Biol. Chem.
253
8337-8339
1978
Lithobates catesbeianus
Manually annotated by BRENDA team
Lusty, C.J.
Carbamyl phosphate synthetase. Bicarbonate-dependent hydrolysis of ATP and potassium activation
J. Biol. Chem.
253
4270-4278
1978
Rattus norvegicus
Manually annotated by BRENDA team
Lusty, C.J.
Carbamoylphosphate synthetase I of rat-liver mitochondria. Purification, properties, and polypeptide molecular weight
Eur. J. Biochem.
85
373-383
1978
Rattus norvegicus
Manually annotated by BRENDA team
Clarke, S.
A major polypeptide component of rat liver mitochondria: carbamyl phosphate synthetase
J. Biol. Chem.
251
950-961
1976
Rattus norvegicus
Manually annotated by BRENDA team
Tatibana, M.; Shigesada, K.
Two carbamyl phosphate synthetases of mammals: specific roles in control of pyrimidine and urea biosynthesis
Adv. Enzyme Regul.
10
249-271
1972
Mammalia, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Elliott, K.R.F.; Tipton, K.F.
Purification and characterisation of carbamoyl phosphate synthetase from beef liver
FEBS Lett.
37
79-81
1973
Bos taurus
Manually annotated by BRENDA team
Brandt, M.; Powers-Lee, S.G.
The interaction of cardiolipin with rat liver carbamoyl phosphate synthetase I
Arch. Biochem. Biophys.
290
14-20
1991
Rattus norvegicus
Manually annotated by BRENDA team
Alonso, E.; Cervera, J.; Garcia-Espana, A.; Bendala, E.; Rubio, V.
Oxidative inactivation of carbamoyl phosphate synthetase (ammonia). Mechanism and sites of oxidation, degradation of the oxidized enzyme, and inactivation by glycerol, EDTA, and thiol protecting agents
J. Biol. Chem.
267
4524-4532
1992
Rattus norvegicus
Manually annotated by BRENDA team
Durbecq, V.; Legrain, C.; Roovers, M.; Pierard, A.; Glansdorff, N.
The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis
Proc. Natl. Acad. Sci. USA
94
12803-12808
1997
Pyrococcus furiosus
Manually annotated by BRENDA team
Alonso, M.J.; De Arriaga, D.; Soler, J.
Carbamoyl-phosphate synthase in Phycomyces blakesleeanus
Biochim. Biophys. Acta
955
175-186
1988
Phycomyces blakesleeanus
Manually annotated by BRENDA team
Britton, H.G.; Garcia-Espana, A.; Goya, P.; Rozas, I.; Rubio, V.
A structure-reactivity study of the binding of acetylglutamate to carbamoyl phosphate synthetase I
Eur. J. Biochem.
188
47-53
1990
Rattus norvegicus
Manually annotated by BRENDA team
Garcia-Espana, A.; Alonso, E.; Rubio, V.
Influence of anions on the activation of carbamoyl phosphate synthetase (ammonia) by acetylglutamate: implications for the activation of the enzyme in the mitochondria
Arch. Biochem. Biophys.
288
414-420
1991
Rattus norvegicus
Manually annotated by BRENDA team
Ramon-Maiques, S.; Marina, A.; Uriarte, M.; Fita, I.; Rubio, V.
The 1.5 A resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic Archaeon pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and provides insight into substrate binding and stability in carbamate kinases
J. Mol. Biol.
299
463-476
2000
Pyrococcus furiosus
Manually annotated by BRENDA team
Uriarte, M.; Marina, A.; Ramon-Maiques, S.; Fita, I.; Rubio, V.
The carbamoyl-phosphate synthetase of Pyrococcus furiosus is enzymologically and structurally a carbamate kinase
J. Biol. Chem.
274
16295-16303
1999
Escherichia coli, Pyrococcus furiosus
Manually annotated by BRENDA team
Purcarea, C.; Herve, G.; Cunin, R.; Evans, D.R.
Cloning, expression, and structure analysis of carbamate kinase-like carbamoyl phosphate synthetase from Pyrococcus abyssi
Extremophiles
5
229-239
2001
Pyrococcus abyssi (Q9UWF8), Pyrococcus abyssi
Manually annotated by BRENDA team
Summar, M.L.; Gainer, J.V.; Pretorius, M.; Malave, H.; Harris, S.; Hall, L.D.; Weisberg, A.; Vaughan, D.E.; Christman, B.W.; Brown, N.J.
Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function
Hypertension
43
186-191
2004
Homo sapiens
Manually annotated by BRENDA team
Corvi, M.M.; Soltys, C.L.; Berthiaume, L.G.
Regulation of mitochondrial carbamoyl-phosphate synthetase 1 activity by active site fatty acylation
J. Biol. Chem.
276
45704-45712
2001
Rattus norvegicus
Manually annotated by BRENDA team
Eroglu, B.; Powers-Lee, S.G.
Unmasking a functional allosteric domain in an allosterically nonresponsive carbamoyl-phosphate synthetase
J. Biol. Chem.
277
45466-45472
2002
Saccharomyces cerevisiae, Saccharomyces cerevisiae LPL26
Manually annotated by BRENDA team
Saeed-Kothe, A.; Powers-Lee, S.G.
Specificity determining residues in ammonia- and glutamine-dependent carbamoyl phosphate synthetases
J. Biol. Chem.
277
7231-7238
2002
Lithobates catesbeianus
Manually annotated by BRENDA team
Saeed-Kothe, A.; Powers-Lee, S.G.
Gain of glutaminase function in mutants of the ammonia-specific frog carbamoyl phosphate synthetase
J. Biol. Chem.
278
26722-26726
2003
Homo sapiens, Lithobates catesbeianus, Rattus norvegicus
Manually annotated by BRENDA team
Saha, N.; Das, L.; Dutta, S.
Types of carbamyl phosphate synthetases and subcellular localization of urea cycle and related enzymes in air-breathing walking catfish, Clarias batrachus
J. Exp. Zool.
283
121-130
1999
Clarias batrachus, Heteropneustes fossilis
-
Manually annotated by BRENDA team
Davis, J.A.; Greer, F.R.; Benevenga, N.J.
Comparison of total body urea production potential with total body carbamoyl phosphate synthetase (CPS-1) activity in newborn piglets infused with alanine at 50% of resting energy expenditure for 36 hours
J. Nutr.
130
1978-1983
2000
Sus scrofa
Manually annotated by BRENDA team
Huo, R.; Zhu, H.; Lu, L.; Ying, L.; Xu, M.; Xu, Z.; Li, J.; Zhou, Z.; Sha, J.
Molecular cloning, identification and characteristics of a novel isoform of carbamyl phosphate synthetase I in human testis
J. Biochem. Mol. Biol.
38
28-33
2005
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Wright, P.; Anderson, P.; Weng, L.; Frick, N.; Wong, W.P.; Ip, Y.K.
The crab-eating frog,Rana cancrivora, up-regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity
J. Exp. Zool. A
301
559-568
2004
Fejervarya cancrivora
Manually annotated by BRENDA team
Summar, M.L.; Hall, L.; Christman, B.; Barr, F.; Smith, H.; Kallianpur, A.; Brown, N.; Yadav, M.; Willis, A.; Eeds, A.; Cermak, E.; Summar, S.; Wilson, A.; Arvin, M.; Putnam, A.; Wills, M.; Cunningham, G.
Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I
Mol. Genet. Metab.
81 Suppl 1
S12-19
2004
Homo sapiens
Manually annotated by BRENDA team
Hoogenkamp, M.; Stallen, J.M.; Lamers, W.H.; Gaemers, I.C.
In vivo footprinting of the carbamoylphosphate synthetase I cAMP-response unit indicates important roles for FoxA and PKA in formation of the enhanceosome
Biochimie
88
1357-1366
2006
Rattus norvegicus
Manually annotated by BRENDA team
Schoneveld, O.J.; Hoogenkamp, M.; Stallen, J.M.; Gaemers, I.C.; Lamers, W.H.
cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstream regulatory units
Biochimie
89
574-580
2007
Rattus norvegicus
Manually annotated by BRENDA team
Crouser, E.D.; Julian, M.W.; Huff, J.E.; Struck, J.; Cook, C.H.
Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis
Crit. Care Med.
34
2439-2446
2006
Mus musculus
Manually annotated by BRENDA team
Hoogenkamp, M.; Gaemers, I.C.; Schoneveld, O.J.; Das, A.T.; Grange, T.; Lamers, W.H.
Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction
FEBS J.
274
37-45
2007
Rattus norvegicus
Manually annotated by BRENDA team
Kim, H.S.; Kim, J.M.; Roh, K.B.; Lee, H.H.; Kim, S.J.; Shin, Y.H.; Lee, B.L.
Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B
J. Biochem. Mol. Biol.
40
604-609
2007
Rattus norvegicus
Manually annotated by BRENDA team
Lindley, T.E.; Laberge, T.; Hall, A.; Hewett-Emmett, D.; Walsh, P.J.; Anderson, P.M.
Sequence, expression and evolutionary relationships of carbamoyl phosphate synthetase I in the toad Xenopus laevis
J. Exp. Zool. A
307A
163-175
2007
Xenopus laevis (Q3S2E9), Xenopus laevis
Manually annotated by BRENDA team
Canter, J.A.; Summar, M.L.; Smith, H.B.; Rice, G.D.; Hall, L.D.; Ritchie, M.D.; Motsinger, A.A.; Christian, K.G.; Drinkwater, D.C.; Scholl, F.G.; Dyer, K.L.; Kavanaugh-McHugh, A.L.; Barr, F.E.
Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study
Mitochondrion
7
204-210
2007
Homo sapiens
Manually annotated by BRENDA team
Poyck, P.P.; Hoekstra, R.; Vermeulen, J.L.; van Wijk, A.C.; Chamuleau, R.A.; Hakvoort, T.B.; van Gulik, T.M.; Lamers, W.H.
Expression of glutamine synthetase and carbamoylphosphate synthetase I in a bioartificial liver: markers for the development of zonation in vitro
Cells Tissues Organs
188
259-269
2008
Sus scrofa
Manually annotated by BRENDA team
Hart, E.J.; Powers-Lee, S.G.
Role of Cys1327 and Cys1337 in redox sensitivity and allosteric monitoring in human carbamoyl phosphate synthetase
J. Biol. Chem.
284
5977-5985
2008
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Ahuja, V.; Powers-Lee, S.G.
Human carbamoyl-phosphate synthetase: insight into N-acetylglutamate interaction and the functional effects of a common single nucleotide polymorphism
J. Inherit. Metab. Dis.
31
481-491
2008
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Butler, S.L.; Dong, H.; Cardona, D.; Jia, M.; Zheng, R.; Zhu, H.; Crawford, J.M.; Liu, C.
The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1
Lab. Invest.
88
78-88
2008
Homo sapiens
Manually annotated by BRENDA team
Ogura, M.; Nakamura, Y.; Tanaka, D.; Zhuang, X.; Fujita, Y.; Obara, A.; Hamasaki, A.; Hosokawa, M.; Inagaki, N.
Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1
Biochem. Biophys. Res. Commun.
393
73-78
2010
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Pekkala, S.; Martinez, A.I.; Barcelona, B.; Gallego, J.; Bendala, E.; Yefimenko, I.; Rubio, V.; Cervera, J.
Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase
Biochem. J.
424
211-220
2009
Escherichia coli, Rattus norvegicus, Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Ono, H.; Suto, T.; Kinoshita, Y.; Sakano, T.; Furue, T.; Ohta, T.
A case of carbamoyl phosphate synthetase 1 deficiency presenting symptoms at one month of age
Brain Dev.
31
779-781
2009
Homo sapiens
Manually annotated by BRENDA team
Nakagawa, T.; Lomb, D.J.; Haigis, M.C.; Guarente, L.
SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
Cell
137
560-570
2009
Mus musculus
Manually annotated by BRENDA team
Klaus, V.; Vermeulen, T.; Minassian, B.; Israelian, N.; Engel, K.; Lund, A.M.; Roebrock, K.; Christensen, E.; Haeberle, J.
Highly variable clinical phenotype of carbamylphosphate synthetase 1 deficiency in one family: an effect of allelic variation in gene expression?
Clin. Genet.
76
263-269
2009
Homo sapiens
Manually annotated by BRENDA team
Kostiuk, M.A.; Keller, B.O.; Berthiaume, L.G.
Non-radioactive detection of palmitoylated mitochondrial proteins using an azido-palmitate analogue
Methods Enzymol.
457
149-165
2009
Rattus norvegicus
Manually annotated by BRENDA team
Moore, P.E.; Ryckman, K.K.; Williams, S.M.; Patel, N.; Summar, M.L.; Sheller, J.R.
Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma
Pediatr. Pulmonol.
44
649-654
2009
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Liu, H.; Dong, H.; Robertson, K.; Liu, C.
DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma
Am. J. Pathol.
178
652-661
2011
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Haeberle, J.; Shchelochkov, O.A.; Wang, J.; Katsonis, P.; Hall, L.; Reiss, S.; Eeds, A.; Willis, A.; Yadav, M.; Summar, S.; Summar, S.; Lichtarge, O.; Rubio, V.; Wong, L.J.; Summar, M.
Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations
Hum. Mutat.
32
579-589
2011
Homo sapiens
Manually annotated by BRENDA team
Purcarea, C.; Simon, V.; Prieur, D.; Herve, G.
Purification and characterization of carbamoyl-phosphate synthetase from the deep-sea hyperthermophilic archaebacterium Pyrococcus abyssi
Eur. J. Biochem.
236
189-199
1996
Pyrococcus abyssi
Manually annotated by BRENDA team
Takakusa, H.; Mohar, I.; Kavanagh, T.J.; Kelly, E.J.; Kaspera, R.; Nelson, S.D.
Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences
Biochem. Biophys. Res. Commun.
420
54-60
2012
Mus musculus (Q8C196), Mus musculus
Manually annotated by BRENDA team
Lopes-Marques, M.; Igrejas, G.; Amorim, A.; Azevedo, L.
Human carbamoyl phosphate synthetase I (CPSI): insights on the structural role of the unknown function domains
Biochem. Biophys. Res. Commun.
421
409-412
2012
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Diez-Fernandez, C.; Martinez, A.I.; Pekkala, S.; Barcelona, B.; Perez-Arellano, I.; Guadalajara, A.M.; Summar, M.; Cervera, J.; Rubio, V.
Molecular characterization of carbamoyl-phosphate synthetase (CPS1) deficiency using human recombinant CPS1 as a key tool
Hum. Mutat.
34
1149-1159
2013
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team
Ip, Y.K.; Loong, A.M.; Chng, Y.R.; Hiong, K.C.; Chew, S.F.
Hepatic carbamoyl phosphate synthetase (CPS) I and urea contents in the hylid tree frog, Litoria caerulea: transition from CPS III to CPS I
J. Comp. Physiol. B
182
1081-1094
2012
Ranoidea caerulea (H9ZVS7), Ranoidea caerulea
Manually annotated by BRENDA team
Popa, E.; Perera, N.; Kibedi-Szabo, C.Z.; Guy-Evans, H.; Evans, D.R.; Purcarea, C.
The smallest active carbamoyl phosphate synthetase was identified in the human gut archaeon Methanobrevibacter smithii
J. Mol. Microbiol. Biotechnol.
22
287-299
2012
Methanobrevibacter smithii (A5UK38), Methanobrevibacter smithii
Manually annotated by BRENDA team
Wang, Y.; Chang, L.; Zhai, J.; Wu, Q.; Wang, D.; Wang, Y.
Generation of carbamoyl phosphate synthetase 1 reporter cell lines for the assessment of ammonia metabolism
J. Cell. Mol. Med.
21
3214-3223
2017
Homo sapiens, Homo sapiens (P31327)
Manually annotated by BRENDA team
Nohara, K.; Shin, Y.; Park, N.; Jeong, K.; He, B.; Koike, N.; Yoo, S.; Chen, Z.
Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid
Nutr. Metab.
12
23
2015
Mus musculus (Q8C196), Mus musculus
Manually annotated by BRENDA team
Lee, Y.Y.; Li, C.F.; Lin, C.Y.; Lee, S.W.; Sheu, M.J.; Lin, L.C.; Chen, T.J.; Wu, T.F.; Hsing, C.H.
Overexpression of CPS1 is an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy
Tumour Biol.
35
11097-11105
2014
Homo sapiens (P31327), Homo sapiens
Manually annotated by BRENDA team