Reference on EC 6.3.4.14 - biotin carboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tipton, P.A.; Cleland, W.W.
Catalytic mechanism of biotin carboxylase: steady-state kinetic investigation
Biochemistry
27
4317-4325
1988
Escherichia coli
Guchhait, R.B.; Polakis, S.E.; Lane, M.D.
Biotin carboxylase component of acetyl-CoA carboxylase from Escherichia coli
Methods Enzymol.
35B
25-31
1975
Escherichia coli
Climent, I.; Rubio, V.
ATPase activity of biotin carboxylase provides evidence for initial activation of HCO3- by ATP in the carboxylation of biotin
Arch. Biochem. Biophys.
251
465-470
1986
Escherichia coli
Polakis, S.E.; Guchhait, R.B.; Lane, M.D.
On the possible involvement of a carbonyl phosphate intermediate in the adenosine triphosphate-dependent carboxylation of biotin
J. Biol. Chem.
247
1335-1337
1972
Escherichia coli
Polakis, S.E.; Guchhait, R.B.; Zwergel, E.E.; Lane, M.D.
Acetyl coenzyme A carboxylase system of Escherichia coli. Studies on the mechanism of the biotin carboxylase- and carboxyltransferase-catalyzed reactions
J. Biol. Chem.
249
6657-6667
1974
Escherichia coli
Guchhait, R.B.; Polakis, S.E.; Hollis, D.; Fenselau, C.; Lane, M.D.
Acetyl coenzyme A carboxylase system of Escherichia coli. Site of carboxylation of biotin and enzymatic reactivity of 1'-N-(ureido)-carboxybiotin derivatives
J. Biol. Chem.
24 9
6646-6656
1974
Escherichia coli
Guchhait, R.B.; Polakis, S.E.; Dimroth, P.; Stoll, E.; Moss, J.; Lane, M.D.
Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyltransferase, and carboxyl carrier protein components
J. Biol. Chem.
249
6633-6645
1974
Escherichia coli, Escherichia coli B / ATCC 11303
Dimroth, P.; Guchhait, R.B.; Lane, M.D.
Crystallization of biotin carboxylase, a component enzyme of the acetyl-CoA carboxylase system from Escherichia coli
Hoppe-Seyler's Z. Physiol. Chem.
352
351-354
1971
Escherichia coli
Dimroth, P.; Guchhait, R.B.; Stoll, E.; Lane, M.D.
Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase
Proc. Natl. Acad. Sci. USA
67
1353-1360
1970
Escherichia coli
Kondo, H.; Shiratsuchi, K.; Yoshimoto, T.; Masuda, T.; Kitazono, A.; Tsuru, D.; Anai, M.; Sekiguchi, M.; Tanabe, T.
Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit
Proc. Natl. Acad. Sci. USA
88
9730-9733
1991
Escherichia coli
Li, S.J.; Cronan, J.E.
The gene encoding the biotin carboxylase subunit of Escherichia coli acetyl-CoA carboxylase
J. Biol. Chem.
267
855-863
1992
Escherichia coli
Waldrop, G.; Holden, H.M.; Rayment, I.
Preliminary X-ray crystallographic analysis of biotin carboxylase isolated from Escherichia coli
J. Mol. Biol.
235
367-369
1994
Escherichia coli
Norman, E.; de Smet, K.A.L.; Stoker, N.G.; Ratledge, C.; Wheeler, P.R.; Dale, J.W.
Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis
J. Bacteriol.
176
2525-2531
1994
Mycobacterium tuberculosis, Mycobacterium leprae
Waldrop, G.L.; Rayment, I.; Holden, H.M.
Three-dimensional structure of the biotin carboxylase subunit of the acetyl-CoA carboxylase
Biochemistry
33
10249-10256
1994
Escherichia coli
Sun, J.; Ke, J.; Johnson, J.L.; Nikolau, B.J.; Wurtele, E.S.
Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-coenzyme A carboxylase
Plant Physiol.
115
1371-1383
1997
Arabidopsis thaliana
Bao, X.; Shorrosh, B.S.; Ohlrogge, J.B.
Isolation and characterization of an Arabidopsis biotin carboxylase gene and its promoter
Plant Mol. Biol.
35
539-550
1997
Arabidopsis thaliana
Shintani, D.; Roesler, K.; Shorrosh, B.; Savage, L.; Ohlrogge, J.
Antisense expression and overexpression of biotin carboxylase in tobacco leaves
Plant Physiol.
114
881-886
1997
Nicotiana tabacum
Jager, W.; Peters-Wendisch, P.G.; Kalinowski, J.; Puhler, A.
A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins
Arch. Microbiol.
166
76-82
1996
Corynebacterium glutamicum
Marini, P.; Li, S.J.; Gardiol, D.; Cronan, J.E.; de Mendoza, D.
The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis
J. Bacteriol.
177
7003-7006
1995
Bacillus subtilis
Elborough, K.M.; Swinhoe, R.; Winz, R.; Kroon, J.T.; Farnsworth, L.; Fawcett, T.; Martinez-Rivas, J.M.; Slabas, A.R.
Isolation of cDNAs from Brassica napus encoding the biotin-binding and transcarboxylase: assignment of the domain structure ina full-length Arabidopsis thaliana genomuic clone
Biochem. J.
301
599-605
1994
Brassica napus
Best, E.A.; Knauf, V.C.
Organization and nucleotide sequences of the genes encoding the biotin carboxyl carrier protein and biotin carboxylase protein of Pseudomonas aeruginosa acetyl coenzyme A carboxylase
J. Bacteriol.
175
6881-6889
1993
Pseudomonas aeruginosa
Shorrosh, B.S.; Roesler, K.R.; Shintani, D.; van de Loo, F.J.; Ohlrogge, J.B.
Structural analysis, plastid localization, and expression of the biotin carboxylase subunit of acetyl-coenzyme A carboxylase from tobacco
Plant Physiol.
108
805-812
1995
Ricinus communis, Medicago sativa, Nicotiana tabacum, Pisum sativum
Sueda, S.; Islam, M.N.; Kondo, H.
Protein engineering of pyruvate carboxylase
Eur. J. Biochem.
271
1391-1400
2004
Geobacillus thermodenitrificans
Kimura, Y.; Miyake, R.; Tokumasu, Y.; Sato, M.
Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus
J. Bacteriol.
182
5462-5469
2000
Myxococcus xanthus (Q9FAF5), Myxococcus xanthus, Myxococcus xanthus IFO13542 / ATCC 25232 (Q9FAF5)
Kondo, S.; Nakajima, Y.; Sugio, S.; Yong-Biao, J.; Sueda, S.; Kondo, H.
Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution
Acta Crystallogr. Sect. D
60
486-492
2004
Aquifex aeolicus
Thelen, J.J.; Ohlrogge, J.B.
The multisubunit acetyl-CoA carboxylase is strongly associated with the chloroplast envelope through non-ionic interactions to the carboxyltransferase subunits
Arch. Biochem. Biophys.
400
245-257
2002
Pisum sativum
Blanchard, C.Z.; Amspacher, D.; Strongin, R.; Waldrop, G.L.
Inhibition of biotin carboxylase by a reaction intermediate analog: implications for the kinetic mechanism
Biochem. Biophys. Res. Commun.
266
466-471
1999
Escherichia coli
Blanchard, C.Z.; Lee, Y.M.; Frantom, P.A.; Waldrop, G.L.
Mutations at four active site residues of biotin carboxylase abolish substrate-induced synergism by biotin
Biochemistry
38
3393-3400
1999
Escherichia coli, Escherichia coli JM109
Levert, K.L.; Lloyd, R.B.; Waldrop, G.L.
Do cysteine 230 and lysine 238 of biotin carboxylase play a role in the activation of biotin?
Biochemistry
39
4122-4128
2000
Escherichia coli
Kazuta, Y.; Tokunaga, E.; Aramaki, E.; Kondo, H.
Identification of lysine-238 of Escherichia coli biotin carboxylase as an ATP-binding residue
FEBS Lett.
427
377-380
1998
Escherichia coli
Blanchard, C.Z.; Chapman-Smith, A.; Wallace, J.C.; Waldrop, G.L.
The biotin domain peptide from the biotin carboxyl carrier protein of Escherichia coli acetyl-CoA carboxylase causes a marked increase in the catalytic efficiency of biotin carboxylase and carboxyltransferase relative to free biotin
J. Biol. Chem.
274
31767-31769
1999
Escherichia coli
Thoden, J.B.; Blanchard, C.Z.; Holden, H.M.; Waldrop, G.L.
Movement of the biotin carboxylase B-domain as a result of ATP binding
J. Biol. Chem.
275
16183-16190
2000
Escherichia coli
Sloane, V.; Blanchard, C.Z.; Guillot, F.; Waldrop, G.L.
Site-directed mutagenesis of ATP binding residues of biotin carboxylase. Insight into the mechanism of catalysis
J. Biol. Chem.
276
24991-24996
2001
Escherichia coli
Janiyani, K.; Bordelon, T.; Waldrop, G.L.; Cronan, J.E., Jr.
Function of Escherichia coli biotin carboxylase requires catalytic activity of both subunits of the homodimer
J. Biol. Chem.
276
29864-29870
2001
Escherichia coli
Sloane, V.; Waldrop, G.L.
Kinetic characterization of mutations found in propionic acidemia and methylcrotonylglycinuria: Evidence for cooperativity in biotin carboxylase
J. Biol. Chem.
279
15772-15778
2004
Escherichia coli
Weatherly, S.C.; Volrath, S.L.; Elich, T.D.
Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain
Biochem. J.
380
105-110
2004
Pyricularia grisea, Phytophthora infestans, Ustilago maydis
Shen, Y.; Volrath, S.L.; Weatherly, S.C.; Elich, T.D.; Tong, L.
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product
Mol. Cell
16
881-891
2004
Saccharomyces cerevisiae (Q00955), Saccharomyces cerevisiae
Kondo, S.; Nakajima, Y.; Sugio, S.; Sueda, S.; Islam, M.N.; Kondo, H.
Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans
Acta Crystallogr. Sect. D
63
885-890
2007
Geobacillus thermodenitrificans
de Queiroz, M.S.; Waldrop, G.L.
Modeling and numerical simulation of biotin carboxylase kinetics: implications for half-sites reactivity
J. Theor. Biol.
246
167-175
2007
Escherichia coli
Shen, Y.; Chou, C.Y.; Chang, G.G.; Tong, L.
Is dimerization required for the catalytic activity of bacterial biotin carboxylase?
Mol. Cell
22
807-818
2006
Escherichia coli (P24182), Escherichia coli
Burton, N.P.; Williams, T.D.; Norris, P.R.
Carboxylase genes of Sulfolobus metallicus
Arch. Microbiol.
172
349-353
1999
Sulfuracidifex metallicus (O52602), Sulfuracidifex metallicus
Auguet, J.C.; Borrego, C.M.; Baneras, L.; Casamayor, E.O.
Fingerprinting the genetic diversity of the biotin carboxylase gene (accC) in aquatic ecosystems as a potential marker for studies of carbon dioxide assimilation in the dark
Environ. Microbiol.
10
2527-2536
2008
Chlorobium limicola, Cupriavidus metallidurans, Cytophaga hutchinsonii, Chlorobium phaeobacteroides, Methanosarcinales, Methanococcales, Sulfurisphaera tokodaii, Natronomonas pharaonis (A0A1U7EYC1), Cenarchaeum symbiosum (A0RY62), Pelobacter propionicus (A1ANN6), Hyperthermus butylicus (A2BLY3), Maribacter sp. HTCC2170 (A4APF1), Polynucleobacter asymbioticus QLW-P1DMWA-1 (A4SVB6), Geotalea uraniireducens (A5G5L1), Nitrosopumilus maritimus (A9A3E8), Chloroflexus aurantiacus (A9W9X0), uncultured bacterium (B1GX36), Sulfuracidifex metallicus (O52602), Trichodesmium erythraeum (Q10YA8), Polaromonas sp. (Q12EJ0), Syntrophotalea carbinolica (Q3A2P1), Synechococcus sp. (Q54755), Acidianus brierleyi (Q877I5), Metallosphaera sedula (Q8J2Z4), Saccharolobus solfataricus (Q97V46), Halobacterium salinarum (Q9HPP8)
Nilsson Lill, S.O.; Gao, J.; Waldrop, G.L.
Molecular dynamics simulations of biotin carboxylase
J. Phys. Chem. B
112
3149-3156
2008
Escherichia coli (P24182), Escherichia coli
Mochalkin, I.; Miller, J.R.; Evdokimov, A.; Lightle, S.; Yan, C.; Stover, C.K.; Waldrop, G.L.
Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase
Protein Sci.
17
1706-1718
2008
Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus aureus Mu50
Lee, C.K.; Cheong, H.K.; Ryu, K.S.; Lee, J.I.; Lee, W.; Jeon, Y.H.; Cheong, C.
Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism
Proteins
72
613-624
2008
Escherichia coli, Homo sapiens
Mochalkin, I.; Miller, J.R.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P.B.; Prasad, J.V.; Lightle, S.; Huband, M.D.; Stover, C.K.
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches
ACS Chem. Biol.
4
473-483
2009
Moraxella catarrhalis, Haemophilus influenzae, Escherichia coli (P24182)
Cho, Y.S.; Lee, J.I.; Shin, D.; Kim, H.T.; Jung, H.Y.; Lee, T.G.; Kang, L.W.; Ahn, Y.J.; Cho, H.S.; Heo, Y.S.
Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK
Biochem. Biophys. Res. Commun.
391
187-192
2010
Homo sapiens (O00763), Homo sapiens
Monnot, S.; Serre, V.; Chadefaux-Vekemans, B.; Aupetit, J.; Romano, S.; De Lonlay, P.; Rival, J.M.; Munnich, A.; Steffann, J.; Bonnefont, J.P.
Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency
Hum. Mutat.
30
734-740
2009
Homo sapiens
Chou, C.Y.; Yu, L.P.; Tong, L.
Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism
J. Biol. Chem.
284
11690-11697
2009
Escherichia coli (P24182), Escherichia coli
Miller, J.R.; Dunham, S.; Mochalkin, I.; Banotai, C.; Bowman, M.; Buist, S.; Dunkle, B.; Hanna, D.; Harwood, H.J.; Huband, M.D.; Karnovsky, A.; Kuhn, M.; Limberakis, C.; Liu, J.Y.; Mehrens, S.; Mueller, W.T.; Narasimhan, L.; Ogden, A.; Ohren, J.; Prasad, J.V.; Shelly, J.A.; Skerlos, L.; Sulavik, M.; Thomas,
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
Proc. Natl. Acad. Sci. USA
106
1737-1742
2009
Escherichia coli (P24182)
Bordelon, T.; Nilsson Lill, S.; Waldrop, G.
The utility of molecular dynamics simulations for understanding site-directed mutagenesis of glycine residues in biotin carboxylase
Proteins Struct. Funct. Bioinform.
74
808-819
2009
Escherichia coli
Yu, L.P.; Xiang, S.; Lasso, G.; Gil, D.; Valle, M.; Tong, L.
A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A
Structure
17
823-832
2009
Staphylococcus aureus (A0A0H3JUV1), Staphylococcus aureus
Gu, K.; Chiam, H.; Tian, D.; Yin, Z.
Molecular cloning and expression of heteromeric ACCase subunit genes from Jatropha curcas
Plant Sci.
180
642-649
2011
Jatropha curcas (F2WMV4), Jatropha curcas
Peters-Wendisch, P.; Stansen, K.C.; Goetker, S.; Wendisch, V.F.
Biotin protein ligase from Corynebacterium glutamicum: role for growth and L: -lysine production
Appl. Microbiol. Biotechnol.
93
2493-2502
2012
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Dimou, M.; Zografou, C.; Venieraki, A.; Katinakis, P.
Functional interaction of Azotobacter vinelandii cytoplasmic cyclophilin with the biotin carboxylase subunit of acetyl-CoA carboxylase
Biochem. Biophys. Res. Commun.
424
736-739
2012
Azotobacter vinelandii (C1DLJ7), Azotobacter vinelandii
Sarosiek, N.; Sarzynska, J.; Podkowinski, J.
Modeling of biotin carboxylase from plants
Biotechnologia
94
96-97
2013
Medicago truncatula
-
Tong, L.
Structure and function of biotin-dependent carboxylases
Cell. Mol. Life Sci.
70
863-891
2013
Escherichia coli
Smith, A.C.; Cronan, J.E.
Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo
J. Bacteriol.
194
72-78
2012
Escherichia coli
Chou, C.Y.; Tong, L.
Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization
J. Biol. Chem.
286
24417-24425
2011
Escherichia coli (P24182), Escherichia coli
Novak, B.; Moldovan, D.; Waldrop, G.; De Queiroz, M.
Behavior of the ATP grasp domain of biotin carboxylase monomers and dimers studied using molecular dynamics simulations
Proteins
79
622-632
2011
Escherichia coli
Broussard, T.C.; Kobe, M.J.; Pakhomova, S.; Neau, D.B.; Price, A.E.; Champion, T.S.; Waldrop, G.L.
The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase
Structure
21
650-657
2013
Escherichia coli (P24182), Escherichia coli
Broussard, T.C.; Pakhomova, S.; Neau, D.B.; Bonnot, R.; Waldrop, G.L.
Structural analysis of substrate, reaction intermediate, and product binding in Haemophilus influenzae biotin carboxylase
Biochemistry
54
3860-3870
2015
Haemophilus influenzae (P43873), Haemophilus influenzae, Haemophilus influenzae DSM 11121 (P43873)
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