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Information on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

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IUBMB Comments
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.
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The enzyme appears in viruses and cellular organisms
Synonyms
udp-n-acetylmuramoyl-l-alanyl-d-glutamate:l-lysine ligase, udp-n-acetylmuramoyl-l-alanyl-d-glutamyl-l-lysine synthetase, udp-n-acetylmuramoyl-l-alanyl-d-glutamate:meso-2,6-diaminopimelate ligase, udp-n-acetylmuramoyl-l-alanyl-d-glutamate l-lysine ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
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