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Information on EC - aerobactin synthase

for references in articles please use BRENDA:EC6.3.2.39
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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
       aerobactin synthase
IUBMB Comments
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation . It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate [3,4,5].
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The enzyme appears in viruses and cellular organisms
aerC, iuacC, iucC, more
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + aerobactin
show the reaction diagram
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