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Information on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase

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EC Tree
IUBMB Comments
Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.
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The enzyme appears in viruses and cellular organisms
Synonyms
aerD, EC 6.3.2.27, iuacA, iucA, Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N6-acetyl-N2-citryl-N6-hydroxy-L-lysine
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