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Disease on EC 6.3.2.17 - tetrahydrofolate synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome.
Alzheimer Disease
Replication of the MTHFD1L Gene Association with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population.
The MTHFD1L Gene rs11754661 Marker is Not Associated with Alzheimer's Disease in a Sample of the Spanish Population.
Arthritis, Rheumatoid
Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis.
Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells: application in rheumatoid arthritis and leukemia patients.
Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis.
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.
Breast Neoplasms
Chapter 4 molecular mechanisms of adaptation to folate deficiency.
Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells.
The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis.
Burkitt Lymphoma
Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma.
Carcinogenesis
MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma.
Carcinoma
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
Carcinoma, Hepatocellular
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma.
Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.
The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates.
Carcinoma, Non-Small-Cell Lung
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Carcinoma, Squamous Cell
Measurement of folylpolyglutamate synthetase activity in head and neck squamous carcinoma cell lines and clinical samples using a new rapid separation procedure.
Colitis
FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri.
Colonic Neoplasms
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.
hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles.
MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer.
Colorectal Neoplasms
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer.
Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients.
Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors.
Molecular basis of antifolate resistance.
MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer.
p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer.
Congenital Abnormalities
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
Coronary Artery Disease
Genetic Polymorphism rs6922269 in the MTHFD1L Gene Is Associated with Survival and Baseline Active Vitamin B12 Levels in Post-Acute Coronary Syndromes Patients.
Cytomegalovirus Infections
Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells.
Esophageal Neoplasms
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
Glioma
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
RESPONSE: Re: Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo.
Head and Neck Neoplasms
Measurement of folylpolyglutamate synthetase activity in head and neck squamous carcinoma cell lines and clinical samples using a new rapid separation procedure.
MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma.
Infections
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
Transcriptomic analysis of responses to cytopathic bovine viral diarrhea virus-1 (BVDV-1) infection in MDBK cells.
Iron Deficiencies
The impact of iron deficiency on the flux of folates within the mammary gland.
Leukemia
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate.
Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells: application in rheumatoid arthritis and leukemia patients.
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia.
Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Effects of antisense-based folypoly-gamma-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells.
Enzymatic synthesis of polyglutamate derivatives of 7-hydroxymethotrexate.
Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues.
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues.
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.
Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.
New insights into methotrexate accumulation in leukemia cells in vivo.
Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients.
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs.
Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells.
Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid.
Variable expression of the folylpolyglutamate synthetase gene at the level of mRNA transcription in human leukemia cell lines sensitive, or made resistant, to various antifolate drugs.
[A novel missense mutation of folypolyglutamate synthetase gene].
Leukemia, Lymphoid
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Leukemia, T-Cell
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Liver Neoplasms
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma.
Lung Neoplasms
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
[Differential gene expression of folylpolyglutamate synthetase in cytoplasm and mitochondria in acquired methotrexate enantiomers resistant to lung cancer A549 cell lines.]
Lymphatic Metastasis
High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer.
Lymphoma, T-Cell
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Lymphoma, T-Cell, Peripheral
Safety and efficacy of pralatrexate in the treatment of patients with relapsed or refractory peripheral T-cell lymphoma.
Malaria
Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.
Melanoma
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Mesothelioma
Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma.
Moyamoya Disease
Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans.
Neoplasm Metastasis
High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Neoplasms
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.
A randomized, double-blind, phase II study of two doses of pemetrexed as first-line chemotherapy for advanced breast cancer.
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.
Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy.
Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: clinical data.
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Determination of thymidine phosphorylase expression level facilitates recurrence risk stratification in stage II/III colorectal cancer following adjuvant chemotherapy with oral fluoropyrimidines.
Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts.
Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer.
Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis.
Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues.
Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs.
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues.
High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer.
hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles.
In vivo evidence for a significant role of folylpolyglutamate synthase in combined chemotherapy with oral fluoropyrimidine, UFT or S-1, and leucovorin.
Integrated Analysis of an lncRNA-Associated ceRNA Network Reveals Potential Biomarkers for Hepatocellular Carcinoma.
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Measurement of folylpolyglutamate synthetase activity in head and neck squamous carcinoma cell lines and clinical samples using a new rapid separation procedure.
Measurement of folylpolyglutamate synthetase in mammalian tissues.
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer.
MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma.
Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice.
PT523 and other aminopterin analogs with a hemiphthaloyl-L-ornithine side chain: exceptionally tight-binding inhibitors of dihydrofolate reductase which are transported by the reduced folate carrier but cannot form polyglutamates.
Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients.
Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.
Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.
Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors.
Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data.
Roles of folylpoly-gamma-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview.
Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity.
Single agent and combination studies of pralatrexate and molecular correlates of sensitivity.
Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.
Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Variable intrinsic sensitivity of human tumor cell lines to raltitrexed (Tomudex) and folylpolyglutamate synthetase activity.
[A novel missense mutation of folypolyglutamate synthetase gene].
[Acquisition of resistance associated with impairment of metabolic activation of anticancer drugs]
Neural Tube Defects
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency.
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density.
Deletion of the neural tube defect-associated gene
Formate and its role in amino acid metabolism.
Osteosarcoma
MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway.
Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia.
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.
Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia.
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.
Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia.
New insights into methotrexate accumulation in leukemia cells in vivo.
Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
[Correlation analysis of FPGS rs10760502G>a polymorphism with prognosis and MTX-related toxicity in pediatric B-cell acute lymphoblastic leukemia].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Sarcoma
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Sarcoma 180
Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
Squamous Cell Carcinoma of Head and Neck
In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate.
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.
Stomach Neoplasms
High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1.
Tuberculosis
Coenzyme F420-dependent glucose-6-phosphate dehydrogenase coupled polyglutamylation of coenzyme F420 in mycobacteria.
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
The inhibition of folylpolyglutamate synthetase (folC) in the prevention of drug resistance in Mycobacterium tuberculosis by traditional Chinese medicine.
Urinary Bladder Neoplasms
Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer.