Reference on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cronan, J.E.; Littel, K.J.; Jackowski, S.
Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium
J. Bacteriol.
149
916-922
1982
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Cronan, J.E.
Enzymatic synthesis of beta-[U-14C]alanine and D-[1,2,3-14C]pantothenate of high specific radioactivity
Anal. Biochem.
103
377-380
1980
Escherichia coli
Miyatake, K.; Nakano, Y.; Kitaoka, S.
Pantothenate synthetase from Escherichia coli [D-pantoate:beta-alanine ligase (AMP-forming), EC 6.3.2.1]
Methods Enzymol.
62
215-219
1979
Escherichia coli
Miyatake, K.; Nakano, Y.; Kitaoka, S.
Enzymological properties of pantothenate synthetase from Escherichia coli B
J. Nutr. Sci. Vitaminol.
24
243-253
1978
Escherichia coli
Miyatake, K.; Nakano, Y.; Kitaoka, S.
Some properties of pantothenate synthetase partially purified from Escherichia coli B
Bull. Univ. Osaka Prefect
27
57-67
1975
Escherichia coli
-
Miyatake, K.; Nakano, Y.; Kitaoka, S.
Pantothenate synthetase of Escherichia coli B. I. Physicochemical properties
J. Biochem.
79
673-678
1976
Escherichia coli, Escherichia coli B / ATCC 11303
Miyatake, K.; Nakano, Y.; Kitaoka, S.
Isotopic determination and optimum reaction conditions of pantothenic acid synthetase
Agric. Biol. Chem.
37
1205-1207
1973
Escherichia coli
-
Ginoza, H.S.; Altenbern, R.A.
The pantothenate-synthesizing enzyme in cell-free extracts of Brucella abortus, strain 19
Arch. Biochem. Biophys.
56
537-541
1955
Brucella abortus, Brucella abortus 19
Baillie, A.C.; Cornell, C.L.; Wright, B.J.; Wright, K.
Synthesis of potential inhibitors of the enzyme pantothenate synthetase
Tetrahedron Lett.
33
5133-5136
1992
Escherichia coli
-
Genschel, U.; Powell, C.A.; Abell, C.; Smith, A.G.
The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)
Biochem. J.
341
669-678
1999
Lotus japonicus (O24035), Oryza sativa (O24210)
-
Zheng, R.; Blanchard, J.S.
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase
Biochemistry
40
12904-12912
2001
Mycobacterium tuberculosis
Williams, L.; Zheng, R.; Blanchard, J.S.; Raushel, F.M.
Positionoal isotope exchange analysis of the pantothenate synthetase reaction
Biochemistry
42
5108-5113
2003
Mycobacterium tuberculosis
Perez-Espinosa, A.; Roldan-Arjona, T.; Ruiz-Rubio, M.
Pantothenate synthetase from Fusarium oxysporum f. sp. lycopersici is induced by alpha-tomatine
Mol. Genet. Genomics
265
922-929
2001
Fusarium oxysporum (Q96VJ9), Fusarium oxysporum
Wang, S.; Eisenberg, D.
Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci.
12
1097-1108
2003
Mycobacterium tuberculosis
von Delft, F.; Lewendon, A.; Dhanaraj, V.; Blundell, T.L.; Abell, C.; Smith, A.G.
The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily
Structure
9
439-450
2001
Escherichia coli
Zheng, R.; Dam, T.K.; Brewer, C.F.; Blanchard, J.S.
Active site residues in Mycobacterium tuberculosis pantothenate synthetase required in the formation and stabilization of the adenylate intermediate
Biochemistry
43
7171-7178
2004
Mycobacterium tuberculosis
Ottenhof, H.H.; Ashurst, J.L.; Whitney, H.M.; Saldanha, S.A.; Schmitzberger, F.; Gweon, H.S.; Blundell, T.L.; Abell, C.; Smith, A.G.
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants
Plant J.
37
61-72
2004
Arabidopsis thaliana
Mitra, A.; Chakrabarti, K.S.; Hameed, M.S.S.; Srinivas, K.V.; Kumar, G.S.; Sarma, S.P.
High level expression of peptides and proteins using cytochrome b5 as a fusion host
Protein Expr. Purif.
41
84-97
2005
Escherichia coli
Wang, S.; Eisenberg, D.
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action
Biochemistry
45
1554-1561
2006
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Jonczyk, R.; Genschel, U.
Molecular adaptation and allostery in plant pantothenate synthetases
J. Biol. Chem.
281
37435-37446
2006
Arabidopsis thaliana, Escherichia coli
White, E.L.; Southworth, K.; Ross, L.; Cooley, S.; Gill, R.B.; Sosa, M.I.; Manouvakhova, A.; Rasmussen, L.; Goulding, C.; Eisenberg, D.; Fletcher, T.M.
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase
J. Biomol. Screen.
12
100-105
2007
Mycobacterium tuberculosis
Tuck, K.L.; Saldanha, S.A.; Birch, L.M.; Smith, A.G.; Abell, C.
The design and synthesis of inhibitors of pantothenate synthetase
Org. Biomol. Chem.
4
3598-3610
2006
Escherichia coli (P31663)
Velaparthi, S.; Brunsteiner, M.; Uddin, R.; Wan, B.; Franzblau, S.G.; Petukhov, P.A.
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs
J. Med. Chem.
51
1999-2002
2008
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Jonczyk, R.; Ronconi, S.; Rychlik, M.; Genschel, U.
Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis
Plant Mol. Biol.
66
1-14
2008
Escherichia coli, Arabidopsis thaliana (Q9FKB3), Arabidopsis thaliana
Chakrabarti, K.S.; Thakur, K.G.; Gopal, B.; Sarma, S.P.
X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate
FEBS J.
277
697-712
2010
Escherichia coli (P31663), Escherichia coli
Sledz, P.; Silvestre, H.L.; Hung, A.W.; Ciulli, A.; Blundell, T.L.; Abell, C.
Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase
J. Am. Chem. Soc.
132
4544-4545
2010
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Satoh, A.; Konishi, S.; Tamura, H.; Stickland, H.G.; Whitney, H.M.; Smith, A.G.; Matsumura, H.; Inoue, T.
Substrate-induced closing of the active site revealed by the crystal structure of pantothenate synthetase from Staphylococcus aureus
Biochemistry
49
6400-6410
2010
Staphylococcus aureus (Q2FV22), Staphylococcus aureus
Yang, Y.; Gao, P.; Liu, Y.; Ji, X.; Gan, M.; Guan, Y.; Hao, X.; Li, Z.; Xiao, C.
A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition
Bioorg. Med. Chem. Lett.
21
3943-3946
2011
Mycobacterium tuberculosis
Tan, Y.S.; Fuentes, G.; Verma, C.
A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies
Proteins
79
1715-1727
2011
Escherichia coli, Mycobacterium tuberculosis
Samala, G.; Devi, P.; Nallangi, R.; Sridevi, J.; Saxena, S.; Yogeeswari, P.; Sriram, D.
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads
Bioorg. Med. Chem.
22
1938-1947
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Samala, G.; Devi, P.B.; Nallangi, R.; Yogeeswari, P.; Sriram, D.
Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors
Eur. J. Med. Chem.
69
356-364
2013
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Kumar, A.; Casey, A.; Odingo, J.; Kesicki, E.A.; Abrahams, G.; Vieth, M.; Masquelin, T.; Mizrahi, V.; Hipskind, P.A.; Sherman, D.R.; Parish, T.
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis
PLoS ONE
8
e72786
2013
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Samala, G.; Nallangi, R.; Devi, P.B.; Saxena, S.; Yadav, R.; Sridevi, J.P.; Yogeeswari, P.; Sriram, D.
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors
Bioorg. Med. Chem.
22
4223-4232
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Samala, G.; Devi, P.B.; Saxena, S.; Meda, N.; Yogeeswari, P.; Sriram, D.
Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors
Bioorg. Med. Chem.
24
1298-1307
2016
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Hung, A.W.; Silvestre, H.L.; Wen, S.; George, G.P.; Boland, J.; Blundell, T.L.; Ciulli, A.; Abell, C.
Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis
ChemMedChem
11
38-42
2016
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Devi, P.B.; Samala, G.; Sridevi, J.P.; Saxena, S.; Alvala, M.; Salina, E.G.; Sriram, D.; Yogeeswari, P.
Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors
ChemMedChem
9
2538-2547
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Ntie-Kang, F.; Kannan, S.; Wichapong, K.; Owono Owono, L.; Sippl, W.; Megnassan, E.
Binding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase docking and MM-GB(PB)SA analysis
Mol. Biosyst.
10
223-239
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Devi, P.B.; Jogula, S.; Reddy, A.P.; Saxena, S.; Sridevi, J.P.; Sriram, D.; Yogeeswari, P.
Design of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors virtual screening, synthesis and in vitro biological activities
Mol. Inform.
34
147-159
2015
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Pandey, B.; Grover, S.; Goyal, S.; Kumari, A.; Singh, A.; Jamal, S.; Kaur, J.; Grover, A.
Alanine mutation of the catalytic sites of pantothenate synthetase causes distinct conformational changes in the ATP binding region
Sci. Rep.
8
903
2018
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
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