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Information on EC 6.3.1.9 - trypanothione synthase

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IUBMB Comments
The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyses two subsequent reactions, leading to production of trypanothione from glutathione and spermidine. Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8, glutathionylspermidine synthase). The enzyme is bifunctional, and also catalyses the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78, glutathionylspermidine amidase).
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The enzyme appears in viruses and cellular organisms
Synonyms
trypanothione synthetase, ldtrys, tctrys, tsh synthetase, litrys, tbtrys, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate
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glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate
show the reaction diagram
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