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Information on EC 6.3.1.8 - glutathionylspermidine synthase

for references in articles please use BRENDA:EC6.3.1.8
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IUBMB Comments
Requires magnesium ions. Involved in the synthesis of trypanothione in trypanosomatids. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine amidase (EC 3.5.1.78) reaction, resulting in a net hydrolysis of ATP.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
glutathionylspermidine synthetase, gsp synthetase, ligsps, bifunctional glutathionylspermidine synthetase/amidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate
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