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Information on EC 6.2.1.36 - 3-hydroxypropionyl-CoA synthase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.36 3-hydroxypropionyl-CoA synthase
IUBMB Comments
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates , and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
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The enzyme appears in viruses and cellular organisms
Synonyms
3-hydroxypropionyl-CoA synthetase (AMP-forming), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate
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