Information on EC 6.2.1.15 - arachidonate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.15
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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.15 arachidonate-CoA ligase
IUBMB Comments
Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate.
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Word Map
  • 6.2.1.15
  • ferroptosis
  • arachidonic
  • acsls
  • erastin
  • ferroptosis-related
  • acid-coa
  • triacsin
  • ferrostatin-1
  • slc7a11
  • alport
  • col4a5
  • erastin-induced
  • liproxstatin-1
The expected taxonomic range for this enzyme is: Tetrapoda
Synonyms
ACSL4, Acyl-CoA synthetase, Arachidonoyl-CoA synthetase, FACL4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA
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