Reference on EC 6.1.1.7 - alanine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bhanot, O.S.; Kucan, Z.; Aoyagi, S.; Lee, F.C.; Chambers, R.W.
Purification of tyrosine:tRNA ligase, valine:tRNA ligase, alanine:tRNA ligase, and isoleucine:tRNA ligase from Saccharomyces cerevisiae alphaS288C
Methods Enzymol.
29E
547-576
1974
Saccharomyces cerevisiae, Saccharomyces cerevisiae alphaS288C
-
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Dignam, S.S.; Dignam, J.D.
Glycyl- and alanyl-tRNA synthetases from Bombyx mori. Purification and properties
J. Biol. Chem.
259
4043-4048
1984
Bombyx mori
Lechler, A.; Martin, A.; Zuleeg, T.; Limmer, S.; Kreutzer, R.
A biologically active 53 kDa fragment of overproduced alanyl-tRNA synthetase from Thermus thermophilus HB8 specifically interacts with tRNAAla acceptor helix
Nucleic Acids Res.
25
2737-2744
1997
Thermus thermophilus (P74941), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (P74941)
Schimmel, P.
Alanine transfer synthetase. Structure-function relationships and molecular recognition of transfer RNA
Adv. Enzymol. Relat. Areas Mol. Biol.
63
233-270
1990
Escherichia coli, Escherichia coli overproducing
Sood, S.M.; Slattery, C.W.; Filley, S.J.; Wu, M.X.; Hill, K.A.
Further characterization of Escherichia coli alanyl-tRNA synthetase
Arch. Biochem. Biophys.
328
295-301
1996
Escherichia coli
Shiba, K.; Ripmaster, T.; Suzuki, N.; Nichols, R.; Plotz, P.; Noda, T.; Schimmel, P.
Human alanyl-tRNA synthetase. Conservation in evolution of catalytic core and microhelix recognition
Biochemistry
34
10340-10349
1995
Escherichia coli, Homo sapiens
Filley, S.J.; Hill, K.A.W.
Amino acid substitutions at position 73 in motif 2 of Escherichia coli alanyl-tRNA synthetase
Arch. Biochem. Biophys.
307
46-51
1993
Escherichia coli
Wu, M.X.; Filley, S.J.; Xiong, J.; Lee, J.J.; Hill, K.A.W.
A cysteine in the C-terminal region of alanyl-tRNA synthetase is important for aminoacylation activity
Biochemistry
33
12260-12266
1994
Escherichia coli
Holley, R.W.; Goldstein, J.
An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate
J. Biol. Chem.
234
1765-1768
1959
Rattus norvegicus
Webster, G.C.
Isolation of an alanine-activating enzyme from pig liver
Biochim. Biophys. Acta
49
141-152
1961
Sus scrofa
Hilderman, R.H.
Isolation of an activator macromolecule for alanyl-tRNA synthetase from rat liver
Biochem. Biophys. Res. Commun.
77
509-517
1977
Rattus norvegicus
Putney, S.D.; Sauer, R.T.; Schimmmel, P.R.
Purification and properties of alanine tRNA synthetase from Escherichia coli
J. Biol. Chem.
256
198-204
1981
Escherichia coli
Kern, D.; Giege, R.; Ebel, J.P.
Purification and some properties of alanyl- and leucyl-tRNA synthetases from baker's yeast
Biochim. Biophys. Acta
653
83-90
1981
Saccharomyces cerevisiae
Chen, Z.Q.; Park Kim, J.J.; Lai, C.S.; Mehler, A.H.
Reactions of the sulfhydryl groups of alanyl-tRNA synthetase
Arch. Biochem. Biophys.
233
611-616
1984
Escherichia coli
Nishio, K.; Kawakami, M.
Purification and properties of alanyl-tRNA synthetase from Bombyx mori. A monomeric enzyme
J. Biochem.
96
1867-1874
1984
Bombyx mori
Sood, S.M.; Wu, M.X.; Hill, K.A.; Slattery, C.W.
Characterization of zinc-depleted alanyl-tRNA synthetase from Escherichia coli: role of zinc
Arch. Biochem. Biophys.
368
380-384
1999
Escherichia coli
Barends, S.; Wower, J.; Kraal, B.
kinetic parameters for tmRNA binding to alanyl-tRNA synthetase and elongation factor Tu from Escherichia coli
Biochemistry
39
2652-2658
2000
Escherichia coli
Pleiss, J.A.; Wolfson, A.D.; Uhlenbeck, O.C.
Mapping contacts between Escherichia coli alanyl tRNA synthetase and 2' hydroxyls using a complete tRNA molecule
Biochemistry
39
8250-8258
2000
Escherichia coli
Stepanov, V.G.; Nyborg, J.
tmRNA from Thermus thermophilus. Interaction with alanyl-tRNA synthetase and elongation factor Tu
Eur. J. Biochem.
270
463-475
2003
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Wrobel, C.; Schmidt, E.V.; Polymenis, M.
CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae
J. Bacteriol.
181
7618-7620
1999
Saccharomyces cerevisiae
Chihade, J.W.; Brown, J.R.; Schimmel, P.R.; De Pouplana, L.R.
Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
97
12153-12157
2000
Dictyostelium discoideum (Q54Y20), Giardia intestinalis (Q9U022), Drosophila melanogaster (Q9VRJ1)
Wang, Y.; Sekiguchi, T.; Noguchi, E.; Nishimoto, T.
A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis
J. Biochem.
135
7-16
2004
Mesocricetus auratus (Q8CFX8)
Tang, H.L.; Yeh, L.S.; Chen, N.K.; Ripmaster, T.; Schimmel, P.; Wang, C.C.
Translation of a yeast mitochondrial tRNA synthetase initiated at redundant non-AUG codons
J. Biol. Chem.
279
49656-49663
2004
Saccharomyces cerevisiae
Swairjo, M.A.; Otero, F.J.; Yang, X.L.; Lovato, M.A.; Skene, R.J.; McRee, D.E.; Ribas de Pouplana, L.; Schimmel, P.
Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition
Mol. Cell
13
829-841
2004
Aquifex aeolicus (O67323), Aquifex aeolicus
Lovato, M.A.; Swairjo, M.A.; Schimmel, P.
Positional recognition of a tRNA determinant dependent on a peptide insertion
Mol. Cell
13
843-851
2004
Drosophila melanogaster
Swairjo, M.A.; Schimmel, P.R.
Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase
Proc. Natl. Acad. Sci. USA
102
988-993
2005
Aquifex aeolicus (O67323), Aquifex aeolicus
Fukunaga, R.; Yokoyama, S.
Crystallization and preliminary X-ray crystallographic study of alanyl-tRNA synthetase from the archaeon Archaeoglobus fulgidus
Acta Crystallogr. Sect. F
63
224-228
2007
Archaeoglobus fulgidus
Zhang, C.M.; Perona, J.J.; Ryu, K.; Francklyn, C.; Hou, Y.M.
Distinct kinetic mechanisms of the two classes of aminoacyl-tRNA synthetases
J. Mol. Biol.
361
300-311
2006
Escherichia coli
Huang, H.Y.; Tang, H.L.; Chao, H.Y.; Yeh, L.S.; Wang, C.C.
An unusual pattern of protein expression and localization of yeast alanyl-tRNA synthetase isoforms
Mol. Microbiol.
60
189-198
2006
Saccharomyces cerevisiae
Ishijima, J.; Uchida, Y.; Kuroishi, C.; Tuzuki, C.; Takahashi, N.; Okazaki, N.; Yutani, K.; Miyano, M.
Crystal structure of alanyl-tRNA synthetase editing-domain homolog (PH0574) from a hyperthermophile, Pyrococcus horikoshii OT3 at 1.45 A resolution
Proteins
62
1133-1137
2006
Pyrococcus horikoshii (O58307), Pyrococcus horikoshii OT-3 (O58307)
Gundllapalli, S.; Ambrogelly, A.; Umehara, T.; Li, D.; Polycarpo, C.; Soell, D.
Misacylation of pyrrolysine tRNA in vitro and in vivo
FEBS Lett.
582
3353-3358
2008
Escherichia coli
Chong, Y.E.; Yang, X.L.; Schimmel, P.
Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation
J. Biol. Chem.
283
30073-30078
2008
Escherichia coli
De Pascale, G.; Lloyd, A.J.; Schouten, J.A.; Gilbey, A.M.; Roper, D.I.; Dowson, C.G.; Bugg, T.D.
Kinetic characterisation of lipid II-Ala:alanyl tRNA ligase (MurN) from Streptococcus pneumoniae using semi-synthetic aminoacyl-lipid II substrates
J. Biol. Chem.
283
34571-34579
2008
Streptococcus pneumoniae
Beebe, K.; Mock, M.; Merriman, E.; Schimmel, P.
Distinct domains of tRNA synthetase recognize the same base pair
Nature
451
90-93
2008
Escherichia coli
Guo, M.; Chong, Y.E.; Shapiro, R.; Beebe, K.; Yang, X.L.; Schimmel, P.
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
Nature
462
808-812
2009
Escherichia coli (P00957)
Sokabe, M.; Ose, T.; Nakamura, A.; Tokunaga, K.; Nureki, O.; Yao, M.; Tanaka, I.
The structure of alanyl-tRNA synthetase with editing domain
Proc. Natl. Acad. Sci. USA
106
11028-11033
2009
Pyrococcus horikoshii (O58035)
Naganuma, M.; Sekine, S.; Fukunaga, R.; Yokoyama, S.
Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization
Proc. Natl. Acad. Sci. USA
106
8489-8494
2009
Archaeoglobus fulgidus (O28029), Archaeoglobus fulgidus
Pasman, Z.; Robey-Bond, S.; Mirando, A.C.; Smith, G.J.; Lague, A.; Francklyn, C.S.
Substrate specificity and catalysis by the editing active site of alanyl-tRNA synthetase from Escherichia coli
Biochemistry
50
1474-1482
2011
Escherichia coli
Goetz, A.; Tyynismaa, H.; Euro, L.; Ellonen, P.; Hyoetylaeinen, T.; Ojala, T.; Haemaelaeinen, R.H.; Tommiska, J.; Raivio, T.; Oresic, M.; Karikoski, R.; Tammela, O.; Simola, K.O.; Paetau, A.; Tyni, T.; Suomalainen, A.
Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy
Am. J. Hum. Genet.
88
635-642
2011
Homo sapiens (Q5JTZ9), Homo sapiens
Dignam, J.D.; Guo, J.; Griffith, W.P.; Garbett, N.C.; Holloway, A.; Mueser, T.
Allosteric interaction of nucleotides and tRNA(Ala) with E. coli alanyl-tRNA synthetase
Biochemistry
50
9886-9900
2011
Escherichia coli
Smal, C.; Zanzoni, S.; DOnofrio, M.; Molinari, H.; Cicero, D.O.; Assfalg, M.
1H, 15N and 13C chemical shift assignments of the C-Ala domain of the alanyl-tRNA synthetase of the psychrophilic bacterium Bizionia argentinensis sp. nov
Biomol. NMR Assign.
8
415-418
2013
Bizionia argentinensis, Bizionia argentinensis JUB59
Banerjee, B.; Banerjee, R.
Guanidine hydrochloride mediated denaturation of E. coli alanyl-tRNA Synthetase: identification of an inactive dimeric intermediate
Protein J.
33
119-127
2014
Escherichia coli
Smal, C.; Zanzoni, S.; D'Onofrio, M.; Molinari, H.; Cicero, D.; Assfalg, M.
1H, 15N and 13C chemical shift assignments of the C-Ala domain of the alanyl-tRNA synthetase of the psychrophilic bacterium Bizionia argentinensis sp. nov
Biomol. NMR Assign.
8
415-418
2014
Bizionia argentinensis (G2EA49), Bizionia argentinensis, Bizionia argentinensis JUB59 (G2EA49)
Euro, L.; Konovalova, S.; Asin-Cayuela, J.; Tulinius, M.; Griffin, H.; Horvath, R.; Taylor, R.W.; Chinnery, P.F.; Schara, U.; Thorburn, D.R.; Suomalainen, A.; Chihade, J.; Tyynismaa, H.
Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation
Front. Genet.
6
21
2015
Homo sapiens (Q5JTZ9), Homo sapiens
Banerjee, B.; Banerjee, R.
Urea unfolding study of E. coli alanyl-tRNA synthetase and its monomeric variants proves the role of C-terminal domain in stability
J. Amino Acids
2015
805681
2015
Escherichia coli (P00957), Escherichia coli
Chang, C.P.; Chang, C.Y.; Lee, Y.H.; Lin, Y.S.; Wang, C.C.
Divergent alanyl-tRNA synthetase genes of Vanderwaltozyma polyspora descended from a common ancestor through whole-genome duplication followed by asymmetric evolution
Mol. Cell. Biol.
35
2242-2253
2015
Vanderwaltozyma polyspora (A7TPK2), Vanderwaltozyma polyspora (A7TRK4), Vanderwaltozyma polyspora, Tetrapisispora phaffii (G8BWM7), Tetrapisispora phaffii (G8C0Z7), Saccharomyces cerevisiae (P40825), Saccharomyces cerevisiae, Vanderwaltozyma polyspora ATCC 22028 / DSM 70294 (A7TPK2), Vanderwaltozyma polyspora ATCC 22028 / DSM 70294 (A7TRK4)
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