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Reference on EC 6.1.1.5 - isoleucine-tRNA ligase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kohda, D.; Yokoyama, S; Miyazawa, T.
Thermostable valyl-tRNA, isoleucyl-tRNA and methionyl-tRNA synthetases from an extreme thermophile Thermus thermophilus HB8. Protein structure and Zn2+ binding
FEBS Lett.
174
20-23
1984
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Manually annotated by BRENDA team
Goldgur, Y.; Safro, M.
Aminoacyl-tRNA synthetases from Haloarcula marismortui: an evidence for a multienzyme complex in a procaryotic system
Biochem. Mol. Biol. Int.
32
1075-1083
1994
Haloarcula marismortui
Manually annotated by BRENDA team
Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Manually annotated by BRENDA team
Yanagisawa, T.; Lee, J.T.; Wu, H.C.; Kawakami, M.
Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli
J. Biol. Chem.
269
24304-24309
1994
Escherichia coli
Manually annotated by BRENDA team
Glasfeld, E.; Landro, J.A.; Schimmel, P.
C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase
Biochemistry
35
4139-4145
1996
Escherichia coli
Manually annotated by BRENDA team
Jakubowski, H.
Proofreading in trans by an aminoacyl-tRNA synthetase. A model for single site editing by isoleucyl-tRNA synthetase
Nucleic Acids Res.
24
2505-2510
1996
Escherichia coli
Manually annotated by BRENDA team
Zhou, L.; Rosevear, P.R.
Mutation of the carboxy terminal zinc finger of E. coli isoleucyl-tRNA synthetase alters zinc binding and aminoacylation activity
Biochem. Biophys. Res. Commun.
216
648-654
1995
Escherichia coli
Manually annotated by BRENDA team
Auld, D.S.; Schimmel., P.
Switching recognition of two tRNA synthetases with an amino acid swap in a designed peptide
Science
267
1994-1996
1995
Escherichia coli
Manually annotated by BRENDA team
Landro, J.A.; Schmidt, E.; Schimmel, P.
Thiol ligation of two zinc atoms to a class I tRNA synthetase. Evidence for unshared thiols and role in amino acid binding and utilization
Biochemistry
33
14213-14220
1994
Escherichia coli
Manually annotated by BRENDA team
Xu, B.; Trawick, B.; Krudy, G.A.; Phillips, R.M.; Zhou.L.; Rosevear, P.R.
Probing the metal binding sites of E. coli isoleucyl-tRNA synthetase
Biochemistry
33
398-402
1994
Escherichia coli
Manually annotated by BRENDA team
Airas, R.K.
Analysis of the isoleucyl-tRNA synthetase reaction by total rate equation. Magnesium and spermidine in the tRNA kinetics
Eur. J. Biochem.
210
451-454
1992
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Schimmel, P.; Landro, J.A.; Schidt, E.
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases
J. Biomol. Struct. Dyn.
11
571-581
1993
Escherichia coli
Manually annotated by BRENDA team
Glasfeld, E.; Schimmel, P.
Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase
Biochemistry
36
6739-6744
1997
Escherichia coli
Manually annotated by BRENDA team
Racher, K.I.; Kalmar, G.B.; Borgford, T.J.
Expression and characterization of a recombinant yeast isoleucyl-tRNA synthetase
J. Biol. Chem.
266
17158-17164
1991
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Englisch, U.; Englisch, S.; Markmeyer, P.; Schischkoff, J.; Sterbach, H.; Kratzin, H.; Cramer, F.
Structure of the yeast isoleucyl-tRNA synthetase gene (ILS1). DNA-sequence, amino-acid sequence of the proteolytic peptides of the enzyme and comparison of the structure to those of other known aminoacyl-tRNA synthetases
Biol. Chem. Hoppe-Seyler
368
971-979
1987
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Jenal.U.; Rechsteiner, T.; Tan, P.Y.; Buhlmann, E.; Meile, L.; Leisinger, T.
Isoleucyl-tRNA synthetase of Methanobacterium thermoautotrophicum Marburg. Cloning of the gene, nucleotide sequence, and localization of a base change conferring resistance to pseudomonic acid
J. Biol. Chem.
266
10570-10577
1991
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
Manually annotated by BRENDA team
Charlier, J.; Grosjean, H.
Isoleucyl-transfer ribonucleic acid synthetase from Bacillus stearothermophilus. Properties of the enzyme
Eur. J. Biochem.
25
163-174
1972
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Grosjean, H.; Charlier, J.
Comparative studies on the isoleucyl-tRNA synthetases from Bacillus stearothermophilus and Escherichia coli. II. The effect of magnesium ions in the transacylation reaction
FEBS Lett.
18
342-346
1971
Geobacillus stearothermophilus, Escherichia coli
Manually annotated by BRENDA team
Steinmetz Kayne , M.; Cohn, M.
Cation requirements of isoleucyl-tRNA synthetase from Escherichia coli
Biochem. Biophys. Res. Commun.
46
1285-1291
1972
Escherichia coli
Manually annotated by BRENDA team
Holler, E.
Isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B. Effects of magnesium and spermine on the amino acid activation reaction
Biochemistry
12
1142-1149
1973
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Durekovic, A.; Flossdorf, J.; Kula, M.R.
Isolation and properties of isoleucyl-tRNA synthetase from Escherichia coli MRE 600
Eur. J. Biochem.
36
528-533
1973
Escherichia coli, Escherichia coli MRE 600
Manually annotated by BRENDA team
Carr, A.C.; Igloi, G.L.; Penzer, G.R.; Plumbridge, J.A.
The effect of spermine anf Mg2+ on the catalytic mechanism of isoleucine:tRNA ligase
Eur. J. Biochem.
54
169-173
1975
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Wakagi, T.; Ohta, T.; Imahori, K.
Studies on isoleucyl-tRNA synthetase of an extreme thermophile, Thermus thermophilus HB8
Agric. Biol. Chem.
39
1573-1580
1975
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
Manually annotated by BRENDA team
Hammer-Raber, B.; Rainey, P.M.; Holler, E.
L-Isoleucyl-tRNA synthetase aus E. coli. pH-Abhngigkeit der Enzym-Substrat Komplexbildung
Hoppe-Seyler's Z. Physiol. Chem.
357
295
1976
Escherichia coli
-
Manually annotated by BRENDA team
Moe, J.G.; Piszkiewicz, D.
Purification of isoleucyl transfer ribonucleic acid synthetase by affinity chromatography on blue dextran-Sepharose
FEBS Lett.
72(1)
147-150
1976
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Freist, W.; von der Haar, F.; Faulhammer, H.; Cramer, F.
Valyl-tRNA, isoleucyl-tRNA and tyrosyl-tRNA synthetase from baker's yeast. Substrate specificity with regard to ATP analogs and mechanism of the aminoacylation reaction
Eur. J. Biochem.
66
493-497
1976
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Igarashi, K.; Eguchi, K.; Tanaka, M.; Hirose, S.
Effect of polyamines on isoleucyl-tRNA formation by rat liver isoleucyl-tRNA synthetase
Eur. J. Biochem.
82
301-307
1978
Rattus norvegicus
Manually annotated by BRENDA team
Hughes, J.; Mellows, G.
Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid
Biochem. J.
176
305-318
1978
Escherichia coli
Manually annotated by BRENDA team
Freist, W.; von der Haar, F.; Cramer, F.
Isoleucyl-tRNA synthetase from baker's yeast
Eur. J. Biochem.
119
151-164
1981
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lazard, M.; Mirande, M.; Waller, J.P.
Purification and characterization of the isoleucyl-tRNA synthetase component from the high molecular weight complex of sheep liver. A hydrophobic metalloprotein
Biochemistry
24
5099-5106
1985
Ovis aries
Manually annotated by BRENDA team
Kiener, A.; Rechsteiner, T.; Leisinger, T.
Mutation to pseudomonic acid resistance of Methanobacterium thermoautotrophicum leads to an altered isoleucyl-tRNA synthetase
FEMS Microbiol. Lett.
33
15-18
1986
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
-
Manually annotated by BRENDA team
Freist, W.; Sternbach, H.; Cramer, F.
Isoleucyl-tRNA synthetase from baker's yeast and from Escherichia coli MRE 600. Discrimination of 20 amino acids in aminoacylation of tRNAIle-C-C-A(3'NH2)
Eur. J. Biochem.
169
33-39
1987
Saccharomyces cerevisiae, Escherichia coli, Escherichia coli MRE 600
Manually annotated by BRENDA team
Crasto, C.F.; Forrest, A.K.; Karoli, T.; March, D.R.; Mensah, L.; O'Hanlon, P.J.; Nairn, M.R.; Oldham, M.D.; Yue, W.; Banwell, M.G.; Easton, C.J.
Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207
Bioorg. Med. Chem.
11
2687-2694
2003
Staphylococcus aureus, Rattus norvegicus, Staphylococcus aureus WCUH29
Manually annotated by BRENDA team
Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Kang, M.K.; Jo, Y.J.; Kim, S.
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
11
961-964
2001
Escherichia coli
Manually annotated by BRENDA team
Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Job, Y.J.; Kim, S.
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
11
965-968
2001
Escherichia coli
Manually annotated by BRENDA team
Lee, J.; Kim, S.E.; Lee, J.Y.; Kim, S.Y.; Kang, S.U.; Seo, S.H.; Chun, M.W.; Kang, T.; Choi, S.Y.; Kim, H.O.
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
13
1087-1092
2003
Escherichia coli
Manually annotated by BRENDA team
Pope, A.J.; Lapointe, J.; Mensah, L.; Benson, N.; Brown, M.J.; Moore, K.J.
Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. I: Kinetic mechanism of the substrate activation reaction studied by transient and steady-state techniques
J. Biol. Chem.
273
31680-31690
1998
Staphylococcus aureus
Manually annotated by BRENDA team
Pope, A.J.; Moore, K.J.; McVey, M.; Mensah, L.; Benson, N.; Osbourne, N.; Broom, N.; Brown, M.J.; O'Hanlon, P.
Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics
J. Biol. Chem.
273
31691-31701
1998
Staphylococcus aureus
Manually annotated by BRENDA team
Pope, A.J.; McVey, M.; Fantom, K.; Moore, K.J.
Effects of substrate and inhibitor binding on proteolysis of isoleucyl-tRNA synthetase from Staphylococcus aureus
J. Biol. Chem.
273
31702-31706
1998
Staphylococcus aureus
Manually annotated by BRENDA team
Nathanson, L.; Deutscher, M.P.
Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex
J. Biol. Chem.
275
31559-31562
2000
Cricetulus griseus, Oryctolagus cuniculus
Manually annotated by BRENDA team
Nakama, T.; Nureki, O.; Yokoyama, S.
Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase
J. Biol. Chem.
276
47387-47393
2001
Thermus thermophilus, Staphylococcus aureus (P41368), Staphylococcus aureus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Manually annotated by BRENDA team
Yanagisawa, T.; Kawakami, M.
How does Pseudomonas fluorescens avoid suicide from its antibiotic pseudomonic acid?: Evidence for two evolutionarily distinct isoleucyl-tRNA synthetases conferring self-defense
J. Biol. Chem.
278
25887-25894
2003
Pseudomonas fluorescens, Pseudomonas fluorescens (Q8L1B1), Pseudomonas fluorescens NCIB 10586, Pseudomonas fluorescens NCIB 10586 (Q8L1B1)
Manually annotated by BRENDA team
Fukunaga, R.; Fukai, S.; Ishitani, R.; Nureki, O.; Yokoyama, S.
Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine
J. Biol. Chem.
279
8396-8402
2004
Thermus thermophilus (P56690), Thermus thermophilus
Manually annotated by BRENDA team
Silvian, L.F.; Wang, J.; Steitz, T.A.
Insights into editing from an Ile-tRNA synthetase structure with tRNAIle and mupirocin
Science
285
1074-1077
1999
Staphylococcus aureus (P41972), Staphylococcus aureus
Manually annotated by BRENDA team
Kim, S.E.; Kim, S.Y.; KI, S.; Kang, T.; Lee, J.
Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetase
Bioorg. Med. Chem. Lett.
15
3389-3393
2005
Escherichia coli
Manually annotated by BRENDA team
Zhai, Y.; Nawaz, M.H.; Lee, K.W.; Kirkbride, E.; Briggs, J.M.; Martinis, S.A.
Modulation of substrate specificity within the amino acid editing site of leucyl-tRNA synthetase
Biochemistry
46
3331-3337
2007
Escherichia coli
Manually annotated by BRENDA team
Yang, J.A.; Park, D.W.; Sohn, J.W.; Yang, I.S.; Kim, K.H.; Kim, M.J.
Molecular analysis of isoleucyl-tRNA synthetase mutations in clinical isolates of methicillin-resistant Staphylococcus aureus with low-level mupirocin resistance
J. Korean Med. Sci.
21
827-832
2006
Staphylococcus aureus (P41972), Staphylococcus aureus
Manually annotated by BRENDA team
Fukunaga, R.; Yokoyama, S.
Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase
J. Mol. Biol.
359
901-912
2006
Thermus thermophilus (P56690), Thermus thermophilus
Manually annotated by BRENDA team
Shimizu, T.; Usui, T.; Fujikura, M.; Kawatani, M.; Satoh, T.; Machida, K.; Kanoh, N.; Woo, J.T.; Osada, H.; Sodeoka, M.
Synthesis and biological activities of reveromycin A and spirofungin A derivatives
Bioorg. Med. Chem. Lett.
18
3756-3760
2008
Homo sapiens
Manually annotated by BRENDA team
De Pascale, G.; Lloyd, A.J.; Schouten, J.A.; Gilbey, A.M.; Roper, D.I.; Dowson, C.G.; Bugg, T.D.
Kinetic characterisation of lipid II-Ala:alanyl tRNA ligase (MurN) from Streptococcus pneumoniae using semi-synthetic aminoacyl-lipid II substrates
J. Biol. Chem.
283
34571-34579
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Salowe, S.P.; Wiltsie, J.; Hawkins, J.C.; Sonatore, L.M.
The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase
J. Biol. Chem.
284
9656-9662
2009
Bacillus subtilis (Q45477), Bacillus subtilis, Bacillus subtilis 168 (Q45477)
Manually annotated by BRENDA team
Yu, Z.; Takai, K.; Slesarev, A.; Xue, H.; Wong, J.T.
Search for primitive Methanopyrus based on genetic distance between Val- and Ile-tRNA synthetases
J. Mol. Evol.
69
386-394
2009
Methanopyrus kandleri
Manually annotated by BRENDA team
Baouz, S.; Schmitter, J.M.; Chenoune, L.; Beauvallet, C.; Blanquet, S.; Woisard, A.; Hountondji, C.
Primary structure revision and active site mapping of E. coli isoleucyl-tRNA synthetase by means of maldi mass spectrometry
Open Biochem. J.
3
26-38
2009
Escherichia coli, Escherichia coli EM20031
Manually annotated by BRENDA team
Paulander, W.; Andersson, D.I.; Maisnier-Patin, S.
Amplification of the gene for isoleucyl-tRNA synthetase facilitates adaptation to the fitness cost of mupirocin resistance in Salmonella enterica
Genetics
185
305-312
2010
Salmonella enterica
Manually annotated by BRENDA team
Dulic, M.; Cvetesic, N.; Perona, J.J.; Gruic-Sovulj, I.
Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases
J. Biol. Chem.
285
23799-23809
2010
Escherichia coli
Manually annotated by BRENDA team
Istvan, E.S.; Dharia, N.V.; Bopp, S.E.; Gluzman, I.; Winzeler, E.A.; Goldberg, D.E.
Validation of isoleucine utilization targets in Plasmodium falciparum
Proc. Natl. Acad. Sci. USA
108
1627-1632
2011
Plasmodium falciparum
Manually annotated by BRENDA team
Cestari, I.; Stuart, K.
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis
J. Biol. Chem.
288
14256-14263
2013
Trypanosoma brucei
Manually annotated by BRENDA team
Rettig, J.; Wang, Y.; Schneider, A.; Ochsenreiter, T.
Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicing
Nucleic Acids Res.
40
1299-1306
2012
Trypanosoma brucei, Trypanosoma brucei 29-13
Manually annotated by BRENDA team
Dulic, M.; Perona, J.J.; Gruic-Sovulj, I.
Determinants for tRNA-dependent pretransfer editing in the synthetic site of isoleucyl-tRNA synthetase
Biochemistry
53
6189-6198
2014
Escherichia coli (P00956), Escherichia coli
Manually annotated by BRENDA team
Perli, E.; Giordano, C.; Pisano, A.; Montanari, A.; Campese, A.F.; Reyes, A.; Ghezzi, D.; Nasca, A.; Tuppen, H.A.; Orlandi, M.; Di Micco, P.; Poser, E.; Taylor, R.W.; Colotti, G.; Francisci, S.; Morea, V.; Frontali, L.; Zeviani, M.; dAmati, G.
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells
EMBO Mol. Med.
6
169-182
2014
Homo sapiens (Q9NSE4), Homo sapiens
Manually annotated by BRENDA team
Airas, R.K.
Kinetic analysis of the isoleucyl-tRNA synthetase mechanism the next reaction cycle can start before the previous one ends
FEBS open bio
8
244-255
2018
Escherichia coli (P00956)
Manually annotated by BRENDA team
Schwartzentruber, J.; Buhas, D.; Majewski, J.; Sasarman, F.; Papillon-Cavanagh, S.; Thiffault, I.; Sheldon, K.; Massicotte, C.; Patry, L.; Simon, M.; Zare, A.; Mckernan, K.; Consortium, F.; Michaud, J.; Boles, R.; Deal, C.; Desilets, V.; Shoubridge, E.; Samuels, M.E.
Mutation in the nuclear-encoded mitochondrial isoleucyl-tRNA synthetase IARS2 in patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome
Hum. Mutat.
36
281-281
2015
Homo sapiens (Q9NSE4), Homo sapiens
Manually annotated by BRENDA team
Cvetesic, N.; Dulic, M.; Bilus, M.; Sostaric, N.; Lenhard, B.; Gruic-Sovulj, I.
Naturally occurring isoleucyl-tRNA synthetase without tRNA-dependent pre-transfer editing
J. Biol. Chem.
291
8618-8631
2016
Escherichia coli (P00956), Escherichia coli, Saccharomyces cerevisiae (P09436), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 / S288c (P09436), Streptomyces griseus
Manually annotated by BRENDA team
Shepherd, J.; Ibba, M.
Relaxed substrate specificity leads to extensive tRNA mischarging by Streptococcus pneumoniae class I and class II aminoacyl-tRNA synthetases
mBio
5
e01656-14
2014
Streptococcus pneumoniae (Q04JB0), Streptococcus pneumoniae, Streptococcus pneumoniae D39 / NCTC 7466 (Q04JB0)
Manually annotated by BRENDA team
Kermgard, E.; Yang, Z.; Michel, A.M.; Simari, R.; Wong, J.; Ibba, M.; Lazazzera, B.A.
Quality control by isoleucyl-tRNA synthetase of Bacillus subtilis is required for efficient sporulation
Sci. Rep.
7
41763
2017
Bacillus subtilis, Bacillus subtilis BAL4574
Manually annotated by BRENDA team