Reference on EC 6.1.1.19 - arginine-tRNA ligase
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Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Sivaram, P.; Vellekamp, G.; Deutscher, M.P.
A role for lipids in the functional and structural properties of the rat liver aminoacyl-tRNA synthetase complex
J. Biol. Chem.
263
18891-18896
1988
Rattus norvegicus
Thiebe, R.
Arginyl-tRNA synthetase from brewer's yeast. Purification, properties, and steady-state mechanism
Eur. J. Biochem.
130
517-524
1983
Saccharomyces pastorianus, Saccharomyces pastorianus C836
Girjes, A.A.; Hobson, K.; Chen, P.; Lavin, M.F.
Cloning and chracterization of cDNA encoding a human arginyl-tRNA synthetase
Gene
27
347-350
1995
Homo sapiens
Huang, S.; Deutscher, M.P.
The NH2-terminal extension of rat liver arginyl-tRNA synthetase is responsible for its hydrophobic properties
Biochem. Biophys. Res. Commun.
180
702-708
1991
Rattus norvegicus
Freist, W.; Sternbach, H.; Cramer, F.
Arginyl-tRNA synthetase from yeast. Discrimination between 20 amino acids in aminoacylation of tRNAArg-C-C-A and tRNAArg-C-C-A(3'NH2)
Eur. J. Biochem.
186
535-541
1989
Saccharomyces cerevisiae
Berbec, H.; Paszkowska, A.
Comparison of the thermolability and hydrophobic properties of high- and low-molecular-weight forms of rabbit liver arginyl-tRNA synthetase
Mol. Cell. Biochem.
86
125-133
1989
Oryctolagus cuniculus
Berg, B.H.
Degradation of the arginyl-tRNA synthetase protein during purification by affinity chromatography on immobilized total tRNA and immobilized tRNA, specific for arginyl-tRNA synthetase
Biochem. Mol. Biol. Int.
31
219-228
1993
Mus musculus
Eriani, G.; Dirheimer, G.; Gangloff, J.
Structure-function relationship of arginyl-tRNA synthetase from Escherichia coli: isolation and characterization of the argS mutation MA5002
Nucleic Acids Res.
18
1475-1479
1990
Escherichia coli
Sivaram, P.; Deutscher, M.P.
Existence of two forms of rat liver arginyl-tRNA synthetase suggests channeling of aminoacyl-tRNA for protein synthesis
Proc. Natl. Acad. Sci. USA
87
3665-3669
1990
Rattus norvegicus
Parfait, R.; Grosjean, H.
Arginyl-transfer ribonucleic-acid synthetase from Bacillus stearothermophilus. Purification, properties and mechanism of action
Eur. J. Biochem.
30
242-249
1972
Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1518
Yem, D.W.; Williams, L.S.
Evidence for the existence of two arginyl-transfer ribonucleic acid synthetase activities in Escherichia coli
J. Bacteriol.
113
891-894
1973
Escherichia coli, Escherichia coli AB1132
Williams, A.L.; Williams, L.S.
Control of arginine biosynthesis in Escherichia coli: characteriation of arginyl-transfer ribonucleic acid synthetase mutants
J. Bacteriol.
113
1433-1441
1973
Escherichia coli
Parfait, R.
Arginyl-tRNA synthetase from Bacillus stearothermophilus: heat inactivation and substrate induced protection
FEBS Lett.
29
323-325
1973
Geobacillus stearothermophilus
Williams, A.L.; Yem, D.W.; McGinnis, E.; Williams, L.S.
Control of arginine biosynthesis in Escherichia coli: inhibition of arginyl-transfer ribonucleic acid synthetase activity
J. Bacteriol.
115
228-234
1973
Escherichia coli
Craine, J.E; Peterkofsky, A.
Studies of arginyl-tRNA synthetase from Escherichia coli B. Dual role of metals in enzyme catalysis
J. Biol. Chem.
251
241-246
1976
Escherichia coli, Escherichia coli B / ATCC 11303
Godeau, J.M.
Arginyl-tRNA synthetase from Bacillus stearothermophilus: subunit structure of enzyme
FEBS Lett.
62
190-193
1976
Geobacillus stearothermophilus
Gangloff, J.; Schutz, A.; Dirheimer, G.
Arginyl-tRNA synthetase from baker's yeast. Purification and some properties
Eur. J. Biochem.
65
177-182
1976
Saccharomyces pastorianus, Saccharomyces pastorianus 836
Freist, W.; Sternbach, H.; von der Haar, F.; Cramer, F.
Threonyl-tRNA, lysyl-tRNA and arginyl-tRNA synthetases from baker's yeast. Substrate specificity with regard to ATP analogues
Eur. J. Biochem.
84
499-502
1978
Saccharomyces pastorianus
Carias, J.R.; Mouricout, M.; Quintard, B.; Thomes, J.C.; Julien, R.
Leucyl-tRNA and arginyl-tRNA synthetases of wheat germ. Inactivation and ribosome effects
Eur. J. Biochem.
87
583-590
1978
Triticum aestivum
Gerlo, E.; Charlier, J.
Irreversible inactivation of arginyl-tRNA ligase by periodate-oxidized tRNA
FEBS Lett.
99
25-28
1979
Escherichia coli
Charlier, J.; Gerlo, E.
Arginyl-tRNA synthetase from Escherichia coli K12. Purification, properties, and sequence of substrate addition
Biochemistry
18
3171-3178
1979
Escherichia coli
Godeau, J.M.
Arginyl-transfer ribonucleic acid synthetase of Bacillus stearothermophilus. Purification and kinetic analysis
Eur. J. Biochem.
103
169-177
1980
Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1518
Freist, W.; Sternbach, H.; Cramer,F.
Arginyl-tRNA synthetase from baker's yeast. Order of substrate addition and action of ATP analogs in aminoacylation reaction. Influence of pyrophosphate on the catalytic mechanism
Eur. J. Biochem.
119
477-482
1981
Saccharomyces pastorianus
Gerlo, E.; Freist, W.; Charlier, J.
Arginyl-tRNA synthetase from Escherichia coli K12: specificity with regard to ATP analogs and their magnesium complexes
Hoppe-Seyler's Z. Physiol. Chem.
363
365-373
1982
Escherichia coli
Deutscher, M.P.; Ni, R.C.
Purification of a low molecular weight form of rat liver arginyl-tRNA synthetase
J. Biol. Chem.
257
6003-6006
1982
Rattus norvegicus
Vellekamp, G.; Sihag, R.K.; Deutscher, M.P.
Comparison of the complexed and free forms of rat liver arginyl-tRNA synthetase and origin of the free form
J. Biol. Chem.
260
9843-9847
1985
Rattus norvegicus
Char, S.; Gopinathan, K.P.
Arginyl-tRNA synthetase from Mycobacterium smegmatis SN2: purification and kinetic mechanism
J. Biochem.
100
349-357
1986
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis SN2
Airas, R.K.
Differences in the magnesium dependences of the class I and class II aminoacyl-tRNA synthetases from Escherichia coli
Eur. J. Biochem.
240
223-231
1996
Escherichia coli
Glinski, R.L.; Gainey, P.C.; Mawhinney, T.P.; Hilderman, R.H.
Evidence that lysyl- and/or arginyl-tRNA synthetases from rat liver contain carbohydrate
Biochem. Biophys. Res. Commun.
88
1052-1061
1979
Rattus norvegicus
Van Dang, C.; Mawhinney, T.P.; Hilderman, R.H.
Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver. Arginyl- and lysyl-tRNA synthetases contain carbohydrates
Biochemistry
21
4891-4895
1982
Rattus norvegicus
Delagoutte, B.; Keith, G.; Moras, D.; Cavarelli, J.
Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes
Acta Crystallogr. Sect. D
56
492-494
2000
Saccharomyces cerevisiae
Shimada, A.; Nureki, O.; Dohmae, N.; Takio, K.; Yokoyama, S.
Gene cloning, expression, crystallization and preliminary X-ray analysis of Thermus thermophilus arginyl-tRNA synthetase
Acta Crystallogr. Sect. D
57
272-275
2001
Thermus thermophilus (Q93RP5), Thermus thermophilus
Yao, Y.N.; Zhang, Q.S.; Yan, X.Z.; Zhu, G.; Wang, E.D.
Escherichia coli tRNA(4)(Arg)(UCU) induces a constrained conformation of the crucial Omega-loop of arginyl-tRNA synthetase
Biochem. Biophys. Res. Commun.
313
129-134
2004
Escherichia coli
Li, J.; Yao, Y.N.; Liu, M.F.; Wang, E.D.
Arginyl-tRNA synthetase with signature sequence KMSK from Bacillus stearothermophilus
Biochem. J.
376
773-779
2003
Geobacillus stearothermophilus
Liu, M.; Huang, Y.; Wu, J.; Wang, E.; Wang, Y.
Effect of cysteine residues on the activity of arginyl-tRNA synthetase from Escherichia coli
Biochemistry
38
11006-11011
1999
Escherichia coli
Zhang, Q.S.; Wang, E.D.; Wang, Y.L.
The role of tryptophan residues in Escherichia coli arginyl-tRNA synthetase
Biochim. Biophys. Acta
1387
136-142
1998
Escherichia coli
Cavarelli, J.; Delagoutte, B.; Eriani, G.; Gangloff, J.; Moras, D.
L-arginine recognition by yeast arginyl-tRNA synthetase
EMBO J.
17
5438-5448
1998
Saccharomyces cerevisiae
Delagoutte, B.; Moras, D.; Cavarelli, J.
tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding
EMBO J.
19
5599-5610
2000
Saccharomyces cerevisiae (Q05506), Saccharomyces cerevisiae
Kiga, D.; Sakamoto, K.; Sato, S.; Hirao, I.; Yokoyama, S.
Shifted positioning of the anticodon nucleotide residues of amber suppressor tRNA species by Escherichia coli arginyl-tRNA synthetase
Eur. J. Biochem.
268
6207-6213
2001
Escherichia coli
Sekine, S.; Shimada, A.; Nureki, O.; Cavarelli, J.; Moras, D.; Vassylyev, D.G.; Yokoyama, S.
Crucial role of the high-loop lysine for the catalytic activity of arginyl-tRNA synthetase
J. Biol. Chem.
276
3723-3726
2001
Thermus thermophilus
Lazard, M.; Agou, F.; Kerjan, P.; Mirande, M.
The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication
J. Mol. Biol.
302
991-1004
2000
Cricetulus griseus
Zhang, Q.S.; Shen, L.; Wang, E.D.; Wang, Y.L.
Biosynthesis and characterization of 4-fluorotryptophan-labeled Escherichia coli arginyl-tRNA synthetase
J. Protein Chem.
18
187-192
1999
Escherichia coli
Shimada, A.; Nureki, O.; Goto, M.; Takahashi, S.; Yokoyama, S.
Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
98
13537-13542
2001
Thermus thermophilus (Q93RP5), Thermus thermophilus
Sissler, M.; Giege, R.; Florentz, C.
The RNA sequence context defines the mechanistic routes by which yeast arginyl-tRNA synthetase charges tRNA
RNA
4
647-657
1998
Saccharomyces cerevisiae
Geslain, R.; Martin, F.; Delagoutte, B.; Cavarelli, J.; Gangloff, J.; Eriani, G.
In vivo selection of lethal mutations reveals two functional domains in arginyl-tRNA synthetase
RNA
6
434-448
2000
Saccharomyces cerevisiae
Guigou, L.; Shalak, V.; Mirande, M.
The tRNA-interacting factor p43 associates with mammalian arginyl-tRNA synthetase but does not modify its tRNA aminoacylation properties
Biochemistry
43
4592-4600
2004
Cricetulus sp.
Guigou, L.; Mirande, M.
Determinants in tRNA for activation of arginyl-tRNA synthetase: evidence that tRNA flexibility is required for the induced-fit mechanism
Biochemistry
44
16540-16548
2005
Cricetulus sp.
Ling, C.; Yao, Y.N.; Zheng, Y.G.; Wei, H.; Wang, L.; Wu, X.F.; Wang, E.D.
The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex
J. Biol. Chem.
280
34755-34763
2005
Homo sapiens
Edvardson, S.; Shaag, A.; Kolesnikova, O.; Gomori, J.M.; Tarassov, I.; Einbinder, T.; Saada, A.; Elpeleg, O.
Deleterious mutation in the mitochondrial arginyl-transfer RNA synthetase gene is associated with pontocerebellar hypoplasia
Am. J. Hum. Genet.
81
857-862
2007
Homo sapiens
Zhou, M.; Azzi, A.; Xia, X.; Wang, E.D.; Lin, S.X.
Crystallization and preliminary X-ray diffraction analysis of E. coli arginyl-tRNA synthetase in complex form with a tRNAArg
Amino Acids
32
479-482
2007
Escherichia coli
Nehme, B.; Ganga, M.A.; Lonvaud-Funel, A.
The arginine deiminase locus of Oenococcus oeni includes a putative arginyl-tRNA synthetase ArgS2 at its 3-end
Appl. Microbiol. Biotechnol.
70
590-597
2006
Oenococcus oeni (Q5Y930), Oenococcus oeni, Oenococcus oeni IOEB 8406 (Q5Y930)
Zheng, Y.G.; Wei, H.; Ling, C.; Xu, M.G.; Wang, E.D.
Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA
Biochemistry
45
1338-1344
2006
Homo sapiens
Airas, R.K.
Analysis of the kinetic mechanism of arginyl-tRNA synthetase
Biochim. Biophys. Acta
1764
307-319
2006
Escherichia coli, Escherichia coli MRE 600
Hogg, J.; Schiefermayr, E.; Schiltz, E.; Igloi, G.L.
Expression and properties of arginyl-tRNA synthetase from jack bean (Canavalia ensiformis)
Protein Expr. Purif.
61
163-167
2008
Canavalia ensiformis (B2G3G6), Canavalia ensiformis
Eichert, A.; Schreiber, A.; Fuerste, J.P.; Perbandt, M.; Betzel, C.; Erdmann, V.A.; Foerster, C.
Escherichia coli tRNA(Arg) acceptor-stem isoacceptors: comparative crystallization and preliminary X-ray diffraction analysis
Acta Crystallogr. Sect. F
65
98-101
2009
Escherichia coli
Eichert, A.; Perbandt, M.; Oberthuer, D.; Schreiber, A.; Fuerste, J.P.; Betzel, C.; Erdmann, V.A.; Foerster, C.
Crystal structure of the E. coli tRNA(Arg) aminoacyl stem isoacceptor RR-1660 at 2.0 A resolution
Biochem. Biophys. Res. Commun.
385
84-87
2009
Escherichia coli
Igloi, G.L.; Schiefermayr, E.
Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural specificity variants
FEBS J.
276
1307-1318
2009
Canavalia ensiformis (B2G3G6), Canavalia ensiformis, Glycine max (B6ETP1), Glycine max
Konno, M.; Sumida, T.; Uchikawa, E.; Mori, Y.; Yanagisawa, T.; Sekine, S.; Yokoyama, S.; Yokoyama, S.
Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP)
FEBS J.
276
4763-4779
2009
Pyrococcus horikoshii (O59147), Pyrococcus horikoshii
Anderson, L.L.; Mao, X.; Scott, B.A.; Crowder, C.M.
Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases
Science
323
630-633
2009
Caenorhabditis elegans (Q19825)
Yang, F.; Xia, X.; Lei, H.Y.; Wang, E.D.
Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity
J. Biol. Chem.
285
39437-39446
2010
Homo sapiens
Godinic-Mikulcic, V.; Jaric, J.; Hausmann, C.D.; Ibba, M.; Weygand-Durasevic, I.
An archaeal tRNA-synthetase complex that enhances aminoacylation under extreme conditions
J. Biol. Chem.
286
3396-3404
2011
Methanothermobacter thermautotrophicus
Akahoshi, A.; Suzue, Y.; Kitamatsu, M.; Sisido, M.; Ohtsuki, T.
Site-specific incorporation of arginine analogs into proteins using arginyl-tRNA synthetase
Biochem. Biophys. Res. Commun.
414
625-630
2011
Saccharomyces cerevisiae
Aldinger, C.A.; Leisinger, A.K.; Igloi, G.L.
The influence of identity elements on the aminoacylation of tRNAArg by plant and Escherichia coli arginyl-tRNA synthetases
FEBS J.
279
3622-3638
2012
Escherichia coli (B1XHE4), Canavalia ensiformis (B2G3G6), Glycine max (B6ETP1), Glycine max
Leisinger, A.K.; Janzen, D.H.; Hallwachs, W.; Igloi, G.L.
Amino acid discrimination by the nuclear encoded mitochondrial arginyl-tRNA synthetase of the larva of a bruchid beetle (Caryedes brasiliensis) from northwestern Costa Rica
Insect Biochem. Mol. Biol.
43
1172-1180
2013
Caryedes brasiliensis
Bi, K.; Zheng, Y.; Gao, F.; Dong, J.; Wang, J.; Wang, Y.; Gong, W.
Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition
Protein Cell
5
151-159
2014
Escherichia coli (P11875), Escherichia coli
Kim, H.S.; Cha, S.Y.; Jo, C.H.; Han, A.; Hwang, K.Y.
The crystal structure of arginyl-tRNA synthetase from Homo sapiens
FEBS Lett.
588
2328-2334
2014
Homo sapiens (P54136), Homo sapiens
Yang, F.; Ji, Q.Q.; Ruan, L.L.; Ye, Q.; Wang, E.D.
The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently
J. Biol. Chem.
289
20953-20959
2014
Homo sapiens (P54136), Homo sapiens
Xu, H.; Malinin, N.L.; Awasthi, N.; Schwarz, R.E.; Schwarz, M.A.
The N terminus of pro-endothelial monocyte-activating polypeptide II (EMAP II) regulates its binding with the C terminus, arginyl-tRNA synthetase, and neurofilament light protein
J. Biol. Chem.
290
9753-9766
2015
Homo sapiens (P54136), Homo sapiens
Fu, R.; Fan, Y.Z.; Fan, Y.C.; Zhao, H.Y.
Expression of arginyl-tRNA synthetase in rats with focal cerebral ischemia
J. Huazhong Univ. Sci. Technol. Med. Sci.
34
172-175
2014
Rattus norvegicus (P40329)
Shen, Y.; Zhao, H.Y.; Wang, H.J.; Wang, W.L.; Zhang, L.Z.; Fu, R.
Ischemic preconditioning inhibits over-expression of arginyl-tRNA synthetase gene Rars in ischemia-injured neurons
J. Huazhong Univ. Sci. Technol. Med. Sci.
36
554-557
2016
Rattus norvegicus (P40329)
Fu, Y.; Kim, Y.; Jin, K.S.; Kim, H.S.; Kim, J.H.; Wang, D.; Park, M.; Jo, C.H.; Kwon, N.H.; Kim, D.; Kim, M.H.; Jeon, Y.H.; Hwang, K.Y.; Kim, S.; Cho, Y.
Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation
Proc. Natl. Acad. Sci. USA
111
15084-15089
2014
Homo sapiens (P54136)
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