Reference on EC 6.1.1.16 - cysteine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Burnell, J.N.; Whatley, F.R.
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of cysteinyl- and methionyl-tRNA synthetase
Biochim. Biophys. Acta
481
266-278
1977
Paracoccus denitrificans
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Eriani, G.; Dirheimer, G.; Gangloff, J.
Cysteinyl-tRNA synthetase: determination of the last E. coli aminoacyl-tRNA synthetase primary structure
Nucleic Acids Res.
19
265-269
1991
Escherichia coli
Cruzen, M.E.; Arfin, S.M.
Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase
DNA Seq.
4
243-248
1994
Homo sapiens
Jakubowski, H.
Editing function of Escherichia coli cysteinyl-tRNA synthetase: cyclization of cysteine to cysteine thiolactone
Nucleic Acids Res.
22
1155-1160
1994
Escherichia coli
Komatsoulis, G.A.; Abelson, J.
Recognition of tRNACys by Escherichia coli cysteinyl-tRNA synthetase [published erratum appears in Biochemistry 1993 Dec 7;32(48):13374]
Biochemistry
32
7435-7444
1993
Escherichia coli
Chang, G.G.; Pan, F.; Deng, P.N.; Wu, B.Y.
Kinetic studies on human cysteinyl-tRNA synthetase
Int. J. Pept. Protein Res.
13
267-273
1979
Homo sapiens
Bohman, K.; Isaksson, L.A.
Temperature-sensitive mutants in cysteinyl-tRNA ligase of E. coli K-12
Mol. Gen. Genet.
176
53-55
1979
Escherichia coli
Bruton, C.J.; Cox, L.A.M.
Cysteinyl-tRNA synthetase from Bacillus stearothermophilus. A structural and functional monomer
Eur. J. Biochem.
100
301-308
1979
Geobacillus stearothermophilus
Burnell, J.N.; Shrift, A.
Cysteinyl-tRNA synthetase from Astragalus species
Plant Physiol.
63
1095-1097
1979
Astragalus bisulcatus, Astragalus crotalariae, Astragalus lentiginosus, Astragalus racemosus, Vigna radiata var. radiata
Fersht, A.R.; Dingwall, C.
Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions
Biochemistry
18
1245-1249
1979
Escherichia coli
Burnell, J.N.; Shrift, A.
Cysteinyl-tRNA synthetase from Phaseolus aureus. Purification and properties
Plant Physiol.
60
670-674
1977
Vigna radiata var. radiata
Shrift, A.; Bechard, D.; Harcup, C.; Fowden L.
Utilization of selenocysteine by a cysteinyl-tRNA synthetase from Phaseolus aureus
Plant Physiol.
58
248-252
1976
Vigna radiata var. radiata
Pan, F.; Yu, T.C.; Duh, G.M.; Lee, H.H.
Specificity and kinetic properties of the cysteinyl-tRNA synthetase from rat liver
J. Chin. Biochem. Soc.
5
45-56
1976
Rattus norvegicus
-
Pan, F.; Lee, H.H.; Pai, S.H.; Yu, T.C.; Guoo, J.Y.; Duh, G.M.
Multiple molecular forms of cysteinyl-tRNA synthetase from rat liver: Purification and subunit structure
Biochim. Biophys. Acta
452
271-283
1976
Rattus norvegicus
Waterson, J.R.; Winter, W.P.; Schmickel, R.D.
Cysteine activation in cultures cystinotic cells
J. Clin. Invest.
54
182-187
1974
Homo sapiens
McCorquodale, D.J.
The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coli
Biochim. Biophys. Acta
91
541-548
1964
Escherichia coli
Newberry, K.J.; Kohn, J.; Hou, Y.M.; Perona, J.J.
Crystallization and preliminary diffraction analysis of Escherichia coli cysteinyl-tRNA synthetase
Acta Crystallogr. Sect. D
55
1046-1047
1999
Escherichia coli
Motorin, Y.; Waller, J.P.
Purification and properties of cysteinyl-tRNA synthetase from rabbit liver
Biochimie
80
579-590
1998
Oryctolagus cuniculus
Newberry, K.J.; Hou, Y.M.; Perona, J.J.
Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase
EMBO J.
21
2778-2787
2002
Escherichia coli (P21888), Escherichia coli
Sherlin, L.D.; Bullock, T.L.; Newberry, K.J.; Lipman, R.S.; Hou, Y.M.; Beijer, B.; Sproat, B.S.; Perona, J.J.
Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases
J. Mol. Biol.
299
431-446
2000
Escherichia coli
Zhang, C.M.; Christian, T.; Newberry, K.J.; Perona, J.J.; Hou, Y.M.
Zinc-mediated amino acid discrimination in cysteinyl-tRNA synthetase
J. Mol. Biol.
327
911-917
2003
Escherichia coli
Stathopoulos, C.; Kim, W.; Li, T.; Anderson, I.; Deutsch, B.; Palioura, S.; Whitman, W.; Soll, D.
Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis
Proc. Natl. Acad. Sci. USA
98
14292-14297
2001
Methanococcus maripaludis (Q9UWP2), Methanococcus maripaludis
Pelchat, M.; Lapointe, J.
In vivo and in vitro processing of the Bacillus subtilis transcript coding for glutamyl-tRNA synthetase, serine acetyltransferase, and cysteinyl-tRNA synthetase
RNA
5
281-289
1999
Bacillus subtilis, Bacillus subtilis 168T
Zhang, C.M.; Hou, Y.M.
Domain-domain communication for tRNA aminoacylation: the importance of covalent connectivity
Biochemistry
44
7240-7249
2005
Escherichia coli
Ruan, B.; Nakano, H.; Tanaka, M.; Mills, J.A.; DeVito, J.A.; Min, B.; Low, K.B.; Battista, J.R.; Soll, D.
Cysteinyl-tRNA(Cys) formation in Methanocaldococcus jannaschii: the mechanism is still unknown
J. Bacteriol.
186
8-14
2004
Escherichia coli
Shitivelband, S.; Hou, Y.M.
Breaking the stereo barrier of amino acid attachment to tRNA by a single nucleotide
J. Mol. Biol.
348
513-521
2005
Escherichia coli
Hauenstein, S.; Zhang, C.M.; Hou, Y.M.; Perona, J.J.
Shape-selective RNA recognition by cysteinyl-tRNA synthetase
Nat. Struct. Mol. Biol.
11
1134-1141
2004
Escherichia coli (P21888), Escherichia coli
Evilia, C.; Hou, Y.M.
Acquisition of an insertion peptide for efficient aminoacylation by a halophile tRNA synthetase
Biochemistry
45
6835-6845
2006
Halobacterium sp., Halobacterium sp. NRC-1
Zhang, C.M.; Perona, J.J.; Ryu, K.; Francklyn, C.; Hou, Y.M.
Distinct kinetic mechanisms of the two classes of aminoacyl-tRNA synthetases
J. Mol. Biol.
361
300-311
2006
Escherichia coli (P21888)
Liu, C.; Gamper, H.; Shtivelband, S.; Hauenstein, S.; Perona, J.J.; Hou, Y.M.
Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase
J. Mol. Biol.
367
1063-1078
2007
Homo sapiens
Fukunaga, R.; Yokoyama, S.
Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus
J. Mol. Biol.
370
128-141
2007
no activity in Archaeoglobus fulgidus
Fukunaga, R.; Yokoyama, S.
Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea
Nat. Struct. Mol. Biol.
14
272-279
2007
no activity in Archaeoglobus fulgidus, no activity in Methanococcus jannaschii
Hauenstein, S.I.; Perona, J.J.
Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei
J. Biol. Chem.
283
22007-22017
2008
Methanosarcina mazei
Zhang, C.M.; Liu, C.; Slater, S.; Hou, Y.M.
Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys)
Nat. Struct. Mol. Biol.
15
507-514
2008
Escherichia coli
Madsen, M.L.; Puttamreddy, S.; Thacker, E.L.; Carruthers, M.D.; Minion, F.C.
Transcriptome changes in Mycoplasma hyopneumoniae during infection
Infect. Immun.
76
658-663
2008
Mycoplasma hyopneumoniae
Soma, H.; Yabe, I.; Takei, A.; Fujiki, N.; Yanagihara, T.; Sasaki, H.
Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes
Mov. Disord.
23
1161-1167
2008
Homo sapiens
Liu, C.; Gamper, H.; Liu, H.; Cooperman, B.S.; Hou, Y.M.
Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding
Nat. Commun.
2
329
2011
Escherichia coli
Ghosh, A.; Sakaguchi, R.; Liu, C.; Vishveshwara, S.; Hou, Y.M.
Allosteric communication in cysteinyl tRNA synthetase: a network of direct and indirect readout
J. Biol. Chem.
286
37721-37731
2011
Escherichia coli (P21888)
Coughlin, C.R.; Scharer, G.H.; Friederich, M.W.; Yu, H.C.; Geiger, E.A.; Creadon-Swindell, G.; Collins, A.E.; Vanlander, A.V.; Coster, R.V.; Powell, C.A.; Swanson, M.A.; Minczuk, M.; Van Hove, J.L.; Shaikh, T.H.
Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder
J. Med. Genet.
52
532-540
2015
Homo sapiens (Q9HA77), Homo sapiens
Akaike, T.; Ida, T.; Wei, F.Y.; Nishida, M.; Kumagai, Y.; Alam, M.M.; Ihara, H.; Sawa, T.; Matsunaga, T.; Kasamatsu, S.; Nishimura, A.; Morita, M.; Tomizawa, K.; Nishimura, A.; Watanabe, S.; Inaba, K.; Shima, H.; Tanuma, N.; Jung, M.; Fujii, S.; Watanabe, Y.; Ohmuraya, M.; Nagy, P.; Feelisch, M.; Fukuto,
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Nat. Commun.
8
1177
2017
Escherichia coli, Homo sapiens, Mus musculus
Ravishankar, S.; Ambady, A.; Swetha, R.G.; Anbarasu, A.; Ramaiah, S.; Sambandamurthy, V.K.
Essentiality assessment of cysteinyl and lysyl-tRNA synthetases of Mycobacterium smegmatis
PLoS ONE
11
e0147188
2016
Mycobacterium leprae, Mycolicibacterium smegmatis, Mycolicibacterium smegmatis (A0R578), Mycolicibacterium smegmatis mc2155 / ATCC 700084 (A0R578)
Reed, C.J.; Bushnell, S.; Evilia, C.
Circular dichroism and fluorescence spectroscopy of cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 demonstrates that group I cations are particularly effective in providing structure and stability to this halophilic protein
PLoS ONE
9
e89452
2014
Halobacterium salinarum
Mohana Parvatha Varddhini, S.; Sankaranarayanan, R.; Udayakumar, M.; Thamotharan, S.
Identification of potential inhibitors of cysteinyl tRNA synthetase from Mycobacterium leprae TN strain through in silico virtual screening
Res. J. Pharm. Biol. Chem. Sci.
6
1737-1743
2015
Mycobacterium leprae (P57990), Mycobacterium leprae TN (P57990)
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