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Disease on EC 5.6.1.3 - plus-end-directed kinesin ATPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
The large GTPase Mx1 binds KIF5B for cargo transport along microtubules.
Acrocallosal Syndrome
Olfactory bulb and olfactory tract abnormalities in acrocallosal syndrome and Greig cephalopolysyndactyly syndrome.
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling.
The many faces of KIF7.
Acrocephalosyndactylia
Developmental expression of specific genes detected in high-quality cDNA libraries from single human preimplantation embryos.
Acute Kidney Injury
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Adenocarcinoma
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.
RET, ROS1 and ALK fusions in lung cancer.
Adenocarcinoma of Lung
A novel KIF5B-ALK variant in nonsmall cell lung cancer.
A rare KIF5B-ALK fusion variant in a lung adenocarcinoma patient who responded to crizotinib and acquired the ALK L1196M mutation after resistance: a case report.
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
Cabozantinib for the treatment of non-small cell lung cancer with KIF5B-RET fusion. An example of swift repositioning.
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma.
Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma.
Genome?wide investigation of the clinical significance and prospective molecular mechanisms of kinesin family member genes in patients with lung adenocarcinoma.
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
High KIF11 expression is associated with poor outcome of NSCLC.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.
KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma.
KIF5B-RET fusions in lung adenocarcinoma.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer.
Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.
Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer.
Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis.
Adenoma, Pleomorphic
MicroRNA expression profiles in head and neck cancer cell lines.
Adenomatous Polyposis Coli
A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs.
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.
APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.
Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.
Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration.
Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells.
Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.
African Swine Fever
Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin.
Alopecia
Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data.
Alzheimer Disease
Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease.
Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease.
Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-? generation in Alzheimer's disease.
GSK3? Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.
Inhibition of interleukin-1? plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2.
Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases.
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
Kinesin light chain-1 variant E disrupts axonal transport and A? generation in Alzheimer's disease (comment on DOI 10.1002/bies.201400131).
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Presenilin influences Glycogen Synthase Kinase-3beta (GSK-3?) for kinesin-1 and dynein function during axonal transport.
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Amyotrophic Lateral Sclerosis
Cohort Analysis of 67 Charcot-Marie-Tooth Italian Patients: Identification of New Mutations and Broadening of Phenotype Expression Produced by Rare Variants.
Generation of two induced pluripotent stem cell (iPSC) lines from an ALS patient with simultaneous mutations in KIF5A and MATR3 genes.
Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.
Genotype-phenotype correlations of KIF5A stalk domain variants.
Hot-spot KIF5A mutations cause familial ALS.
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Kinesin Expression in the Central Nervous System of Humans and Transgenic hSOD1G93A Mice with Amyotrophic Lateral Sclerosis.
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients.
Mutation screening of the KIF5A gene in Chinese patients with amyotrophic lateral sclerosis.
Splice-site mutations in KIF5A in the Japanese case series of amyotrophic lateral sclerosis.
Sural biopsy to detect the axonal cytoskeleton defects in KIF5A-related Charcot-Marie-Tooth disease type 2.
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Whole-exome sequencing identified novel KIF5A mutations in Chinese patients with amyotrophic lateral sclerosis and Charcot-Marie-Tooth type 2.
Anaphylaxis
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
Anemia
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23.
Anemia, Dyserythropoietic, Congenital
Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23.
Anthrax
Quickening the pace of anthrax research: three advances point towards possible therapies.
Apnea
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Asthma
Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Genetic variations in KIFC1 and the risk of aspirin exacerbated respiratory disease in a Korean population: an association analysis.
Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.
Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
MicroRNA-145-5p promotes asthma pathogenesis by inhibiting kinesin family member 3A expression in mouse airway epithelial cells.
Astrocytoma
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
Ataxia
BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.
Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
Atherosclerosis
[Motor protein Kinesin-6 and ischemic heart disease]
Autoimmune Diseases
Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province.
Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.
Azoospermia
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.
Bardet-Biedl Syndrome
Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
Bone Diseases, Metabolic
Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.
Impairment of Primary Cilia Contributes to Visceral Adiposity of High Fat Diet-Fed Mice.
Bone Neoplasms
Kinesin superfamily protein 17 contributes to the development of bone cancer pain by participating in NR2B transport in the spinal cord of mice.
Brain Diseases
De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.
Brain Injuries
Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.
Brain Injuries, Traumatic
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Brain Ischemia
Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity.
[Effect of hypothermia on activities of tubule motor protein and constructure protein after cerebral ischemia in gerbils].
Brain Neoplasms
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
Breast Neoplasms
A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer.
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.
Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.
Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells.
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Circular RNA KIF4A promotes cell migration, invasion and inhibits apoptosis through miR-152/ZEB1 axis in breast cancer.
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity.
Discovery of a novel inhibitor of kinesin-like protein KIFC1.
Distinct Diagnostic and Prognostic Values of Kinesin Family Member Genes Expression in Patients with Breast Cancer.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells.
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Genetic and functional analyses do not explain the association of high PRC1 expression with poor survival of breast carcinoma patients.
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer.
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
Identification of epithelial-mesenchymal transition-related circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer.
Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico.
Identification of key genes unique to the luminal a and basal-like breast cancer subtypes via bioinformatic analysis.
Identification of Potential Crucial Genes and Key Pathways in Breast Cancer Using Bioinformatic Analysis.
Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques.
Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features.
Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.
KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer.
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.
KIF15 contributes to cell proliferation and migration in breast cancer.
Kif18A is involved in human breast carcinogenesis.
KIFC1 is a novel potential therapeutic target for breast cancer.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance.
Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.
Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics.
Kinesin-1 translocation: Surprising differences between bovine brain and MCF7-derived microtubules.
Knockdown of kinesin KIF11 abrogates directed migration in response to epidermal growth factor-mediated chemotaxis.
Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells.
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
Overexpression of Kinesin Associated Protein 3 (KIFAP3) in Breast Cancer.
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.
Overexpression of kinesins mediates docetaxel resistance in breast cancer cells.
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells.
The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells.
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells.
TPX2 promotes migration and invasion of human breast cancer cells.
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Burkitt Lymphoma
KIF15 is involved in development and progression of Burkitt lymphoma.
Carcinogenesis
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma.
Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Identification of therapeutic targets and mechanisms of tumorigenesis in non-small cell lung cancer using multiple-microarray analysis.
Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas.
Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.
KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
KIF15 plays a role in promoting the tumorigenicity of melanoma.
KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
Kif18A is involved in human breast carcinogenesis.
KIF20A silence inhibits the migration, invasion and proliferation of non-small cell lung cancer and regulates the JNK pathway.
KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.
KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
Kif4A mediate the accumulation and reeducation of THP-1 derived macrophages via regulation of CCL2-CCR2 expression in crosstalking with OSCC.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
miR-635 targets KIFC1 to inhibit the progression of gastric cancer.
Molecular characterization of a KIF3A-like kinesin gene in the testis of the Chinese fire-bellied newt Cynops orientalis.
Mutation and Copy Number Alterations Analysis of KIF23 in Glioma.
Novel intergenic KIF5B-MET fusion variant in a patient with gastric cancer: A case report.
Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis.
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.
Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review).
Screening and Identification of Potential Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma by Bioinformatics Analysis.
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3?/?-catenin pathway.
Stable knockdown of Kif5b in MDCK cells leads to epithelial-mesenchymal transition.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Suppression of KIF3B Expression Inhibits Human Hepatocellular Carcinoma Proliferation.
Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy.
TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
[Expression of KIF18A in gastric cancer and its association with prognosis].
Carcinoma
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217.
AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer.
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Death receptor 6 promotes ovarian cancer cell migration through KIF11.
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Relation between the expression of mitotic centromere-associated kinesin and the progression of squamous cell carcinoma of the tongue.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma.
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Carcinoma, Basal Cell
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Carcinoma, Ductal
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Hepatocellular
A genetic variant at KIF1B predicts clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
ASPM combined with KIF11 promotes the malignant progression of hepatocellular carcinoma via the Wnt/?-catenin signaling pathway.
Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis.
Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.
Association between KIF1B rs17401966 polymorphism and hepatocellular carcinoma risk: a meta-analysis involving 17,210 subjects.
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort.
FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression.
Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Host genetic variants influencing the clinical course of hepatitis B virus infection.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.
Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis.
KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma.
KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.
KIF18B promotes hepatocellular carcinoma progression through activating Wnt/?-catenin-signaling pathway.
KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
KIF2C promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo.
KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA.
Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma.
Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.
miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway.
Overexpression of CDCA5, KIF4A, TPX2, and FOXM1 Coregulated Cell Cycle and Promoted Hepatocellular Carcinoma Development.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma.
Suppression of KIF3B Expression Inhibits Human Hepatocellular Carcinoma Proliferation.
The clinical value of kinesin superfamily protein 2A in hepatocellular carcinoma.
The KIF1B (rs17401966) Single Nucleotide Polymorphism is not Associated with the Development of HBV-related Hepatocellular Carcinoma in Thai Patients.
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
[The relationship between the KIF1B (rs17401966) single nucleotide polymorphism and the genetic susceptibility to Hepatocellular carcinoma].
Carcinoma, Intraductal, Noninfiltrating
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Non-Small-Cell Lung
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer.
AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients.
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
High KIF11 expression is associated with poor outcome of NSCLC.
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Low expression of KIF7 indicates poor prognosis in epithelial ovarian cancer.
Overexpression of kinesin family member 20A is associated with unfavorable clinical outcome and tumor progression in epithelial ovarian cancer.
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
Carcinoma, Renal Cell
A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217.
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Carcinoma, Squamous Cell
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Relation between the expression of mitotic centromere-associated kinesin and the progression of squamous cell carcinoma of the tongue.
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
Cardiomegaly
Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes.
Cataract
Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population.
Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases.
The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Cerebellar Ataxia
A novel KIF5A gene variant causes spastic paraplegia and cerebellar ataxia.
Cerebral Hemorrhage
Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.
Charcot-Marie-Tooth Disease
A Novel Mutation in the Stalk Domain of KIF5A Causes a Slowly Progressive Atypical Motor Syndrome.
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Biochemical and molecular characterization of diseases linked to motor proteins.
Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation.
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Hot-spot KIF5A mutations cause familial ALS.
New structural variations responsible for Charcot-Marie-Tooth disease: The first two large KIF5A deletions detected by CovCopCan software.
The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.
Unique function of Kinesin Kif5A in localization of mitochondria in axons.
[Intracellular transport proteins: classification, structure and function of kinesins].
Chickenpox
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Cholangiocarcinoma
Identification of key genes associated with the progression of intrahepatic cholangiocarcinoma using weighted gene co-expression network analysis.
KIF4A as a novel prognostic biomarker in cholangiocarcinoma.
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.
TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
Ciliopathies
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Gli2 Rescues Delays in Brain Development Induced by Kif3a Dysfunction.
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
Loss of function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Cleft Palate
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
The correlative hypotheses between Pitchfork and Kif3a in palate development.
Colitis
Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia.
Colonic Diseases
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.
Colonic Neoplasms
A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patients.
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.
Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/?-Catenin.
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma.
Colorectal Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Aberrant KIF23 expression is associated with adverse clinical outcome and promotes cellular malignant behavior through the Wnt/?-catenin signaling pathway in Colorectal Cancer.
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Evidence of Colorectal Cancer-Associated Mutation in MCAK: A Computational Report.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells.
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer.
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.
Kinesin 18A expression clinical relevance to colorectal cancer progression.
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review).
Somatic frameshift mutations of cancer-related genes KIF3C and BARD1 in colorectal cancers.
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.
[Establishment of a targeting protein for Xenopus kinesin-like protein 2 C' terminal SBP-3 x Flag tagged HCT 116 colorectal cancer cell model].
Confusion
A standardized kinesin nomenclature.
Congenital Abnormalities
'Kinesinopathies': emerging role of the kinesin family member genes in birth defects.
Contracture
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Coronary Artery Disease
Investigation of KIF6 Trp719Arg in a Case-Control Study of Coronary Artery Disease in Western Indians.
Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study.
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
Coronary Disease
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism versus coronary heart disease.
Craniosynostoses
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Cysts
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Analysis of Kif5b expression during mouse kidney development.
Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Kinesin-2 mediates apical endosome transport during epithelial lumen formation.
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx.
Deafness
A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness.
Mutation analysis of the mouse myosin VIIA deafness gene.
Deglutition Disorders
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Dehydration
Proteome Analysis of Dormancy-Released Seeds of Fraxinus mandshurica Rupr. in Response to Re-Dehydration under Different Conditions.
Role of the ERK signaling pathway in regulating vasopressin secretion in dehydrated rats.
Dementia
Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro.
Demyelinating Diseases
Sarcotubular Myopathy Due to Novel TRIM32 Mutation in Association with Multiple Sclerosis.
Dent Disease
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
Dermatitis, Atopic
Association Of Kif3a, But Not Ovol1 And Actl9, With Atopic Eczema In Italian Patients.
Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Diabetes Mellitus, Type 1
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.
Diabetes Mellitus, Type 2
Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.
The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials).
Diabetic Cardiomyopathies
Mitochondrial Arrest on the Microtubule Highway-A Feature of Heart Failure and Diabetic Cardiomyopathy?
DiGeorge Syndrome
A Novel Mutation of KIF11 in a Child with 22q11.2 Deletion Syndrome Associated with MCLMR.
Digestive System Neoplasms
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis.
Down Syndrome
Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model.
Drug Resistant Epilepsy
RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS.
Dwarfism
Brittle Culm12, a dual-targeting Kinesin-4 protein, controls cell cycle progression and wall properties in rice.
Mutation of Rice BC12/GDD1, Which Encodes a Kinesin-Like Protein That Binds to a GA Biosynthesis Gene Promoter, Leads to Dwarfism with Impaired Cell Elongation.
Dystonia
The early onset dystonia protein torsinA interacts with kinesin light chain 1.
Eczema
Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Endometrial Neoplasms
Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling.
Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway.
Macrophage ER? promoted invasion of endometrial cancer cell by mTOR/KIF5B -mediated epithelial to mesenchymal transition.
MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2.
STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.
Epilepsy
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Challenges in the clinical interpretation of small de novo copy number variants in neurodevelopmental disorders.
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Evaluation of candidate genes in a Chinese cohort of atypical Rolandic epilepsy.
Expanding the KIF4A-associated phenotype.
Interaction of different proteins with GABAA receptor and their modulatory effect on inhibitory neural transmission leads to epilepsy.
Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.
Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Preliminary report for Epilepsia Open A case of West syndrome with severe global developmental delay and confirmed KIF5A gene variant.
Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
Epilepsy, Rolandic
Evaluation of candidate genes in a Chinese cohort of atypical Rolandic epilepsy.
Equine Infectious Anemia
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Esophageal Neoplasms
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
MicroRNA-2053 involves in the progression of esophageal cancer by targeting KIF3C.
Prognostic significance of TPX2 and NIBP in esophageal cancer.
Esophageal Squamous Cell Carcinoma
KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma.
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Familial Exudative Vitreoretinopathies
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Detection and quantification of a KIF11 mosaicism in a subject presenting familial exudative vitreoretinopathy with microcephaly.
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Retinal Features of Family Members With Familial Exudative Vitreoretinopathy Caused By Mutations in KIF11 Gene.
Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy.
Fanconi Anemia
Screening and Identification of Therapeutic Targets for Pulmonary Arterial Hypertension Through Microarray Technology.
Fasciculation
Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance.
Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating.
Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).
Two binding partners cooperate to activate the molecular motor Kinesin-1.
Fowlpox
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Frontotemporal Dementia
Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients.
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Gait Disorders, Neurologic
Monoallelic KIF1A-related disorders: a multicenter cross sectional study and systematic literature review.
Gallbladder Neoplasms
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Gastrointestinal Neoplasms
Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis.
Genetic Diseases, Inborn
Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
Glaucoma
The Effect of Adjuvant Dimethylenastron, a Mitotic Kinesin Eg5 Inhibitor, in Experimental Glaucoma Filtration Surgery.
Glioblastoma
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma.
Further Investigation About Copy Number Variations and Methylation of AURKA, KIF4A, and NUSAP1 in Glioblastoma.
Identification of Driver Genes and Key Pathways of Glioblastoma Shows JNJ-7706621 as a Novel Antiglioblastoma Drug.
Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis and Evaluating Their Prognostic Value.
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells.
The Microarray Gene Profiling Analysis of Glioblastoma Cancer Cells Reveals Genes Affected by Fak Inhibitor Y15 and Combination of Y15 and Temozolomide.
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Glioma
Downregulation of KIF23 suppresses glioma proliferation.
Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines.
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma.
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.
KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.
KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients.
Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas.
Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A24+ glioma patients.
Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway.
MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.
MicroRNA-424 inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting KIF23 and functions as a novel prognostic predictor.
Mutation and Copy Number Alterations Analysis of KIF23 in Glioma.
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Heart Defects, Congenital
Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease.
Heart Diseases
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism versus coronary heart disease.
Hematologic Neoplasms
Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
Hepatitis
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Hepatitis B
A genetic variant at KIF1B predicts clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.
Genetic insights on host and hepatitis B virus in liver diseases.
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
Hepatitis B virus upregulates the expression of kinesin family member 4A.
Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Hepatitis B, Chronic
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
Hepatitis C
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Hereditary Sensory and Autonomic Neuropathies
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
KIF1A, an Axonal Transporter of Synaptic Vesicles, Is Mutated in Hereditary Sensory and Autonomic Neuropathy Type 2.
Herpes Simplex
Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.
Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro.
Coupling viruses to dynein and kinesin-1.
Downregulation of KIF23 suppresses glioma proliferation.
Herpes Simplex Virus 1 US3 Phosphorylates Cellular KIF3A To Downregulate CD1d Expression.
Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain.
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A.
Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons.
Herpes Zoster
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Hirschsprung Disease
Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Histiocytosis
ALK-Positive Histiocytosis: A Case Report and Literature Review.
Huntington Disease
Interrogating Emergent Transport Properties for Molecular Motor Ensembles: A Semi-analytical Approach.
Hydrocephalus
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Expanding the KIF4A-associated phenotype.
Primary cilia are required in a unique subpopulation of neural progenitors.
Hypercholesterolemia
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Hyperglycemia
Targeted Inactivation of Kinesin-1 in Pancreatic {beta}-Cells in vivo Leads to Insulin Secretory Deficiency.
Hypersensitivity
Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response.
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.
TORC1 kinase and the S-phase cyclin Clb5 collaborate to promote mitotic spindle assembly and DNA replication in S. cerevisiae.
Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception.
Hypertelorism
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Hypertension
Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.
Hypopigmentation
Postzygotic inactivating mutation of KIF13A located at chromosome 6p22.3 in a patient with a novel mosaic neuroectodermal syndrome.
Hypothyroidism
Thyroid-specific inactivation of KIF3A alters TSH signaling pathway and leads to hypothyroidism.
Immune System Diseases
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Infections
A Botrytis cinerea KLP-7 Kinesin acts as a Virulence Determinant during Plant Infection.
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
African trypanosome control in the insect vector and mammalian host.
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis.
Comparison of Recombinant Proteins of Kinesin 39, Heat Shock Protein 70, Heat Shock Protein 83 and Glycoprotein 63 for Antibody Detection of Leishmania martiniquensis Infection.
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site.
Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei.
Genetic insights on host and hepatitis B virus in liver diseases.
Glycoproteins gE and gI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons.
Hepatitis B virus upregulates the expression of kinesin family member 4A.
High Transcriptional Activity and Diverse Functional Repertoires of Hundreds of Giant Viruses in a Coastal Marine System.
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.
Involvement of microtubular network and its motors in productive endocytic trafficking of mouse polyomavirus.
KIF13A mediates trafficking of influenza A virus ribonucleoproteins.
KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection.
Kinesin-1 plays multiple roles during the vaccinia virus life cycle.
Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons.
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
Role of kinesins in directed adenovirus transport and cytoplasmic exploration.
Role of Microtubules and Microtubule-Associated Proteins in HIV-1 Infection.
Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle.
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Significance of host cell kinesin in the development of Chlamydia psittaci.
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells.
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors required during Trypanosoma cruzi parasitophorous vacuole development.
The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.
The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection.
Tobacco mosaic virus movement protein functions as a structural microtubule-associated protein.
Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.
Infertility
Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.
Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele.
Inflammatory Bowel Diseases
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.
Replication of KIF21B as a susceptibility locus for multiple sclerosis.
Influenza, Human
KIF13A mediates trafficking of influenza A virus ribonucleoproteins.
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Insulin Resistance
Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity.
Insulinoma
The identification, purification, and characterization of a pancreatic beta-cell form of the microtubule adenosine triphosphatase kinesin.
Intellectual Disability
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
De novo KIF1A mutations cause intellectual deficit, cerebellar atrophy, lower limb spasticity and visual disturbance.
Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis.
Expanding the KIF4A-associated phenotype.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Identification of microduplications at Xp21.2 and Xq13.1 in neurodevelopmental disorders.
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.
KIF11 microdeletion is associated with microcephaly, chorioretinopathy and intellectual disability.
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome.
KIF1A mutation in a patient with progressive neurodegeneration.
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations.
Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Phenotypic Expansion in KIF1A-related Dominant Disorders: A Description of Novel Variants and Review of Published Cases.
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation.
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization.
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.
Ischemic Stroke
Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
Joint Instability
A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene.
Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.
Kidney Diseases
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Kidney Diseases, Cystic
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Kidney Neoplasms
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Leiomyosarcoma
Expression Profiling of the Cellular Processes in Uterine Leiomyomas: Omic Approaches and IGF-2 Association with Leiomyosarcomas.
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
Leishmaniasis
Serodiagnosis of Asian leishmaniasis with a recombinant antigen from the repetitive domain of a Leishmania kinesin.
Leishmaniasis, Visceral
Kinesin motor domain of Leishmania donovani as a future vaccine candidate.
Leishmania infantum recombinant kinesin degenerated derived repeat (rKDDR): A novel potential antigen for serodiagnosis of visceral leishmaniasis.
Leukemia
Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis.
Fluorescent proteins in zebrafish cell and developmental biology.
Leukemia, Myeloid
Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion.
Leukemia, Myeloid, Acute
Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia.
Leukemia, T-Cell
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Leukodystrophy, Globoid Cell
The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3? and deregulation of molecular motors.
Leukoencephalopathies
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
Lipomatosis
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Lissencephaly
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Recurrent KIF5C mutation leading to frontal pachygyria without microcephaly.
Somatic mutations in cerebral cortical malformations.
Liver Diseases
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Liver Diseases, Alcoholic
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Liver Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Lung Neoplasms
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
Anaplastic lymphoma kinase as a new target for the treatment of non-small-cell lung cancer.
AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients.
Corrigendum: KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.
Downregulation of lumican enhanced mitotic defects and aneuploidy in lung cancer cells.
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
Hepatitis B virus upregulates the expression of kinesin family member 4A.
High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.
High KIF11 expression is associated with poor outcome of NSCLC.
Identification of a novel KIF13A-RET fusion in lung adenocarcinoma by next-generation sequencing.
Identification of prognostic markers of lung cancer through bioinformatics analysis and in vitro experiments.
Impaired DNA double-strand breaks repair by kinesin family member 4A inhibition renders human H1299 non-small-cell lung cancer cells sensitive to cisplatin.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
Similarity and difference of pathogenesis among lung cancer subtypes suggested by expression profile data.
Small non-mucinous bronchioloalveolar carcinoma with anaplastic lymphoma kinase immunoreactivity: a novel ALK fusion gene?
Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases.
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
Verification of expression of LINC00648 in the serum of lung cancer patients by TCGA database.
Lupus Erythematosus, Systemic
The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus.
Lymphatic Metastasis
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
High KIF11 expression is associated with poor outcome of NSCLC.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
KIF15 contributes to cell proliferation and migration in breast cancer.
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Lymphedema
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family.
Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11.
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Lymphoma
Genistein and cancer: current status, challenges, and future directions.
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
Novel molecular targets for the treatment of lung cancer.
Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer: a case report.
Small non-mucinous bronchioloalveolar carcinoma with anaplastic lymphoma kinase immunoreactivity: a novel ALK fusion gene?
Lymphoma, B-Cell
Genistein and cancer: current status, challenges, and future directions.
Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
Lymphoma, Large B-Cell, Diffuse
Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
Lymphoma, T-Cell
Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.
Macular Degeneration
VEGFR2 Trafficking by KIF13B Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration.
Malaria
Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5.
Malformations of Cortical Development
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
Medulloblastoma
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Kif3a is necessary for initiation and maintenance of medulloblastoma.
The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
Melanoma
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells.
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
KIF15 plays a role in promoting the tumorigenicity of melanoma.
Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma.
MicroRNA-203 Regulates Melanosome Transport and Tyrosinase Expression in Melanoma Cells by Targeting Kinesin Superfamily Protein 5b.
Meningioma
Identification of KIF11 As a Novel Target in Meningioma.
KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.
Mesothelioma
Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Mesothelioma, Malignant
Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Microcephaly
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family.
Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11.
Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: five novel mutations and review of the literature.
Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes.
Corrigendum to "Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: Five novel mutations and review of the literature. Am J Med Genet Part A 2014 164A:2879-86".
Detection and quantification of a KIF11 mosaicism in a subject presenting familial exudative vitreoretinopathy with microcephaly.
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Goldberg-Shprintzen syndrome protein KIF1BP is a CITK interactor implicated in cytokinesis.
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects.
Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
KIF11 microdeletion is associated with microcephaly, chorioretinopathy and intellectual disability.
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations.
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
NEW FINDINGS FROM MULTIMODAL FUNDUS IMAGING OVER 3 YEARS OF A PATIENT WITH MICROCEPHALY, CHORIORETINOPATHY, AND KIF11 MUTATION.
Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Recurrent KIF5C mutation leading to frontal pachygyria without microcephaly.
Motor Neuron Disease
Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors.
Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease.
Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila.
Mouth Neoplasms
Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Screening for oral premalignancy and cancer: what platform and which biomarkers?
Multiple Myeloma
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Multiple Sclerosis
A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Common genetic variants of the mitochondrial trafficking system and mitochondrial uncoupling proteins affect the development of two slowly developing demyelinating disorders, leukoaraiosis and multiple sclerosis.
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis.
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort.
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.
No influence of KIF1B on neurodegenerative markers in multiple sclerosis.
Polymorphic locus rs10492972 of the KIF1B gene association with multiple sclerosis in Russia: Case control study.
Replication of KIF21B as a susceptibility locus for multiple sclerosis.
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
The rs10492972 KIF1B polymorphism and disease progression in Greek patients with multiple sclerosis.
When is the absence of evidence, evidence of absence? Use of equivalence-based analyses in genetic epidemiology and a conclusion for the KIF1B rs10492972*C allelic association in multiple sclerosis.
[Clinical and electrophysiological and molecular genetic characteristics of the course of relapsing-remitting multiple sclerosis].
Multiple Sclerosis, Chronic Progressive
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort.
Multiple Sclerosis, Relapsing-Remitting
[Clinical and electrophysiological and molecular genetic characteristics of the course of relapsing-remitting multiple sclerosis].
Muscle Hypotonia
KIF1A mutation in a patient with progressive neurodegeneration.
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Muscle Spasticity
Co-existence of spastic paraplegia-30 with novel KIF1A mutation and spinocerebellar ataxia 31 with intronic expansion of BEAN and TK2 in a family.
Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Intrafamilial variable spastic paraplegia/ataxia/ALS phenotype linked to a novel KIF5A mutation.
Muscle Weakness
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Muscular Atrophy, Spinal
Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.
Small molecule suppressors of Drosophila Kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.
Muscular Diseases
Sarcotubular Myopathy Due to Novel TRIM32 Mutation in Association with Multiple Sclerosis.
Myocardial Infarction
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction.
[Motor protein Kinesin-6 and ischemic heart disease]
Myocardial Ischemia
[Motor protein Kinesin-6 and ischemic heart disease]
Myoclonus
Genotype-phenotype correlations of KIF5A stalk domain variants.
Hot-spot KIF5A mutations cause familial ALS.
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Myopia
Novel Myopia Genes and Pathways Identified From Syndromic Forms of Myopia.
Myositis
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies.
Nasal Polyps
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Nasopharyngeal Neoplasms
Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.
Neoplasm Metastasis
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
High KIF11 expression is associated with poor outcome of NSCLC.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico.
Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma.
KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
KIF15 contributes to cell proliferation and migration in breast cancer.
Kif18A is involved in human breast carcinogenesis.
KIF18B promotes tumor progression in osteosarcoma by activating ?-catenin.
KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells.
KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway.
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
KIFC1: a promising chemotherapy target for cancer treatment?
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma.
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
Kinesin superfamily proteins: roles in osteosarcoma.
Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.
Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
Neoplasms
"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.
1p36 tumor suppression--a matter of dosage?
3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking.
9-Angström structure of a microtubule-bound mitotic motor.
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation.
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number.
A Monastrol-derived Compound, LaSOM 63, Inhibits Ecto-5'Nucleotidase/CD73 Activity and Induces Apoptotic Cell Death of Glioma Cell Lines.
A neuronal network of mitochondrial dynamics regulates metastasis.
A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs.
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.
A specific gene expression signature for visceral organ metastasis in breast cancer.
A unique insertion in STARD9's motor domain regulates its stability.
Aberrant genes promoter methylation in neural crest-derived tumors.
Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis.
Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
An EB1-binding motif acts as a microtubule tip localization signal.
An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer.
An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Antiangiogenic Therapeutic Potential of Peptides Derived from the Molecular Motor KIF13B that Transports VEGFR2 to Plasmalemma in Endothelial Cells.
Antitumor activity of a kinesin inhibitor.
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer.
Biallelic variants in KIF14 cause intellectual disability with microcephaly.
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Cancer drug therapy and stochastic modeling of "nano-motors".
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.
Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.
Chaperonin-Dendrimer Conjugates for siRNA Delivery.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.
Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor.
Clinical relevance of cytoskeleton associated proteins for ovarian cancer.
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma.
Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis.
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.
Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma.
Combination of active and inactive siRNA targeting the mitotic kinesin Eg5 impairs silencing efficiency in several cancer cell lines.
Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A.
Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells.
Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens.
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.
Correlation between BRAF mutation and promoter methylation of TIMP3, RAR?2 and RASSF1A in thyroid cancer.
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Death receptor 6 promotes ovarian cancer cell migration through KIF11.
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.
Deviant kinetochore microtubule dynamics underlie chromosomal instability.
Dihydropyrazole and dihydropyrrole structures based design of Kif15 inhibitors as novel therapeutic agents for cancer.
Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1.
Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia.
Discovery of a novel inhibitor of kinesin-like protein KIFC1.
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Distinct Diagnostic and Prognostic Values of Kinesin Family Member Genes Expression in Patients with Breast Cancer.
Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells.
Distinct retrograde microtubule motor sets drive early and late endosome transport.
Distinctions between dynamic characteristics of the single EG5 motor protein along neural vs. cancerous microtubules.
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity.
Effects of KIF2A on the prognosis of nasopharyngeal carcinoma and nasopharyngeal carcinoma cells.
Eg5 as a Prognostic Biomarker and Potential Therapeutic Target for Hepatocellular Carcinoma.
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.
Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy.
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Exclusive destruction of mitotic spindles in human cancer cells.
Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5.
Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements.
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
Expression of meiotic genes in the germline progenitors of Drosophila embryos.
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
Fluorescent proteins in zebrafish cell and developmental biology.
FOXM1 modulates docetaxel resistance in prostate cancer by regulating KIF20A.
Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells.
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
Gene expression differences predict treatment outcome of merkel cell carcinoma patients.
Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer.
Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
Germline variant in REXO2 is a novel candidate gene in familial pheochromocytoma.
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
High Eg5 expression predicts poor prognosis in breast cancer.
High expression of KIF14 is associated with poor prognosis in patients with epithelial ovarian cancer.
High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma.
High KIF11 expression is associated with poor outcome of NSCLC.
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
High KIFC1 expression is associated with poor prognosis in prostate cancer.
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Higher Glucose Enhances Breast Cancer Cell Aggressiveness.
How Essential Kinesin-5 Becomes Non-Essential in Fission Yeast: Force Balance and Microtubule Dynamics Matter.
Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer.
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
Identification and validation of core genes for serous ovarian adenocarcinoma via bioinformatics analysis.
Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
Identification of a link between the tumour suppressor APC and the kinesin superfamily.
Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells.
Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A.
Identification of KIF11 As a Novel Target in Meningioma.
Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma.
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling.
Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques.
Identification of prognostic markers by weighted gene co-expression network analysis in non-small cell lung cancer.
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.
Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.
Increased KIF4A expression is a potential prognostic factor in prostate cancer.
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint.
Induction of KIFC1 expression in gastric cancer spheroids.
Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma.
Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
Inhibition of kinesin motor proteins by adociasulfate-2.
Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.
Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.
KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer.
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
KIF11 silencing and inhibition induces chromosome instability that may contribute to cancer.
KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer.
KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
KIF15 contributes to cell proliferation and migration in breast cancer.
KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma.
KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis.
KIF15 is involved in development and progression of Burkitt lymphoma.
KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics.
KIF15 plays a role in promoting the tumorigenicity of melanoma.
KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.
KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species-mediated apoptosis.
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.
Kif18A is involved in human breast carcinogenesis.
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
KIF18B promotes tumor progression in osteosarcoma by activating ?-catenin.
KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear?cell carcinoma cells.
KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway.
KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway.
KIF20A silence inhibits the migration, invasion and proliferation of non-small cell lung cancer and regulates the JNK pathway.
KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122.
KIF23 promotes triple negative breast cancer through activating epithelial-mesenchymal transition.
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.
KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
KIF2C promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo.
KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
Kif3a is necessary for initiation and maintenance of medulloblastoma.
KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
KIF4A as a novel prognostic biomarker in cholangiocarcinoma.
KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.
KIF4A: A potential biomarker for prediction and prognostic of prostate cancer.
KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo.
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.
KIFC1 is a novel potential therapeutic target for breast cancer.
KIFC1 Is Essential for Bipolar Spindle Formation and Genomic Stability in the Primary Human Fibroblast IMR-90 Cell.
KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo.
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.
KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
KIFC1: a promising chemotherapy target for cancer treatment?
KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Kinesin and dynein mechanics: measurement methods and research applications.
Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance.
Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Kinesin Family Member 11 mRNA Expression Predicts Prostate Cancer Aggressiveness.
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA.
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway.
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+?breast cancer.
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx.
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Kinesin motor proteins as targets for cancer therapy.
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma.
Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
Kinesin superfamily proteins: roles in osteosarcoma.
Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.
Kinesin-5 mitotic motors: Is loop5 the on/off switch?
Knockdown of KIF15 promotes cell apoptosis by activating crosstalk of multiple pathways in ovarian cancer: bioinformatic and experimental analysis.
Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion.
Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer.
Knockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis.
LDL receptor related protein 1 requires the I3 domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B.
Machine learning-based investigation of the cancer protein secretory pathway.
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d.
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
MicroRNA expression profiles in head and neck cancer cell lines.
miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1.
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2.
miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway.
miR-485-3p suppresses colorectal cancer via targeting TPX2.
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.
Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.
Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR.
Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma.
Monastrol derivatives: in silico and in vitro cytotoxicity assessments.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas.
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.
Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.
New insights into the mechanism of force generation by kinesin-5 molecular motors.
New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations.
Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.
Novel Amide Compounds as KIF18A Inhibitors for Treating Cancer.
Novel KIF18A Inhibitors for Treating Cancer.
Novel photochromic inhibitor for mitotic kinesin Eg5 which forms multiple isomerization states.
Novel tubulin-targeted cell penetrating antimitotic octapeptide.
Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.
Oncogenic Role of Kinesin Proteins and Targeting Kinesin Therapy.
Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer.
Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-beta.
Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.
Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis.
Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.
Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.
Overexpression of kinesin family member 20A is associated with unfavorable clinical outcome and tumor progression in epithelial ovarian cancer.
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer.
Paragangliomas/Pheochromocytomas: clinically oriented genetic testing.
Pgp efflux pump decreases the cytostatic effect of CENP-E inhibitor GSK923295.
Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer.
Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor.
Potential new biomarkers for squamous carcinoma of the uterine cervix.
Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.
Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.
Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Prognostic Genes of Breast Cancer Identified by Gene Co-expression Network Analysis.
Prognostic implications of immune-related eight-gene signature in pediatric brain tumors.
Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.
Prognostic significance of KIF2A and KIF20A expression in human cancer: A systematic review and meta-analysis.
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
Properties of kinesin isolated from human prostatic DU 145 tumor cells and bovine brain.
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.
Ras transformation uncouples the kinesin-coordinated cellular nutrient response.
Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.
Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features.
Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma.
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A.
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Role of a Kinesin Motor in Cancer Cell Mechanics.
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
SCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis.
Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2.
Screening for inhibitors of microtubule-associated motor proteins.
Screening for oral premalignancy and cancer: what platform and which biomarkers?
Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation.
Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.
Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma.
Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma.
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3?/?-catenin pathway.
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Simul-seq: combined DNA and RNA sequencing for whole-genome and transcriptome profiling.
Single functionalized graphene oxide reconstitutes kinesin mediated intracellular cargo transport and delivers multiple cytoskeleton proteins and therapeutic molecules into the cell.
Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.
Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.
Structure-activity relationship of pyrazolo pyrimidine derivatives as inhibitors of mitotic kinesin Eg5 and anticancer agents.
Structure-activity relationship of S-trityl-l-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
Successful imatinib therapy for neuroendocrine carcinoma with activating Kit mutation: a case study.
Sumoylation of Kif18A plays a role in regulating mitotic progression.
Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A.
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
Targeting cell cycle by ?-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer.
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation.
The clinical significance and prognostic value of Xenopus kinesin-like protein 2 expressions in human tumors: A systematic review and meta-analysis.
The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.
The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma.
The identification, purification, and characterization of a pancreatic beta-cell form of the microtubule adenosine triphosphatase kinesin.
The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing.
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy.
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma.
TPX2 as a Novel Prognostic Indicator and Promising Therapeutic Target in Triple-negative Breast Cancer.
TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
Transcriptional and Epigenetic Regulation of KIF14 Overexpression in Ovarian Cancer.
Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
Triphenylbutanamines: Kinesin spindle protein inhibitors with in vivo antitumor activity.
Triton X-100-Modified Adenosine Triphosphate-Responsive siRNA Delivery Agent for Antitumor Therapy.
Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.
Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.
Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.
Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome.
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor.
Whole Exome Sequencing of Multiple Atypical Meningiomas in a Patient without History of Neurofibromatosis Type II: A Case Report.
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Nervous System Diseases
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity.
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.
The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.
Neuralgia
Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception.
Neuritis
Disruption of Fast Axonal Transport in the Rat Induces Behavioral Changes Consistent With Neuropathic Pain.
Neuroaxonal Dystrophies
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neuroblastoma
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Age related gene DST represents an independent prognostic factor for MYCN non-amplified neuroblastoma.
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells.
Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients.
Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2.
Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon.
KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.
Localization of kinesin in cultured cells.
Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA.
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma.
Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
XAF1 promotes neuroblastoma tumor suppression and is required for KIF1B?-mediated apoptosis.
Neurodegenerative Diseases
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation.
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.
Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation.
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Kinesin and dynein mechanics: measurement methods and research applications.
Monoallelic KIF1A-related disorders: a multicenter cross sectional study and systematic literature review.
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.
Reductions in kinesin expression are associated with nitric oxide-induced axonal damage.
Remodeling Tau and Prion Proteins Using Nanochaperons.
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development.
Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis.
[Intracellular transport proteins: classification, structure and function of kinesins].
Neurofibromatoses
The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.
Neurofibrosarcoma
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Neurologic Manifestations
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Non-alcoholic Fatty Liver Disease
miR-122-5p/KIF5B/AMPK/AKT regulatory network regulates the progression of NAFLD.
Obesity
Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Ocular Motility Disorders
Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling.
Oculomotor Nerve Diseases
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Oligodendroglioma
Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas.
Optic Nerve Hypoplasia
Optic nerve hypoplasia in a patient with a de novo KIF1A heterozygous mutation.
Orchitis
Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
Osteoporosis
Clinical and molecular characterization of familial exudative vitreoretinopathy associated with microcephaly.
Osteosarcoma
Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma.
Kinesin superfamily proteins: roles in osteosarcoma.
Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?
Knockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis.
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Ovarian Neoplasms
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
Clinical relevance of cytoskeleton associated proteins for ovarian cancer.
Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells.
Death receptor 6 promotes ovarian cancer cell migration through KIF11.
Identification of an energy metabolism?related gene signature in ovarian cancer prognosis.
Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis.
Identification of Differentially Expressed Genes (DEGs) Relevant to Prognosis of Ovarian Cancer by Use of Integrated Bioinformatics Analysis and Validation by Immunohistochemistry Assay.
Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation.
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling.
Integrative analysis of key candidate genes and signaling pathways in ovarian cancer by bioinformatics.
KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression.
KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.
Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
Knockdown of KIF15 promotes cell apoptosis by activating crosstalk of multiple pathways in ovarian cancer: bioinformatic and experimental analysis.
miR-29c-3p regulates proliferation and migration in ovarian cancer by targeting KIF4A.
Overexpression of KIF2A is Suppressed by miR-206 and Associated with Poor Prognosis in Ovarian Cancer.
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.
Pancreatic Diseases
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
Pancreatic Neoplasms
A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer.
Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
Characterization of Novel Diaryloxazole-Based Compounds as Potential Agents to Treat Pancreas Cancer.
Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5.
Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.
Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.
KIF3B Promotes the Proliferation of Pancreatic Cancer.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin Family Member 20A is a Novel Melanoma-associated Antigen.
Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer.
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor.
Pancreatitis
The potential role of kinesin and dynein in Golgi scattering and cytoplasmic vacuole formation during acute experimental pancreatitis.
Paraganglioma
KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
Whole Exome Sequencing Identifies Novel Genetic Alterations in Patients with Pheochromocytoma/Paraganglioma.
Paralysis
APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.
Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides.
Kinesin heavy chain function in Drosophila glial cells controls neuronal activity.
Late endosome motility depends on lipids via the small GTPase Rab7.
Paraparesis, Spastic
A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia.
A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness.
Altered CSF levels of monoamines in hereditary spastic paraparesis 10: A case series.
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Usefulness of exome sequencing in the study of spastic paraparesis and cerebellar atrophy: De novo mutation of the KIF1A gene, a new hope in prognosis.
Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis.
Paraplegia
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
A novel KIF5A gene variant causes spastic paraplegia and cerebellar ataxia.
A novel KIF5a mutation identified in two-family members with spastic paraplegia type 10.
A novel mutation in KIF5A in a Malian family with spastic paraplegia and sensory loss.
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity.
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Hot-spot KIF5A mutations cause familial ALS.
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations.
KIF1A mutation in a patient with progressive neurodegeneration.
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
KIF1A-related autosomal dominant spastic paraplegias (SPG30) in Russian families.
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2.
Phenotypic Expansion in KIF1A-related Dominant Disorders: A Description of Novel Variants and Review of Published Cases.
Role of Kinesin-1 in the Pathogenesis of SPG10, a Rare Form of Hereditary Spastic Paraplegia.
Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.
Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia.
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Parkinson Disease
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases.
Parkinsonian Disorders
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Pemphigoid, Bullous
[Comparison of urinary proteomics between steroid-sensitive and steroid-resistant minimal change nephrotic syndrome in children.]
Peripheral Nervous System Diseases
A Database of Caenorhabditis elegans Locomotion and Body Posture Phenotypes for the Peripheral Neuropathy Model.
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation.
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.
Hippocampal to basal forebrain transport of Mn(2+) is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor.
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials).
Wide phenotypic spectrum in axonal Charcot-Marie-Tooth neuropathy type 2 patients with KIF5A mutations.
Pheochromocytoma
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
Plasmacytoma
Chromosome 8q as the most frequent target for amplification in early gastric carcinoma.
plus-end-directed kinesin atpase deficiency
A novel role of the chromokinesin Kif4A in DNA damage response.
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
An orphan kinesin in trypanosomes cooperates with a kinetoplastid-specific kinesin to maintain cell morphology through regulating subpellicular microtubules.
Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.
Kif18a is specifically required for mitotic progression during germ line development.
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner.
Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.
Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal.
Small molecule suppressors of Drosophila Kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.
Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe.
Pneumonia
Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Polycystic Kidney Diseases
Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.
HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.
Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.
Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease.
Polydactyly
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Polyneuropathies
Hereditary Spastic Paraplegia with Axonal Sensorimotor Polyneuropathy in a Korean Family Caused by Pathogenic Variant of KIF5A (c.611G>A).
Progressive Lower Extremity Weakness and Axonal Sensorimotor Polyneuropathy from a Mutation in KIF5A (c.611G>A;p.Arg204Gln).
Prion Diseases
Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain.
Prostatic Neoplasms
AIM1 promoter hypermethylation as a predictor of decreased risk of recurrence following radical prostatectomy.
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Effects of KIF2A on the prognosis of nasopharyngeal carcinoma and nasopharyngeal carcinoma cells.
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
High KIFC1 expression is associated with poor prognosis in prostate cancer.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Increased KIF4A expression is a potential prognostic factor in prostate cancer.
Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.
KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
KIF4A: A potential biomarker for prediction and prognostic of prostate cancer.
KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition.
KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer.
KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Kinesin Family Member 11 mRNA Expression Predicts Prostate Cancer Aggressiveness.
Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d.
Mitosis phase enrichment with identification of mitotic centromere-associated Kinesin as a therapeutic target in castration-resistant prostate cancer.
Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes.
Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.
Pseudorabies
A kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids.
Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion.
Coupling viruses to dynein and kinesin-1.
Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro.
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
receptor protein-tyrosine kinase deficiency
KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor.
Renal Insufficiency
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Analysis of Kif5b expression during mouse kidney development.
Reperfusion Injury
Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia-reperfusion injury in rats by targeting multiple cellular processes.
Retinal Degeneration
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.
Kinesin-2 and photoreceptor cell death: requirement of motor subunits.
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Retinal Detachment
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Total retinal detachment caused by a KIF11 mutation.
Retinal Diseases
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Kinesin-2 and photoreceptor cell death: requirement of motor subunits.
Retinal Dystrophies
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Retinitis Pigmentosa
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Retinoblastoma
Expression analysis of 6p22 genomic gain in retinoblastoma.
Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.
Rett Syndrome
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).
Rhinitis, Allergic
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Scleroderma, Systemic
The centromere kinesin-like protein, CENP-E. An autoantigen in systemic sclerosis.
Scrapie
Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain.
Seizures
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity.
prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies.
Seminoma
A novel role of KIF3b in the seminoma cell cycle.
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Sertoli Cell-Only Syndrome
Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.
Silicosis
Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex.
Situs Inversus
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
Spasms, Infantile
Preliminary report for Epilepsia Open A case of West syndrome with severe global developmental delay and confirmed KIF5A gene variant.
Spastic Paraplegia, Hereditary
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10).
A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia.
A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy.
A Novel Mutation in Motor Domain of KIF5A Associated With an HSP/Axonal Neuropathy Phenotype.
A Novel Mutation in the Stalk Domain of KIF5A Causes a Slowly Progressive Atypical Motor Syndrome.
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia.
Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors.
Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia.
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation.
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Genotype-phenotype correlations of KIF5A stalk domain variants.
Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia.
Hereditary spastic paraplegia caused by compound heterozygous mutations outside the motor domain of the KIF1A gene.
Hereditary Spastic Paraplegia with Axonal Sensorimotor Polyneuropathy in a Korean Family Caused by Pathogenic Variant of KIF5A (c.611G>A).
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral sclerosis.
Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report.
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia.
Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2.
Novel De Novo Mutations in KIF1A as a Cause of Hereditary Spastic Paraplegia With Progressive Central Nervous System Involvement.
Novel SPG10 mutation associated with dysautonomia, spinal cord atrophy, and skin biopsy abnormality.
Role of Kinesin-1 in the Pathogenesis of SPG10, a Rare Form of Hereditary Spastic Paraplegia.
SPG10 is a rare cause of spastic paraplegia in European families.
Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin.
Sural biopsy to detect the axonal cytoskeleton defects in KIF5A-related Charcot-Marie-Tooth disease type 2.
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development.
The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation.
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Theoretical Investigations of the Role of Mutations in Dynamics of Kinesin Motor Proteins.
Three routes to suppression of the neurodegenerative phenotypes caused by Kinesin heavy chain mutations.
Unique function of Kinesin Kif5A in localization of mitochondria in axons.
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Wide phenotypic spectrum in axonal Charcot-Marie-Tooth neuropathy type 2 patients with KIF5A mutations.
[Intracellular transport proteins: classification, structure and function of kinesins].
Spinal Cord Injuries
Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury.
Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats.
Spinocerebellar Ataxias
Co-existence of spastic paraplegia-30 with novel KIF1A mutation and spinocerebellar ataxia 31 with intronic expansion of BEAN and TK2 in a family.
Squamous Cell Carcinoma of Head and Neck
Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses.
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
[Analysis of key genes and signal pathways of human papilloma virus-related head and neck squamous cell carcinoma].
Starvation
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers.
Stomach Neoplasms
CDK6 is stimulated by hyperthermia and protects gastric cancer cells from hyperthermia?induced damage.
Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer.
Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer.
FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin.
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Induction of KIFC1 expression in gastric cancer spheroids.
KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis.
KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species-mediated apoptosis.
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
KIF23 activated Wnt/?-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.
KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1.
miR-635 targets KIFC1 to inhibit the progression of gastric cancer.
Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype.
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
[Expression of KIF18A in gastric cancer and its association with prognosis].
Stroke
A simulation model of the conventional kinesin based on the Driven-by-Detachment mechanism.
A torque component in the kinesin-1 power stroke.
Bidirectional power stroke by ncd kinesin.
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Kinesin takes one 8-nm step for each ATP that it hydrolyzes.
Kinesin's Biased Stepping Mechanism: Amplification of Neck Linker Zippering.
Mechanical control of the directional stepping dynamics of the kinesin motor.
Mechanochemical Model of the Power Stroke of the Single-Headed Motor Protein KIF1A.
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.
Multiscale Coarse-Grained Model for the Stepping of Molecular Motors with Application to Kinesin.
Overview of the mechanism of cytoskeletal motors based on structure.
Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope.
Searching for kinesin's mechanical amplifier.
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.
Structure of a kinesin-tubulin complex and implications for kinesin motility.
Three phase model of the processive motor protein kinesin.
Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.
Tauopathies
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.
Remodeling Tau and Prion Proteins Using Nanochaperons.
Teratozoospermia
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.
Testicular Neoplasms
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Tetanus
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
Thrombocytopenia
Loss-of-Function Mutations in KIF15 Underlying a Braddock-Carey Genocopy.
Thrombosis
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Kinesin-1: A New Actor Involved in Platelet Secretion and Thrombus Stability.
Thymoma
Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.
Thyroid Neoplasms
Effects of small interfering RNA-mediated silencing of susceptibility genes of non-syndromic cleft lip with or without cleft palate on cell proliferation and migration.
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Tics
Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.
Tongue Neoplasms
Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
Tooth Diseases
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.
Triple Negative Breast Neoplasms
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
KIFC1 is a novel potential therapeutic target for breast cancer.
Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer.
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Trypanosomiasis
Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.
Tuberculosis
Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis.
Immunogenicity of candidate chimeric DNA vaccine against tuberculosis and leishmaniasis.
Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.
Tuberous Sclerosis
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.
Ureteral Obstruction
[Expression of kinesin KIF3A in the kidney of mice with unilateral ureteral obstruction].
Urinary Bladder Neoplasms
GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).
KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway.
KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells.
KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.
KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo.
Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo.
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Role of a Kinesin Motor in Cancer Cell Mechanics.
Screening and identification of hub genes in bladder cancer by bioinformatics analysis and KIF11 is a potential prognostic biomarker.
TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
Uterine Cervical Neoplasms
Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma.
Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells.
SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
Vaccinia
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
Coupling viruses to dynein and kinesin-1.
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Kinesin-1 plays multiple roles during the vaccinia virus life cycle.
Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.
Phototracking Vaccinia Virus Transport Reveals Dynamics of Cytoplasmic Dispersal and a Requirement for A36R and F12L for Exit from the Site of Wrapping.
The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin.
Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.
Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin.
Vaccinia virus egress mediated by virus protein A36 is reliant on the F12 protein.
Vaccinia virus protein complex f12/e2 interacts with Kinesin light chain isoform 2 to engage the Kinesin-1 motor complex.
Vaccinia virus proteins A36 and F12/E2 show strong preferences for different kinesin light chain isoforms.
Varicocele
Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele.
Vascular Diseases
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Vesicular Stomatitis
A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating.
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic.
Virus Diseases
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
von Hippel-Lindau Disease
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Wilms Tumor
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
Wiskott-Aldrich Syndrome
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Yellow Fever
Evolutionary analysis of the kinesin light chain genes in the yellow fever mosquito Aedes aegypti: gene duplication as a source for novel early zygotic genes.