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Disease on EC 5.6.1.2 - dynein ATPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery.
Protein structural transitions and their functional role.
Adenocarcinoma
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Adenocarcinoma of Lung
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Adenomatous Polyposis Coli
A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport.
Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
African Swine Fever
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide.
Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein.
Alzheimer Disease
Cytoplasmic dynein in neurodegeneration.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.
LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease.
Presenilin influences Glycogen Synthase Kinase-3beta (GSK-3?) for kinesin-1 and dynein function during axonal transport.
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
Amyotrophic Lateral Sclerosis
Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Dynactin Deficiency in the CNS of Humans with Sporadic ALS and Mice with Genetically Determined Motor Neuron Degeneration.
Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS.
Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
Anthrax
Anthrax: a motor protein determines anthrax susceptibility.
Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor.
Aortic Aneurysm, Thoracic
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Aortic Diseases
Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.
Asthenozoospermia
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia.
Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency.
Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.
Further studies on knockout mice lacking a functional dynein heavy chain (MDHC7). 2. A developmental explanation for the asthenozoospermia.
Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251 Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in Men.
Motor apparatus in human spermatozoa that lack central pair microtubules.
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.
Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.
Two mutations in the axonemal dynein heavy chain gene 5 in a Chinese asthenozoospermia patient: A case report.
Whole-exome sequencing of familial cases of multiple morphological abnormalities of the sperm flagella (MMAF) reveals new DNAH1 mutations.
Asthma
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Ataxia
Cytoplasmic dynein in neurodegeneration.
Bardet-Biedl Syndrome
Protein profile of Dabry's sturgeon (Acipenser dabryanus) spermatozoa and relationship to sperm quality.
Blast Crisis
Regulation and Targeting of Eg5, a Mitotic Motor Protein in Blast Crisis CML: Overcoming Imatinib Resistance.
Bone Resorption
Tctex-1, a Novel Interaction Partner of Rab3D, Is Required for Osteoclastic Bone Resorption.
Brain Injuries, Traumatic
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Brain Ischemia
Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia.
Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice.
[Effect of hypothermia on activities of tubule motor protein and constructure protein after cerebral ischemia in gerbils].
Breast Neoplasms
Biochemical and structural characterization of the Pak1-LC8 interaction.
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Bronchiectasis
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
Inherited factors in diffuse bronchiectasis in the adult: a prospective study.
Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Bronchitis
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
[Results of nasal brushing in the study of ciliary conformation and function in chronic bronchopneumopathies in childhood]
Bronchopneumonia
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Bulbo-Spinal Atrophy, X-Linked
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Carcinogenesis
Corrigendum: Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression.
Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis.
Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein.
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.
Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
Carcinoma
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Carcinoma, Hepatocellular
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.
Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis.
Carcinoma, Ovarian Epithelial
Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74.
Carcinoma, Renal Cell
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Cardiomyopathies
Deciphering the super relaxed state of human ?-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Size and speed of the working stroke of cardiac myosin in situ.
Cardiomyopathy, Hypertrophic
Myosin VI Is a Mediator of the p53-Dependent Cell Survival Pathway.
The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.
Cardiomyopathy, Hypertrophic, Familial
Altered myocyte contractility and calcium homeostasis in alpha-myosin heavy chain point mutations linked to familial dilated cardiomyopathy.
In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy.
Charcot-Marie-Tooth Disease
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
iMotor-CNN: Identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule.
Motor neurons rely on motor proteins.
Cholangitis, Sclerosing
Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.
Cholestasis, Intrahepatic
A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations.
Ciliary Motility Disorders
A New Tool Improves Diagnostic Test Performance for Transmission EM Evaluation of Axonemal Dynein Arms.
A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.
Abnormal central complex is a marker of severity in the presence of partial ciliary defect.
Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia.
Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome).
Axonemal Localization of the Dynein Component DNAH5 Is Not Altered in Secondary Ciliary Dyskinesia.
Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure.
Biochemical and molecular characterization of diseases linked to motor proteins.
CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.
CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.
CFAP300: Mutations in Slavic Primary Ciliary Dyskinesia Patients and a Role in Ciliary Dynein Arms Trafficking.
Characterization of the medaka (Oryzias latipes) primary ciliary dyskinesia mutant, jaodori: Redundant and distinct roles of dynein axonemal intermediate chain 2 (dnai2) in motile cilia.
Ciliary beating recovery in deficient human airway epithelial cells after lentivirus ex vivo gene therapy.
Ciliary Dyneins and Dynein Related Ciliopathies.
Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: advantages of ciliogenesis in culture.
Ciliary function and motor protein composition of human fallopian tubes.
Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm.
Computer-assisted analysis helps detect inner dynein arm abnormalities.
Cytoplasmic factories for axonemal dynein assembly.
Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects.
Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia.
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.
DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects.
DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.
Genetic heterogeneity of dynein-deficiency in cilia from patients with respiratory disease.
Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia.
Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate gene.
Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia.
Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.
Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.
Immotile cilia syndrome in children.
Inherited factors in diffuse bronchiectasis in the adult: a prospective study.
Inner dynein arm defects causing Primary Ciliary Dyskinesia: Repeat testing required.
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.
Loss-of-function mutations in CCDC114 cause primary ciliary dyskinesia.
Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia.
Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia.
LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm Defects.
Microtubular protofilaments and subunits of the outer dynein arm in cilia from dogs with primary ciliary dyskinesia.
Motor domain-based motility system and motile properties of alpha heavy chain in Tetrahymena outer arm dynein.
Mouse dynein axonemal intermediate chain 2: cloning and expression.
Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.
Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.
Mutations in SPAG1 Cause Primary Ciliary Dyskinesia Associated with Defective Outer and Inner Dynein Arms.
Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Normal ciliary ultrastructure in children with Kartagener's syndrome.
Novel dynein axonemal assembly factor 1 mutations identified using whole?exome sequencing in patients with primary ciliary dyskinesia.
Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD).
Primary ciliary dyskinesia in the dog.
Primary ciliary dyskinesia: diagnosis in children with inconclusive ultrastructural evaluation.
Repetitive ejaculation before intracytoplasmic sperm injection in patients with absolute immotile spermatozoa.
Respiratory distress in a newborn with primary ciliary dyskinesia, situs inversus and Turner syndrome.
Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.
Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease.
Teratozoospermia: spotlight on the main genetic actors in the human.
Testing ciliary activity in patients with chronic and recurrent infections of the upper airways: experiences in 68 cases.
The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia.
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
The Oligomeric Outer Dynein Arm Assembly Factor CCDC103 is Tightly Integrated within the Ciliary Axoneme and Exhibits Periodic Binding to Microtubules.
TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.
TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.
Two novel mutations in the DNAH11 gene in primary ciliary dyskinesia (CILD7) with considerable variety in the clinical and beating cilia phenotype.
Ultrastructural abnormalities of cilia in the human respiratory tract.
Ultrastructural diagnosis in the immotile cilia syndrome.
Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture.
Ultrastructural study of immotile cilia syndrome.
Utilization of digital image processing to study dynein arms (ATPase) in normal and immotile cilia.
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3.
ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
[Genetically Determined and Functional Human Sperm Motility Decrease].
[Immotile cilia syndrome]
[Kartagener syndrome with lung cancer and mediastinal tumor]
[The absence of the internal arms of dynein as a cause of the immotile cilia syndrome]
[The Kartagener syndrome]
Ciliopathies
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Ciliary Dyneins and Dynein Related Ciliopathies.
Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Structure of human cytoplasmic dynein-2 primed for its power stroke.
Subunit composition of the human cytoplasmic dynein-2 complex.
Classical Lissencephalies and Subcortical Band Heterotopias
A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis.
Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.
Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry.
Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract.
N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration.
NuMA1 promotes axon initial segment assembly through inhibition of endocytosis.
Regulators of the cytoplasmic dynein motor.
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
The phospholipase complex PAFAH Ib regulates the functional organization of the Golgi complex.
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.
Colonic Neoplasms
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Colorectal Neoplasms
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Confusion
Ciliary ultrastructure and nasal mucociliary clearance in chronic and allergic rhinitis.
Electron microscopy assessment of the recovery of sinus mucosa after sinus surgery.
Ultrastructural ciliary findings in nasal obstructive diseases.
[Ultrastructural changes of the nasal mucosa in primary ciliary dyskinesia]
Congenital Abnormalities
Ciliary dyskinesis: the immotile cilia syndrome.
Cystic Fibrosis
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
Ultrastructural features of respiratory cilia in cystic fibrosis.
Cysts
Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton.
Cutaneous ciliated cyst: a case report with immunohistochemical evidence for dynein in ciliated cells.
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
Retrograde Intraflagellar Transport by Cytoplasmic Dynein-2 is Required for Outer Segment Extension in Vertebrate Photoreceptors but not Arrestin Translocation.
Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila.
The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila.
Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.
Cytomegalovirus Infections
Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations.
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
Extraintestinal manifestations in an infant with microvillus inclusion disease: complications or features of the disease?
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection.
Deafness
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.
Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a.
Myosin VI Is a Mediator of the p53-Dependent Cell Survival Pathway.
Myosin VI is required for E-cadherin-mediated border cell migration.
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes.
Decompression Sickness
Computer simulation of flagellar movement: VII. Conventional but functionally different cross-bridge models for inner and outer arm dyneins can explain the effects of outer arm dynein removal.
Different structural states of a microtubule cross-linking molecule, captured by quick-freezing motile axostyles in protozoa.
Dynein heavy chain isoforms and axonemal motility.
Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.
How molecular motors shape the flagellar beat.
Induction of temporary beating in paralyzed flagella of Chlamydomonas mutants by application of external force.
Methods for analysis of calcium/calmodulin signaling in cilia and flagella.
Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis.
The reactivation of demembranated human spermatozoa lacking outer dynein arms is independent of pH.
Transient Pinning and Pulling: A Mechanism for Bending Microtubules.
Dehydration
Role of the ERK signaling pathway in regulating vasopressin secretion in dehydrated rats.
Dementia
Dynactin is involved in Lewy body pathology.
Dengue
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Dextrocardia
Ciliary ultrastructure in primary ciliary dyskinesia and other chronic respiratory conditions: the relevance of microtubular abnormalities.
Immotile cilia syndrome in children.
[Primary ciliary dyskinesia, immotile cilia syndrome, and Kartagener syndrome: diagnostic criteria]
Diabetes Mellitus, Type 1
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.
Down Syndrome
Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model.
Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
dynein atpase deficiency
A case of severe asthenozoospermia: a novel sperm tail defect of possible genetic origin identified by electron microscopy and immunocytochemistry.
Cilia motility and structure in primary and secondary ciliary dyskinesia.
Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: advantages of ciliogenesis in culture.
Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease.
The effects of ropy-1 mutation on cytoplasmic organization and intracellular motility in mature hyphae of Neurospora crassa.
The secondary nature of ciliary (dis)orientation in secondary and primary ciliary dyskinesia.
Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture.
[Immotile cilia syndrome. Presentation of 3 cases]
[The Kartagener syndrome]
Dyskinesias
Human oocyte cytometry and fertilisation rate after subzonal insemination.
Influence of sperm movement parameters on human sperm-oolemma fusion.
Pregnancy after subzonal insemination with spermatozoa lacking outer dynein arms.
Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly.
The dyskinetic cilia syndrome in childhood. Modifications of ultrastructural patterns.
Dyslexia
Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.
Ear Diseases
Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
Encephalitis, Japanese
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Familial Primary Pulmonary Hypertension
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.
Fibrosarcoma
Arf6, JIP3, and dynein shape and mediate macropinocytosis.
Genetic Diseases, Inborn
Lack of dynein arms in immotile human spermatozoa.
Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly.
[The absence of the internal arms of dynein as a cause of the immotile cilia syndrome]
Glaucoma
Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma.
The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells.
Glioblastoma
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma.
Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide.
Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope.
Glioma
Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation.
Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
The effects of dynein inhibition on the autophagic pathway in glioma cells.
Glucose Intolerance
Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
Hearing Loss
A novel MYO6 splice site mutation causes autosomal dominant sensorineural hearing loss type DFNA22 with a favourable outcome after cochlear implantation.
Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear.
Echolocating Whales and Bats Express the Motor Protein Prestin in the Inner Ear: A Potential Marker for Hearing Loss.
High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss.
Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss.
Hearing Loss, Sensorineural
Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System.
Hepatitis B
The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids.
Hepatitis C
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
Herpes Simplex
Coupling viruses to dynein and kinesin-1.
Function of dynein and dynactin in herpes simplex virus capsid transport.
Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A.
The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
Herpes Zoster
Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement.
Heterotaxy Syndrome
A novel mutation of the axonemal dynein heavy chain gene 5 (DNAH5) in a Japanese neonate with asplenia syndrome.
Homozygous Familial Hypercholesterolemia
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Huntington Disease
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Cytoplasmic dynein in neurodegeneration.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.
Role of Dynein Axonemal Heavy Chain 6 Gene Expression as a Possible Biomarker for Huntington's Disease: a Translational Study.
Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKC?, a case study.
Hydatidiform Mole
Absent inner dynein arms in a fetus with familial hydrocephalus-situs abnormality.
Hydrocephalus
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.
Absent inner dynein arms in a fetus with familial hydrocephalus-situs abnormality.
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation.
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Hypercholesterolemia
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Hypersensitivity
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Mutations in genes encoding inner arm dynein heavy chains in Tetrahymena thermophila lead to axonemal hypersensitivity to Ca2+.
Hypothyroidism
Effect of thyroid hormone T3 on Myosin-Va expression in the central nervous system.
Infections
A "Driver Switchover" Mechanism of Influenza Virus Transport from Microfilaments to Microtubules.
A geminivirus replication protein interacts with a protein kinase and a motor protein that display different expression patterns during plant development and infection.
Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.
Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis.
Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection.
Cellular and Viral Determinants of HSV-1 Entry and Intracellular Transport towards Nucleus of Infected Cells.
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Chlamydia trachomatis utilizes the host cell microtubule network during early events of infection.
Ciliary Dyneins and Dynein Related Ciliopathies.
Ciliary ultrastructure in experimental sinusitis.
Cloning and characterization of cytoplasmic dynein intermediate chain in Fenneropenaeus chinensis and its essential role in white spot syndrome virus infection.
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Dynein and dynein-related genes.
Dynein engages and disassembles cytosol-localized SV40 to promote infection.
Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry.
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection.
Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells.
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.
Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo.
Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus.
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase (Salmonella typhimurium) and protective antigen (Bacillus anthraci) might be the potential cause of human infection.
Intracellular trafficking pathway of BK Virus in human renal proximal tubular epithelial cells.
Large-Scale Comparative Analysis of Codon Models Accounting for Protein and Nucleotide Selection.
Microtubules and Dynein Regulate Human Neutrophil Nuclear Volume and Hypersegmentation During H. pylori Infection.
Neonatal cilia: ultrastructure.
Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection.
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique.
Role of cytoplasmic dynein and kinesins in adenovirus transport.
Role of Microtubules and Microtubule-Associated Proteins in HIV-1 Infection.
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection.
The dynactin complex enhances the speed of microtubule-dependent motions of adenovirus both towards and away from the nucleus.
The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.
The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection.
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Two cases of primary ciliary dyskinesia with different responses to macrolide treatment.
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Infertility
A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus.
An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers.
Ciliary Dyneins and Dynein Related Ciliopathies.
Cytoplasmic factories for axonemal dynein assembly.
DNAH1 gene mutations and their potential association with dysplasia of the sperm fibrous sheath and infertility in the Han Chinese population.
Identification of a germ-cell-specific transcriptional repressor in the promoter of Tctex-1.
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.
tctex-1: a candidate gene family for a mouse t complex sterility locus.
The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein.
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Infertility, Female
Cytoplasmic dynein function is essential in Drosophila melanogaster.
Infertility, Male
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.
An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers.
Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.
Drosophila Dynein intermediate chain gene, Dic61B, is required for spermatogenesis.
Drosophila melanogaster kl-3 and kl-5 Y-loops harbor triple-stranded nucleic acids.
ENU-induced mutant allele of Dnah1, ferf1, causes abnormal sperm behavior and fertilization failure in mice.
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.
Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Pregnancy after subzonal insemination with spermatozoa lacking outer dynein arms.
Relationship between DYNLT1 and Beclin1 expression and the fertilising potential of human spermatozoa.
tctex-1: a candidate gene family for a mouse t complex sterility locus.
The murine Dnali1 gene encodes a flagellar protein that interacts with the cytoplasmic dynein heavy chain 1.
The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.
Whole-exome sequencing of familial cases of multiple morphological abnormalities of the sperm flagella (MMAF) reveals new DNAH1 mutations.
Inflammatory Bowel Diseases
Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum.
The association of MYO9B gene in Italian patients with inflammatory bowel diseases.
Influenza, Human
Immunohistochemistry of a cytoplasmic dynein (MAP 1C)-like molecule in rodent and human brain tissue: an example of molecular mimicry between cytoplasmic dynein and influenza A virus.
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
Role of the actin cytoskeleton during influenza virus internalization into polarized epithelial cells.
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Insulin Resistance
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.
Intellectual Disability
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
Native disorder mediates binding of dynein to NudE and dynactin.
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
The clinical-phenotype continuum in DYNC1H1-related disorders-genomic profiling and proposal for a novel classification.
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.
Ischemic Stroke
Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
Kartagener Syndrome
Amyotrophic lateral sclerosis in a patient with Kartagener syndrome.
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Cell motility and microtubules in cultured fibroblasts from patients with Kartagener syndrome.
Ciliary Dyneins and Dynein Related Ciliopathies.
Ciliary ultrastructure in a child with Kartagener's syndrome. A transmission electron microscopic study using tannic acid staining.
Correlation of absent inner dynein arms and mucociliary clearance in a patient with Kartagener's syndrome.
Dynein and dynein-related genes.
Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.
Kartagener's syndrome with absence of inner dynein arms of respiratory cilia.
Kartagener's syndrome--a reappraisal.
Kartagener's Syndrome.
Kartagener's syndrome: a genetic defect affecting the function of cilia.
Kartagener's syndrome: a re-visit with Chinese perspectives.
Laterality disturbance and hypopituitarism. A case report of co-existing situs inversus totalis and combined pituitary hormone deficiency.
New developments in the diagnosis of Kartagener's syndrome.
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Normal ciliary ultrastructure in children with Kartagener's syndrome.
Primary atrophic rhinitis: a scanning electron microscopic (SEM) study.
Problems in the differential diagnosis of Kartagener's syndrome and ATP-ase deficiency.
Relationship between dynein arms and ciliary motility in Kartagener's syndrome.
Screening for ciliary dyskinesia - a spectrum of defects of motility and structure.
The dyskinetic cilia syndrome. Ciliary motility in immotile cilia syndrome.
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Ultrastructure and function of cilia and spermatozoa flagella in a patient with Kartagener's syndrome.
Ultrastructure of bronchial epithelium in children with chronic or recurrent respiratory diseases.
[Are ciliary abnormalities always present in Kartagener's syndrome? A study of 16 patients]
[Ciliary changes with abscence of dynein arms in Kartagener's syndrome]
[Kartagener syndrome with absence of internal dynein arms. Report of and commentary on a case]
[Primary ciliary dyskinesia, immotile cilia syndrome, and Kartagener syndrome: diagnostic criteria]
Kidney Diseases
iMotor-CNN: Identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule.
Kidney Failure, Chronic
Hypertension-associated kidney disease: perhaps no more.
Leukemia
Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry.
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection.
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein.
Leukemia, Lymphoid
Research progress on neurobiology of neuronal nitric oxide synthase.
Lissencephaly
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.
Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning.
Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation.
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Lis1 Acts as a "Clutch" between the ATPase and Microtubule-Binding Domains of the Dynein Motor.
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
LIS1 at the microtubule plus end and its role in dynein-mediated nuclear migration.
LIS1: cellular function of a disease-causing gene.
Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development.
mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth.
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis.
The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.
TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity.
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?]
[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein]
Lung Diseases
Ciliary Dyneins and Dynein Related Ciliopathies.
Lung Neoplasms
Hepatitis B virus upregulates the expression of kinesin family member 4A.
Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer.
Lymphoma
Interaction of p59fyn kinase with the dynein light chain, Tctex-1, and colocalization during cytokinesis.
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
Lymphoma, B-Cell
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity.
Malformations of Cortical Development
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Malformations of Cortical Development, Group II
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
Melanoma
A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells.
Melanoma dynein: evidence that dynein is a general "motor" for microtubule-associated cell motilities.
Microcephaly
Biallelic variants in KIF14 cause intellectual disability with microcephaly.
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Motor Neuron Disease
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Cytoplasmic dynein in neurodegeneration.
Defective axonal transport in motor neuron disease.
Distal spinal and bulbar muscular atrophy caused by dynactin mutation.
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease.
Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.
Mice with Mutation in Dynein Heavy Chain 1 Do Not Share the Same Tau Expression Pattern with Mice with SOD1-Related Motor Neuron Disease.
Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction.
Motor neurons rely on motor proteins.
Motor protein diseases of the nervous system.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach.
No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.
The Legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.
Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies.
Unraveling the mechanisms involved in motor neuron degeneration in ALS.
Movement Disorders
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice.
Role of Myosin Va in the plasticity of the vertebrate neuromuscular junction in vivo.
Moyamoya Disease
6C.02: EXOME SEQUENCING IN SEVEN FAMILIES AND GENE-BASED ASSOCIATION STUDIES SUPPORT GENETIC HETEROGENEITY AND SUGGEST POSSIBLE CANDIDATES FOR FIBROMUSCULAR DYSPLASIA.
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Multiple Sclerosis
A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Reduced axonal motor protein expression in non-lesional grey matter in multiple sclerosis.
Multiple System Atrophy
Dynactin is involved in Lewy body pathology.
Muscle Weakness
Acute quadriplegic myopathy: an acquired "myosinopathy".
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).
Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.
Muscular Atrophy
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Muscular Atrophy, Spinal
A novel DYNC1H1 mutation causing spinal muscular atrophy with lower extremity predominance.
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
Morphological changes and altered expression of antioxidant proteins in a heterozygous dynein mutant; a mouse model of spinal muscular atrophy.
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy.
Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.
Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding.
The clinical-phenotype continuum in DYNC1H1-related disorders-genomic profiling and proposal for a novel classification.
Muscular Diseases
Accumulation of microtubule-based motor protein in a patient with colchicine myopathy.
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle.
The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).
Muscular Dystrophy, Duchenne
Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin ?/? and CRM1 nuclear transporters and microtubule motor dynein.
Myocardial Ischemia
[Motor protein Kinesin-6 and ischemic heart disease]
Myopathies, Nemaline
[Results of nasal brushing in the study of ciliary conformation and function in chronic bronchopneumopathies in childhood]
Myositis
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies.
Nasal Polyps
An Integrated Analysis of Radial Spoke Head and Outer Dynein Arm Protein Defects and Ciliogenesis Abnormality in Nasal Polyps.
Nasopharyngeal Carcinoma
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Nasopharyngeal Neoplasms
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
Neoplasm Metastasis
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Neoplasms
Altered gene expression in glycolysis-cholesterol synthesis axis correlates with outcome of triple-negative breast cancer.
An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase.
An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
Antitumor activity of a kinesin inhibitor.
Biochemical and structural characterization of the Pak1-LC8 interaction.
Calcium can mobilize and activate myosin-VI.
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.
Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.
Could microtubule inhibitors be the best choice of therapy in gastric cancer with high immune activity: mutant DYNC1H1 as a biomarker.
Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74.
Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses.
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.
Differential gene expression in premalignant human trophoblast: role of IGFBP-5.
Distinct retrograde microtubule motor sets drive early and late endosome transport.
Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression.
Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression.
Dynein function and protein clearance changes in tumor cells induced by a Kunitz-type molecule, Amblyomin-X.
Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Emanuel Strehler's work on calcium pumps and calcium signaling.
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5.
Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein.
High Eg5 expression predicts poor prognosis in breast cancer.
High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
High KIFC1 expression is associated with poor prognosis in prostate cancer.
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint.
Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.
Identification of mRNAs differentially expressed in lymphocytes following interleukin-2 activation.
In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant.
Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression.
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells.
Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.
Kinesin and dynein mechanics: measurement methods and research applications.
Motor protein function in skeletal abdominal muscle of cachectic cancer patients.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Muscle paralysis and myosin loss in a patient with cancer cachexia.
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.
Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.
Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A.
Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein.
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.
Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X.
Spindle multipolarity is prevented by centrosomal clustering.
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Targeting a kinetochore-associated motor protein to kill cancer cells.
The Aurora kinases: role in cell transformation and tumorigenesis.
The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
The prognostic role of Eg5 expression in laryngeal squamous cell carcinoma.
Tumor formation via loss of a molecular motor protein.
Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.
Nephrosis, Lipoid
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Nephrotic Syndrome
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Nervous System Diseases
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Neuroaxonal Dystrophies
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neuroblastoma
Aging attenuates dynactin-dynein interaction: Down-regulation of dynein causes accumulation of endogenous tau and amyloid precursor protein in human neuroblastoma cells.
MiRNA-335 Suppresses Neuroblastoma Cell Invasiveness By Direct Targeting of Multiple Genes from the non-Canonical TGF-? Signalling Pathway.
Neurodegenerative Diseases
A cytoplasmic dynein tail mutation impairs motor processivity.
A novel de novo mutation in DYNC1H1 gene underlying malformation of cortical development and cataract.
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation.
Axonal transport defects: a common theme in neurodegenerative diseases.
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Cytoplasmic dynein in neurodegeneration.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Dynein at odd angles?
Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone.
Dynein motors transport activated Trks to promote survival of target-dependent neurons.
DYNLRB1 is essential for dynein mediated transport and neuronal survival.
Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.
Internal Dynamics of Dynactin CAP-Gly Is Regulated by Microtubules and Plus End Tracking Protein EB1.
Kinesin and dynein mechanics: measurement methods and research applications.
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Mechanism and regulation of cytoplasmic dynein.
Molecular motors in neuronal development, intracellular transport and diseases.
Motor neurons rely on motor proteins.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
Neurofibromatoses
The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.
Neurologic Manifestations
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Neuromuscular Diseases
Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish.
Niemann-Pick Disease, Type C
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.
Oculomotor Nerve Diseases
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Otitis
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Ototoxicity
Salicylate ototoxicity and its implications for cochlear microphonic potential generation.
Ovarian Neoplasms
A transforming growth factor-beta receptor-interacting protein frequently mutated in human ovarian cancer.
Effects of dynein light chain Tctex-type 3 on the biological behavior of ovarian cancer.
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Pancreatic Neoplasms
Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis.
Pancreatitis
The potential role of kinesin and dynein in Golgi scattering and cytoplasmic vacuole formation during acute experimental pancreatitis.
Papillomavirus Infections
Identification of the Dynein Light Chains required for Human Papillomavirus Infection.
Identification of the dynein light chains required for human papillomavirus infection.
Paralysis
Analysis of Ni(2+)-induced arrest of Paramecium axonemes.
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.
Late endosome motility depends on lipids via the small GTPase Rab7.
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms.
Paraplegia
Mutation screen reveals novel variants and expands the phenotypes associated with DYNC1H1.
Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.
Parkinson Disease
Alteration of dynein function affects ?-synuclein degradation via the autophagosome-lysosome pathway.
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Cytoplasmic dynein in neurodegeneration.
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Dynactin is involved in Lewy body pathology.
Mitochondrial quality control in neurodegenerative diseases.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Pemphigoid, Bullous
[Comparison of urinary proteomics between steroid-sensitive and steroid-resistant minimal change nephrotic syndrome in children.]
Peripheral Nervous System Diseases
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
[Changes in expression of motor protein for axonal transport in nerve tissues of carbon disulfide-intoxicated rats].
Persistent Infection
Abnormal central complex is a marker of severity in the presence of partial ciliary defect.
Pheochromocytoma
Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
Pneumonia
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production.
Pneumonia, Viral
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Polycystic Kidney Diseases
Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Polycystic Kidney, Autosomal Dominant
The ubiquitin conjugation system is involved in the disassembly of cilia and flagella.
Polydactyly
Mutations in DYNC2H1, the cytoplasmic dynein 2, heavy chain 1 motor protein gene, cause short-rib polydactyly type I, Saldino-Noonan type.
Polymicrogyria
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
Pregnancy, Ectopic
Using dynein heavy chain 5 and creatine kinase levels in cervical fluid and blood for early diagnosing of ectopic pregnancy.
Prion Diseases
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Prostatic Neoplasms
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression.
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
Pseudomonas Infections
Two cases of primary ciliary dyskinesia with different responses to macrolide treatment.
Pseudorabies
Coupling viruses to dynein and kinesin-1.
The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion.
The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.
Pulmonary Disease, Chronic Obstructive
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.
Of dung and dynein arms: understanding COPD in nonsmokers.
Rabies
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.
Comparative pathogenesis of the SAD-L16 strain of rabies virus and a mutant modifying the dynein light chain binding site of the rabies virus phosphoprotein in young mice.
Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein.
Dynein light chain association sequences can facilitate nuclear protein import.
Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein.
High throughput differentiation and screening of a library of mutant stem cell clones defines new host-based genes involved in rabies virus infection.
Interaction of the rabies virus P protein with the LC8 dynein light chain.
Molecular basis for the interaction between rabies virus phosphoprotein P and the dynein light chain LC8: dissociation of dynein-binding properties and transcriptional functionality of P.
The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription.
Respiratory Tract Infections
Dynein and dynein-related genes.
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Retinitis Pigmentosa
Mutations in DNAH5 account for only 15% of a non-preselected cohort of patients with primary ciliary dyskinesia.
Primary atrophic rhinitis: a scanning electron microscopic (SEM) study.
Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1.
RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa.
Retinoblastoma
Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint.
Rhinitis
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
Rotavirus Infections
Rotavirus viroplasm biogenesis involves microtubule-based dynein transport mediated by an interaction between NSP2 and dynein intermediate chain.
Sarcoma
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.
Scoliosis
Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.
Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Scrapie
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Seizures
Pharmacogenetic Analysis Reveals a Post-Developmental Role for Rac GTPases in Caenorhabditis elegans GABAergic Neurotransmission.
Sinusitis
Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Situs Inversus
Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome).
Dynein and dynein-related genes.
Function and morphology of respiratory cilia in situs inversus.
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Mutation analysis in patients with total sperm immotility.
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.
Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Primary ciliary dyskinesia: a genome-wide linkage analysis reveals extensive locus heterogeneity.
Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.
Reflection of structural abnormality in the axoneme of respiratory cilia in the clinical features of immotile cilia syndrome.
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
[Ultrastructural study of bronchial mucosa in suspicion of ciliary dyskinesia]
Spastic Paraplegia, Hereditary
A Novel Mutation in Motor Domain of KIF5A Associated With an HSP/Axonal Neuropathy Phenotype.
Generation of the CRISPR/Cas9-mediated KIF1C knock-out human iPSC line HIHRSi003-A-1.
Motor neurons rely on motor proteins.
Motor protein mutations cause a new form of hereditary spastic paraplegia.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Theoretical Investigations of the Role of Mutations in Dynamics of Kinesin Motor Proteins.
Starvation
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.
Regulation of the intracellular distribution of cytoplasmic dynein by serum factors and calcium.
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers.
Stomach Neoplasms
Somatic mutation of DNAH genes implicated higher chemotherapy response rate in gastric adenocarcinoma patients.
Stroke
A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules.
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale.
ATP hydrolysis cycle-dependent tail motions in cytoplasmic dynein.
Calcium-dependent bidirectional power stroke of the dynein arms in sea urchin sperm axonemes.
Coarse-grained modeling of the structural states and transition underlying the powerstroke of dynein motor domain.
Complex movements of motor protein relay helices during the power stroke.
Does axonemal dynein push, pull, or oscillate?
Dynamics of Allosteric Transitions in Dynein.
Dynein structure and power stroke.
Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.
Early stages of the recovery stroke in myosin II studied by molecular dynamics simulations.
Energetic considerations of ciliary beating and the advantage of metachronal coordination.
Forces applied by cilia measured on explants from mucociliary tissue.
Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein.
Mechanochemical Model of the Power Stroke of the Single-Headed Motor Protein KIF1A.
Overview of the mechanism of cytoskeletal motors based on structure.
Slow axonemal dynein e facilitates the motility of faster dynein c.
Splitting the ciliary axoneme: implications for a "switch-point" model of dynein arm activity in ciliary motion.
Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers.
Structural mechanism of the dynein power stroke.
Structure of human cytoplasmic dynein-2 primed for its power stroke.
Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.
The mechanism of the converter domain rotation in the recovery stroke of myosin motor protein.
The motor protein myosin-I produces its working stroke in two steps.
Three-dimensional structure of cytoplasmic dynein bound to microtubules.
Twirling motion of actin filaments in gliding assays with nonprocessive Myosin motors.
Two independent switches regulate cytoplasmic dynein's processivity and directionality.
Two modes of microtubule sliding driven by cytoplasmic dynein.
Working strokes by single molecules of the kinesin-related microtubule motor ncd.
[Lever-arm motion and power stroke in myosin motor protein]
Sunburn
Role of cytoplasmic dynein in melanosome transport in human melanocytes.
Superinfection
[Ciliary disorders of the bronchi in children]
Teratozoospermia
Teratozoospermia: spotlight on the main genetic actors in the human.
Tetanus
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
Trypanosomiasis, African
Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.
tubulin gtpase deficiency
Scanning electron microscopy and human sperm pathology.
tubulin-glutamate ligase deficiency
Tubulin glutamylation regulates ciliary motility by altering inner dynein arm activity.
Urinary Bladder Neoplasms
Role of a Kinesin Motor in Cancer Cell Mechanics.
Usher Syndromes
Human myosin VIIa is a very slow processive motor protein on various cellular actin structures.
Primary atrophic rhinitis: a scanning electron microscopic (SEM) study.
Vaccinia
Coupling viruses to dynein and kinesin-1.
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.
Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin.
Virus Diseases
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
Cloning and characterization of cytoplasmic dynein intermediate chain in Fenneropenaeus chinensis and its essential role in white spot syndrome virus infection.
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection.
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP.
Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.
Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique.
Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein.
Smoke and viral infection cause cilia loss detectable by bronchoalveolar lavage cytology and dynein ELISA.
The association of viral proteins with host cell dynein components during virus infection.
The dynein microtubule motor: architecture and force generation, cellular roles of dynein light chain DYNLL and role of dynein during virus infection.
Williams Syndrome
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.