Reference on EC 5.4.99.8 - cycloartenol synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Taton, M.; Benveniste, P.; Rahier, A.
N-[(1,5,9)-Trimethyl-decyl]-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases
Biochem. Biophys. Res. Commun.
138
764-770
1986
Zea mays
Rees, H.H.; Goad, L.J.; Goodwin, T.W.
2,3-Oxidosqualene cycloartenol cyclase from Ochromonas malhamensis
Biochim. Biophys. Acta
176
892-894
1969
Ochromonas malhamensis
Beastall, G.H.; Rees, H.H.; Goodwin, T.W.
Properties of a 2,3-oxidosqualene-cycloartenol cyclase from Ochromonas malhamensis
FEBS Lett.
18
175-178
1971
Ochromonas malhamensis
Fang, T.Y.; Baisted, D.J.
2,3-Oxidosqualene cyclase and cycloartenol-S-adenosylmethionine methyltransferase activities in vivo the cotyledon and axis tissues of germinating pea seeds
Biochem. J.
150
323-328
1975
Pisum sativum
Cattel, L.; Anding, C.; Benveniste, P.
Cyclisation of 1-trans-1'-norsqualene-2,3-epoxide and 1-cis-1'-norsqualene-2,3-epoxide by a cell free system of corn embryos
Phytochemistry
15
931-935
1976
Zea mays
-
Delprino, L.; Balliano, G.; Cattel, L.; Benveniste, P.; Bouvier, P.
Inhibition of higher plant 2,3-oxidosqualene cyclase by 2-aza-2,3-dihydrosqualene and its derivatives
J. Chem. Soc. Chem. Commun.
1983
381-382
1983
Pisum sativum
-
Taton, M.; Benveniste, P.; Rahier, A.; Johnson, W.S.; Liu, H.; Sudhakar, A.R.
Inhibition of 2,3-oxidosqualene cyclases
Biochemistry
31
7892-7898
1992
Zea mays
Morita, M.; Shibuya, M.; Lee, M.S.; Sankawa, U.; Ebizuka, Y
Molecular cloning of pea cDNA encoding cycloartenol synthase and its functional expression in yeast
Biol. Pharm. Bull.
20
770-775
1997
Pisum sativum
Abe, I.; Ebizuka, Y.; Sankawa, U.
Purification of 2,3-oxidosqualene:cycloartenol cyclase from pea seedlings
Chem. Pharm. Bull.
36
5031-5034
1988
Pisum sativum
-
Abe, I.; Sankawa, U.; Ebizuka, Y.
Purification and properties of squalene-2,3-epoxide cyclase from pea seedlings
Chem. Pharm. Bull.
40
1755-1760
1992
Pisum sativum
-
Fenner, G.P.; Raphiou, I.
Growth of Cucurbita maxima L. plants in the presence of the cycloartenol synthase inhibitor U18666A
Lipids
30
253-256
1995
Cucurbita maxima
Corey, E.J.; Matsuda, S.P.T.; Bartel, B.
Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen
Proc. Natl. Acad. Sci. USA
90
11628-11632
1993
Arabidopsis thaliana
Abe, I.; Ebizuka, Y.; Seo, S.; Sankawa, U.
Purification of squalene-2,3-epoxide cyclase from cell suspension cultures of Rabdosia japonica Hara
FEBS Lett.
249
100-104
1989
Isodon japonicus
-
Schmitt, P.; Gonzales, R.; Benveniste, P.; Cerutti, M.; Cattel, L.
Inhibition of sterol biosynthesis and accumulation of 2,3-oxidosqualene in bramble cell suspension cultures treated with 2-aza-2,3-dihydro-squalene and 2-aza-2,3-dihydrosqualene-N-oxide
Phytochemistry
26
2709-2714
1987
Rubus plicatus
-
Godzina, S.M.; Lovato, M.A.; Meyer, M.M.; Foster, K.A.; Wilson, W.K.; Gu, W.; de Hostos, E.L.; Matsuda, S.P.
Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA
Lipids
35
249-255
2000
Dictyostelium discoideum
Matsuda, S.P.; Darr, L.B.; Hart, E.A.; Herrera, J.B.; McCann, K.E.; Meyer, M.M.; Pang, J.; Schepmann, H.G.
Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation
Org. Lett.
2
2261-2263
2000
Arabidopsis thaliana
Segura, M.J.; Lodeiro, S.; Meyer, M.M.; Patel, A.J.; Matsuda, S.P.
Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis
Org. Lett.
4
4459-4462
2002
Arabidopsis thaliana
Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M.; Ebizuka, Y.
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra
Biol. Pharm. Bull.
27
1086-1092
2004
Glycyrrhiza glabra (Q9SXV6), Glycyrrhiza glabra
Kim, O.T.; Kim, M.Y.; Hwang, S.J.; Ahn, J.C.; Hwang, B.
Cloning and molecular analysis of cDNA encoding cycloartenol synthase from Centella asiatica (L.) urban
Biotechnol. Bioprocess Eng.
10
16-22
2005
Centella asiatica
-
Lodeiro, S.; Segura, M.J.R.; Stahl, M.; Schulz-Gasch, T.; Matsuda, S.P.T.
Oxidosqualene cyclase second-sphere residues profoundly influence the product profile
ChemBioChem
5
1581-1585
2004
Arabidopsis thaliana (P38605)
Lodeiro, S.; Schulz-Gasch, T.; Matsuda, S.P.T.
Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase
J. Am. Chem. Soc.
127
14132-14133
2005
Arabidopsis thaliana
Kolesnikova, M.D.; Xiong, Q.; Lodeiro, S.; Hua, L.; Matsuda, S.P.
Lanosterol biosynthesis in plants
Arch. Biochem. Biophys.
447
87-95
2006
Arabidopsis thaliana
Guhling, O.; Hobl, B.; Yeats, T.; Jetter, R.
Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis
Arch. Biochem. Biophys.
448
60-72
2006
Ricinus communis (Q2XPU6), Ricinus communis
Basyuni, M.; Oku, H.; Tsujimoto, E.; Baba, S.
Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce
Biosci. Biotechnol. Biochem.
71
1788-1792
2007
Rhizophora stylosa (A7BJ35), Rhizophora stylosa, Kandelia candel (A7BJ36), Kandelia candel
Sawai, S.; Akashi, T.; Sakurai, N.; Suzuki, H.; Shibata, D.; Ayabe, S.; Aoki, T.
Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes
Plant Cell Physiol.
47
673-677
2006
Lotus japonicus
Sawai, S.; Shindo, T.; Sato, S.; Kaneko, T.; Tabata, S.; Ayabe, S.; Aoki, T.
Functional and structural analysis of genes encoding oxidosqualene cyclases of Lotus japonicus
Plant Sci.
170
247-257
2006
Lotus japonicus
Shinozaki, J.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
Squalene cyclase and oxidosqualene cyclase from a fern
FEBS Lett.
582
310-318
2008
Adiantum capillus-veneris (A8R7G3), Adiantum capillus-veneris
Babiychuk, E.; Bouvier-Nave, P.; Compagnon, V.; Suzuki, M.; Muranaka, T.; Van Montagu, M.; Kushnir, S.; Schaller, H.
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis
Proc. Natl. Acad. Sci. USA
105
3163-3168
2008
Arabidopsis thaliana
Ohyama, K.; Suzuki, M.; Kikuchi, J.; Saito, K.; Muranaka, T.
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
725-730
2009
Arabidopsis thaliana
Hu, F.; Zhong, J.
Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate
Process Biochem.
43
113-118
2008
Panax notoginseng (A8UHA2)
-
Kim, O.; Bang, K.; Kim, Y.; Hyun, D.; Kim, M.; Cha, S.
Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate
Plant Cell Tissue Organ Cult.
98
25-33
2009
Panax ginseng (O82139)
-
Liang, Y.; Zhao, S.; Zhang, X.
Antisense suppression of cycloartenol synthase results in elevated ginsenoside levels in Panax ginseng hairy roots
Plant Mol. Biol. Rep.
27
298-304
2009
Panax ginseng (O82139)
-
Wang, Z.; Yeats, T.; Han, H.; Jetter, R.
Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids
J. Biol. Chem.
285
29703-29712
2010
Kalanchoe daigremontiana
Ito, R.; Mori, K.; Hashimoto, I.; Nakano, C.; Sato, T.; Hoshino, T.
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases
Org. Lett.
13
2678-2681
2011
Oryza sativa (Q6Z2X6)
Dhar, N.; Rana, S.; Razdan, S.; Bhat, W.W.; Hussain, A.; Dhar, R.S.; Vaishnavi, S.; Hamid, A.; Vishwakarma, R.; Lattoo, S.K.
Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) Dunal
J. Biol. Chem.
289
17249-17267
2014
Withania somnifera (D6R1X1), Withania somnifera, Withania somnifera WS-Y-08 (D6R1X1)
Zhao, H.; Tang, Q.; Mo, C.; Bai, L.; Tu, D.; Ma, X.
Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii
Acta Pharm. Sin. B
7
215-222
2017
Siraitia grosvenorii (K7NBR1), Siraitia grosvenorii
Jin, M.; Lee, W.; Kim, O.
Two cycloartenol synthases for phytosterol biosynthesis in Polygala tenuifolia willd
Int. J. Mol. Sci.
18
2426-2437
2017
Polygala tenuifolia (A9QW75), Polygala tenuifolia (A9QW77)
Gas-Pascual, E.; Simonovik, B.; Heintz, D.; Bergdoll, M.; Schaller, H.; Bach, T.J.
Inhibition of cycloartenol synthase (CAS) function in tobacco BY-2 cell suspensions a proteomic analysis
Lipids
50
773-784
2015
Nicotiana tabacum (A0A0A1ER86), Nicotiana tabacum
Yang, Y.; Ge, F.; Sun, Y.; Liu, D.; Chen, C.
Strengthening triterpene saponins biosynthesis by over-expression of farnesyl pyrophosphate synthase gene and RNA interference of cycloartenol synthase gene in Panax notoginseng cells
Molecules
22
581-592
2017
Panax notoginseng (A8UHA2), Panax notoginseng
Mishra, S.; Bansal, S.; Mishra, B.; Sangwan, R.S.; Asha, R.S.; Jadaun, J.S.; Sangwan, N.S.
RNAi and homologous overexpression based functional approaches reveal triterpenoid synthase gene-cycloartenol synthase is involved in downstream withanolide biosynthesis in Withania somnifera
PLoS ONE
11
e0149691
2016
Withania somnifera (D6R1X1), Withania somnifera
Calegario, G.; Pollier, J.; Arendt, P.; de Oliveira, L.S.; Thompson, C.; Soares, A.R.; Pereira, R.C.; Goossens, A.; Thompson, F.L.
Cloning and functional characterization of cycloartenol synthase from the red seaweed Laurencia dendroidea
PLoS ONE
11
e0165954
2016
Laurencia dendroidea (A0A1I9Q605), Laurencia dendroidea
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