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Information on EC 5.4.2.1 - phosphoglycerate mutase for references in articles please use BRENDA:EC5.4.2.1
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EC Tree
Synonyms
pgm, pgam,
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DPGM
-
-
independent PGM
the enzyme requires 2,3-bisphosphoglycerate as a cofactor
independent PGM
the enzyme requires 2,3-bisphosphoglycerate as a cofactor
iPGM
the enzyme requires 2,3-bisphosphoglycerate as a cofactor
iPGM
the enzyme requires 2,3-bisphosphoglycerate as a cofactor
PGM
-
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2-phospho-D-glycerate
3-phospho-D-glycerate
3-phospho-D-glycerate
2-phospho-D-glycerate
2-phospho-D-glycerate
3-phospho-D-glycerate
-
-
-
r
2-phospho-D-glycerate
3-phospho-D-glycerate
-
-
-
r
3-phospho-D-glycerate
2-phospho-D-glycerate
-
-
-
r
3-phospho-D-glycerate
2-phospho-D-glycerate
-
-
-
-
?
3-phospho-D-glycerate
2-phospho-D-glycerate
-
-
-
-
?
3-phospho-D-glycerate
2-phospho-D-glycerate
-
-
-
r
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additional information
2,3-bisphosphoglycerate is not required as a cofactor
-
additional information
2,3-bisphosphoglycerate is not required as a cofactor
-
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metavanadate
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less than 5% residual activity at 10 mM after 10 min incubation
-
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2,3-bisphosphoglyceric acid
-
dependent on 2,3-bisphosphoglyceric acid for activity
Cysteine hydrochloride
-
phosphoglycerate mutase activity requires the reductant dithiothreitol, cysteine hydrochloride, or glutathione for full activity
dithiothreitol
-
phosphoglycerate mutase activity requires the reductant dithiothreitol, cysteine hydrochloride, or glutathione for full activity
glutathione
-
phosphoglycerate mutase activity requires the reductant dithiothreitol, cysteine hydrochloride, or glutathione for full activity
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0.55 - 1.03
3-phospho-D-glycerate
0.55
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
0.58
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
1.03
3-phospho-D-glycerate
-
in triethanol-HCl buffer (125 mM, pH 7.2, 5 mM MgCl2, 10 mM KCl), 0.1 mM 2,3-bisphosphoglyceric acid, temperature not specified in the publication
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102 - 3200
3-phospho-D-glycerate
102
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
132
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
3200
3-phospho-D-glycerate
-
in triethanol-HCl buffer (125 mM, pH 7.2, 5 mM MgCl2, 10 mM KCl), 0.1 mM 2,3-bisphosphoglyceric acid, temperature not specified in the publication
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186 - 228
3-phospho-D-glycerate
186
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
228
3-phospho-D-glycerate
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
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0.078
-
pH 7.5, 37°C, activity in undialyzed cell extracts
71
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
225
in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C
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6.3
calculated from amino acid sequence
7.4
calculated from amino acid sequence
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UniProt
brenda
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brenda
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brenda
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brenda
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UniProt
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malfunction
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knockdown of PGAM1 expression induces cancer cell apoptosis
physiological function
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the enzyme is involved in glycogen catabolism
metabolism
-
despite the low level of PGM present in the cell, the enzyme is not rate limiting for glycolysis in Lactococcus lactis, probably due to a high catalytic processivity
metabolism
-
despite the low level of PGM present in the cell, the enzyme is not rate limiting for glycolysis in Lactococcus lactis, probably due to a high catalytic processivity
-
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Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Mycobacterium leprae (strain Br4923)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Q53WB3
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Q53WB3
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Q53WB3
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
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26000
-
2 * 26000, calculated from amino acid sequence
56000
x * 56000, calculated from amino acid sequence
57000
x * 57000, calculated from amino acid sequence
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?
x * 57000, calculated from amino acid sequence
?
x * 56000, calculated from amino acid sequence
homotetramer
-
2 * 26000, calculated from amino acid sequence
homotetramer
-
2 * 26000, calculated from amino acid sequence
-
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HiTrap nickel chelating column chromatography and HiTrap Q column chromatography
HiTrap nickel chelating column chromatography and HiTrap Q column chromatography
HiTrap nickel chelating column chromatography and HiTrap Q column chromatography
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expressed in Escherichia coli C2566/T7 cells
expressed in Escherichia coli C2566/T7 cells
expressed in Escherichia coli C2566/T7 cells
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phosphoglycerate mutase 1 is markedly upregulated in hepatocellular carcinoma
-
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Solem, C.; Petranovic, D.; Koebmann, B.; Mijakovic, I.; Jensen, P.R.
Phosphoglycerate mutase is a highly efficient enzyme without flux control in Lactococcus lactis
J. Mol. Microbiol. Biotechnol.
18
174-180
2010
Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis IL1403
brenda
Li, Z.; Galvin, B.D.; Raverdy, S.; Carlow, C.K.
Identification and characterization of the cofactor-independent phosphoglycerate mutases of Dirofilaria immitis and its Wolbachia endosymbiont
Vet. Parasitol.
176
350-356
2011
Dirofilaria immitis, Dirofilaria immitis (F4ZE01), Wolbachia endosymbiont of Dirofilaria immitis (F4ZE02)
brenda
Yu, J.P.; Ladapo, J.; Whitman, W.B.
Pathway of glycogen metabolism in Methanococcus maripaludis
J. Bacteriol.
176
325-332
1994
Methanococcus maripaludis
brenda
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