Reference on EC 5.3.99.4 - prostaglandin-I synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McNamara, D.B.; Hussey, J.L.; Kerstein, M.D.; Rosenson, R.S.; Hyman, A.L.; Kadowitz, P.J.
Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes
Biochem. Biophys. Res. Commun.
118
33-39
1984
Bos taurus, Canis lupus familiaris, Ovis aries, Homo sapiens
Haurand, M.; Ullrich, V.
Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis
Front. Biotransform.
6
183-199
1992
Bos taurus, Sus scrofa
-
Wlodawer, P.; Hammarstrm, S.
Some properties of prostacyclin synthase from pig aorta
FEBS Lett.
97
32-36
1979
Sus scrofa
Ham, E.A.; Egan, R.W.; Soderman, D.D.; Gale, P.H.; Kuehl, F.A.
Peroxidase-dependent deactivation of prostacyclin synthetase
J. Biol. Chem.
254
2191-2194
1979
Ovis aries
Terashita, Z.i.; Nishikawa, K.; Terao, S.; Nakagawa, M.; Hino, T.
A specific prostaglandin I2 synthetase inhibitor, 3-hydroperoxy-3-methyl-2-phenyl-3H-indole
Biochem. Biophys. Res. Commun.
91
72-78
1979
Bos taurus
Turk, J.; Wyche, A.; Needlman, P.
Inactivation of vascular prostacyclin synthetase by platelet lipoxygenase products
Biochem. Biophys. Res. Commun.
95
1628-1634
1980
Bos taurus
Beitz, J.; Forster, W.
Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity
Biochim. Biophys. Acta
620
352-355
1980
Sus scrofa
Ullrich, V.; Castle, L.; Weber, P.
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase
Biochem. Pharmacol.
30
2033-2036
1981
Sus scrofa
Salmon, J.A.; Flower, R.J.
Preparation and assay of prostacyclin synthase
Methods Enzymol.
86
91-99
1982
Sus scrofa
DeWitt, D.L.; Smith, W.L.
Monoclonal antibodies against PGI2 synthase: an immunoradiometric assay for quantitating the enzyme
Methods Enzymol.
86
240-246
1982
Bos taurus
Tai, H.H.; Sih, C.J.
Assay of prostacyclin synthase using [5,6-3H]PGH2
Methods Enzymol.
86
99-105
1982
Sus scrofa
Graf, H.; Ullrich, V.
Prostacyclin synthase as a cytochrome P450 enzyme
Dev. Biochem.
23
103-106
1982
Sus scrofa
-
DeWitt, D.L.; Smith, W.L.
Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein
J. Biol. Chem.
258
3285-3293
1983
Bos taurus
Smith, W.L.; DeWitt, D.L.; Day, J.S.
Purification, quantitation, and localization of PGI2 synthase using monoclonal antibodies
Adv. Prostaglandin Thromboxane Leukot. Res.
11
87-92
1983
Bos taurus
Graf, H.; Ruf, H.H.; Ullrich, V.
Die Prostacyclin-Synthase, ein Cytochrom-P450-Enzym
Angew. Chem.
95
497-498
1983
Sus scrofa
-
Hara, S.; Miyata, A.; Yokoyama, C.; Inoue, H.; Brugger, R.; Lottspeich, F.; Ullrich, V.; Tanabe, T.
Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells
J. Biol. Chem.
269
19897-19903
1994
Bos taurus
Lin, Y.Z.; Wu, K.K.; Ruan K.H.
Characterization of the secondary structure and membrane interaction of the putative membrane anchor domains of prostaglandin I2 synthase and cytochrome P450 2C1
Arch. Biochem. Biophys.
352
78-84
1988
Homo sapiens
Ullrich, V.; Brugger, R.
Prostacyclin- und Thromboxan-Synthase, neue Aspekte der Katalyse durch Hmthiolat-Enzyme
Angew. Chem.
106
1987-1996
1994
Bos taurus, Sus scrofa
-
Tanabe, T.; Ullrich, V.
Prostacyclin and thromboxane synthases
J. Lipid Mediat. Cell Signal.
12
243-255
1995
Homo sapiens, Sus scrofa
Ullrich, V.; Brugger, R.; Lottspeich, F.; Siegle, I.
Properties of prostacyclin synthase
Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, (Honn, K. V. et al. , eds. ) Plenum Press New York
2
113-119
1997
Bos taurus
Wade, M.L.; Voelkel, N.F.; Fitzpatrick, F.A.
"Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells
Arch. Biochem. Biophys.
321
435-458
1995
Bos taurus
-
Zou, M.H.; Ullrich, V.
Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase
FEBS Lett.
382
101-104
1996
Bos taurus
Pereira, B.; Wu, K.K.; Wang, L.H.
Bovine prostacyclin synthase: purification and isolation of partial cDNA
Biochem. Biophys. Res. Commun.
197
1041-1048
1993
Bos taurus
Pereira, B.; Wu, K.K.; Wang, L.H.
Molecular cloning and characterization of bovine prostacyclin synthase
Biochem. Biophys. Res. Commun.
203
59-66
1994
Bos taurus
McLennan, I.S.; MacDonald, R.E.
Prostaglandin synthetase and prostacyclin synthetase in mature rat skeletal muscles: immunohistochemical localisation to arterioles, tendons and connective tissues
J. Anat.
178
243-253
1991
Rattus norvegicus
Chegini, N.; Lei, Z.M.; Rao, C.V.
Cellular distribution of prostacyclin synthase and specific prostacyclin binding sites in bovine corpora lutea of pregnancy
Mol. Cell. Endocrinol.
71
133-140
1990
Bos taurus
Zou, M.; Martin, C.; Ullrich, V.
Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite
Biol. Chem.
378
707-713
1997
Homo sapiens
Wade, M.L.; Fitzpatrick, F.A.
Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase
Arch. Biochem. Biophys.
347
174-180
1997
Bos taurus
Deng, H.; Huang, A.; So, S.P.; Lin, Y.Z.; Ruan, K.H.
Substrate access channel topology in membrane-bound prostacyclin synthase
Biochem. J.
362
545-551
2002
Homo sapiens
Ruan, K.H.; Deng, H.; Wu, J.; So, S.P.
The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase
Arch. Biochem. Biophys.
435
372-381
2005
Homo sapiens
Wu, K.K.; Liou, J.Y.
Cellular and molecular biology of prostacyclin synthase
Biochem. Biophys. Res. Commun.
338
45-52
2005
Bos taurus, Homo sapiens, Mus musculus
Yeh, H.C.; Hsu, P.Y.; Wang, J.S.; Tsai, A.L.; Wang, L.H.
Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase
Biochim. Biophys. Acta
1738
121-132
2005
Homo sapiens
Keith, R.L.; Miller, Y.E.; Hudish, T.M.; Girod, C.E.; Sotto-Santiago, S.; Franklin, W.A.; Nemenoff, R.A.; March, T.H.; Nana-Sinkam, S.P.; Geraci, M.W.
Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice
Cancer Res.
64
5897-5904
2004
Rattus norvegicus
Wada, M.; Yokoyama, C.; Hatae, T.; Shimonishi, M.; Nakamura, M.; Imai, Y.; Ullrich, V.; Tanabe, T.
Purification and characterization of recombinant human prostacyclin synthase
J. Biochem.
135
455-463
2004
Homo sapiens
Fang, Y.C.; Wu, J.S.; Chen, J.J.; Cheung, W.M.; Tseng, P.H.; Tam, K.B.; Shyue, S.K.; Lin, T.N.
Induction of prostacyclin/PGI(2) synthase expression after cerebral ischemia-reperfusion
J. Cereb. Blood Flow Metab.
26
491-501
2006
Rattus norvegicus
Kajita, S.; Ruebel, K.H.; Casey, M.B.; Nakamura, N.; Lloyd, R.V.
Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth
Mod. Pathol.
18
221-227
2005
Homo sapiens
Wang, W.; Zolty, E.; Falk, S.; Summer, S.; Stearman, R.; Geraci, M.; Schrier, R.
Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice
Am. J. Physiol. Renal Physiol.
293
F1131-F1136
2007
Rattus norvegicus (Q62969)
Yeh, H.C.; Tsai, A.L.; Wang, L.H.
Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases
Arch. Biochem. Biophys.
461
159-168
2007
Homo sapiens (Q16647), Homo sapiens
Ruan, K.H.; Deng, H.; So, S.P.
Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin
Biochemistry
45
14003-14011
2006
Homo sapiens
Kawka, D.W.; Ouellet, M.; Hetu, P.; Singer, I.I.; Riendeau, D.
Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium
Biochim. Biophys. Acta
1771
45-54
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Poole, E.M.; Bigler, J.; Whitton, J.; Sibert, J.G.; Potter, J.D.; Ulrich, C.M.
Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps
Cancer Epidemiol. Biomarkers Prev.
15
502-508
2006
Homo sapiens
Nie, H.; Wu, J.L.; Zhang, M.; Xu, J.; Zou, M.H.
Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo
Diabetes
55
3133-3141
2006
Bos taurus, Mus musculus
Li, Y.C.; Chiang, C.W.; Yeh, H.C.; Hsu, P.Y.; Whitby, F.G.; Wang, L.H.; Chan, N.L.
Structures of prostacyclin synthase and its complexes with substrate-analog and inhibitor reveal a ligand-specific heme conformation change
J. Biol. Chem.
283
2917-2926
2008
Danio rerio
Griffoni, C.; Spisni, E.; Strillacci, A.; Toni, M.; Bachschmid, M.M.; Tomasi, V.
Selective inhibition of prostacyclin synthase activity by rofecoxib
J. Cell. Mol. Med.
11
327-338
2007
Bos taurus, Homo sapiens
Kengni, J.H.; St-Louis, I.; Parent, S.; Leblanc, V.; Shooner, C.; Asselin, E.
Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids
J. Endocrinol.
195
301-311
2007
Rattus norvegicus
Lee, I.Y.; Cho, W.; Kim, J.; Park, C.S.; Choe, J.
Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases
J. Immunol.
180
1390-1397
2008
Homo sapiens
Camacho, M.; Rodriguez, C.; Salazar, J.; Martinez-Gonzalez, J.; Ribalta, J.; Escudero, J.R.; Masana, L.; Vila, L.
Retinoic acid induces PGI synthase expression in human endothelial cells
J. Lipid Res.
49
1707-1714
2008
Homo sapiens
Pakrasi, P.L.; Jain, A.K.
Cyclooxygenase-2-derived endogenous prostacyclin reduces apoptosis and enhances embryo viability in mouse
Prostaglandins Leukot. Essent. Fatty Acids
79
27-33
2008
Mus musculus
Gillio-Meina, C.; Phang, S.H.; Mather, J.P.; Knight, B.S.; Kennedy, T.G.
Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization
Reproduction
137
537-552
2009
Rattus norvegicus (Q62969)
He, C.; Choi, H.C.; Xie, Z.
Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients
Am. J. Pathol.
176
2542-2549
2010
Homo sapiens
Ishii, M.; Numaguchi, Y.; Okumura, K.; Kubota, R.; Ma, X.; Murakami, R.; Naruse, K.; Murohara, T.
Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia
Atherosclerosis
206
109-118
2009
Rattus norvegicus (Q62969)
Cyrus, T.; Ding, T.; Pratico, D.
Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition
Atherosclerosis
208
376-381
2010
Mus musculus
Yeh, H.C.; Gerfen, G.J.; Wang, J.S.; Tsai, A.L.; Wang, L.H.
Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate
Biochemistry
48
917-928
2009
Homo sapiens (Q16647)
Cathcart, M.C.; Reynolds, J.V.; OByrne, K.J.; Pidgeon, G.P.
The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer
Biochim. Biophys. Acta
1805
153-166
2010
Homo sapiens
Gurgul-Convey, E.; Lenzen, S.
Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells
J. Biol. Chem.
285
11121-11128
2010
Homo sapiens
Hein, T.W.; Qamirani, E.; Ren, Y.; Kuo, L.
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite
J. Mol. Cell. Cardiol.
47
196-202
2009
Sus scrofa
Keith, R.L.; Karoor, V.; Mozer, A.B.; Hudish, T.M.; Le, M.; Miller, Y.E.
Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression
Lung Cancer
70
37-42
2010
Mus musculus
Galan, M.; Miguel, M.; Beltran, A.E.; Rodriguez, C.; Garcia-Redondo, A.B.; Rodriguez-Calvo, R.; Alonso, M.J.; Martinez-Gonzalez, J.; Salaices, M.
Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli
J. Hypertens.
29
529-536
2011
Rattus norvegicus
Lian, W.S.; Cheng, W.T.; Cheng, C.C.; Hsiao, F.S.; Chen, J.J.; Cheng, C.F.; Wu, S.C.
In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice
Life Sci.
88
455-464
2011
Homo sapiens (Q16647)
Chao, W.C.; Lu, J.F.; Wang, J.S.; Yang, H.C.; Chen, H.H.; Lan, Y.K.; Yu, Y.C.; Chou, P.T.; Wang, L.H.
Probing the interaction between prostacyclin synthase and prostaglandin H2 analogues or inhibitors via a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches
J. Am. Chem. Soc.
133
18870-18879
2011
Danio rerio, Homo sapiens
Tsai, M.J.; Huang, C.T.; Huang, Y.S.; Weng, C.F.; Shyue, S.K.; Huang, M.C.; Liou, D.Y.; Lin, Y.R.; Cheng, C.H.; Kuo, H.S.; Lin, Y.; Lee, M.J.; Huang, W.H.; Huang, W.C.; Cheng, H.
Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair
J. Biomed. Sci.
24
34
2017
Rattus norvegicus
Camacho, M.; Pineiro, Z.; Alcolea, S.; Garcia, J.; Balart, J.; Terra, X.; Aviles-Jurado, F.X.; Soler, M.; Quer, M.; Leon, X.; Vila, L.
Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy
J. Pathol.
235
125-135
2015
Homo sapiens
Yang, H.C.; Yang, C.H.; Huang, M.Y.; Lu, J.F.; Wang, J.S.; Yeh, Y.Q.; Jeng, U.S.
Homology modeling and molecular dynamics simulation combined with X-ray solution scattering defining protein structures of thromboxane and prostacyclin synthases
J. Phys. Chem. B
121
11229-11240
2017
Homo sapiens
Klein, T.; Klaus, G.; Koemhoff, M.
Prostacyclin synthase upregulation during renal development and in glomerular disease as well as its constitutive expression in cultured human mesangial cells
Mediators Inflamm.
2015
654151
2015
Homo sapiens
Sasaki, Y.; Ochiai, T.; Takamura, M.; Kondo, Y.; Yokoyama, C.; Hara, S.
Role of prostacyclin synthase in carcinogenesis
Prostaglandins Other Lipid Mediat.
133
49-52
2017
Homo sapiens
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