Information on EC 5.3.3.8 - DELTA3-DELTA2-enoyl-CoA isomerase

for references in articles please use BRENDA:EC5.3.3.8
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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomerase
IUBMB Comments
The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C3, which cannot be processed further by the regular enzymes of the beta-oxidation system. This enzyme isomerizes the bond to a trans bond at position C2, which can be processed further. The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. The enzyme can also catalyse the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
eci1p, delta3,delta2-enoyl-coa isomerase, 3,2-trans-enoyl-coa isomerase, ateci3, ateci2, delta3-delta2-enoyl-coa isomerase, ateci1, 3-cis-2-trans-enoyl-coa isomerase, 2,3-enoyl-coa isomerase, 3-2trans-enoyl-coa isomerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
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a (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
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